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Article

Silencing NOB1 enhances doxorubicin antitumor activity of the papillary thyroid carcinoma in vitro and in vivo

Retraction in: /10.3892/or.2022.8297
  • Authors:
    • Jia Liu
    • Bing-Fei Dong
    • Pei-Song Wang
    • Pei-You Ren
    • Shuai Xue
    • Xiao-Νan Zhang
    • Zhe Han
    • Guang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Thyroid Surgery, The First Bethune Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 1551-1559
    |
    Published online on: January 15, 2015
       https://doi.org/10.3892/or.2015.3730
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Abstract

Doxorubicin (DOX), a broad‑spectrum anthra­cyclin, is in wide clinical use for the treatment and prevention of thyroid cancer. However, the effectiveness of the treatment remains limited due to inherent tumor resistance to DOX. Results of a previous study demonstrated that downregulation of NIN1/RPN12 binding protein 1 homolog (NOB1) expression via adenovirus expression vector carrying NOB1 siRNA (Ad/sh-NOB1) induced cancer apoptosis and increased the radiosensitivity of papillary thyroid carcinoma (PTC) cells. However, whether knockout NOB1 can decrease DOX resistance remains unclear. Therefore, in the present study, the effect of Ad/sh-NOB1 infection, independently or in combination with DOX, was determined in a PTC cell line to identify more effective therapeutics against PTC cancer. Furthermore, tumor growth ability in nude mice was determined to identify the combination treatment effect in tumorigenesis in vivo. The results showed that Ad/sh-NOB1 combined with DOX treatment in PTC cells significantly suppressed proliferation, colony formation, migration and invasion, and induced cell apoptosis and arrest in the G0/G1 stage as compared to Ad/sh-NOB1 or DOX monotherapy. We also found that this combination suppressed the tumor growth of a nude mouse model as compared to Ad/sh-NOB1 or DOX monotherapy. In addition, Ad/sh-NOB1 combined with DOX treatment significantly increased activation of the p38 MAPK pathway, which may contribute to inhibition of PTC cell growth and decreased DOX resistance. Taken together, the experimental results indicate that Ad/sh-NOB1 combined with DOX treatment is a potential drug candidate for the treatment of papillary thyroid carcinoma.
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View References

1 

Brown RL, de Souza JA and Cohen EE: Thyroid cancer: burden of illness and management of disease. J Cancer. 2:193–199. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Pitoia F, Bueno F, Urciuoli C, Abelleira E, Cross G and Tuttle RM: Outcomes of patients with differentiated thyroid cancer risk-stratified according to the American thyroid association and Latin American thyroid society risk of recurrence classification systems. Thyroid. 23:1401–1407. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Thompson L: World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Ear Nose Throat J. 85:742006.PubMed/NCBI

4 

Nikiforova MN and Nikiforov YE: Molecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosis. Expert Rev Mol Diagn. 8:83–95. 2008. View Article : Google Scholar

5 

Carvalho C, Santos RX, Cardoso S, et al: Doxorubicin: the good, the bad and the ugly effect. Curr Med Chem. 16:3267–3285. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Gottesman MM, Fojo T and Bates SE: Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer. 2:48–58. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Silber JH and Barber G: Doxorubicin-induced cardiotoxicity. N Engl J Med. 333:1359–1360. 1995. View Article : Google Scholar : PubMed/NCBI

8 

King PD and Perry MC: Hepatotoxicity of chemotherapy. Oncologist. 6:162–176. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Zhang Y, Ni J, Zhou G, et al: Cloning, expression and characterization of the human NOB1 gene. Mol Biol Rep. 32:185–189. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Arcus VL, Bäckbro K, Roos A, Daniel EL and Baker EN: Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease. J Biol Chem. 279:16471–16478. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Lin Y, Peng S, Yu H, et al: RNAi-mediated downregulation of NOB1 suppresses the growth and colony-formation ability of human ovarian cancer cells. Med Oncol. 29:311–317. 2012. View Article : Google Scholar

12 

Che JP, Li W, Yan Y, et al: Expression and clinical significance of the nin one binding protein and p38 MAPK in prostate carcinoma. Int J Clin Exp Pathol. 6:2300–2311. 2013.PubMed/NCBI

13 

Li XY, Luo QF, Li J, et al: Clinical significance of NOB1 expression in breast infiltrating ductal carcinoma. Int J Clin Exp Pathol. 6:2137–2144. 2013.PubMed/NCBI

14 

Li Y, Ma C, Qian M, Wen Z, Jing H and Qian D: Downregulation of NOB1 suppresses the proliferation and tumor growth of non-small cell lung cancer in vitro and in vivo. Oncol Rep. 31:1271–1276. 2014.PubMed/NCBI

15 

Huang WY, Chen DH, Ning L and Wang LW: siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells. Asian Pac J Cancer Prev. 13:1823–1827. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Lu Z, Guo Q, Shi A, et al: Downregulation of NIN/RPN12 binding protein inhibit the growth of human hepatocellular carcinoma cells. Mol Biol Rep. 39:501–507. 2012. View Article : Google Scholar

17 

Lin S, Meng W, Zhang W, et al: Expression of the NOB1 gene and its clinical significance in papillary thyroid carcinoma. J Int Med Res. 41:568–572. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Meng W, Wang PS, Liu J, et al: Adenovirus-mediated siRNA targeting NOB1 inhibits tumor growth and enhances radiosensitivity of human papillary thyroid carcinoma in vitro and in vivo. Oncol Rep. 32:2411–2420. 2014.PubMed/NCBI

