Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
July-2015 Volume 34 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2015 Volume 34 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Melatonin decreases cell proliferation, impairs myogenic differentiation and triggers apoptotic cell death in rhabdomyosarcoma cell lines

  • Authors:
    • Silvia Codenotti
    • Michela Battistelli
    • Sabrina Burattini
    • Sara Salucci
    • Elisabetta Falcieri
    • Rita Rezzani
    • Fiorella Faggi
    • Marina Colombi
    • Eugenio Monti
    • Alessandro Fanzani
  • View Affiliations / Copyright

    Affiliations: Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, I-25123 Brescia, Italy, Department of Earth, Life and Environmental Sciences (DiSTeVA), University Carlo Bo, I-61029 Urbino, Italy, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, I-25123 Brescia, Italy
  • Pages: 279-287
    |
    Published online on: May 19, 2015
       https://doi.org/10.3892/or.2015.3987
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Melatonin is a small indole produced by the pineal gland and other tissues, and has numerous functions that aid in the maintenance of the whole body homeostasis, ranging from the regulation of circadian rhythms and sleep to protection from oxidative stress. Melatonin has also been reported to counteract cell growth and chemoresistance in different types of cancer. In the present study, we investigated the effects of exogenous melatonin administration on different human cell lines and primary mouse tumor cultures of rhabdomyosarcoma (RMS), the most frequent soft tissue sarcoma affecting childhood. The results showed that melatonin significantly affected the behavior of RMS cells, leading to inhibition of cell proliferation and impairment of myogenic differentiation followed by increased apoptotic cell death, as observed by immunoblotting analysis of apoptosis-related markers including Bax, Bcl-2 and caspase-3. Similar findings were observed using a combination of microscopy techniques, including scanning/transmission electron and confocal microscopy. Furthermore, melatonin in combination with doxorubicin or cisplatin, two compounds commonly used for the treatment of solid tumors, increased the sensitivity of RMS cells to apoptosis. These data indicated that melatonin may be effective in counteracting RMS tumor growth and chemoresistance.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Saab R, Spunt SL and Skapek SX: Myogenesis and rhabdomyosarcoma the Jekyll and Hyde of skeletal muscle. Curr Top Dev Biol. 94:197–234. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Dasgupta R and Rodeberg DA: Update on rhabdomyosarcoma. Semin Pediatr Surg. 21:68–78. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Parham DM, Alaggio R and Coffin CM: Myogenic tumors in children and adolescents. Pediatr Dev Pathol. 15(Suppl 1): S211–S238. 2012. View Article : Google Scholar

4 

Ognjanovic S, Linabery AM, Charbonneau B and Ross JA: Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975–2005. Cancer. 115:4218–4226. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Williamson D, Missiaglia E, de Reyniès A, Pierron G, Thuille B, Palenzuela G, Thway K, Orbach D, Laé M, Fréneaux P, et al: Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma. J Clin Oncol. 28:2151–2158. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Chen X, Stewart E, Shelat AA, Qu C, Bahrami A, Hatley M, Wu G, Bradley C, McEvoy J, Pappo A, et al: St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project: Targeting oxidative stress in embryonal rhabdomyosarcoma. Cancer Cell. 24:710–724. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Shukla N, Ameur N, Yilmaz I, Nafa K, Lau CY, Marchetti A, Borsu L, Barr FG and Ladanyi M: Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways. Clin Cancer Res. 18:748–757. 2012. View Article : Google Scholar :

8 

Shern JF, Chen L, Chmielecki J, Wei JS, Patidar R, Rosenberg M, Ambrogio L, Auclair D, Wang J, Song YK, et al: Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors. Cancer Discov. 4:216–231. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Abraham J, Prajapati SI, Nishijo K, Schaffer BS, Taniguchi E, Kilcoyne A, McCleish AT, Nelon LD, Giles FG, Efstratiadis A, et al: Evasion mechanisms to Igf1r inhibition in rhabdomyosarcoma. Mol Cancer Ther. 10:697–707. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Taylor JG VI, Cheuk AT, Tsang PS, Chung JY, Song YK, Desai K, Yu Y, Chen QR, Shah K, Youngblood V, et al: Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models. J Clin Invest. 119:3395–3407. 2009.PubMed/NCBI

