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Article

IL-33-induced JNK pathway activation confers gastric cancer chemotherapy resistance

  • Authors:
    • Xiao-Lei Ye
    • Ya-Rong Zhao
    • Guo-Bin Weng
    • Yi-Chen Chen
    • Xue-Ni Wei
    • Jing-Ping Shao
    • Hui Ji
  • View Affiliations / Copyright

    Affiliations: Cancer Institute, Yinzhou People's Hospital, Ningbo, Zhejiang 315020, P.R. China, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, P.R. China, Division of Drugs and Pharmacology, Ningbo Institute of Medical Sciences, Ningbo, Zhejiang 315020, P.R. China
  • Pages: 2746-2752
    |
    Published online on: April 3, 2015
       https://doi.org/10.3892/or.2015.3898
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Abstract

Inflammation is regarded as one of the major hallmarks of tumors, and has a very close relationship with gastric cancer. Interleukin-33 (IL-33), a new member of the IL-1 family, plays an important role in both inflammatory disease and tumors. The present study was designed to explore the effects of IL-33 on the proliferation, drug sensitivity, and the invasiveness of gastric cancer cells in vitro. IL-33 at concentrations lower than 100 pg/ml did not alter the inhibitory rate of gastric cancer cells. Moreover, IL-33 at these low concentrations protected against platinum-induced apoptosis in various gastric cancer cell lines, yet not in normal gastric epithelial cells. We also found that IL-33 increased the activation of the JNK pathway, and enhanced the expression of ST2. Furthermore, SP600125, a selective inhibitor of the JNK pathway, significantly blocked the protective effects of IL-33 in gastric cancer cells. In addition, Matrigel invasion assay showed that IL-33 markedly promoted gastric cancer cell invasion. In conclusion, the present study demonstrated that IL-33 protected against platinum-induced apoptosis and promoted cell invasion via activation of the JNK pathway in gastric cancer cells. In light of the prevalence of platinum-based chemotherapeutics in the treatment of gastric cancer, our results suggest that the level of IL-33 should be monitored during the treatment of gastric cancer, particularly when using platinum-based chemotherapeutics.
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Copy and paste a formatted citation
Spandidos Publications style
Ye X, Zhao Y, Weng G, Chen Y, Wei X, Shao J and Ji H: IL-33-induced JNK pathway activation confers gastric cancer chemotherapy resistance. Oncol Rep 33: 2746-2752, 2015.
APA
Ye, X., Zhao, Y., Weng, G., Chen, Y., Wei, X., Shao, J., & Ji, H. (2015). IL-33-induced JNK pathway activation confers gastric cancer chemotherapy resistance. Oncology Reports, 33, 2746-2752. https://doi.org/10.3892/or.2015.3898
MLA
Ye, X., Zhao, Y., Weng, G., Chen, Y., Wei, X., Shao, J., Ji, H."IL-33-induced JNK pathway activation confers gastric cancer chemotherapy resistance". Oncology Reports 33.6 (2015): 2746-2752.
Chicago
Ye, X., Zhao, Y., Weng, G., Chen, Y., Wei, X., Shao, J., Ji, H."IL-33-induced JNK pathway activation confers gastric cancer chemotherapy resistance". Oncology Reports 33, no. 6 (2015): 2746-2752. https://doi.org/10.3892/or.2015.3898
Copy and paste a formatted citation
x
Spandidos Publications style
Ye X, Zhao Y, Weng G, Chen Y, Wei X, Shao J and Ji H: IL-33-induced JNK pathway activation confers gastric cancer chemotherapy resistance. Oncol Rep 33: 2746-2752, 2015.
APA
Ye, X., Zhao, Y., Weng, G., Chen, Y., Wei, X., Shao, J., & Ji, H. (2015). IL-33-induced JNK pathway activation confers gastric cancer chemotherapy resistance. Oncology Reports, 33, 2746-2752. https://doi.org/10.3892/or.2015.3898
MLA
Ye, X., Zhao, Y., Weng, G., Chen, Y., Wei, X., Shao, J., Ji, H."IL-33-induced JNK pathway activation confers gastric cancer chemotherapy resistance". Oncology Reports 33.6 (2015): 2746-2752.
Chicago
Ye, X., Zhao, Y., Weng, G., Chen, Y., Wei, X., Shao, J., Ji, H."IL-33-induced JNK pathway activation confers gastric cancer chemotherapy resistance". Oncology Reports 33, no. 6 (2015): 2746-2752. https://doi.org/10.3892/or.2015.3898
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