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Article

Upregulated Annexin A1 promotes cellular invasion in triple-negative breast cancer

  • Authors:
    • Maiko Okano
    • Kensuke Kumamoto
    • Motonobu Saito
    • Hisashi Onozawa
    • Katsuharu Saito
    • Noriko Abe
    • Tohru Ohtake
    • Seiichi Takenoshita
  • View Affiliations / Copyright

    Affiliations: Department of Organ Regulatory Surgery, Fukushima Medical University School of Medicine, Fukushima 960‑1295, Japan
  • Pages: 1064-1070
    |
    Published online on: January 14, 2015
       https://doi.org/10.3892/or.2015.3720
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Abstract

Annexin A1 (ANXA1) is a calcium-dependent phospholipid-linked protein, involved in anti-inflammatory effects, regulation of cellular differentiation, proliferation and apoptosis. While many studies have investigated the ANXA1 expression in various tumor types, the role of ANXA1 is not fully understood. Therefore, in the present study, we evaluated the ANXA1 expression in 211 breast cancer patients and compared the levels with clinicopathological factors. ANXA1 was positively expressed in 31 (14.7%) of the 211 cases in our cohort, and these positive cases were associated with triple-negative breast cancer (TNBC) (P=0.007) and venous invasion (P=0.028). The in vitro cell experiment found that the MDA-MB-231 cell line, which is a TNBC cell line, highly expressed ANXA1. Using this cell line, the functional role of ANXA1 in breast cancer was revealed and the knockdown of ANXA1 by specific siRNA demonstrated a significant reduction in cellular invasion. Further experiments indicated that ANXA1 was induced by hypoxia with hypoxia-inducible factor-1α induction. These results suggested that ANXA1, which enhanced breast cancer invasion and metastasis under hypoxia, were significantly associated with the worst patient outcome. This is particularly noted in TNBC, the group of breast cancer with the worst outcome for which new therapeutic implications are required.
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Copy and paste a formatted citation
Spandidos Publications style
Okano M, Kumamoto K, Saito M, Onozawa H, Saito K, Abe N, Ohtake T and Takenoshita S: Upregulated Annexin A1 promotes cellular invasion in triple-negative breast cancer. Oncol Rep 33: 1064-1070, 2015.
APA
Okano, M., Kumamoto, K., Saito, M., Onozawa, H., Saito, K., Abe, N. ... Takenoshita, S. (2015). Upregulated Annexin A1 promotes cellular invasion in triple-negative breast cancer. Oncology Reports, 33, 1064-1070. https://doi.org/10.3892/or.2015.3720
MLA
Okano, M., Kumamoto, K., Saito, M., Onozawa, H., Saito, K., Abe, N., Ohtake, T., Takenoshita, S."Upregulated Annexin A1 promotes cellular invasion in triple-negative breast cancer". Oncology Reports 33.3 (2015): 1064-1070.
Chicago
Okano, M., Kumamoto, K., Saito, M., Onozawa, H., Saito, K., Abe, N., Ohtake, T., Takenoshita, S."Upregulated Annexin A1 promotes cellular invasion in triple-negative breast cancer". Oncology Reports 33, no. 3 (2015): 1064-1070. https://doi.org/10.3892/or.2015.3720
Copy and paste a formatted citation
x
Spandidos Publications style
Okano M, Kumamoto K, Saito M, Onozawa H, Saito K, Abe N, Ohtake T and Takenoshita S: Upregulated Annexin A1 promotes cellular invasion in triple-negative breast cancer. Oncol Rep 33: 1064-1070, 2015.
APA
Okano, M., Kumamoto, K., Saito, M., Onozawa, H., Saito, K., Abe, N. ... Takenoshita, S. (2015). Upregulated Annexin A1 promotes cellular invasion in triple-negative breast cancer. Oncology Reports, 33, 1064-1070. https://doi.org/10.3892/or.2015.3720
MLA
Okano, M., Kumamoto, K., Saito, M., Onozawa, H., Saito, K., Abe, N., Ohtake, T., Takenoshita, S."Upregulated Annexin A1 promotes cellular invasion in triple-negative breast cancer". Oncology Reports 33.3 (2015): 1064-1070.
Chicago
Okano, M., Kumamoto, K., Saito, M., Onozawa, H., Saito, K., Abe, N., Ohtake, T., Takenoshita, S."Upregulated Annexin A1 promotes cellular invasion in triple-negative breast cancer". Oncology Reports 33, no. 3 (2015): 1064-1070. https://doi.org/10.3892/or.2015.3720
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