Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
July-2015 Volume 34 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2015 Volume 34 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effect of sodium/iodide symporter (NIS)-mediated radioiodine therapy on estrogen receptor-negative breast cancer

  • Authors:
    • Chen Yao
    • Yi Pan
    • Yongxin Li
    • Xiangdong Xu
    • Ying Lin
    • Wenjian Wang
    • Shenming Wang
  • View Affiliations / Copyright

    Affiliations: Department of Vascular, Thyroid and Breast Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China, Southern Medical University, Guangzhou, Guangdong 510080, P.R. China, Laboratory of the Department of Surgery, The First Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China
  • Pages: 59-66
    |
    Published online on: May 5, 2015
       https://doi.org/10.3892/or.2015.3946
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Since the sodium/iodide symporter (NIS) stimulates the iodine uptake in normal lactating breast, our study aimed to study the effect of NIS-mediated radioiodide therapy on ER-negative breast cancers. A recombinant lentivirus plasmid encoding the human NIS (hNIS) gene and firefly luciferase (Fluc) was constructed. MDA-MB-231 cells were transfected with the recombinant lentivirus, and the hNIS gene expression was identified by western blot analysis and real-time PCR. Tissue-specific expression of the NIS gene was confirmed by immunohistochemical (IHC) staining. Functional NIS activity in the MDA-hNIS cells was confirmed by the uptake of 131I and cytotoxicity assays. The relative expression level of hNIS mRNA exhibited a 10-fold higher expression in the MDA-hNIS cells compared with the level in the control cells without the endogenous NIS gene. Abundant expression of hNIS protein was noted in the cell membrane compared to the cytoplasm which confirmed the efficient expression of the functional hNIS gene. Iodine uptake into the MDA-hNIS cells was rapid, reaching a maximum after 15 min, followed by a decline. Exposure of the MDA-hNIS cells with 131I resulted in a time‑dependent reduction in colony formation compared with the survival of the control (MDA) cells. Our results confirmed that NIS overexpression enhances the sensitivity of ER-negative breast cancer cells to radioiodide therapy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

El Saghir NS, Khalil MK, Eid T, El Kinge AR, Charafeddine M, Geara F, Seoud M and Shamseddine AI: Trends in epidemiology and management of breast cancer in developing Arab countries: a literature and registry analysis. Int J Surg. 5:225–233. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Tfayli A, Temraz S, Abou Mrad R and Shamseddine A: Breast cancer in low- and middle-income countries: an emerging and challenging epidemic. J Oncol. 2010:4906312010. View Article : Google Scholar

3 

Garcia-Closas M and Chanock S: Genetic susceptibility loci for breast cancer by estrogen receptor status. Clin Cancer Res. 14:8000–8009. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Ma H, Bernstein L, Pike MC and Ursin G: Reproductive factors and breast cancer risk according to joint estrogen and progesterone receptor status: a meta-analysis of epidemiological studies. Breast Cancer Res. 8:R432006. View Article : Google Scholar : PubMed/NCBI

5 

Reeves GK, Beral V, Green J, Gathani T and Bull D; Million Women Study Collaborators: Hormonal therapy for menopause and breast-cancer risk by histological type: a cohort study and meta-analysis. Lancet Oncol. 7:910–918. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Althuis MD, Fergenbaum JH, Garcia-Closas M, Brinton LA, Madigan MP and Sherman ME: Etiology of hormone receptor- defined breast cancer: a systematic review of the literature. Cancer Epidemiol Biomarkers Prev. 13:1558–1568. 2004.PubMed/NCBI

7 

Nakagawa M, Bando Y, Nagao T, Takai C, Ohnishi T, Honda J, Moriya T, Izumi K, Takahashi M, Tangoku A, et al: Among triple-negative breast cancers, HER2(0) breast cancer shows a strong tendency to be basal-like compared with HER2(1+) breast cancer: preliminary results. Breast Cancer. 19:54–59. 2012. View Article : Google Scholar

8 

Vaklavas C and Forero-Torres A: How do I treat ‘triple-negative’ disease. Curr Treat Options Oncol. 12:369–388. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Berry DA, Cirrincione C, Henderson IC, Citron ML, Budman DR, Goldstein LJ, Martino S, Perez EA, Muss HB, Norton L, et al: Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer. JAMA. 295:1658–1667. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Altman MB, Flynn MJ, Nishikawa RM, Chetty IJ, Barton KN, Movsas B, Kim JH and Brown SL: The potential of iodine for improving breast cancer diagnosis and treatment. Med Hypotheses. 80:94–98. 2013. View Article : Google Scholar

11 

Blows FM, Driver KE, Schmidt MK, Broeks A, van Leeuwen FE, Wesseling J, Cheang MC, Gelmon K, Nielsen TO, Blomqvist C, et al: Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies. PLoS Med. 7:e10002792010. View Article : Google Scholar : PubMed/NCBI

