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Article

Concentrative nucleoside transporter 3 as a prognostic indicator for favorable outcome of t(8;21)-positive acute myeloid leukemia patients after cytarabine-based chemotherapy

  • Authors:
    • Ju Han Song
    • Kyung-Min Cho
    • Hyeoung-Joon Kim
    • Yeo-Kyeoung Kim
    • Nan Young Kim
    • Hee-Je Kim
    • Tae-Hyang Lee
    • Seung Yong Hwang
    • Tae Sung Kim
  • View Affiliations / Copyright

    Affiliations: Division of Life Sciences, School of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea, Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea, Division of Molecular and Life Science and GenoCheck Co., Ltd., Hanyang University, Ansan, Republic of Korea
  • Pages: 488-494
    |
    Published online on: May 7, 2015
       https://doi.org/10.3892/or.2015.3959
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Abstract

Although acute myeloid leukemia (AML) exhibits diverse responses to chemotherapy, patients harboring the t(8;21) translocation are part of a favorable risk group. However, the reason why this subgroup is more responsive to cytarabine-based therapy has not been elucidated. In the present study, we analyzed expression levels of cytarabine metabolism-related genes in patients diagnosed with AML with or without t(8;21) and investigated their correlation with clinical outcomes after cytarabine-based therapy. Among the 8 genes studied, expression of the concentrative nucleoside transporter 3 (CNT3) gene was significantly higher in t(8;21)-positive patients compared to the others in the test population and the validation cohort (P<0.001 in Mann-Whitney U test; P<0.002 in Pearson's correlation analysis). Additionally, in both multivariate and univariate analyses, t(8;21)-positive patients categorized in a higher CNT3 expression tertile had longer disease-free survival [hazard ratio (HR), 0.117; 95% confidence interval (CI), 0.025-0.557; P=0.008] and overall survival (HR, 0.062; 95% CI, 0.007-0.521; P=0.010) compared to t(8;21)-positive patients in a lower CNT3 expression tertile. Notably, these trends did not occur in t(8;21)-negative patients. Our results demonstrate that CNT3 expression is associated with overall favorable outcomes and is predictive of clinical outcomes in AML patients with t(8;21). This suggests that CNT3 expression can be used to optimize treatment strategies for AML patients.
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1 

Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G, Rees J, Hann I, Stevens R, Burnett A, et al The Medical Research Council Adult and Children’s Leukaemia Working Parties: The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial. Blood. 92:2322–2333. 1998.PubMed/NCBI

2 

Estey EH: Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management. Am J Hematol. 87:89–99. 2012. View Article : Google Scholar

3 

Bloomfield CD, Herzig GP, Peterson BA and Wolff SN: Long-term survival of patients with acute myeloid leukemia: Updated results from two trials evaluating postinduction chemotherapy. Cancer. 80(Suppl): 2186–2190. 1997. View Article : Google Scholar : PubMed/NCBI

4 

O’Brien S, Kantarjian HM, Keating M, Gagnon G, Cork A, Trujillo J and McCredie KB: Association of granulocytosis with poor prognosis in patients with acute myelogenous leukemia and translocation of chromosomes 8 and 21. J Clin Oncol. 7:1081–1086. 1989.

5 

Prébet T, Boissel N, Reutenauer S, Thomas X, Delaunay J, Cahn JY, Pigneux A, Quesnel B, Witz F, Thépot S, et al Acute Leukemia French Association; Groupe Ouest-Est des leucémies et autres maladies du sang (GOELAMS); Core Binding Factor Acute Myeloid Leukemia (CBF AML) intergroup: Acute myeloid leukemia with translocation (8;21) or inversion (16) in elderly patients treated with conventional chemotherapy: A collaborative study of the French CBF-AML intergroup. J Clin Oncol. 27:4747–4753. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Baer MR, Stewart CC, Lawrence D, Arthur DC, Byrd JC, Davey FR, Schiffer CA and Bloomfield CD: Expression of the neural cell adhesion molecule CD56 is associated with short remission duration and survival in acute myeloid leukemia with t(8;21)(q22;q22). Blood. 90:1643–1648. 1997.PubMed/NCBI

7 

Schaich M, Koch R, Soucek S, Repp R, Ehninger G and Illmer T: A sensitive model for prediction of relapse in adult acute myeloid leukaemia with t(8;21) using white blood cell count, CD56 and MDR1 gene expression at diagnosis. Br J Haematol. 125:477–479. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Yang DH, Lee JJ, Mun YC, Shin HJ, Kim YK, Cho SH, Chung IJ, Seong CM and Kim HJ: Predictable prognostic factor of CD56 expression in patients with acute myeloid leukemia with t(8:21) after high dose cytarabine or allogeneic hematopoietic stem cell transplantation. Am J Hematol. 82:1–5. 2007. View Article : Google Scholar

