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Article

miR-34a inhibits the migration and invasion of esophageal squamous cell carcinoma by targeting Yin Yang-1

  • Authors:
    • Jihua Nie
    • Xin Ge
    • Yangyang Geng
    • Han Cao
    • Wei Zhu
    • Yang Jiao
    • Jinchang Wu
    • Jundong Zhou
    • Jianping Cao
  • View Affiliations / Copyright

    Affiliations: School of Radiation Medicine and Protection and Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu 215123, P.R. China, The Core Laboratory of Suzhou Cancer Center and Department of Radiotherapy of Suzhou Municipal Hospital, Suzhou, Jiangsu 215001, P.R. China
  • Pages: 311-317
    |
    Published online on: May 7, 2015
       https://doi.org/10.3892/or.2015.3962
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Abstract

Esophageal squamous cell carcinoma (ESCC), one of the most common gastrointestinal tumors, is known for its high mortality rate. microRNAs (miRNAs) have been reported to play important regulatory roles in cancer metastasis and progression. miR-34a has been demonstrated to be associated with the development of and metastasis in certain types of cancer via various target genes, but its function and targets in ESCC are unknown. The aim of this study was to examine whether the expression of miR-34a was significantly decreased in ESCC tissues, compared with normal esophageal tissues using RT-PCR and western blot analysis. The results showed that miR-34a overexpression increased apoptosis and decreased clonogenic formation, but inhibited invasion and migration in ESCC cells by suppressing MMP-2 and -9 expression. Yin Yang-1 (YY1), a widely distributed transcription factor that belongs to the GLI-Kruppel class of zinc finger proteins, was found to be a direct target of miR-34a in ESCC cell lines. Rescue experiments indicated that the suppressive effect of miR-34a on invasion and migration was mediated by activating YY1 expression. Results of the present study showed that miR-34a is associated with ESCC migration and provides a potential therapeutic and diagnostic target for ESCC.
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Copy and paste a formatted citation
Spandidos Publications style
Nie J, Ge X, Geng Y, Cao H, Zhu W, Jiao Y, Wu J, Zhou J and Cao J: miR-34a inhibits the migration and invasion of esophageal squamous cell carcinoma by targeting Yin Yang-1. Oncol Rep 34: 311-317, 2015.
APA
Nie, J., Ge, X., Geng, Y., Cao, H., Zhu, W., Jiao, Y. ... Cao, J. (2015). miR-34a inhibits the migration and invasion of esophageal squamous cell carcinoma by targeting Yin Yang-1. Oncology Reports, 34, 311-317. https://doi.org/10.3892/or.2015.3962
MLA
Nie, J., Ge, X., Geng, Y., Cao, H., Zhu, W., Jiao, Y., Wu, J., Zhou, J., Cao, J."miR-34a inhibits the migration and invasion of esophageal squamous cell carcinoma by targeting Yin Yang-1". Oncology Reports 34.1 (2015): 311-317.
Chicago
Nie, J., Ge, X., Geng, Y., Cao, H., Zhu, W., Jiao, Y., Wu, J., Zhou, J., Cao, J."miR-34a inhibits the migration and invasion of esophageal squamous cell carcinoma by targeting Yin Yang-1". Oncology Reports 34, no. 1 (2015): 311-317. https://doi.org/10.3892/or.2015.3962
Copy and paste a formatted citation
x
Spandidos Publications style
Nie J, Ge X, Geng Y, Cao H, Zhu W, Jiao Y, Wu J, Zhou J and Cao J: miR-34a inhibits the migration and invasion of esophageal squamous cell carcinoma by targeting Yin Yang-1. Oncol Rep 34: 311-317, 2015.
APA
Nie, J., Ge, X., Geng, Y., Cao, H., Zhu, W., Jiao, Y. ... Cao, J. (2015). miR-34a inhibits the migration and invasion of esophageal squamous cell carcinoma by targeting Yin Yang-1. Oncology Reports, 34, 311-317. https://doi.org/10.3892/or.2015.3962
MLA
Nie, J., Ge, X., Geng, Y., Cao, H., Zhu, W., Jiao, Y., Wu, J., Zhou, J., Cao, J."miR-34a inhibits the migration and invasion of esophageal squamous cell carcinoma by targeting Yin Yang-1". Oncology Reports 34.1 (2015): 311-317.
Chicago
Nie, J., Ge, X., Geng, Y., Cao, H., Zhu, W., Jiao, Y., Wu, J., Zhou, J., Cao, J."miR-34a inhibits the migration and invasion of esophageal squamous cell carcinoma by targeting Yin Yang-1". Oncology Reports 34, no. 1 (2015): 311-317. https://doi.org/10.3892/or.2015.3962
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