11 

Crose LE and Linardic CM: Receptor tyrosine kinases as therapeutic targets in rhabdomyosarcoma. Sarcoma. 2011:7569822011. View Article : Google Scholar : PubMed/NCBI

12 

Lee Y, Kawagoe R, Sasai K, Li Y, Russell HR, Curran T and McKinnon PJ: Loss of suppressor-of-fused function promotes tumorigenesis. Oncogene. 26:6442–6447. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Petricoin EF III, Espina V, Araujo RP, Midura B, Yeung C, Wan X, Eichler GS, Johann DJ Jr, Qualman S, Tsokos M, et al: Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival. Cancer Res. 67:3431–3440. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Guenther MK, Graab U and Fulda S: Synthetic lethal interaction between PI3K/Akt/mTOR and Ras/MEK/ERK pathway inhibition in rhabdomyosarcoma. Cancer Lett. 337:200–209. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Hahn H, Wojnowski L, Specht K, Kappler R, Calzada-Wack J, Potter D, Zimmer A, Müller U, Samson E, Quintanilla-Martinez L, et al: Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma. J Biol Chem. 275:28341–28344. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Marshall AD and Grosveld GC: Alveolar rhabdomyosarcoma-The molecular drivers of PAX3/7-FOXO1-induced tumorigenesis. Skelet Muscle. 2:252012. View Article : Google Scholar

17 

Barr FG, Galili N, Holick J, Biegel JA, Rovera G and Emanuel BS: Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma. Nat Genet. 3:113–117. 1993. View Article : Google Scholar : PubMed/NCBI

18 

Graf Finckenstein F, Shahbazian V, Davicioni E, Ren YX and Anderson MJ: PAX-FKHR function as pangenes by simultaneously inducing and inhibiting myogenesis. Oncogene. 27:2004–2014. 2008. View Article : Google Scholar

19 

Keller C and Guttridge DC: Mechanisms of impaired differentiation in rhabdomyosarcoma. FEBS J. 280:4323–4334. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Carlberg C: Gene regulation by melatonin. Ann NY Acad Sci. 917:387–396. 2000. View Article : Google Scholar

21 

Stehle JH, Saade A, Rawashdeh O, Ackermann K, Jilg A, Sebestény T and Maronde E: A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases. J Pineal Res. 51:17–43. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Hardeland R: Melatonin: Signaling mechanisms of a pleiotropic agent. Biofactors. 35:183–192. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Challet E: Minireview: Entrainment of the suprachiasmatic clockwork in diurnal and nocturnal mammals. Endocrinology. 148:5648–5655. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Luchetti F, Betti M, Canonico B, Arcangeletti M, Ferri P, Galli F and Papa S: ERK MAPK activation mediates the antiapoptotic signaling of melatonin in UVB-stressed U937 cells. Free Radic Biol Med. 46:339–351. 2009. View Article : Google Scholar

25 

Luchetti F, Canonico B, Betti M, Arcangeletti M, Pilolli F, Piroddi M, Canesi L, Papa S and Galli F: Melatonin signaling and cell protection function. FASEB J. 24:3603–3624. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Tengattini S, Reiter RJ, Tan DX, Terron MP, Rodella LF and Rezzani R: Cardiovascular diseases: Protective effects of melatonin. J Pineal Res. 44:16–25. 2008.

27 

Zhang HM and Zhang Y: Melatonin: A well-documented antioxidant with conditional pro-oxidant actions. J Pineal Res. 57:131–146. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Bukowska A: Anticarcinogenic role of melatonin - potential mechanisms. Med Pr. 62:425–434. 2011.In Polish.

