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High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia

  • Authors:
    • Jorge Organista-Nava
    • Yazmín Gómez-Gómez
    • Berenice Illades-Aguiar
    • Luz Del Carmen Alarcón-Romero
    • Mónica Virginia Saavedra-Herrera
    • Ana Bertha Rivera‑Ramírez
    • Víctor Hugo Garzón-Barrientos
    • Marco Antonio Leyva-Vázquez
  • View Affiliations / Copyright

    Affiliations: Institute of Cellular Physiology, National Autonomous University of Mexico (UNAM), University City, D.F., Mexico, Research Department, State Cancer Institute, ‘Arturo Beltran Ortega’, Acapulco, Guerrero, Mexico, Laboratory of Molecular Biomedicine, School of Chemical-Biological Sciences, Guerrero State University, Chilpancingo, Guerrero, Mexico, Laboratory of Cytopathology, School of Chemical-Biological Sciences, Guerrero State University, Chilpancingo, Guerrero, Mexico
    Copyright: © Organista-Nava et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1639-1649
    |
    Published online on: February 6, 2015
       https://doi.org/10.3892/or.2015.3787
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Abstract

MicroRNAs (miRNAs) play an essential role in the development and progression of acute leukemia (AL). miR-24 promotes the survival of hematopoietic cells. However, little is known concerning the function of miR-24 in human AL. The aim of the present study was to investigate the clinical significance of miR-24 expression in AL. miR-24 expression in 147 patients with AL and 100 healthy individuals was measured by quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR). The results showed that compared with the healthy individuals, the expression of miR-24 in AL patients was significantly higher (p<0.001). In addition, miR-24 was expressed at significantly higher levels in acute myeloid leukemia (AML) patients and at significantly lower levels in acute lymphoblastic leukemia (ALL) (p<0.001). More importantly, Kaplan-Meier analysis showed that AL patients with high miR-24 expression tended to have shorter overall survival (p<0.05). In the multivariate analysis stratified for known prognostic variables, miR-24 was identified as an independent prognostic marker. Our data indicated that miR-24 upregulation was associated with poor prognosis in AL. miR-24 was identified for the first time as an independent marker for predicting the clinical outcome of AL patients.
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Copy and paste a formatted citation
Spandidos Publications style
Organista-Nava J, Gómez-Gómez Y, Illades-Aguiar B, Del Carmen Alarcón-Romero L, Saavedra-Herrera MV, Rivera‑Ramírez AB, Garzón-Barrientos VH and Leyva-Vázquez MA: High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia. Oncol Rep 33: 1639-1649, 2015.
APA
Organista-Nava, J., Gómez-Gómez, Y., Illades-Aguiar, B., Del Carmen Alarcón-Romero, L., Saavedra-Herrera, M.V., Rivera‑Ramírez, A.B. ... Leyva-Vázquez, M.A. (2015). High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia. Oncology Reports, 33, 1639-1649. https://doi.org/10.3892/or.2015.3787
MLA
Organista-Nava, J., Gómez-Gómez, Y., Illades-Aguiar, B., Del Carmen Alarcón-Romero, L., Saavedra-Herrera, M. V., Rivera‑Ramírez, A. B., Garzón-Barrientos, V. H., Leyva-Vázquez, M. A."High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia". Oncology Reports 33.4 (2015): 1639-1649.
Chicago
Organista-Nava, J., Gómez-Gómez, Y., Illades-Aguiar, B., Del Carmen Alarcón-Romero, L., Saavedra-Herrera, M. V., Rivera‑Ramírez, A. B., Garzón-Barrientos, V. H., Leyva-Vázquez, M. A."High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia". Oncology Reports 33, no. 4 (2015): 1639-1649. https://doi.org/10.3892/or.2015.3787
Copy and paste a formatted citation
x
Spandidos Publications style
Organista-Nava J, Gómez-Gómez Y, Illades-Aguiar B, Del Carmen Alarcón-Romero L, Saavedra-Herrera MV, Rivera‑Ramírez AB, Garzón-Barrientos VH and Leyva-Vázquez MA: High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia. Oncol Rep 33: 1639-1649, 2015.
APA
Organista-Nava, J., Gómez-Gómez, Y., Illades-Aguiar, B., Del Carmen Alarcón-Romero, L., Saavedra-Herrera, M.V., Rivera‑Ramírez, A.B. ... Leyva-Vázquez, M.A. (2015). High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia. Oncology Reports, 33, 1639-1649. https://doi.org/10.3892/or.2015.3787
MLA
Organista-Nava, J., Gómez-Gómez, Y., Illades-Aguiar, B., Del Carmen Alarcón-Romero, L., Saavedra-Herrera, M. V., Rivera‑Ramírez, A. B., Garzón-Barrientos, V. H., Leyva-Vázquez, M. A."High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia". Oncology Reports 33.4 (2015): 1639-1649.
Chicago
Organista-Nava, J., Gómez-Gómez, Y., Illades-Aguiar, B., Del Carmen Alarcón-Romero, L., Saavedra-Herrera, M. V., Rivera‑Ramírez, A. B., Garzón-Barrientos, V. H., Leyva-Vázquez, M. A."High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia". Oncology Reports 33, no. 4 (2015): 1639-1649. https://doi.org/10.3892/or.2015.3787
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