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Article

HBx co-localizes with COXIII in HL-7702 cells to upregulate mitochondrial function and ROS generation

  • Authors:
    • Lai-Yu Zou
    • Bi-Yun Zheng
    • Xue-Fen Fang
    • Dan Li
    • Yue-Hong Huang
    • Zhi-Xin Chen
    • Lin-Ying Zhou
    • Xiao-Zhong Wang
  • View Affiliations / Copyright

    Affiliations: Department of Infection, Union Hospital of Fujian Medical University, Gulou, Fuzhou, Fujian 350001, P.R. China, Department of Gastroenterology, Union Hospital of Fujian Medical University, Gulou, Fuzhou, Fujian 350001, P.R. China, Laboratory of Electron Microscopy, Fujian Medical University, Gulou, Fuzhou, Fujian 350001, P.R. China
  • Pages: 2461-2467
    |
    Published online on: March 13, 2015
       https://doi.org/10.3892/or.2015.3852
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Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignant diseases, and HBx leads to the development of HBV-associated HCC. Mitochondria are key organelles that regulate apoptosis, cellular energetics and signal transduction pathways, and are the source of HBx-induced reactive oxygen species (ROS). Recent findings have shown that HBx interacts with the inner mitochondrial membrane protein, COXIII, via the yeast two‑hybrid system, mating experiment and coimmunoprecipitation. The aim of the present study was to examine the co-localizaiton of HBx and COXIII in HL-7702 cells and to investigate ensuing alterations of mitochondrial function. An HL-7702 cell line stably expressing the HBx gene by lentivirus vectors was constructed. Confocal microscopy was utilized to assess the interaction between HBx protein and COXIII. Expression of COXIII, activities of cytochrome c oxidase (COX) and the mitochondrial membrane potential, which were functionally relevant to the HBx protein-COXIII interaction, were investigated in cell cultures. Moreover, the intracellular ROS levels were detected by flow cytometry. The results demonstrated that HBx co-localized with the inner mitochondrial protein, COXIII, in HL-7702 cells, causing the upregulation of COXIII protein expression as well as COX activity. However, HBx did not alter the mitochondrial membrane potential and mitochondria exhibited only slight swelling in HL-7702-HBx cells. Moreover, HBx elevated the generation of mitochondrial ROS in HL-7702-HBx cells. The main finding of the present study was that the co-localization of HBx and COXIII leads to upregulation of the mitochondrial function and ROS generation, which are associated with the oncogenesis of HBV-associated HCC.
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1 

Motavaf M, Safari S, Saffari Jourshari M and Alavian SM: Hepatitis B virus-induced hepatocellular carcinoma: The role of the virus x protein. Acta Virol. 57:389–396. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Neuveut C, Wei Y and Buendia MA: Mechanisms of HBV-related hepatocarcinogenesis. J Hepatol. 52:594–604. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Bouchard MJ and Schneider RJ: The enigmatic X gene of hepatitis B virus. J Virol. 78:12725–12734. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Henkler F, Hoare J, Waseem N, Goldin RD, McGarvey MJ, Koshy R and King IA: Intracellular localization of the hepatitis B virus HBx protein. J Gen Virol. 82:871–882. 2001.PubMed/NCBI

5 

Clippinger AJ and Bouchard MJ: Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential. J Virol. 82:6798–6811. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Li SK, Ho SF, Tsui KW, Fung KP and Waye MY: Identification of functionally important amino acid residues in the mitochondria targeting sequence of hepatitis B virus X protein. Virology. 381:81–88. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Chen J and Siddiqui A: Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress. J Virol. 81:6757–6760. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Rahmani Z, Huh KW, Lasher R and Siddiqui A: Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its trans-membrane potential. J Virol. 74:2840–2846. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Takada S, Shirakata Y, Kaneniwa N and Koike K: Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death. Oncogene. 18:6965–6973. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Huh KW and Siddiqui A: Characterization of the mitochondrial association of hepatitis B virus X protein, HBx. Mitochondrion. 1:349–359. 2002. View Article : Google Scholar

11 

Li D, Wang XZ, Yu JP, Chen ZX, Huang YH and Tao QM: Cytochrome c oxidase III interacts with hepatitis B virus X protein in vivo by yeast two-hybrid system. World J Gastroenterol. 10:2805–2808. 2004.PubMed/NCBI