29 

Hrushesky WJ, Grutsch J, Wood P, Yang X, Oh EY, Ansell C, Kidder S, Ferrans C, Quiton DF, Reynolds J, et al: Circadian clock manipulation for cancer prevention and control and the relief of cancer symptoms. Integr Cancer Ther. 8:387–397. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Mao L, Yuan L, Slakey LM, Jones FE, Burow ME and Hill SM: Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen-activated protein kinase signaling pathway. Breast Cancer Res. 12:R1072010. View Article : Google Scholar : PubMed/NCBI

31 

Mediavilla MD, Sanchez-Barcelo EJ, Tan DX, Manchester L and Reiter RJ: Basic mechanisms involved in the anti-cancer effects of melatonin. Curr Med Chem. 17:4462–4481. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Santoro R, Marani M, Blandino G, Muti P and Strano S: Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation. Oncogene. 31:2931–2942. 2012. View Article : Google Scholar

33 

Schernhammer ES, Razavi P, Li TY, Qureshi AA and Han J: Rotating night shifts and risk of skin cancer in the nurses’ health study. J Natl Cancer Inst. 103:602–606. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Fan L, Sun G, Ma T, Zhong F and Wei W: Melatonin overcomes apoptosis resistance in human hepatocellular carcinoma by targeting survivin and XIAP. J Pineal Res. 55:174–183. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Liu L, Xu Y and Reiter RJ: Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63. Bone. 55:432–438. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Trubiani O, Recchioni R, Moroni F, Pizzicannella J, Caputi S and Di Primio R: Melatonin provokes cell death in human B-lymphoma cells by mitochondrial-dependent apoptotic pathway activation. J Pineal Res. 39:425–431. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Hong Y, Won J, Lee Y, Lee S, Park K, Chang KT and Hong Y: Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells. J Pineal Res. 56:264–274. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Jardim-Perassi BV, Arbab AS, Ferreira LC, Borin TF, Varma NR, Iskander AS, Shankar A, Ali MM and de Campos Zuccari DA: Effect of melatonin on tumor growth and angiogenesis in xenograft model of breast cancer. PLoS One. 9:e853112014. View Article : Google Scholar : PubMed/NCBI

39 

Jung-Hynes B, Schmit TL, Reagan-Shaw SR, Siddiqui IA, Mukhtar H and Ahmad N: Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model. J Pineal Res. 50:140–149. 2011.

40 

Paroni R, Terraneo L, Bonomini F, Finati E, Virgili E, Bianciardi P, Favero G, Fraschini F, Reiter RJ, Rezzani R, et al: Antitumour activity of melatonin in a mouse model of human prostate cancer: Relationship with hypoxia signalling. J Pineal Res. 57:43–52. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Rubin BP, Nishijo K, Chen HI, Yi X, Schuetze DP, Pal R, Prajapati SI, Abraham J, Arenkiel BR, Chen QR, et al: Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma. Cancer Cell. 19:177–191. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Borenfreund E and Puerner JA: Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol Lett. 24:119–124. 1985. View Article : Google Scholar : PubMed/NCBI

43 

Repetto G, del Peso A and Zurita JL: Neutral red uptake assay for the estimation of cell viability/cytotoxicity. Nat Protoc. 3:1125–1131. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Battistelli M, Salucci S, Burattini S and Falcieri E: Further considerations on in vitro skeletal muscle cell death. Muscles Ligaments Tendons J. 3:267–274. 2013.

45 

Salucci S, Burattini S, Battistelli M, Baldassarri V, Curzi D, Valmori A and Falcieri E: Melatonin prevents chemical-induced haemopoietic cell death. Int J Mol Sci. 15:6625–6640. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Oltvai ZN, Milliman CL and Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 74:609–619. 1993. View Article : Google Scholar : PubMed/NCBI

47 

Youle RJ and Strasser A: The BCL-2 protein family: Opposing activities that mediate cell death. Nat Rev Mol Cell Biol. 9:47–59. 2008. View Article : Google Scholar

