|
1
|
Friedman HS, Kerby T and Calvert H:
Temozolomide and treatment of malignant glioma. Clin Cancer Res.
6:2585–2597. 2000.PubMed/NCBI
|
|
2
|
Gunther W, Pawlak E, Damasceno R, Arnold H
and Terzis AJ: Temozolomide induces apoptosis and senescence in
glioma cells cultured as multicellular spheroids. Br J Cancer.
88:463–469. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Knauth M, Wirtz CR, Tronnier VM, Aras N,
Kunze S and Sartor K: Intraoperative MR imaging increases the
extent of tumor resection in patients with high-grade gliomas. AJNR
Am J Neuroradiol. 20:1642–1646. 1999.PubMed/NCBI
|
|
4
|
Nakada M, Nakada S, Demuth T, Tran NL,
Hoelzinger DB and Berens ME: Molecular targets of glioma invasion.
Cell Mol Life Sci. 64:458–478. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Stupp R, Mason WP, van den Bent MJ, et al:
Radiotherapy plus concomitant and adjuvant temozolomide for
glioblastoma. N Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Burnet NG, Jefferies SJ, Benson RJ, Hunt
DP and Treasure FP: Years of life lost (YLL) from cancer is an
important measure of population burden - and should be considered
when allocating research funds. Br J Cancer. 92:241–245.
2005.PubMed/NCBI
|
|
7
|
Bocangel DB, Finkelstein S, Schold SC,
Bhakat KK, Mitra S and Kokkinakis DM: Multifaceted resistance of
gliomas to temozolomide. Clin Cancer Res. 8:2725–2734.
2002.PubMed/NCBI
|
|
8
|
Hegi ME, Diserens A, Gorlia T, et al: MGMT
gene silencing and benefit from temozolomide in glioblastoma. New
Engl J Med. 352:997–1003. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Conrad M and Sato H: The oxidative
stress-inducible cystine/glutamate antiporter, system x (c) (−):
cystine supplier and beyond. Amino Acids. 42:231–246. 2012.
View Article : Google Scholar
|
|
10
|
Sato H, Tamba M, Ishii T and Bannai S:
Cloning and expression of a plasma membrane cystine/glutamate
exchange transporter composed of two distinct proteins. J Biol
Chem. 274:11455–11458. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Okuno S, Sato H, Kuriyama-Matsumura K, et
al: Role of cystine transport in intracellular glutathione level
and cisplatin resistance in human ovarian cancer cell lines. Br J
Cancer. 88:951–956. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Lu SC: Glutathione synthesis. Biochim
Biophys Acta. 1830:3143–3153. 2013. View Article : Google Scholar :
|
|
13
|
Ye P, Mimura J, Okada T, et al: Nrf2- and
ATF4-dependent up-regulation of xCT modulates the sensitivity of
T24 bladder carcinoma cells to proteasome inhibition. Mol Cell
Biol. 34:3421–3434. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Toyoda M, Kaira K, Ohshima Y, et al:
Prognostic significance of amino-acid transporter expression (LAT1,
ASCT2, and xCT) in surgically resected tongue cancer. Br J Cancer.
110:2506–2513. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Yoshikawa M, Tsuchihashi K, Ishimoto T, et
al: xCT inhibition depletes CD44v-expressing tumor cells that are
resistant to EGFR-targeted therapy in head and neck squamous cell
carcinoma. Cancer Res. 73:1855–1866. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Guo W, Zhao Y, Zhang Z, et al: Disruption
of xCT inhibits cell growth via the ROS/autophagy pathway in
hepatocellular carcinoma. Cancer Lett. 312:55–61. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Chen RS, Song YM, Zhou ZY, et al:
Disruption of xCT inhibits cancer cell metastasis via the
caveolin-1/beta-catenin pathway. Oncogene. 28:599–609. 2009.
View Article : Google Scholar
|
|
18
|
Gout PW, Buckley AR, Simms CR and
Bruchovsky N: Sulfasalazine, a potent suppressor of lymphoma growth
by inhibition of the x(c)- cystine transporter: a new action for an
old drug. Leukemia. 15:1633–1640. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Robe PA, Martin DH, Nguyen-Khac MT, et al:
Early termination of ISRCTN45828668, a phase 1/2 prospective,
randomized study of sulfasalazine for the treatment of progressing
malignant gliomas in adults. BMC Cancer. 9:3722009. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Takeuchi S, Wada K, Nagatani K, Otani N,
Osada H and Nawashiro H: Sulfasalazine and temozolomide with
radiation therapy for newly diagnosed glioblastoma. Neurol India.
62:42–47. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Yagoda N, von Rechenberg M, Zaganjor E, et
al: RAS-RAF-MEK-dependent oxidative cell death involving
voltage-dependent anion channels. Nature. 447:864–868. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Dixon SJ, Lemberg KM, Lamprecht MR, et al:
Ferroptosis: an iron-dependent form of nonapoptotic cell death.
Cell. 149:1060–1072. PubMed/NCBI
|
|
23
|
Yang WS, SriRamaratnam R, Welsch ME, et
al: Regulation of ferroptotic cancer cell death by GPX4. Cell.
156:317–331. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Giordana L, Mantilla BS, Santana M, Silber
AM and Nowicki C: Cystathionine γ-lyase, an enzyme related to the
reverse transsulfuration pathway, is functional in Leishmania spp.
J Eukaryot Microbiol. 61:204–213. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Romero I, Téllez J, Yamanaka LE, Steindel
M, Romanha AJ and Grisard EC: Transsulfuration is an active pathway
for cysteine biosynthesis in Trypanosoma rangeli. Parasit Vectors.