12 

Wang XZ, Li D, Tao QM, Lin N and Chen ZX: A novel hepatitis B virus X-interactive protein: Cytochrome C oxidase III. J Gastroenterol Hepatol. 21:711–715. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Zheng BY, Fang XF, Zou LY, Huang YH, Chen ZX, Li D, Zhou LY, Chen H and Wang XZ: The co-localization of HBx and COXIII upregulates COX-2 promoting HepG2 cell growth. Int J Oncol. 45:1143–1150. 2014.PubMed/NCBI

14 

Salvioli S, Bonafè M, Capri M, Monti D and Franceschi C: Mitochondria, aging and longevity - a new perspective. FEBS Lett. 492:9–13. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Lee YI, Hwang JM, Im JH, Lee YI, Kim NS, Kim DG, Yu DY, Moon HB and Park SK: Human hepatitis B virus-X protein alters mitochondrial function and physiology in human liver cells. J Biol Chem. 279:15460–15471. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Nishida N, Arizumi T, Takita M, et al: Reactive oxygen species induce epigenetic instability through the formation of 8-hydroxy-deoxyguanosine in human hepatocarcinogenesis. Dig Dis. 31:459–466. 2013. View Article : Google Scholar

17 

Castello G, Costantini S and Scala S: Targeting the inflammation in HCV-associated hepatocellular carcinoma: A role in the prevention and treatment. J Transl Med. 8:1092010. View Article : Google Scholar : PubMed/NCBI

18 

Mkaouar-Rebai E, Ellouze E, Chamkha I, Kammoun F, Triki C and Fakhfakh F: Molecular-clinical correlation in a family with a novel heteroplasmic Leigh syndrome missense mutation in the mitochondrial cytochrome c oxidase III gene. J Child Neurol. 26:12–20. 2011. View Article : Google Scholar

19 

Bauerfeld CP, Rastogi R, Pirockinaite G, Lee I, Hüttemann M, Monks B, Birnbaum MJ, Franchi L, Nuñez G and Samavati L: TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages. J Immunol. 188:2847–2857. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Liang L, Qu L and Ding Y: Protein and mRNA characterization in human colorectal carcinoma cell lines with different metastatic potentials. Cancer Invest. 25:427–434. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Bafna S, Singh AP, Moniaux N, Eudy JD, Meza JL and Batra SK: MUC4, a multifunctional transmembrane glycoprotein, induces oncogenic transformation of NIH3T3 mouse fibroblast cells. Cancer Res. 68:9231–9238. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Wu H, Rao GN, Dai B and Singh P: Autocrine gastrins in colon cancer cells up-regulate cytochrome c oxidase Vb and down-regulate efflux of cytochrome c and activation of caspase-3. J Biol Chem. 275:32491–32498. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Nybo K: GFP imaging in fixed cells. Biotechniques. 52:359–360. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Hu B, Tai A and Wang P: Immunization delivered by lentiviral vectors for cancer and infectious diseases. Immunol Rev. 239:45–61. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Kim S, Kim HY, Lee S, Kim SW, Sohn S, Kim K and Cho H: Hepatitis B virus x protein induces perinuclear mitochondrial clustering in microtubule- and Dynein-dependent manners. J Virol. 81:1714–1726. 2007. View Article : Google Scholar :

26 

Naldini L, Blömer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM and Trono D: In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 272:263–267. 1996. View Article : Google Scholar : PubMed/NCBI

27 

Ohashi K, Park F, Schwall R and Kay M: Efficient gene transduction to cultured hepatocytes by HIV-1 derived lentiviral vector. Transplant Proc. 34:1431–1433. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Jung SY and Kim YJ: C-terminal region of HBx is crucial for mitochondrial DNA damage. Cancer Lett. 331:76–83. 2013. View Article : Google Scholar

29 

Zaslavsky D and Gennis RB: Proton pumping by cytochrome oxidase: Progress, problems and postulates. Biochim Biophys Acta. 1458:164–179. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Qi Z, He J, Su Y, et al: Physical exercise regulates p53 activity targeting SCO2 and increases mitochondrial COX biogenesis in cardiac muscle with age. PLoS One. 6:e211402011. View Article : Google Scholar : PubMed/NCBI

31 

Wang FL, Wang Y, Wong WK, Liu Y, Addivinola FJ, Liang P, Chen LB, Kantoff PW and Pardee AB: Two differentially expressed genes in normal human prostate tissue and in carcinoma. Cancer Res. 56:3634–3637. 1996.PubMed/NCBI

32 

Bini L, Magi B, Marzocchi B, et al: Protein expression profiles in human breast ductal carcinoma and histologically normal tissue. Electrophoresis. 18:2832–2841. 1997. View Article : Google Scholar