12 

Chu KC and Anderson WF: Rates for breast cancer characteristics by estrogen and progesterone receptor status in the major racial/ethnic groups. Breast Cancer Res Treat. 74:199–211. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Argiris A, Wang CX, Whalen SG and DiGiovanna MP: Synergistic interactions between tamoxifen and trastuzumab (Herceptin). Clin Cancer Res. 10:1409–1420. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Madsen MW and Briand P: Relationship between tumorigenicity, in vitro invasiveness, and plasminogen activator production of human breast cell lines. Eur J Cancer. 26:793–797. 1990. View Article : Google Scholar : PubMed/NCBI

15 

Thompson EW, Paik S, Brünner N, Sommers CL, Zugmaier G, Clarke R, Shima TB, Torri J, Donahue S, Lippman ME, et al: Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines. J Cell Physiol. 150:534–544. 1992. View Article : Google Scholar : PubMed/NCBI

16 

Sommers CL, Byers SW, Thompson EW, Torri JA and Gelmann EP: Differentiation state and invasiveness of human breast cancer cell lines. Breast Cancer Res Treat. 31:325–335. 1994. View Article : Google Scholar : PubMed/NCBI

17 

Skoog L, Humla S, Axelsson M, Frost M, Norman A, Nordenskjöld B and Wallgren A: Estrogen receptor levels and survival of breast cancer patients. A study on patients participating in randomized trials of adjuvant therapy. Acta Oncol. 26:95–100. 1987. View Article : Google Scholar : PubMed/NCBI

18 

Sandelin K, Skoog L, Humla S and Farnebo LO: Oestrogen, progesterone, and glucocorticoid receptors in normal and neoplastic parathyroid glands. Eur J Surg. 158:467–472. 1992.PubMed/NCBI

19 

Dohán O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS and Carrasco N: The sodium/iodide symporter (NIS): characterization, regulation, and medical significance. Endocr Rev. 24:48–77. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Chung JK: Sodium iodide symporter: its role in nuclear medicine. J Nucl Med. 43:1188–1200. 2002.PubMed/NCBI

21 

Tazebay UH, Wapnir IL, Levy O, Dohan O, Zuckier LS, Zhao QH, Deng HF, Amenta PS, Fineberg S, Pestell RG, et al: The mammary gland iodide transporter is expressed during lactation and in breast cancer. Nat Med. 6:871–878. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Mitchell AM, Manley SW, Morris JC, Powell KA, Bergert ER and Mortimer RH: Sodium iodide symporter (NIS) gene expression in human placenta. Placenta. 22:256–258. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Wapnir IL, van de Rijn M, Nowels K, Amenta PS, Walton K, Montgomery K, Greco RS, Dohán O and Carrasco N: Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections. J Clin Endocrinol Metab. 88:1880–1888. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Upadhyay G, Singh R, Agarwal G, Mishra SK, Pal L, Pradhan PK, Das BK and Godbole MM: Functional expression of sodium iodide symporter (NIS) in human breast cancer tissue. Breast Cancer Res Treat. 77:157–165. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Kogai T, Taki K and Brent GA: Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. Endocr Relat Cancer. 13:797–826. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Mazzaferri EL: Carcinoma of the follicular epithelium. The Thyroid: A Fundamental and Clinical Text. Braverman LE and Utiger R: 8th. Lippincott Williams and Wilkins; Philadelphia, PA: pp. 904–930. 2000

27 

Dai G, Levy O and Carrasco N: Cloning and characterization of the thyroid iodide transporter. Nature. 379:458–460. 1996. View Article : Google Scholar : PubMed/NCBI

28 

Smanik PA, Liu Q, Furminger TL, Ryu K, Xing S, Mazzaferri EL and Jhiang SM: Cloning of the human sodium lodide symporter. Biochem Biophys Res Commun. 226:339–345. 1996. View Article : Google Scholar : PubMed/NCBI

29 

Paire A, Bernier-Valentin F, Selmi-Ruby S and Rousset B: Characterization of the rat thyroid iodide transporter using anti-peptide antibodies. Relationship between its expression and activity. J Biol Chem. 272:18245–18249. 1997. View Article : Google Scholar : PubMed/NCBI

30 

Caillou B, Troalen F, Baudin E, Talbot M, Filetti S, Schlumberger M and Bidart JM: Na+/I− symporter distribution in human thyroid tissues: an immunohistochemical study. J Clin Endocrinol Metab. 83:4102–4106. 1998.PubMed/NCBI

31 

Carrasco N: Iodide transport in the thyroid gland. Biochim Biophys Acta. 1154:65–82. 1993. View Article : Google Scholar : PubMed/NCBI

32 

Shen DH, Kloos RT, Mazzaferri EL and Jhian SM: Sodium iodide symporter in health and disease. Thyroid. 11:415–425. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Kogai T, Schultz JJ, Johnson LS, Huang M and Brent GA: Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line. Proc Natl Acad Sci USA. 97:8519–8524. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Mandell RB, Mandell LZ and Link CJ Jr: Radioisotope concentrator gene therapy using the sodium/iodide symporter gene. Cancer Res. 59:661–668. 1999.PubMed/NCBI

