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Article

Cellular leiomyoma with necrosis and mucinous degeneration presenting as pseudo-Meigs' syndrome with elevated CA125

  • Authors:
    • Ruiying Dong
    • Chengjuan Jin
    • Qing Zhang
    • Xingsheng Yang
    • Beihua Kong
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China
  • Pages: 3033-3037
    |
    Published online on: April 16, 2015
       https://doi.org/10.3892/or.2015.3912
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Abstract

Pseudo-Meigs' syndrome is a syndrome rarely caused by leiomyomas. Elevated CA125 usually suggests malignancy of the ovary. No reported case of pseudo-Meigs' syndrome presenting with necrosis and mucinous degeneration of uterine cellular leiomyomas (CLs) and an elevated CA125 level was found upon a PubMed search. A 37-year-old woman presenting with massive ascites, bilateral pleural effusions and a pelvic mass measuring 20x18x10 cm is described. The pre-operative serum CA125 was 920.4 U/ml. After total abdominal hysterectomy and partial omentumectomy, the final pathologic diagnosis was CL with focal hemorrhage, necrosis and mucinous degeneration. The ascites and pleural effusion disappeared, and the CA125 level returned to normal in one month. Benign leiomyoma accompanied by pseudo-Meigs' syndrome and elevated serum CA125 can mimic a pelvic malignancy.
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1 

Meigs JV and Cass J: Fibroma of the ovary with ascites and hydrothorax: with a report of seven cases. Am J Obstet Gynecol. 33:249–267. 1937.

2 

Meigs JV: Fibroma of the ovary with ascites and hydrothorax; Meigs’ syndrome. Am J Obstet Gynecol. 67:962–985. 1954.PubMed/NCBI

3 

Meigs JV: Pelvic tumors other than fibromas of the ovary with ascites and hydrothorax. Obstet Gynecol. 3:471–486. 1954.PubMed/NCBI

4 

Solomon LA, Schimp VL, Ali-Fehmi R, Diamond MP and Munkarah AR: Clinical update of smooth muscle tumors of the uterus. J Minim Invasive Gynecol. 12:401–408. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Wilkinson N and Rollason TP: Recent advances in the pathology of smooth muscle tumours of the uterus. Histopathology. 39:331–341. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Taran FA, Weaver AL, Gostout BS and Stewart EA: Understanding cellular leiomyomas: a case-control study. Am J Obstet Gynecol. 203:109.e1–109.e6. 2010. View Article : Google Scholar

7 

Guan R, Zheng W and Xu M: A retrospective analysis of the clinicopathologic characteristics of uterine cellular leiomyomas in China. Int J Gynaecol Obstet. 118:52–55. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Reed SD, Newton KM, Thompson LB, McCrummen BA and Warolin AK: The incidence of repeat uterine surgery following myomectomy. J Womens Health (Larchmt). 15:1046–1052. 2006. View Article : Google Scholar

9 

Schwartz LB, Diamond MP and Schwartz PE: Leiomyosarcomas: clinical presentation. Am J Obstet Gynecol. 168:180–183. 1993. View Article : Google Scholar : PubMed/NCBI

10 

Agoff SN, Grieco VS, Garcia R and Gown AM: Immunohistochemical distinction of endometrial stromal sarcoma and cellular leiomyoma. Appl Immunohistochem Mol Morphol. 9:164–169. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Nucci MR, O’Connell JT, Huettner PC, Cviko A, Sun D and Quade BJ: h-Caldesmon expression effectively distinguishes endometrial stromal tumors from uterine smooth muscle tumors. Am J Surg Pathol. 25:455–463. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Oliva E, Young RH, Amin MB and Clement PB: An immunohistochemical analysis of endometrial stromal and smooth muscle tumors of the uterus: a study of 54 cases emphasizing the importance of using a panel because of overlap in immunoreactivity for individual antibodies. Am J Surg Pathol. 26:403–412. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Zhu XQ, Shi YF, Cheng XD, Zhao CL and Wu YZ: Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. Gynecol Oncol. 92:71–79. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Robboy SJ, Bentley RC, Butnor K and Anderson MC: Pathology and pathophysiology of uterine smooth-muscle tumors. Environ Health Perspect. 108(Suppl 5): 779–784. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Amant F, Gabriel C, Timmerman D and Vergote I: Pseudo-Meigs’ syndrome caused by a hydropic degenerating uterine leiomyoma with elevated CA 125. Gynecol Oncol. 83:153–157. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Zannoni GF, Gallotta V, Legge F, Tarquini E, Scambia G and Ferrandina G: Pseudo-Meigs’ syndrome associated with malignant struma ovarii: a case report. Gynecol Oncol. 94:226–228. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Terada S, Suzuki N, Uchide K and Akasofu K: Uterine leiomyoma associated with ascites and hydrothorax. Gynecol Obstet Invest. 33:54–58. 1992. View Article : Google Scholar : PubMed/NCBI

18 

Jacobs I and Bast RC JR: The Ca 125 tumour-associated antigen: a review of the literature. Hum Reprod. 4:1–12. 1989.PubMed/NCBI

19 

Lin JY, Angel C and Sickel JZ: Meigs syndrome with elevated serum CA 125. Obstet Gynecol. 80:563–566. 1992.PubMed/NCBI

