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May-2015 Volume 33 Issue 5

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Article

BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR‑29b and enhancing MMP2 expression

  • Authors:
    • Shutaro Habata
    • Masahiro Iwasaki
    • Asuka Sugio
    • Miwa Suzuki
    • Masato Tamate
    • Seiro Satohisa
    • Ryoichi Tanaka
    • Tsuyoshi Saito
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan
  • Pages: 2613-2621
    |
    Published online on: March 4, 2015
       https://doi.org/10.3892/or.2015.3831
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Abstract

Approximately 30% of uterine corpus carcinomas are diagnosed at an advanced stage and have a poor prognosis. Our previous study indicated that BCL2-associated athanogene 3 (BAG3) enhances matrix metalloproteinase-2 (MMP2) expression and binds to MMP2 to positively regulate the process of cell invasion in ovarian cancer cells. Recently, altered miRNA expression patterns were observed in several groups of patients with endometrial cancers. One of the altered miRNAs, miR‑29b, reportedly reduces tumor invasiveness by suppressing MMP2 expression. Our aim in the present study was to examine the relationships among BAG3, miR‑29b and MMP2 in endometrioid adenocarcinoma cells. We found that BAG3 suppresses miR‑29b expression and enhances MMP2 expression, which in turn increases cell motility and invasiveness. Moreover, restoration of miR‑29b through BAG3 knockdown reduced MMP2 expression, as well as cell motility and invasiveness. Collectively, our findings indicate that BAG3 enhances MMP2 expression by suppressing miR‑29b, thereby increasing the metastatic potential of endometrioid adenocarcinomas.
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Copy and paste a formatted citation
Spandidos Publications style
Habata S, Iwasaki M, Sugio A, Suzuki M, Tamate M, Satohisa S, Tanaka R and Saito T: BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR‑29b and enhancing MMP2 expression. Oncol Rep 33: 2613-2621, 2015.
APA
Habata, S., Iwasaki, M., Sugio, A., Suzuki, M., Tamate, M., Satohisa, S. ... Saito, T. (2015). BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR‑29b and enhancing MMP2 expression. Oncology Reports, 33, 2613-2621. https://doi.org/10.3892/or.2015.3831
MLA
Habata, S., Iwasaki, M., Sugio, A., Suzuki, M., Tamate, M., Satohisa, S., Tanaka, R., Saito, T."BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR‑29b and enhancing MMP2 expression". Oncology Reports 33.5 (2015): 2613-2621.
Chicago
Habata, S., Iwasaki, M., Sugio, A., Suzuki, M., Tamate, M., Satohisa, S., Tanaka, R., Saito, T."BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR‑29b and enhancing MMP2 expression". Oncology Reports 33, no. 5 (2015): 2613-2621. https://doi.org/10.3892/or.2015.3831
Copy and paste a formatted citation
x
Spandidos Publications style
Habata S, Iwasaki M, Sugio A, Suzuki M, Tamate M, Satohisa S, Tanaka R and Saito T: BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR‑29b and enhancing MMP2 expression. Oncol Rep 33: 2613-2621, 2015.
APA
Habata, S., Iwasaki, M., Sugio, A., Suzuki, M., Tamate, M., Satohisa, S. ... Saito, T. (2015). BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR‑29b and enhancing MMP2 expression. Oncology Reports, 33, 2613-2621. https://doi.org/10.3892/or.2015.3831
MLA
Habata, S., Iwasaki, M., Sugio, A., Suzuki, M., Tamate, M., Satohisa, S., Tanaka, R., Saito, T."BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR‑29b and enhancing MMP2 expression". Oncology Reports 33.5 (2015): 2613-2621.
Chicago
Habata, S., Iwasaki, M., Sugio, A., Suzuki, M., Tamate, M., Satohisa, S., Tanaka, R., Saito, T."BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR‑29b and enhancing MMP2 expression". Oncology Reports 33, no. 5 (2015): 2613-2621. https://doi.org/10.3892/or.2015.3831
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