35 

Campa D, Barrdahl M, Tsilidis KK, Severi G, Diver WR, Siddiq A, Chanock S, Hoover RN, Ziegler RG, Berg CD, et al: A genome-wide ‘pleiotropy scan’ does not identify new susceptibility loci for estrogen receptor negative breast cancer. PLoS One. 9:e859552014. View Article : Google Scholar

36 

Dwyer RM, Bergert ER, O’connor MK, Gendler SJ and Morris JC: In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter. Clin Cancer Res. 11:1483–1489. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Boland A, Ricard M, Opolon P, Bidart JM, Yeh P, Filetti S, Schlumberger M and Perricaudet M: Adenovirus-mediated transfer of the thyroid sodium/iodide symporter gene into tumors for a targeted radiotherapy. Cancer Res. 60:3484–3492. 2000.PubMed/NCBI

38 

Kilbane MT, Ajjan RA, Weetman AP, Dwyer R, McDermott EW, O’Higgins NJ and Smyth PP: Tissue iodine content and serum-mediated 125I uptake-blocking activity in breast cancer. J Clin Endocrinol Metab. 85:1245–1250. 2000.PubMed/NCBI

39 

Zhang M, Guo R, Shi S, Miao Y, Zhang Y and Li B: Baculovirus vector-mediated transfer of sodium iodide symporter and plasminogen kringle 5 genes for tumor radioiodide therapy. PLoS One. 9:e923262014. View Article : Google Scholar : PubMed/NCBI

40 

Spitzweg C, O’Connor MK, Bergert ER, Tindall DJ, Young CY and Morris JC: Treatment of prostate cancer by radioiodine therapy after tissue-specific expression of the sodium iodide symporter. Cancer Res. 60:6526–6530. 2000.PubMed/NCBI

41 

Scholz IV, Cengic N, Baker CH, Harrington KJ, Maletz K, Bergert ER, Vile R, Göke B, Morris JC and Spitzweg C: Radioiodine therapy of colon cancer following tissue-specific sodium iodide symporter gene transfer. Gene Ther. 12:272–280. 2005. View Article : Google Scholar

42 

Cengic N, Baker CH, Schütz M, Göke B, Morris JC and Spitzweg C: A novel therapeutic strategy for medullary thyroid cancer based on radioiodine therapy following tissue-specific sodium iodide symporter gene expression. J Clin Endocrinol Metab. 90:4457–4464. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Knostman KA, Cho JY, Ryu KY, Lin X, McCubrey JA, Hla T, Liu CH, Di Carlo E, Keri R, Zhang M, et al: Signaling through 3′,5′-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer. J Clin Endocrinol Metab. 89:5196–5203. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yao C, Pan Y, Li Y, Xu X, Lin Y, Wang W and Wang S: Effect of sodium/iodide symporter (NIS)-mediated radioiodine therapy on estrogen receptor-negative breast cancer. Oncol Rep 34: 59-66, 2015.
APA
Yao, C., Pan, Y., Li, Y., Xu, X., Lin, Y., Wang, W., & Wang, S. (2015). Effect of sodium/iodide symporter (NIS)-mediated radioiodine therapy on estrogen receptor-negative breast cancer. Oncology Reports, 34, 59-66. https://doi.org/10.3892/or.2015.3946
MLA
Yao, C., Pan, Y., Li, Y., Xu, X., Lin, Y., Wang, W., Wang, S."Effect of sodium/iodide symporter (NIS)-mediated radioiodine therapy on estrogen receptor-negative breast cancer". Oncology Reports 34.1 (2015): 59-66.
Chicago
Yao, C., Pan, Y., Li, Y., Xu, X., Lin, Y., Wang, W., Wang, S."Effect of sodium/iodide symporter (NIS)-mediated radioiodine therapy on estrogen receptor-negative breast cancer". Oncology Reports 34, no. 1 (2015): 59-66. https://doi.org/10.3892/or.2015.3946
Copy and paste a formatted citation
x
Spandidos Publications style
Yao C, Pan Y, Li Y, Xu X, Lin Y, Wang W and Wang S: Effect of sodium/iodide symporter (NIS)-mediated radioiodine therapy on estrogen receptor-negative breast cancer. Oncol Rep 34: 59-66, 2015.
APA
Yao, C., Pan, Y., Li, Y., Xu, X., Lin, Y., Wang, W., & Wang, S. (2015). Effect of sodium/iodide symporter (NIS)-mediated radioiodine therapy on estrogen receptor-negative breast cancer. Oncology Reports, 34, 59-66. https://doi.org/10.3892/or.2015.3946
MLA
Yao, C., Pan, Y., Li, Y., Xu, X., Lin, Y., Wang, W., Wang, S."Effect of sodium/iodide symporter (NIS)-mediated radioiodine therapy on estrogen receptor-negative breast cancer". Oncology Reports 34.1 (2015): 59-66.
Chicago
Yao, C., Pan, Y., Li, Y., Xu, X., Lin, Y., Wang, W., Wang, S."Effect of sodium/iodide symporter (NIS)-mediated radioiodine therapy on estrogen receptor-negative breast cancer". Oncology Reports 34, no. 1 (2015): 59-66. https://doi.org/10.3892/or.2015.3946
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team