9 

Bloomfield CD, Lawrence D, Byrd JC, Carroll A, Pettenati MJ, Tantravahi R, Patil SR, Davey FR, Berg DT, Schiffer CA, et al: Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype. Cancer Res. 58:4173–4179. 1998.PubMed/NCBI

10 

Weick JK, Kopecky KJ, Appelbaum FR, Head DR, Kingsbury LL, Balcerzak SP, Bickers JN, Hynes HE, Welborn JL, Simon SR, et al: A randomized investigation of high-dose versus standard-dose cytosine arabinoside with daunorubicin in patients with previously untreated acute myeloid leukemia: A Southwest Oncology Group study. Blood. 88:2841–2851. 1996.PubMed/NCBI

11 

Schnetzke U, Fix P, Spies-Weisshart B, Schrenk K, Glaser A, Fricke HJ, La Rosée P, Hochhaus A and Scholl S: Efficacy and feasibility of cyclophosphamide combined with intermediate- dose or high-dose cytarabine for relapsed and refractory acute myeloid leukemia (AML). J Cancer Res Clin Oncol. 140:1391–1397. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Damaraju VL, Damaraju S, Young JD, Baldwin SA, Mackey J, Sawyer MB and Cass CE: Nucleoside anticancer drugs: The role of nucleoside transporters in resistance to cancer chemotherapy. Oncogene. 22:7524–7536. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Zhang J, Visser F, King KM, Baldwin SA, Young JD and Cass CE: The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs. Cancer Metastasis Rev. 26:85–110. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Momparler RL and Fischer GA: Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase: Purification, properties, and kinetic studies with cytosine arabinoside. J Biol Chem. 243:4298–4304. 1968.PubMed/NCBI

15 

Galmarini CM, Thomas X, Graham K, El Jafaari A, Cros E, Jordheim L, Mackey JR and Dumontet C: Deoxycytidine kinase and cN-II nucleotidase expression in blast cells predict survival in acute myeloid leukaemia patients treated with cytarabine. Br J Haematol. 122:53–60. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Molina-Arcas M, Bellosillo B, Casado FJ, Montserrat E, Gil J, Colomer D and Pastor-Anglada M: Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. Blood. 101:2328–2334. 2003. View Article : Google Scholar

17 

Song JH, Kim SH, Kweon SH, Lee TH, Kim HJ, Kim HJ and Kim TS: Defective expression of deoxycytidine kinase in cytarabine-resistant acute myeloid leukemia cells. Int J Oncol. 34:1165–1171. 2009.PubMed/NCBI

18 

Takagaki K, Katsuma S, Kaminishi Y, Horio T, Nakagawa S, Tanaka T, Ohgi T and Yano J: Gene-expression profiling reveals down-regulation of equilibrative nucleoside transporter 1 (ENT1) in Ara-C-resistant CCRF-CEM-derived cells. J Biochem. 136:733–740. 2004. View Article : Google Scholar

19 

Abraham A, Varatharajan S, Abbas S, Zhang W, Shaji RV, Ahmed R, Abraham A, George B, Srivastava A, Chandy M, et al: Cytidine deaminase genetic variants influence RNA expression and cytarabine cytotoxicity in acute myeloid leukemia. Pharmacogenomics. 13:269–282. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Galmarini CM, Cros E, Graham K, Thomas X, Mackey JR and Dumontet C: 5′-(3′)-nucleotidase mRNA levels in blast cells are a prognostic factor in acute myeloid leukemia patients treated with cytarabine. Haematologica. 89:617–619. 2004.PubMed/NCBI

21 

Momparler RL, Eliopoulos N, Bovenzi V, Létourneau S, Greenbaum M and Cournoyer D: Resistance to cytosine arabi-noside by retrovirally mediated gene transfer of human cytidine deaminase into murine fibroblast and hematopoietic cells. Cancer Gene Ther. 3:331–338. 1996.PubMed/NCBI

22 

Ujházy P, Berleth ES, Pietkiewicz JM, Kitano H, Skaar JR, Ehrke MJ and Mihich E: Evidence for the involvement of ecto-5′-nucleotidase (CD73) in drug resistance. Int J Cancer. 68:493–500. 1996. View Article : Google Scholar

