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Article

OY-TES-1 may regulate the malignant behavior of liver cancer via NANOG, CD9, CCND2 and CDCA3: A bioinformatic analysis combine with RNAi and oligonucleotide microarray

  • Authors:
    • Qiping Hu
    • Jun Fu
    • Bin Luo
    • Miao Huang
    • Wenwen Guo
    • Yongda Lin
    • Xiaoxun Xie
    • Shaowen Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Histology and Embryology, School of Pre-Clinical Medicine, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Radiology, Affiliated Cancer Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Neurosurgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
  • Pages: 1965-1975
    |
    Published online on: February 10, 2015
       https://doi.org/10.3892/or.2015.3792
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Abstract

Given its tumor-specific expression, including liver cancer, OY-TES-1 is a potential molecular marker for the diagnosis and immunotherapy of liver cancers. However, investigations of the mechanisms and the role of OY-TES-1 in liver cancer are rare. In the present study, based on a comprehensive bioinformatic analysis combined with RNA interference (RNAi) and oligonucleotide microarray, we report for the first time that downregulation of OY-TES-1 resulted in significant changes in expression of NANOG, CD9, CCND2 and CDCA3 in the liver cancer cell line BEL-7404. NANOG, CD9, CCND2 and CDCA3 may be involved in cell proliferation, migration, invasion and apoptosis, yet also may be functionally related to each other and OY-TES-1. Among these molecules, we identified that NANOG, containing a Kazal-2 binding motif and homeobox, may be the most likely candidate protein interacting with OY-TES-1 in liver cancer. Thus, the present study may provide important information for further investigation of the roles of OY-TES-1 in liver cancer.
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Hu Q, Fu J, Luo B, Huang M, Guo W, Lin Y, Xie X and Xiao S: OY-TES-1 may regulate the malignant behavior of liver cancer via NANOG, CD9, CCND2 and CDCA3: A bioinformatic analysis combine with RNAi and oligonucleotide microarray. Oncol Rep 33: 1965-1975, 2015.
APA
Hu, Q., Fu, J., Luo, B., Huang, M., Guo, W., Lin, Y. ... Xiao, S. (2015). OY-TES-1 may regulate the malignant behavior of liver cancer via NANOG, CD9, CCND2 and CDCA3: A bioinformatic analysis combine with RNAi and oligonucleotide microarray. Oncology Reports, 33, 1965-1975. https://doi.org/10.3892/or.2015.3792
MLA
Hu, Q., Fu, J., Luo, B., Huang, M., Guo, W., Lin, Y., Xie, X., Xiao, S."OY-TES-1 may regulate the malignant behavior of liver cancer via NANOG, CD9, CCND2 and CDCA3: A bioinformatic analysis combine with RNAi and oligonucleotide microarray". Oncology Reports 33.4 (2015): 1965-1975.
Chicago
Hu, Q., Fu, J., Luo, B., Huang, M., Guo, W., Lin, Y., Xie, X., Xiao, S."OY-TES-1 may regulate the malignant behavior of liver cancer via NANOG, CD9, CCND2 and CDCA3: A bioinformatic analysis combine with RNAi and oligonucleotide microarray". Oncology Reports 33, no. 4 (2015): 1965-1975. https://doi.org/10.3892/or.2015.3792
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Spandidos Publications style
Hu Q, Fu J, Luo B, Huang M, Guo W, Lin Y, Xie X and Xiao S: OY-TES-1 may regulate the malignant behavior of liver cancer via NANOG, CD9, CCND2 and CDCA3: A bioinformatic analysis combine with RNAi and oligonucleotide microarray. Oncol Rep 33: 1965-1975, 2015.
APA
Hu, Q., Fu, J., Luo, B., Huang, M., Guo, W., Lin, Y. ... Xiao, S. (2015). OY-TES-1 may regulate the malignant behavior of liver cancer via NANOG, CD9, CCND2 and CDCA3: A bioinformatic analysis combine with RNAi and oligonucleotide microarray. Oncology Reports, 33, 1965-1975. https://doi.org/10.3892/or.2015.3792
MLA
Hu, Q., Fu, J., Luo, B., Huang, M., Guo, W., Lin, Y., Xie, X., Xiao, S."OY-TES-1 may regulate the malignant behavior of liver cancer via NANOG, CD9, CCND2 and CDCA3: A bioinformatic analysis combine with RNAi and oligonucleotide microarray". Oncology Reports 33.4 (2015): 1965-1975.
Chicago
Hu, Q., Fu, J., Luo, B., Huang, M., Guo, W., Lin, Y., Xie, X., Xiao, S."OY-TES-1 may regulate the malignant behavior of liver cancer via NANOG, CD9, CCND2 and CDCA3: A bioinformatic analysis combine with RNAi and oligonucleotide microarray". Oncology Reports 33, no. 4 (2015): 1965-1975. https://doi.org/10.3892/or.2015.3792
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