p62 participates in the inhibition of NF-κB signaling and apoptosis induced by sulfasalazine in human glioma U251 cells

  • Authors:
    • Jing Su
    • Fei Liu
    • Meihui Xia
    • Ye Xu
    • Xiaoning Li
    • Jinsong Kang
    • Yulin Li
    • Liankun Sun
  • View Affiliations

  • Published online on: May 4, 2015     https://doi.org/10.3892/or.2015.3944
  • Pages: 235-243
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Nuclear factor-κB (NF-κB) is constitutively activated in most malignant gliomas and is involved in cancer progression and drug resistance to chemotherapy. Sulfasalazine (SAS) is a classic inhibitor of NF-κB. Apoptosis and autophagy were induced by SAS accompanied by inhibition of NF-κB signaling in U251 cells. Inhibition of autophagy by 3-MA suppressed the effects of SAS on NF-κB signaling and apoptosis in U251 cells. Multifunctional scaffold protein p62 is well known as an autophagy marker protein and provides crosstalk for important signaling pathways, including NF-κB signaling. SAS-induced decrease in the p62 protein levels may be the result of degradation through autophagy. SAS induced the inhibition of NF-κB signaling and apoptosis at least partly via a p62-dependent effect in U251 cells. Collectively, our data shed light on the link between p62 and the NF-κB signaling pathway, particularly in glioma cells. The results may facilitate the design of more effective targeted therapies for the treatment of tumors in which NF-κB signaling is altered.
View Figures
View References

Related Articles

Journal Cover

July-2015
Volume 34 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Su J, Liu F, Xia M, Xu Y, Li X, Kang J, Li Y and Sun L: p62 participates in the inhibition of NF-κB signaling and apoptosis induced by sulfasalazine in human glioma U251 cells. Oncol Rep 34: 235-243, 2015
APA
Su, J., Liu, F., Xia, M., Xu, Y., Li, X., Kang, J. ... Sun, L. (2015). p62 participates in the inhibition of NF-κB signaling and apoptosis induced by sulfasalazine in human glioma U251 cells. Oncology Reports, 34, 235-243. https://doi.org/10.3892/or.2015.3944
MLA
Su, J., Liu, F., Xia, M., Xu, Y., Li, X., Kang, J., Li, Y., Sun, L."p62 participates in the inhibition of NF-κB signaling and apoptosis induced by sulfasalazine in human glioma U251 cells". Oncology Reports 34.1 (2015): 235-243.
Chicago
Su, J., Liu, F., Xia, M., Xu, Y., Li, X., Kang, J., Li, Y., Sun, L."p62 participates in the inhibition of NF-κB signaling and apoptosis induced by sulfasalazine in human glioma U251 cells". Oncology Reports 34, no. 1 (2015): 235-243. https://doi.org/10.3892/or.2015.3944