23 

Smid K, Bergman AM, Eijk PP, Veerman G, van Haperen VW, van den Ijssel P, Ylstra B and Peters GJ: Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits. Nucleosides Nucleotides Nucleic Acids. 25:1001–1007. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Song JH, Kweon SH, Kim HJ, Lee TH, Min WS, Kim HJ, Kim YK, Hwang SY and Kim TS: High TOP2B/TOP2A expression ratio at diagnosis correlates with favourable outcome for standard chemotherapy in acute myeloid leukaemia. Br J Cancer. 107:108–115. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Cho EK, Bang SM, Ahn JY, Yoo SM, Park PW, Seo YH, Shin DB and Lee JH: Prognostic value of AML 1/ETO fusion transcripts in patients with acute myelogenous leukemia. Korean J Intern Med. 18:13–20. 2003.PubMed/NCBI

26 

Downing JR: The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: Biology and clinical significance. Br J Haematol. 106:296–308. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Schaich M, Harbich-Brutscher E, Pascheberg U, Mohr B, Soucek S, Ehninger G and Illmer T: Association of specific cytogenetic aberrations with mdr1 gene expression in adult myeloid leukemia and its implication in treatment outcome. Haematologica. 87:455–464. 2002.PubMed/NCBI

28 

Jin G, Matsushita H, Asai S, Tsukamoto H, Ono R, Nosaka T, Yahata T, Takahashi S and Miyachi H: FLT3-ITD induces ara-C resistance in myeloid leukemic cells through the repression of the ENT1 expression. Biochem Biophys Res Commun. 390:1001–1006. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Jordheim LP and Dumontet C: Review of recent studies on resistance to cytotoxic deoxynucleoside analogues. Biochim Biophys Acta. 1776:138–159. 2007.PubMed/NCBI

30 

Mackey JR, Galmarini CM, Graham KA, Joy AA, Delmer A, Dabbagh L, Glubrecht D, Jewell LD, Lai R, Lang T, et al: Quantitative analysis of nucleoside transporter and metabolism gene expression in chronic lymphocytic leukemia (CLL): Identification of fludarabine-sensitive and -insensitive populations. Blood. 105:767–774. 2005. View Article : Google Scholar

31 

Guo Y, Köck K, Ritter CA, Chen ZS, Grube M, Jedlitschky G, Illmer T, Ayres M, Beck JF, Siegmund W, et al: Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: Relation to long-term survival. Clin Cancer Res. 15:1762–1769. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Griffiths M, Beaumont N, Yao SY, Sundaram M, Boumah CE, Davies A, Kwong FY, Coe I, Cass CE, Young JD, et al: Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs. Nat Med. 3:89–93. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Hubeek I, Stam RW, Peters GJ, Broekhuizen R, Meijerink JP, van Wering ER, Gibson BE, Creutzig U, Zwaan CM, Cloos J, et al: The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia. Br J Cancer. 93:1388–1394. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Ritzel MW, Ng AM, Yao SY, Graham K, Loewen SK, Smith KM, Ritzel RG, Mowles DA, Carpenter P, Chen XZ, et al: Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). J Biol Chem. 276:2914–2927. 2001. View Article : Google Scholar

35 

Galmarini CM, Thomas X, Calvo F, Rousselot P, El Jafaari A, Cros E and Dumontet C: Potential mechanisms of resistance to cytarabine in AML patients. Leuk Res. 26:621–629. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Stam RW, den Boer ML, Meijerink JP, Ebus ME, Peters GJ, Noordhuis P, Janka-Schaub GE, Armstrong SA, Korsmeyer SJ and Pieters R: Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia. Blood. 101:1270–1276. 2003. View Article : Google Scholar

37 

Fotoohi AK, Lindqvist M, Peterson C and Albertioni F: Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines. Biochem Biophys Res Commun. 343:208–215. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Karim H, Hashemi J, Larsson C, Moshfegh A, Fotoohi AK and Albertioni F: The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells. Biochem Biophys Res Commun. 411:156–161. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Verhaak RG, Wouters BJ, Erpelinck CA, Abbas S, Beverloo HB, Lugthart S, Löwenberg B, Delwel R and Valk PJ: Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling. Haematologica. 94:131–134. 2009. View Article : Google Scholar :

40 

Balgobind BV, Van den Heuvel-Eibrink MM, De Menezes RX, Reinhardt D, Hollink IH, Arentsen-Peters ST, van Wering ER, Kaspers GJ, Cloos J, de Bont ES, et al: Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemia. Haematologica. 96:221–230. 2011. View Article : Google Scholar :

