Inhibitory effect of maple syrup on the cell growth and invasion of human colorectal cancer cells

Yamamoto,Tetsushi; Uemura,Kentaro; Moriyama,Kaho; Mitamura,Kuniko; Taga,Atsushi

doi:10.3892/or.2015.3777

Inhibitory effect of maple syrup on the cell growth and invasion of human colorectal cancer cells

Authors:
- Tetsushi Yamamoto
- Kentaro Uemura
- Kaho Moriyama
- Kuniko Mitamura
- Atsushi Taga
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Affiliations: Pathological and Biomolecule Analyses Laboratory, Faculty of Pharmacy, Kinki University, Higashi-Osaka, Osaka 577-8502, Japan
Published online on: February 2, 2015 https://doi.org/10.3892/or.2015.3777
Pages: 1579-1584
Copyright: © Yamamoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Maple syrup is a natural sweetener consumed by individuals of all ages throughout the world. Maple syrup contains not only carbohydrates such as sucrose but also various components such as organic acids, amino acids, vitamins and phenolic compounds. Recent studies have shown that these phenolic compounds in maple syrup may possess various activities such as decreasing the blood glucose level and an anticancer effect. In this study, we examined the effect of three types of maple syrup, classified by color, on the cell proliferation, migration and invasion of colorectal cancer (CRC) cells in order to investigate whether the maple syrup is suitable as a phytomedicine for cancer treatment. CRC cells that were administered maple syrup showed significantly lower growth rates than cells that were administered sucrose. In addition, administration of maple syrup to CRC cells caused inhibition of cell invasion, while there was no effect on cell migration. Administration of maple syrup clearly inhibited AKT phosphorylation, while there was no effect on ERK phosphorylation. These data suggest that maple syrup might inhibit cell proliferation and invasion through suppression of AKT activation and be suitable as a phytomedicine for CRC treatment, with fewer adverse effects than traditional chemotherapy.

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