48 

Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ and Green DR: The BCL-2 family reunion. Mol Cell. 37:299–310. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Zhang S, Zuo L, Gui S, Zhou Q, Wei W and Wang Y: Induction of cell differentiation and promotion of endocan gene expression in stomach cancer by melatonin. Mol Biol Rep. 39:2843–2849. 2012. View Article : Google Scholar

50 

Sainz RM, Mayo JC, Tan DX, León J, Manchester L and Reiter RJ: Melatonin reduces prostate cancer cell growth leading to neuroendocrine differentiation via a receptor and PKA independent mechanism. Prostate. 63:29–43. 2005. View Article : Google Scholar

51 

Vijayalaxmi Thomas CR Jr, Reiter RJ and Herman TS: Melatonin: From basic research to cancer treatment clinics. J Clin Oncol. 20:2575–2601. 2002. View Article : Google Scholar : PubMed/NCBI

52 

Panzer A and Viljoen M: The validity of melatonin as an oncostatic agent. J Pineal Res. 22:184–202. 1997. View Article : Google Scholar : PubMed/NCBI

53 

Lissoni P, Barni S, Mandalà M, Ardizzoia A, Paolorossi F, Vaghi M, Longarini R, Malugani F and Tancini G: Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status. Eur J Cancer. 35:1688–1692. 1999. View Article : Google Scholar

54 

Reiter RJ, Tan DX, Sainz RM, Mayo JC and Lopez-Burillo S: Melatonin: Reducing the toxicity and increasing the efficacy of drugs. J Pharm Pharmacol. 54:1299–1321. 2002. View Article : Google Scholar : PubMed/NCBI

55 

Fan LL, Sun GP, Wei W, Wang ZG, Ge L, Fu WZ and Wang H: Melatonin and doxorubicin synergistically induce cell apoptosis in human hepatoma cell lines. World J Gastroenterol. 16:1473–1481. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Reiter RJ and Tan DX: What constitutes a physiological concentration of melatonin? J Pineal Res. 34:79–80. 2003. View Article : Google Scholar

57 

Venegas C, García JA, Escames G, Ortiz F, López A, Doerrier C, García-Corzo L, López LC, Reiter RJ and Acuña-Castroviejo D: Extrapineal melatonin: Analysis of its subcellular distribution and daily fluctuations. J Pineal Res. 52:217–227. 2012. View Article : Google Scholar

58 

Seabra ML, Bignotto M, Pinto LR Jr and Tufik S: Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment. J Pineal Res. 29:193–200. 2000. View Article : Google Scholar : PubMed/NCBI

59 

Reiter RJ, Tan DX, Rosales-Corral S and Manchester LC: The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives. Mini Rev Med Chem. 13:373–384. 2013.

60 

Sainz RM, Mayo JC, Rodriguez C, Tan DX, Lopez-Burillo S and Reiter RJ: Melatonin and cell death: Differential actions on apoptosis in normal and cancer cells. Cell Mol Life Sci. 60:1407–1426. 2003. View Article : Google Scholar : PubMed/NCBI

61 

Wölfler A, Caluba HC, Abuja PM, Dohr G, Schauenstein K and Liebmann PM: Prooxidant activity of melatonin promotes fas-induced cell death in human leukemic Jurkat cells. FEBS Lett. 502:127–131. 2001. View Article : Google Scholar : PubMed/NCBI

62 

Bizzarri M, Proietti S, Cucina A and Reiter RJ: Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: A review. Expert Opin Ther Targets. 17:1483–1496. 2013. View Article : Google Scholar : PubMed/NCBI

63 

Galano A, Tan DX and Reiter RJ: On the free radical scavenging activities of melatonin’s metabolites, AFMK and AMK. J Pineal Res. 54:245–257. 2013. View Article : Google Scholar

64 

Bejarano I, Espino J, Barriga C, Reiter RJ, Pariente JA and Rodríguez AB: Pro-oxidant effect of melatonin in tumour leucocytes: Relation with its cytotoxic and pro-apoptotic effects. Basic Clin Pharmacol Toxicol. 108:14–20. 2011. View Article : Google Scholar