41 

Ichikawa H, Tanabe K, Mizushima H, Hayashi Y, Mizutani S, Ishii E, Hongo T, Kikuchi A and Satake M: Common gene expression signatures in t(8;21)- and inv(16)-acute myeloid leukaemia. Br J Haematol. 135:336–347. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Duflot S, Riera B, Fernández-Veledo S, Casadó V, Norman RI, Casado FJ, Lluís C, Franco R and Pastor-Anglada M: ATP-sensitive K+ channels regulate the concentrative adenosine transporter CNT2 following activation by A1 adenosine receptors. Mol Cell Biol. 24:2710–2719. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Fernández-Veledo S, Valdés R, Wallenius V, Casado FJ and Pastor-Anglada M: Up-regulation of the high-affinity pyrimidine-preferring nucleoside transporter concentrative nucleoside transporter 1 by tumor necrosis factor-alpha and interleukin-6 in liver parenchymal cells. J Hepatol. 41:538–544. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Soler C, Felipe A, García-Manteiga J, Serra M, Guillén-Gómez E, Casado FJ, MacLeod C, Modolell M, Pastor-Anglada M and Celada A: Interferon-gamma regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways. Biochem J. 375:777–783. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Song JH, Cho K, Kim H, Kim Y, Kim NY, Kim H, Lee T, Hwang SY and Kim TS: Concentrative nucleoside transporter 3 as a prognostic indicator for favorable outcome of t(8;21)-positive acute myeloid leukemia patients after cytarabine-based chemotherapy. Oncol Rep 34: 488-494, 2015.
APA
Song, J.H., Cho, K., Kim, H., Kim, Y., Kim, N.Y., Kim, H. ... Kim, T.S. (2015). Concentrative nucleoside transporter 3 as a prognostic indicator for favorable outcome of t(8;21)-positive acute myeloid leukemia patients after cytarabine-based chemotherapy. Oncology Reports, 34, 488-494. https://doi.org/10.3892/or.2015.3959
MLA
Song, J. H., Cho, K., Kim, H., Kim, Y., Kim, N. Y., Kim, H., Lee, T., Hwang, S. Y., Kim, T. S."Concentrative nucleoside transporter 3 as a prognostic indicator for favorable outcome of t(8;21)-positive acute myeloid leukemia patients after cytarabine-based chemotherapy". Oncology Reports 34.1 (2015): 488-494.
Chicago
Song, J. H., Cho, K., Kim, H., Kim, Y., Kim, N. Y., Kim, H., Lee, T., Hwang, S. Y., Kim, T. S."Concentrative nucleoside transporter 3 as a prognostic indicator for favorable outcome of t(8;21)-positive acute myeloid leukemia patients after cytarabine-based chemotherapy". Oncology Reports 34, no. 1 (2015): 488-494. https://doi.org/10.3892/or.2015.3959
Copy and paste a formatted citation
x
Spandidos Publications style
Song JH, Cho K, Kim H, Kim Y, Kim NY, Kim H, Lee T, Hwang SY and Kim TS: Concentrative nucleoside transporter 3 as a prognostic indicator for favorable outcome of t(8;21)-positive acute myeloid leukemia patients after cytarabine-based chemotherapy. Oncol Rep 34: 488-494, 2015.
APA
Song, J.H., Cho, K., Kim, H., Kim, Y., Kim, N.Y., Kim, H. ... Kim, T.S. (2015). Concentrative nucleoside transporter 3 as a prognostic indicator for favorable outcome of t(8;21)-positive acute myeloid leukemia patients after cytarabine-based chemotherapy. Oncology Reports, 34, 488-494. https://doi.org/10.3892/or.2015.3959
MLA
Song, J. H., Cho, K., Kim, H., Kim, Y., Kim, N. Y., Kim, H., Lee, T., Hwang, S. Y., Kim, T. S."Concentrative nucleoside transporter 3 as a prognostic indicator for favorable outcome of t(8;21)-positive acute myeloid leukemia patients after cytarabine-based chemotherapy". Oncology Reports 34.1 (2015): 488-494.
Chicago
Song, J. H., Cho, K., Kim, H., Kim, Y., Kim, N. Y., Kim, H., Lee, T., Hwang, S. Y., Kim, T. S."Concentrative nucleoside transporter 3 as a prognostic indicator for favorable outcome of t(8;21)-positive acute myeloid leukemia patients after cytarabine-based chemotherapy". Oncology Reports 34, no. 1 (2015): 488-494. https://doi.org/10.3892/or.2015.3959
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