19 

Abe S, Nishimoto Y, Isu K, Ishii T and Goto T; Japanese Musculoskeletal Oncology Group. Preoperative cisplatin for initial treatment of limb osteosarcoma: its local effect and impact on prognosis. Cancer Chemother Pharmacol. 50:320–324. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Zhao BX, Sun YB, Wang SQ, et al: Grape seed procyanidin reversal of P-glycoprotein associated multi-drug resistance via down-regulation of NF-κB and MAPK/ERK mediated YB-1 activity in A2780/T cells. PLoS One. 8:e710712013. View Article : Google Scholar

21 

el-Deiry WS: Role of oncogenes in resistance and killing by cancer therapeutic agents. Curr Opin Oncol. 9:79–87. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Tone Y and Toh-E A: Nob1p is required for biogenesis of the 26S proteasome and degraded upon its maturation in Saccharomyces cerevisiae. Genes Dev. 16:3142–3157. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Tone Y, Tanahashi N, Tanaka K, Fujimuro M, Yokosawa H and Toh-E A: Nob1p, a new essential protein, associates with the 26S proteasome of growing Saccharomyces cerevisiae cells. Gene. 243:37–45. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Xu G, Bernaudo S, Fu G, et al: Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7. Mol Biol Cell. 19:4968–4979. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Pandit B and Gartel AL: Thiazole antibiotic thiostrepton synergize with bortezomib to induce apoptosis in cancer cells. PLoS One. 6:e171102011. View Article : Google Scholar : PubMed/NCBI

26 

Piperdi B, Ling YH, Liebes L, Muggia F and Perez-Soler R: Bortezomib: understanding the mechanism of action. Mol Cancer Ther. 10:2029–2030. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Dick LR and Fleming PE: Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy. Drug Discov Today. 15:243–249. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Elbashir SM, Harborth J, Weber K and Tuschl T: Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods. 26:199–213. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Dhillon AS, Hagan S, Rath O and Kolch W: MAP kinase signalling pathways in cancer. Oncogene. 26:3279–3290. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Zhou J, Xu T, Yan Y, et al: MicroRNA-326 functions as a tumor suppressor in glioma by targeting the Nin one binding protein (NOB1). PLoS One. 8:e684692013. View Article : Google Scholar : PubMed/NCBI

31 

Li W, Liu M, Feng Y, et al: Downregulated miR-646 in clear cell renal carcinoma correlated with tumour metastasis by targeting the nin one binding protein (NOB1). Br J Cancer. 111:1188–1200. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Dong B, Wang P, Ren P, Xue S, Zhang X, Han Z and Chen G: Silencing NOB1 enhances doxorubicin antitumor activity of the papillary thyroid carcinoma in vitro and in vivo Retraction in /10.3892/or.2022.8297. Oncol Rep 33: 1551-1559, 2015.
APA
Liu, J., Dong, B., Wang, P., Ren, P., Xue, S., Zhang, X. ... Chen, G. (2015). Silencing NOB1 enhances doxorubicin antitumor activity of the papillary thyroid carcinoma in vitro and in vivo Retraction in /10.3892/or.2022.8297. Oncology Reports, 33, 1551-1559. https://doi.org/10.3892/or.2015.3730
MLA
Liu, J., Dong, B., Wang, P., Ren, P., Xue, S., Zhang, X., Han, Z., Chen, G."Silencing NOB1 enhances doxorubicin antitumor activity of the papillary thyroid carcinoma in vitro and in vivo Retraction in /10.3892/or.2022.8297". Oncology Reports 33.3 (2015): 1551-1559.
Chicago
Liu, J., Dong, B., Wang, P., Ren, P., Xue, S., Zhang, X., Han, Z., Chen, G."Silencing NOB1 enhances doxorubicin antitumor activity of the papillary thyroid carcinoma in vitro and in vivo Retraction in /10.3892/or.2022.8297". Oncology Reports 33, no. 3 (2015): 1551-1559. https://doi.org/10.3892/or.2015.3730
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Dong B, Wang P, Ren P, Xue S, Zhang X, Han Z and Chen G: Silencing NOB1 enhances doxorubicin antitumor activity of the papillary thyroid carcinoma in vitro and in vivo Retraction in /10.3892/or.2022.8297. Oncol Rep 33: 1551-1559, 2015.
APA
Liu, J., Dong, B., Wang, P., Ren, P., Xue, S., Zhang, X. ... Chen, G. (2015). Silencing NOB1 enhances doxorubicin antitumor activity of the papillary thyroid carcinoma in vitro and in vivo Retraction in /10.3892/or.2022.8297. Oncology Reports, 33, 1551-1559. https://doi.org/10.3892/or.2015.3730
MLA
Liu, J., Dong, B., Wang, P., Ren, P., Xue, S., Zhang, X., Han, Z., Chen, G."Silencing NOB1 enhances doxorubicin antitumor activity of the papillary thyroid carcinoma in vitro and in vivo Retraction in /10.3892/or.2022.8297". Oncology Reports 33.3 (2015): 1551-1559.
Chicago
Liu, J., Dong, B., Wang, P., Ren, P., Xue, S., Zhang, X., Han, Z., Chen, G."Silencing NOB1 enhances doxorubicin antitumor activity of the papillary thyroid carcinoma in vitro and in vivo Retraction in /10.3892/or.2022.8297". Oncology Reports 33, no. 3 (2015): 1551-1559. https://doi.org/10.3892/or.2015.3730
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