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Article

Synergistic growth inhibition by sorafenib and cisplatin in human osteosarcoma cells

Retraction in: /10.3892/or.2021.8144
  • Authors:
    • Qu Yang
    • Shanyong Zhang
    • Mingyang Kang
    • Rongpeng Dong
    • Jianwu Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The Second Hospital of Jilin University, Changchun, Jilin 130042, P.R. China
  • Pages: 2537-2544
    |
    Published online on: March 4, 2015
       https://doi.org/10.3892/or.2015.3832
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Abstract

Molecular-targeted therapy has shown promise as a treatment for advanced osteosarcoma (OS). Sorafenib (SOR), a multikinase inhibitor, is the approved systemic drug of choice for OS, but has demonstrated limited benefits due to its toxicity and other adverse effects. Therapy strategies for reducing toxicity include using lower doses of SOR in combination with other complementary agents. Cisplatin (CDDP) has been shown to be a promising anticancer drug against various types of cancer including OS. In the present study, SOR was combined with CDDP to determine whether this combinatorial treatment suppressed tumor growth thereby simultaneously reducing doses of the two drugs for the treatment of OS. Human Saos-2 OS cells were treated with SOR and CDDP, alone and in combination, and the effect of these treatments on cell proliferation, colony formation, cell cycle, apoptosis, migration, and invasion, and involvement in receptor signaling, as well as tumor growth ability in nude mice was determined. It was found that the combination of low concentrations of SOR and CDDP significantly suppressed the cell proliferation, colony formation, migration and invasion, and induced cell apoptosis and cell cycle arrest in the G0/G1 stage, and suppressed tumor growth in a nude mouse model compared to the actions of either agent alone. The results also showed that SOR in combination with CDDP significantly suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), which may contribute to the inhibition of tumor growth. These results suggested that SOR in combination with CDDP acts synergistically in the treatment of OS.
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Copy and paste a formatted citation
Spandidos Publications style
Yang Q, Zhang S, Kang M, Dong R and Zhao J: Synergistic growth inhibition by sorafenib and cisplatin in human osteosarcoma cells Retraction in /10.3892/or.2021.8144. Oncol Rep 33: 2537-2544, 2015.
APA
Yang, Q., Zhang, S., Kang, M., Dong, R., & Zhao, J. (2015). Synergistic growth inhibition by sorafenib and cisplatin in human osteosarcoma cells Retraction in /10.3892/or.2021.8144. Oncology Reports, 33, 2537-2544. https://doi.org/10.3892/or.2015.3832
MLA
Yang, Q., Zhang, S., Kang, M., Dong, R., Zhao, J."Synergistic growth inhibition by sorafenib and cisplatin in human osteosarcoma cells Retraction in /10.3892/or.2021.8144". Oncology Reports 33.5 (2015): 2537-2544.
Chicago
Yang, Q., Zhang, S., Kang, M., Dong, R., Zhao, J."Synergistic growth inhibition by sorafenib and cisplatin in human osteosarcoma cells Retraction in /10.3892/or.2021.8144". Oncology Reports 33, no. 5 (2015): 2537-2544. https://doi.org/10.3892/or.2015.3832
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Q, Zhang S, Kang M, Dong R and Zhao J: Synergistic growth inhibition by sorafenib and cisplatin in human osteosarcoma cells Retraction in /10.3892/or.2021.8144. Oncol Rep 33: 2537-2544, 2015.
APA
Yang, Q., Zhang, S., Kang, M., Dong, R., & Zhao, J. (2015). Synergistic growth inhibition by sorafenib and cisplatin in human osteosarcoma cells Retraction in /10.3892/or.2021.8144. Oncology Reports, 33, 2537-2544. https://doi.org/10.3892/or.2015.3832
MLA
Yang, Q., Zhang, S., Kang, M., Dong, R., Zhao, J."Synergistic growth inhibition by sorafenib and cisplatin in human osteosarcoma cells Retraction in /10.3892/or.2021.8144". Oncology Reports 33.5 (2015): 2537-2544.
Chicago
Yang, Q., Zhang, S., Kang, M., Dong, R., Zhao, J."Synergistic growth inhibition by sorafenib and cisplatin in human osteosarcoma cells Retraction in /10.3892/or.2021.8144". Oncology Reports 33, no. 5 (2015): 2537-2544. https://doi.org/10.3892/or.2015.3832
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