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Article

p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB

  • Authors:
    • Quan Zhang
    • Li-Ye Cao
    • Shu-Jie Cheng
    • Ai-Min Zhang
    • Xiao-Shi Jin
    • Yong Li
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China, Department of Ultrasound, The Affiliated Hospital of Hebei University, Baoding, Hebei, P.R. China, Department of Surgery, The Affiliated Hospital of Hebei University, Baoding, Hebei, P.R. China
  • Pages: 1335-1341
    |
    Published online on: January 14, 2015
       https://doi.org/10.3892/or.2015.3715
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Abstract

In recent years, miR-1246 has been identified as a transcriptional target of p53 in Down syndrome and may provide a new p53-miR-1246-DYRK1A-NFAT pathway in cancer. The present study aimed to explore the role of miR-1246 in the tumorigenesis of human hepatocellular carcinoma (HCC). We found that wild-type p53 regulated the expression of miR-1246 in HCC cell lines, and alteration of miR-1246 modulated cell proliferation, colony formation ability and apoptosis. The nuclear factor I/B (NFIB), an oncogene, was identified as a direct target gene of miR-1246 using a fluorescent reporter assay. Overexpression of NFIB abolished the regulation of cell apoptosis caused by miR-1246 in HepG2 cells. This finding suggests that miR-1246 is regulated by p53 and suppresses the growth of human HCC by targeting NFIB. Here, we propose a new p53-miR-1246-NFIB pathway in HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Cao L, Cheng S, Zhang A, Jin X and Li Y: p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB. Oncol Rep 33: 1335-1341, 2015.
APA
Zhang, Q., Cao, L., Cheng, S., Zhang, A., Jin, X., & Li, Y. (2015). p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB. Oncology Reports, 33, 1335-1341. https://doi.org/10.3892/or.2015.3715
MLA
Zhang, Q., Cao, L., Cheng, S., Zhang, A., Jin, X., Li, Y."p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB". Oncology Reports 33.3 (2015): 1335-1341.
Chicago
Zhang, Q., Cao, L., Cheng, S., Zhang, A., Jin, X., Li, Y."p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB". Oncology Reports 33, no. 3 (2015): 1335-1341. https://doi.org/10.3892/or.2015.3715
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Cao L, Cheng S, Zhang A, Jin X and Li Y: p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB. Oncol Rep 33: 1335-1341, 2015.
APA
Zhang, Q., Cao, L., Cheng, S., Zhang, A., Jin, X., & Li, Y. (2015). p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB. Oncology Reports, 33, 1335-1341. https://doi.org/10.3892/or.2015.3715
MLA
Zhang, Q., Cao, L., Cheng, S., Zhang, A., Jin, X., Li, Y."p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB". Oncology Reports 33.3 (2015): 1335-1341.
Chicago
Zhang, Q., Cao, L., Cheng, S., Zhang, A., Jin, X., Li, Y."p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB". Oncology Reports 33, no. 3 (2015): 1335-1341. https://doi.org/10.3892/or.2015.3715
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