7:1972014. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
McBean GJ: The transsulfuration pathway: a
source of cysteine for glutathione in astrocytes. Amino Acids.
42:199–205. 2012. View Article : Google Scholar
|
|
27
|
Manna P and Jain SK: Vitamin D
up-regulates glucose transporter 4 (GLUT4) translocation and
glucose utilization mediated by cystathionine-gamma-lyase (CSE)
activation and H2S formation in 3T3L1 adipocytes. J Biol Chem.
287:42324–42332. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Rao AM, Drake MR and Stipanuk MH: Role of
the transsulfuration pathway and of gamma-cystathionase activity in
the formation of cysteine and sulfate from methionine in rat
hepatocytes. J Nutr. 120:837–845. 1990.PubMed/NCBI
|
|
29
|
Liu G, Casqueiro J, Bañuelos O, Cardoza
RE, Gutiérrez S and Martín JF: Targeted inactivation of the mecB
gene, encoding cystathionine-gamma-lyase, shows that the reverse
transsulfuration pathway is required for high-level cephalosporin
biosynthesis in Acremonium chrysogenum C10 but not for methionine
induction of the cephalosporin genes. J Bacteriol. 183:1765–1772.
2001. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Yang G, Cao K, Wu L and Wang R:
Cystathionine gamma-lyase overexpression inhibits cell
proliferation via a H2S-dependent modulation of ERK1/2
phosphorylation and p21Cip/WAK-1. J Biol Chem. 279:49199–49205.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Sasaki H, Sato H, Kuriyama-Matsumura K, et
al: Electrophile response element-mediated induction of the
cystine/glutamate exchange transporter gene expression. J Biol
Chem. 277:44765–44771. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Wu G, Fang YZ, Yang S, Lupton JR and
Turner ND: Glutathione metabolism and its implications for health.
J Nutr. 134:489–492. 2004.PubMed/NCBI
|
|
33
|
Chung WJ and Sontheimer H: Sulfasalazine
inhibits the growth of primary brain tumors independent of nuclear
factor-kappaB. J Neurochem. 110:182–193. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Kandil S, Brennan L and McBean GJ:
Glutathione depletion causes a JNK and p38MAPK-mediated increase in
expression of cystathionine-gamma-lyase and upregulation of the
transsulfuration pathway in C6 glioma cells. Neurochem Int.
56:611–619. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Hottinger AF, Aissa AB, Espeli V, et al:
Phase I study of sorafenib combined with radiation therapy and
temozolomide as first-line treatment of high-grade glioma. Br J
Cancer. 110:2655–2661. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Bartels U, Wolff J, Gore L, et al: Phase 2
study of safety and efficacy of nimotuzumab in pediatric patients
with progressive diffuse intrinsic pontine glioma. Neuro Oncol.
16:1554–1559. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Margison GP and Santibanez-Koref MF:
O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and
chemotherapy. Bioessays. 24:255–266. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Zhang J, Stevens MF and Bradshaw TD:
Temozolomide: mechanisms of action, repair and resistance. Curr Mol
Pharmacol. 5:102–114. 2012. View Article : Google Scholar
|
|
39
|
She X, Yu Z, Cui Y, et al: miR-128 and
miR-149 enhance the chemosensitivity of temozolomide by
Rap1B-mediated cytoskeletal remodeling in glioblastoma. Oncol Rep.
32:957–964. 2014.PubMed/NCBI
|
|
40
|
Lin CJ, Lee CC, Shih YL, et al:
Resveratrol enhances the therapeutic effect of temozolomide against
malignant glioma in vitro and in vivo by inhibiting autophagy. Free
Radic Biol Med. 52:377–391. 2012. View Article : Google Scholar
|
|
41
|
Yin H, Zhou Y, Wen C, et al: Curcumin
sensitizes glioblastoma to temozolomide by simultaneously
generating ROS and disrupting AKT/mTOR signaling. Oncol Rep.
32:1610–1616. 2014.PubMed/NCBI
|
|
42
|
Dai L, Cao Y, Chen Y, Parsons C and Qin Z:
Targeting xCT, a cystine-glutamate transporter induces apoptosis
and tumor regression for KSHV/HIV-associated lymphoma. J Hematol
Oncol. 7:302014. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Doxsee DW, Gout PW, Kurita T, et al:
Sulfasalazine-induced cystine starvation: potential use for
prostate cancer therapy. Prostate. 67:162–171. 2007. View Article : Google Scholar
|
|
44
|
Ehren JL and Maher P: Concurrent
regulation of the transcription factors Nrf2 and ATF4 mediates the
enhancement of glutathione levels by the flavonoid fisetin. Biochem
Pharmacol. 85:1816–1826. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Dickhout JG, Carlisle RE, Jerome DE, et
al: Integrated stress response modulates cellular redox state via
induction of cystathionine gamma-lyase: cross-talk between
integrated stress response and thiol metabolism. J Biol Chem.
287:7603–7614. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Yang BC, Wang YS, Liu HS and Lin SJ: Ras
signaling is involved in the expression of Fas-L in glioma. Lab
Invest. 80:529–537. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Bermano G, Smyth E, Goua M, Heys SD and
Wahle KW: Impaired expression of glutathione peroxidase-4 gene in
peripheral blood mononuclear cells: a biomarker of increased breast
cancer risk. Cancer Biomark. 7:39–46. 2010.PubMed/NCBI
|
|
48
|
Schneider M, Wortmann M, Mandal PK, et al:
Absence of Absence of glutathione peroxidase 4 affects tumor
angiogenesis through increased 12/15-lipoxygenase activity.
Neoplasia. 12:254–263. 2010.PubMed/NCBI
|