33 

Lin N, Li D, Chen HY, Chen ZX and Wang XZ: Effect of HBV X gene on mitochondria in HL-7702 cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 24:972–974. 2008.In Chinese. PubMed/NCBI

34 

Lee WP, Lan KH, Li CP, Chao Y, Lin HC and Lee SD: Pro-apoptotic or anti-apoptotic property of X protein of hepatitis B virus is determined by phosphorylation at Ser31 by Akt. Arch Biochem Biophys. 528:156–162. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Adrie C, Bachelet M, Vayssier-Taussat M, Russo-Marie F, Bouchaert I, Adib-Conquy M, Cavaillon JM, Pinsky MR, Dhainaut JF and Polla BS: Mitochondrial membrane potential and apoptosis peripheral blood monocytes in severe human sepsis. Am J Respir Crit Care Med. 164:389–395. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Shirakata Y and Koike K: Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential. J Biol Chem. 278:22071–22078. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Ray AM, Zuhlke KA, Levin AM, Douglas JA, Cooney KA and Petros JA: Sequence variation in the mitochondrial gene cytochrome c oxidase subunit I and prostate cancer in African American men. Prostate. 69:956–960. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Athar M, Chaudhury NK, Hussain ME and Varshney R: Hoechst 33342 induced reactive oxygen species and impaired expression of cytochrome c oxidase subunit 1 leading to cell death in irradiated human cancer cells. Mol Cell Biochem. 352:281–292. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Bernstein C, Facista A, Nguyen H, et al: Cancer and age related colonic crypt deficiencies in cytochrome c oxidase I. World J Gastrointest Oncol. 2:429–442. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Gutierrez-Gonzalez L, Graham TA, Rodriguez-Justo M, et al: The clonal origins of dysplasia from intestinal metaplasia in the human stomach. Gastroenterology. 140:1251–1260.e1–6. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Ha HL and Yu DY: HBx-induced reactive oxygen species activates hepatocellular carcinogenesis via dysregulation of PTEN/Akt pathway. World J Gastroenterol. 16:4932–4937. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zou L, Zheng B, Fang X, Li D, Huang Y, Chen Z, Zhou L and Wang X: HBx co-localizes with COXIII in HL-7702 cells to upregulate mitochondrial function and ROS generation. Oncol Rep 33: 2461-2467, 2015.
APA
Zou, L., Zheng, B., Fang, X., Li, D., Huang, Y., Chen, Z. ... Wang, X. (2015). HBx co-localizes with COXIII in HL-7702 cells to upregulate mitochondrial function and ROS generation. Oncology Reports, 33, 2461-2467. https://doi.org/10.3892/or.2015.3852
MLA
Zou, L., Zheng, B., Fang, X., Li, D., Huang, Y., Chen, Z., Zhou, L., Wang, X."HBx co-localizes with COXIII in HL-7702 cells to upregulate mitochondrial function and ROS generation". Oncology Reports 33.5 (2015): 2461-2467.
Chicago
Zou, L., Zheng, B., Fang, X., Li, D., Huang, Y., Chen, Z., Zhou, L., Wang, X."HBx co-localizes with COXIII in HL-7702 cells to upregulate mitochondrial function and ROS generation". Oncology Reports 33, no. 5 (2015): 2461-2467. https://doi.org/10.3892/or.2015.3852
Copy and paste a formatted citation
x
Spandidos Publications style
Zou L, Zheng B, Fang X, Li D, Huang Y, Chen Z, Zhou L and Wang X: HBx co-localizes with COXIII in HL-7702 cells to upregulate mitochondrial function and ROS generation. Oncol Rep 33: 2461-2467, 2015.
APA
Zou, L., Zheng, B., Fang, X., Li, D., Huang, Y., Chen, Z. ... Wang, X. (2015). HBx co-localizes with COXIII in HL-7702 cells to upregulate mitochondrial function and ROS generation. Oncology Reports, 33, 2461-2467. https://doi.org/10.3892/or.2015.3852
MLA
Zou, L., Zheng, B., Fang, X., Li, D., Huang, Y., Chen, Z., Zhou, L., Wang, X."HBx co-localizes with COXIII in HL-7702 cells to upregulate mitochondrial function and ROS generation". Oncology Reports 33.5 (2015): 2461-2467.
Chicago
Zou, L., Zheng, B., Fang, X., Li, D., Huang, Y., Chen, Z., Zhou, L., Wang, X."HBx co-localizes with COXIII in HL-7702 cells to upregulate mitochondrial function and ROS generation". Oncology Reports 33, no. 5 (2015): 2461-2467. https://doi.org/10.3892/or.2015.3852
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