65 

Sánchez-Sánchez AM, Martín V, García-Santos G, Rodríguez-Blanco J, Casado-Zapico S, Suarez-Garnacho S, Antolín I and Rodriguez C: Intracellular redox state as determinant for melatonin antiproliferative vs cytotoxic effects in cancer cells. Free Radic Res. 45:1333–1341. 2011. View Article : Google Scholar : PubMed/NCBI

66 

Büyükavci M, Ozdemir O, Buck S, Stout M, Ravindranath Y and Savaşan S: Melatonin cytotoxicity in human leukemia cells: Relation with its pro-oxidant effect. Fundam Clin Pharmacol. 20:73–79. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Codenotti S, Battistelli M, Burattini S, Salucci S, Falcieri E, Rezzani R, Faggi F, Colombi M, Monti E, Fanzani A, Fanzani A, et al: Melatonin decreases cell proliferation, impairs myogenic differentiation and triggers apoptotic cell death in rhabdomyosarcoma cell lines. Oncol Rep 34: 279-287, 2015.
APA
Codenotti, S., Battistelli, M., Burattini, S., Salucci, S., Falcieri, E., Rezzani, R. ... Fanzani, A. (2015). Melatonin decreases cell proliferation, impairs myogenic differentiation and triggers apoptotic cell death in rhabdomyosarcoma cell lines. Oncology Reports, 34, 279-287. https://doi.org/10.3892/or.2015.3987
MLA
Codenotti, S., Battistelli, M., Burattini, S., Salucci, S., Falcieri, E., Rezzani, R., Faggi, F., Colombi, M., Monti, E., Fanzani, A."Melatonin decreases cell proliferation, impairs myogenic differentiation and triggers apoptotic cell death in rhabdomyosarcoma cell lines". Oncology Reports 34.1 (2015): 279-287.
Chicago
Codenotti, S., Battistelli, M., Burattini, S., Salucci, S., Falcieri, E., Rezzani, R., Faggi, F., Colombi, M., Monti, E., Fanzani, A."Melatonin decreases cell proliferation, impairs myogenic differentiation and triggers apoptotic cell death in rhabdomyosarcoma cell lines". Oncology Reports 34, no. 1 (2015): 279-287. https://doi.org/10.3892/or.2015.3987
Copy and paste a formatted citation
x
Spandidos Publications style
Codenotti S, Battistelli M, Burattini S, Salucci S, Falcieri E, Rezzani R, Faggi F, Colombi M, Monti E, Fanzani A, Fanzani A, et al: Melatonin decreases cell proliferation, impairs myogenic differentiation and triggers apoptotic cell death in rhabdomyosarcoma cell lines. Oncol Rep 34: 279-287, 2015.
APA
Codenotti, S., Battistelli, M., Burattini, S., Salucci, S., Falcieri, E., Rezzani, R. ... Fanzani, A. (2015). Melatonin decreases cell proliferation, impairs myogenic differentiation and triggers apoptotic cell death in rhabdomyosarcoma cell lines. Oncology Reports, 34, 279-287. https://doi.org/10.3892/or.2015.3987
MLA
Codenotti, S., Battistelli, M., Burattini, S., Salucci, S., Falcieri, E., Rezzani, R., Faggi, F., Colombi, M., Monti, E., Fanzani, A."Melatonin decreases cell proliferation, impairs myogenic differentiation and triggers apoptotic cell death in rhabdomyosarcoma cell lines". Oncology Reports 34.1 (2015): 279-287.
Chicago
Codenotti, S., Battistelli, M., Burattini, S., Salucci, S., Falcieri, E., Rezzani, R., Faggi, F., Colombi, M., Monti, E., Fanzani, A."Melatonin decreases cell proliferation, impairs myogenic differentiation and triggers apoptotic cell death in rhabdomyosarcoma cell lines". Oncology Reports 34, no. 1 (2015): 279-287. https://doi.org/10.3892/or.2015.3987
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team