Expression of NEDD9 in hepatocellular carcinoma and its clinical significance

  • Authors:
    • Peng Lu
    • Zhi-Peng Wang
    • Zheng Dang
    • Zhi-Gang Zheng
    • Xiao Li
    • Liang Zhou
    • Rui Ding
    • Shu-Qiang Yue
    • Ke-Feng Dou
  • View Affiliations

  • Published online on: March 18, 2015     https://doi.org/10.3892/or.2015.3863
  • Pages: 2375-2383
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Abstract

Neural precursor cell expressed, developmentally downregulated 9 (NEDD9) plays an integral role in natural and pathological cell biology. Overexpression of NEDD9 protein has been correlated with poor prognosis in various types of cancer. However, few available data address the precise function of the NEDD9 gene in hepatocellular carcinoma (HCC). In the present study, we investigated NEDD9 expression in 40 primary human HCC tissues compared with matched adjacent non-tumor hepatic tissues using RT-qPCR and western blot analysis. Immunohistochemistry was performed to analyze the correlations between NEDD9 expression and clinicopathological factors. Statistical analyses were applied to derive prognostic values of NEDD9 in HCC. The results showed that the NEDD9 mRNA and protein expression levels in HCC tissues were significantly higher than those in matched adjacent non-tumor hepatic tissues. High NEDD9 expression was correlated with larger tumor size, advanced tumor grade, metastasis, intrahepatic venous invasion and high UICC TNM stages in HCC patients. Patients with high NEDD9 expression levels exhibited poorer recurrence-free and overall survival than those with a low NEDD9 expression. Additionally, NEDD9 expression status was an independent prognostic factor for survival. This correlation remained significant in patients with early-stage HCC or with normal serum AFP levels. The results of this study suggest that NEDD9 may be a valuable prognostic biomarker for HCC, including early-stage and AFP-normal patients.
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May-2015
Volume 33 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Lu P, Wang Z, Dang Z, Zheng Z, Li X, Zhou L, Ding R, Yue S and Dou K: Expression of NEDD9 in hepatocellular carcinoma and its clinical significance. Oncol Rep 33: 2375-2383, 2015
APA
Lu, P., Wang, Z., Dang, Z., Zheng, Z., Li, X., Zhou, L. ... Dou, K. (2015). Expression of NEDD9 in hepatocellular carcinoma and its clinical significance. Oncology Reports, 33, 2375-2383. https://doi.org/10.3892/or.2015.3863
MLA
Lu, P., Wang, Z., Dang, Z., Zheng, Z., Li, X., Zhou, L., Ding, R., Yue, S., Dou, K."Expression of NEDD9 in hepatocellular carcinoma and its clinical significance". Oncology Reports 33.5 (2015): 2375-2383.
Chicago
Lu, P., Wang, Z., Dang, Z., Zheng, Z., Li, X., Zhou, L., Ding, R., Yue, S., Dou, K."Expression of NEDD9 in hepatocellular carcinoma and its clinical significance". Oncology Reports 33, no. 5 (2015): 2375-2383. https://doi.org/10.3892/or.2015.3863