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Article

Cycloartan-24-ene-1α,2α,3β-triol, a cycloartane-type triterpenoid from the resinous exudates of Commiphora myrrha, induces apoptosis in human prostatic cancer PC-3 cells

  • Authors:
    • Wenyan Gao
    • Xiaojie Su
    • Xiaoyan Dong
    • Yingli Chen
    • Chunlan Zhou
    • Ping Xin
    • Chunhao Yu
    • Taiming Wei
  • View Affiliations / Copyright

    Affiliations: Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University-Daqing, Daqing, Heilongjiang 163000, P.R. China, School of Life Science and Chemical Engineering, Huaiyin Institute of Technology, Huaian, Jiangsu 223003, P.R. China
  • Pages: 1107-1114
    |
    Published online on: January 15, 2015
       https://doi.org/10.3892/or.2015.3725
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Abstract

Plant-derived antitumor drugs are currently used in chemotherapy. Cycloartane triterpenoids have shown a cytotoxic effect on human prostate cancer cells. The aim of the present study was to isolate a cycloartane triterpenoid from Commiphora myrrha and evaluate its anticancer potential. Cycloartan-24-ene-1α,2α,3β-triol (MY-1) was isolated from Commiphora myrrha, and its structure was determined through 1H and 13C nuclear magnetic resonance spectroscopy. The cytotoxic and apoptotic effects of MY-1 on human prostatic cancer PC-3 cells were estimated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometric analysis and terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) staining assay, and the expression of apoptotic-related proteins were evaluated by western blotting. MY-1 showed cytotoxic activity on PC-3 cells in a concentration-dependent manner with an IC50 value of 9.6 µM at 24 h. MY-1 induced cell cycle arrest and apoptosis. Western blot analysis revealed that MY-1 regulated the expression levels of B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), p53 and caspase-3 in the PC-3 cells. These findings indicate that MY-1 exerts significantly pro-apoptotic activity against human hormone-independent prostatic cancer and support MY-1 as a potential anticancer drug.
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Copy and paste a formatted citation
Spandidos Publications style
Gao W, Su X, Dong X, Chen Y, Zhou C, Xin P, Yu C and Wei T: Cycloartan-24-ene-1α,2α,3β-triol, a cycloartane-type triterpenoid from the resinous exudates of Commiphora myrrha, induces apoptosis in human prostatic cancer PC-3 cells. Oncol Rep 33: 1107-1114, 2015.
APA
Gao, W., Su, X., Dong, X., Chen, Y., Zhou, C., Xin, P. ... Wei, T. (2015). Cycloartan-24-ene-1α,2α,3β-triol, a cycloartane-type triterpenoid from the resinous exudates of Commiphora myrrha, induces apoptosis in human prostatic cancer PC-3 cells. Oncology Reports, 33, 1107-1114. https://doi.org/10.3892/or.2015.3725
MLA
Gao, W., Su, X., Dong, X., Chen, Y., Zhou, C., Xin, P., Yu, C., Wei, T."Cycloartan-24-ene-1α,2α,3β-triol, a cycloartane-type triterpenoid from the resinous exudates of Commiphora myrrha, induces apoptosis in human prostatic cancer PC-3 cells". Oncology Reports 33.3 (2015): 1107-1114.
Chicago
Gao, W., Su, X., Dong, X., Chen, Y., Zhou, C., Xin, P., Yu, C., Wei, T."Cycloartan-24-ene-1α,2α,3β-triol, a cycloartane-type triterpenoid from the resinous exudates of Commiphora myrrha, induces apoptosis in human prostatic cancer PC-3 cells". Oncology Reports 33, no. 3 (2015): 1107-1114. https://doi.org/10.3892/or.2015.3725
Copy and paste a formatted citation
x
Spandidos Publications style
Gao W, Su X, Dong X, Chen Y, Zhou C, Xin P, Yu C and Wei T: Cycloartan-24-ene-1α,2α,3β-triol, a cycloartane-type triterpenoid from the resinous exudates of Commiphora myrrha, induces apoptosis in human prostatic cancer PC-3 cells. Oncol Rep 33: 1107-1114, 2015.
APA
Gao, W., Su, X., Dong, X., Chen, Y., Zhou, C., Xin, P. ... Wei, T. (2015). Cycloartan-24-ene-1α,2α,3β-triol, a cycloartane-type triterpenoid from the resinous exudates of Commiphora myrrha, induces apoptosis in human prostatic cancer PC-3 cells. Oncology Reports, 33, 1107-1114. https://doi.org/10.3892/or.2015.3725
MLA
Gao, W., Su, X., Dong, X., Chen, Y., Zhou, C., Xin, P., Yu, C., Wei, T."Cycloartan-24-ene-1α,2α,3β-triol, a cycloartane-type triterpenoid from the resinous exudates of Commiphora myrrha, induces apoptosis in human prostatic cancer PC-3 cells". Oncology Reports 33.3 (2015): 1107-1114.
Chicago
Gao, W., Su, X., Dong, X., Chen, Y., Zhou, C., Xin, P., Yu, C., Wei, T."Cycloartan-24-ene-1α,2α,3β-triol, a cycloartane-type triterpenoid from the resinous exudates of Commiphora myrrha, induces apoptosis in human prostatic cancer PC-3 cells". Oncology Reports 33, no. 3 (2015): 1107-1114. https://doi.org/10.3892/or.2015.3725
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