20 

Timmerman D, Moerman P and Vergote I: Meigs’ syndrome with elevated serum CA 125 levels: two case reports and review of the literature. Gynecol Oncol. 59:405–408. 1995. View Article : Google Scholar : PubMed/NCBI

21 

Brown RSD, Marley JL and Cassoni AM: Pseudo-Meigs’ syndrome due to broad ligament leiomyoma: a mimic of metastatic ovarian carcinoma. Clin Oncol (R Coll Radiol). 10:198–201. 1998. View Article : Google Scholar

22 

Domingo P, Montiel JA, Monill JM and Prat J: Pseudo-Meigs syndrome with elevated CA 125 levels. Arch Intern Med. 158:1378–1379. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Dunn JS JR, Anderson CD, Method MW and Brost BC: Hydropic degenerating leiomyoma presenting as pseudo-Meigs syndrome with elevated CA 125. Obstet Gynecol. 92:648–649. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Migishima F, Jobo T, Hata H, Sato R, Ikeda Y, Arai M and Kuramoto H: Uterine leiomyoma causing massive ascites and left pleural effusion with elevated CA 125: a case report. J Obstet Gynaecol Res. 26:283–287. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Kebapci M, Aslan O, Kaya T, Yalcin OT and Ozalp S: Pedunculated uterine leiomyoma associated with pseudo-Meigs’ syndrome and elevated CA-125 level: CT features. Eur Radiol. 12(Suppl 3): S127–S129. 2002.

26 

Weise M, Westphalen S, Fayyazi A, Emons G and Krauss T: Pseudo-Meigs syndrome: uterine leiomyoma with bladder attachment associated with ascites and hydrothorax - a rare case of a rare syndrome. Onkologie. 25:443–446. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Weinrach DM, Wang KL, Keh P and Sambasiva Rao M: Pathologic quiz case: a 40-year-old woman with a large pelvic mass, ascites, massive right hydrothorax, and elevated CA 125. Uterine symplastic leiomyoma associated with pseudo-Meigs syndrome and elevated CA 125. Arch Pathol Lab Med. 128:933–934. 2004.PubMed/NCBI

28 

Ricci G, Inglese S, Candiotto A, Maso G, Piccoli M, Alberico S and Guaschino S: Ascites in puerperium: a rare case of atypical pseudo-Meigs’ syndrome complicating the puerperium. Arch Gynecol Obstet. 280:1033–1037. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Yip HK, Huang LW, Lin YH and Hwang JL: Massive ascites caused by a large pedunculated subserosal uterine leiomyoma that has feeding arteries from peripheral tissues and exhibits elevated Ca125: a case report of atypical pseudo-Meigs’ syndrome. J Obstet Gynaecol. 34:1072014. View Article : Google Scholar

30 

Ueda H, Togashi K, Konishi I, Kataoka ML, Koyama T, Fujiwara T, Kobayashi H, Fujii S and Konishi J: Unusual appearances of uterine leiomyomas: MR imaging findings and their histopathologic backgrounds. Radiographics. 19:S131–S145. 1999. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dong R, Jin C, Zhang Q, Yang X and Kong B: Cellular leiomyoma with necrosis and mucinous degeneration presenting as pseudo-Meigs' syndrome with elevated CA125. Oncol Rep 33: 3033-3037, 2015.
APA
Dong, R., Jin, C., Zhang, Q., Yang, X., & Kong, B. (2015). Cellular leiomyoma with necrosis and mucinous degeneration presenting as pseudo-Meigs' syndrome with elevated CA125. Oncology Reports, 33, 3033-3037. https://doi.org/10.3892/or.2015.3912
MLA
Dong, R., Jin, C., Zhang, Q., Yang, X., Kong, B."Cellular leiomyoma with necrosis and mucinous degeneration presenting as pseudo-Meigs' syndrome with elevated CA125". Oncology Reports 33.6 (2015): 3033-3037.
Chicago
Dong, R., Jin, C., Zhang, Q., Yang, X., Kong, B."Cellular leiomyoma with necrosis and mucinous degeneration presenting as pseudo-Meigs' syndrome with elevated CA125". Oncology Reports 33, no. 6 (2015): 3033-3037. https://doi.org/10.3892/or.2015.3912
Copy and paste a formatted citation
x
Spandidos Publications style
Dong R, Jin C, Zhang Q, Yang X and Kong B: Cellular leiomyoma with necrosis and mucinous degeneration presenting as pseudo-Meigs' syndrome with elevated CA125. Oncol Rep 33: 3033-3037, 2015.
APA
Dong, R., Jin, C., Zhang, Q., Yang, X., & Kong, B. (2015). Cellular leiomyoma with necrosis and mucinous degeneration presenting as pseudo-Meigs' syndrome with elevated CA125. Oncology Reports, 33, 3033-3037. https://doi.org/10.3892/or.2015.3912
MLA
Dong, R., Jin, C., Zhang, Q., Yang, X., Kong, B."Cellular leiomyoma with necrosis and mucinous degeneration presenting as pseudo-Meigs' syndrome with elevated CA125". Oncology Reports 33.6 (2015): 3033-3037.
Chicago
Dong, R., Jin, C., Zhang, Q., Yang, X., Kong, B."Cellular leiomyoma with necrosis and mucinous degeneration presenting as pseudo-Meigs' syndrome with elevated CA125". Oncology Reports 33, no. 6 (2015): 3033-3037. https://doi.org/10.3892/or.2015.3912
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