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Article

Assessment of MLL methyltransferase gene expression in larynx carcinoma

  • Authors:
    • David Livingstone Alves Figueiredo
    • Doralina do Amaral Rabello
    • Dalila Luciola Zanette
    • Fabiano Pinto Saggioro
    • Rui Celso Martins Mamede
    • Marco Antonio Zago
    • Wilson Araújo da Silva
    • Felipe Saldanha-Araújo
    • Fabio Pittella Silva
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Pathology of Cancer, Faculty of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, Brasília, DF 70.910-900, Brazil, Center for Cell Therapy and Regional Blood Center, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP 14.048-900, Brazil, Department of Internal Medicine, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP 14.048-900, Brazil
  • Pages: 2017-2022
    |
    Published online on: January 28, 2015
       https://doi.org/10.3892/or.2015.3756
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Abstract

Larynx cancer is the second most common type of cancer among all head and neck cancers. Deregulation of epigenetic effectors, including altered expression of histone methyltransferases from the MLL (mixed lineage leukemia) family, have been reported in many cancer types, yet little is known concerning their involvement in larynx cancer. Our objective was to determine the expression profile of MLL genes in larynx carcinoma and normal adjacent tissues and correlate this profile to tumor characteristics. We analyzed the expression profile of 5 MLL genes in 13 cases of larynx carcinoma and their adjacent non-tumor tissues using quantitative real-time PCR. MLL3 was significantly downregulated in tumor samples compared to their normal counterparts, and all MLL genes showed decreased expression in advanced tumors compared to tumors in the initial stage. Altered expression in a single MLL gene was associated with a similar alteration in the other MLL genes, revealing a strong correlation of expression in each individual patient. In conclusion, MLL genes may have similar transcriptional control, and decreased expression of these genes may contribute to larynx cancer progression.
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Copy and paste a formatted citation
Spandidos Publications style
Figueiredo DL, Rabello Dd, Zanette DL, Saggioro FP, Mamede RC, Zago MA, da Silva WA, Saldanha-Araújo F and Pittella Silva F: Assessment of MLL methyltransferase gene expression in larynx carcinoma. Oncol Rep 33: 2017-2022, 2015.
APA
Figueiredo, D.L., Rabello, D.d., Zanette, D.L., Saggioro, F.P., Mamede, R.C., Zago, M.A. ... Pittella Silva, F. (2015). Assessment of MLL methyltransferase gene expression in larynx carcinoma. Oncology Reports, 33, 2017-2022. https://doi.org/10.3892/or.2015.3756
MLA
Figueiredo, D. L., Rabello, D. d., Zanette, D. L., Saggioro, F. P., Mamede, R. C., Zago, M. A., da Silva, W. A., Saldanha-Araújo, F., Pittella Silva, F."Assessment of MLL methyltransferase gene expression in larynx carcinoma". Oncology Reports 33.4 (2015): 2017-2022.
Chicago
Figueiredo, D. L., Rabello, D. d., Zanette, D. L., Saggioro, F. P., Mamede, R. C., Zago, M. A., da Silva, W. A., Saldanha-Araújo, F., Pittella Silva, F."Assessment of MLL methyltransferase gene expression in larynx carcinoma". Oncology Reports 33, no. 4 (2015): 2017-2022. https://doi.org/10.3892/or.2015.3756
Copy and paste a formatted citation
x
Spandidos Publications style
Figueiredo DL, Rabello Dd, Zanette DL, Saggioro FP, Mamede RC, Zago MA, da Silva WA, Saldanha-Araújo F and Pittella Silva F: Assessment of MLL methyltransferase gene expression in larynx carcinoma. Oncol Rep 33: 2017-2022, 2015.
APA
Figueiredo, D.L., Rabello, D.d., Zanette, D.L., Saggioro, F.P., Mamede, R.C., Zago, M.A. ... Pittella Silva, F. (2015). Assessment of MLL methyltransferase gene expression in larynx carcinoma. Oncology Reports, 33, 2017-2022. https://doi.org/10.3892/or.2015.3756
MLA
Figueiredo, D. L., Rabello, D. d., Zanette, D. L., Saggioro, F. P., Mamede, R. C., Zago, M. A., da Silva, W. A., Saldanha-Araújo, F., Pittella Silva, F."Assessment of MLL methyltransferase gene expression in larynx carcinoma". Oncology Reports 33.4 (2015): 2017-2022.
Chicago
Figueiredo, D. L., Rabello, D. d., Zanette, D. L., Saggioro, F. P., Mamede, R. C., Zago, M. A., da Silva, W. A., Saldanha-Araújo, F., Pittella Silva, F."Assessment of MLL methyltransferase gene expression in larynx carcinoma". Oncology Reports 33, no. 4 (2015): 2017-2022. https://doi.org/10.3892/or.2015.3756
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