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Article

AURKA upregulation plays a role in fibroblast-reduced gefitinib sensitivity in the NSCLC cell line HCC827

  • Authors:
    • Jia Chen
    • Huiqi Lu
    • Wang Zhou
    • Huabin Yin
    • Lishuang Zhu
    • Chang Liu
    • Pengfei Zhang
    • Huimin Hu
    • Yili Yang
    • Huanxing Han
  • View Affiliations / Copyright

    Affiliations: Translational Medicine Center, Changzheng Hospital, Affiliated to The Second Military Medical University, Shanghai, P.R. China, Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, P.R. China, Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, MD, USA
  • Pages: 1860-1866
    |
    Published online on: January 29, 2015
       https://doi.org/10.3892/or.2015.3764
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Abstract

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs) have been used to treat non-small cell lung carcinoma (NSCLC) patients that have EGFR-activating mutations. EGFR-TKI monotherapy in most NSCLC patients with EGFR mutations who initially respond to EGFR-TKIs results in the development of acquired resistance. We investigated the role of fibroblasts in stromal cell-mediated resistance to gefitinib-induced apoptosis in EGFR-mutant NSCLC cells. While gefitinib induced apoptosis in EGFR-mutant NSCLC cells, apoptosis induction was diminished under stromal co-culture conditions. Protection appeared to be mediated in part by Aurora-A kinase (AURKA) upregulation. The protective effect of stromal cells was significantly reduced by pre-exposure to AURKA-shRNA. We suggest that combinations of AURKA antagonists and EGFR inhibitors may be effective in clinical trials targeting mutant EGFR NSCLCs.
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Copy and paste a formatted citation
Spandidos Publications style
Chen J, Lu H, Zhou W, Yin H, Zhu L, Liu C, Zhang P, Hu H, Yang Y, Han H, Han H, et al: AURKA upregulation plays a role in fibroblast-reduced gefitinib sensitivity in the NSCLC cell line HCC827. Oncol Rep 33: 1860-1866, 2015.
APA
Chen, J., Lu, H., Zhou, W., Yin, H., Zhu, L., Liu, C. ... Han, H. (2015). AURKA upregulation plays a role in fibroblast-reduced gefitinib sensitivity in the NSCLC cell line HCC827. Oncology Reports, 33, 1860-1866. https://doi.org/10.3892/or.2015.3764
MLA
Chen, J., Lu, H., Zhou, W., Yin, H., Zhu, L., Liu, C., Zhang, P., Hu, H., Yang, Y., Han, H."AURKA upregulation plays a role in fibroblast-reduced gefitinib sensitivity in the NSCLC cell line HCC827". Oncology Reports 33.4 (2015): 1860-1866.
Chicago
Chen, J., Lu, H., Zhou, W., Yin, H., Zhu, L., Liu, C., Zhang, P., Hu, H., Yang, Y., Han, H."AURKA upregulation plays a role in fibroblast-reduced gefitinib sensitivity in the NSCLC cell line HCC827". Oncology Reports 33, no. 4 (2015): 1860-1866. https://doi.org/10.3892/or.2015.3764
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Lu H, Zhou W, Yin H, Zhu L, Liu C, Zhang P, Hu H, Yang Y, Han H, Han H, et al: AURKA upregulation plays a role in fibroblast-reduced gefitinib sensitivity in the NSCLC cell line HCC827. Oncol Rep 33: 1860-1866, 2015.
APA
Chen, J., Lu, H., Zhou, W., Yin, H., Zhu, L., Liu, C. ... Han, H. (2015). AURKA upregulation plays a role in fibroblast-reduced gefitinib sensitivity in the NSCLC cell line HCC827. Oncology Reports, 33, 1860-1866. https://doi.org/10.3892/or.2015.3764
MLA
Chen, J., Lu, H., Zhou, W., Yin, H., Zhu, L., Liu, C., Zhang, P., Hu, H., Yang, Y., Han, H."AURKA upregulation plays a role in fibroblast-reduced gefitinib sensitivity in the NSCLC cell line HCC827". Oncology Reports 33.4 (2015): 1860-1866.
Chicago
Chen, J., Lu, H., Zhou, W., Yin, H., Zhu, L., Liu, C., Zhang, P., Hu, H., Yang, Y., Han, H."AURKA upregulation plays a role in fibroblast-reduced gefitinib sensitivity in the NSCLC cell line HCC827". Oncology Reports 33, no. 4 (2015): 1860-1866. https://doi.org/10.3892/or.2015.3764
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