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Article

Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer

  • Authors:
    • Jin‑Lai Wei
    • Zhong‑Xue Fu
    • Min Fang
    • Jin‑Bao Guo
    • Qing‑Ning Zhao
    • Wei‑Dong Lu
    • Qiu‑Yuan Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China, Department of Emergency and Intensive Care Unit, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China, Department of Pathology, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China, Department of Pathology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200080, P.R. China
  • Pages: 1349-1357
    |
    Published online on: December 30, 2014
       https://doi.org/10.3892/or.2014.3701
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Abstract

Sestrin 2 is a conserved antioxidant protein that is involved in p53‑dependent antioxidant defenses and protects cells against oxidative stresses. The present study was conducted to examine the expression of sestrin 2 in colorectal cancer (CRC) and investigate a possible relationship between sestrin 2 expression and prognosis in CRC. The expression of sestrin 2 in human CRC tissues and cell lines was evaluated by immunohistochemical or immunofluorescent staining and western blot analysis. The correlations between sestrin 2 expression in human CRC tissues and clinicopathological variables, including overall survival (OS) and disease‑free survival (DFS), were analyzed. Both human CRC tissues and cell lines showed a decreased expression of sestrin 2. Furthermore, a low expression of sestrin 2 was significantly correlated with advanced tumor stage, lymphatic invasion, lymph node metastasis, vascular invasion and liver metastasis. Survival analysis showed that patients with low sestrin 2 staining had a significantly worse DFS and OS. Additionally, early or advanced stage CRC patients with a low expression of sestrin 2 had a shorter survival. In univariate analysis, the patients with low sestrin 2 expression, advanced tumor stage, lymphatic invasion, lymphatic node metastasis, vascular invasion, liver metastasis and peritoneal metastasis had shorter OS and DFS. In multivariate analysis, only low sestrin 2 expression, advanced tumor stage, lymphatic node metastasis, vascular invasion and liver metastasis remained as independent prognostic factors of poor OS and DFS. The findings suggested that a decreased expression of sestrin 2 is associated with an unfavorable prognosis, which suggests that it is a novel and crucial predictor for CRC metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Wei JL, Fu ZX, Fang M, Guo JB, Zhao QN, Lu WD and Zhou QY: Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer. Oncol Rep 33: 1349-1357, 2015.
APA
Wei, J., Fu, Z., Fang, M., Guo, J., Zhao, Q., Lu, W., & Zhou, Q. (2015). Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer. Oncology Reports, 33, 1349-1357. https://doi.org/10.3892/or.2014.3701
MLA
Wei, J., Fu, Z., Fang, M., Guo, J., Zhao, Q., Lu, W., Zhou, Q."Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer". Oncology Reports 33.3 (2015): 1349-1357.
Chicago
Wei, J., Fu, Z., Fang, M., Guo, J., Zhao, Q., Lu, W., Zhou, Q."Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer". Oncology Reports 33, no. 3 (2015): 1349-1357. https://doi.org/10.3892/or.2014.3701
Copy and paste a formatted citation
x
Spandidos Publications style
Wei JL, Fu ZX, Fang M, Guo JB, Zhao QN, Lu WD and Zhou QY: Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer. Oncol Rep 33: 1349-1357, 2015.
APA
Wei, J., Fu, Z., Fang, M., Guo, J., Zhao, Q., Lu, W., & Zhou, Q. (2015). Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer. Oncology Reports, 33, 1349-1357. https://doi.org/10.3892/or.2014.3701
MLA
Wei, J., Fu, Z., Fang, M., Guo, J., Zhao, Q., Lu, W., Zhou, Q."Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer". Oncology Reports 33.3 (2015): 1349-1357.
Chicago
Wei, J., Fu, Z., Fang, M., Guo, J., Zhao, Q., Lu, W., Zhou, Q."Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer". Oncology Reports 33, no. 3 (2015): 1349-1357. https://doi.org/10.3892/or.2014.3701
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