|
1
|
Pancreatic Cancer-National Cancer
Institute, U.S. National Institutes of Health: Cancer Gov.
http:www.cancer.gov/cancer-topics/types/pancreatic.
Retrieved 06-04-2010.
|
|
2
|
Maitra A and Hruban RH: Pancreatic cancer.
Annu Rev Pathol. 3:157–188. 2008. View Article : Google Scholar
|
|
3
|
Li D, Xie K, Wolff R and Abbruzzese JL:
Pancreatic cancer. Lancet. 363:1049–1057. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Mulcahy MF, Wahl AO and Small W Jr: The
current status of combined radiotherapy and chemotherapy for
locally advanced or resected pancreas cancer. J Natl Compr Canc
Netw. 3:637–642. 2005.PubMed/NCBI
|
|
5
|
Pino SM, Xiong HQ, McConkey D and
Abbruzzese JL: Novel therapies for pancreatic adenocarcinoma. Curr
Oncol Rep. 6:199–206. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Vaccaro V, Sperduti I and Milella M:
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N
Engl J Med. 365:768–769; author reply 769. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Costa PM1, Ferreira PM, Bolzani Vda S,
Furlan M, de Freitas Formenton Macedo Dos Santos VA, Corsino J, de
Moraes MO, Costa-Lotufo LV, Montenegro RC and Pessoa C:
Antiproliferative activity of pristimerin isolated from Maytenus
ilicifolia (Celastraceae) in human HL-60 cells. Toxicol In Vitro.
22:854–863. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Yang H, Landis-Piwowar KR, Lu D, Yuan P,
Li L, Reddy GP, Yuan X and Dou QP: Pristimerin induces apoptosis by
targeting the proteasome in prostate cancer cells. J Cell Biochem.
103:234–244. 2008. View Article : Google Scholar
|
|
9
|
Yan YY, Bai JP, Xie Y, Yu JZ and Ma CG:
The triterpenoid pristimerin induces U87 glioma cell apoptosis
through reactive oxygen species-mediated mitochondrial dysfunction.
Oncol Lett. 5:242–248. 2013.
|
|
10
|
Wu CC, Chan ML, Chen WY, Tsai CY, Chang FR
and Wu YC: Pristimerin induces caspase-dependent apoptosis in
MDA-MB-231 cells via direct effects on mitochondria. Mol Cancer
Ther. 4:1277–1285. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Wang Y, Zhou Y, Zhou H, Jia G, Liu J, Han
B, Cheng Z, Jiang H, Pan S and Sun B: Pristimerin causes G1 arrest,
induces apoptosis, and enhances the chemosensitivity to gemcitabine
in pancreatic cancer cells. PLoS One. 7:e438262012. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Lu Z, Jin Y, Chen C, Li J, Cao Q and Pan
J: Pristimerin induces apoptosis in imatinib-resistant chronic
myelogenous leukemia cells harboring T315I mutation by blocking
NF-kappaB signaling and depleting Bcr-Abl. Mol Cancer. 9:1122010.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Deeb D, Gao X, Liu YB, Pindolia K and
Gautam SC: Pristimerin, a quinonemethide triterpenoid, induces
apoptosis in pancreatic cancer cells through the inhibition of
pro-survival Akt/NF-κB/mTOR signaling proteins and anti-apoptotic
Bcl-2. Int J Oncol. 44:1707–1715. 2014.PubMed/NCBI
|
|
14
|
Greider CW: Chromosome first aid. Cell.
67:645–647. 1991. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Blackburn EH: Structure and function of
telomeres. Nature. 350:569–573. 1991. View
Article : Google Scholar : PubMed/NCBI
|
|
16
|
Kilian A, Bowtell DD, Abud HE, Hime GR,
Venter DJ, Keese PK, Duncan EL, Reddel RR and Jefferson RA:
Isolation of a candidate human telomerase catalytic subunit gene,
which reveals complex splicing patterns in different cell types.
Hum Mol Genet. 6:2011–2019. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Feng J, Funk WD, Wang SS, Weinrich SL,
Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC, Yu J, et al:
The RNA component of human telomerase. Science. 269:1236–1241.
1995. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Palm W and de Lange T: How shelterin
protects mammalian telomeres. Annu Rev Genet. 42:301–334. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
De Boeck G, Forsyth RG, Praet M and
Hogendoorn PC: Telomere-associated proteins: Cross-talk between
telomere maintenance and telomere-lengthening mechanisms. J Pathol.
217:327–344. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Blasco MA and Hahn WC: Evolving views of
telomerase and cancer. Trends Cell Biol. 13:289–294. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Newbold RF: The significance of telomerase
activation and cellular immortalization in human cancer.
Mutagenesis. 17:539–550. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Janknecht R: On the road to immortality:
hTERT upregulation in cancer cells. FEBS Lett. 564:9–13. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Ohuchida K, Mizumoto K, Yamada D,
Yamaguchi H, Konomi H, Nagai E, Yamaguchi K, Tsuneyoshi M and
Tanaka M: Quantitative analysis of human telomerase reverse
transcriptase in pancreatic cancer. Clin Cancer Res. 12:2066–2069.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Grochola LF, Greither T, Taubert HW,
Möller P, Knippschild U, Udelnow A, Henne-Bruns D and Würl P:
Prognostic relevance of hTERT mRNA expression in ductal
adenocarcinoma of the pancreas. Neoplasia. 10:973–976. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Hashimoto Y, Murakami Y, Uemura K,
Hayashidani Y, Sudo T, Ohge H, Fukuda E, Sueda T and Hiyama E:
Detection of human telomerase reverse transcriptase (hTERT)
expression in tissue and pancreatic juice from pancreatic cancer.
Surgery. 143:113–125. 2008. View Article : Google Scholar
|
|
26
|
Kyo S, Takakura M, Taira T, Kanaya T, Itoh
H, Yutsudo M, Ariga H and Inoue M: Sp1 cooperates with c-Myc to
activate transcription of the human telomerase reverse
transcriptase gene (hTERT). Nucleic Acids Res. 28:669–677. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Konnikova L, Simeone MC, Kruger MM,
Kotecki M and Cochran BH: Signal transducer and activator of
transcription 3 (STAT3) regulates human telomerase reverse
transcriptase (hTERT) expression in human cancer and primary cells.
Cancer Res. 65:6516–6520. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Kang SS, Kwon T, Kwon DY and Do SI: Akt
protein kinase enhances human telomerase activity through
phosphorylation of telomerase reverse transcriptase subunit. J Biol
Chem. 274:13085–13090. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Chung J, Khadka P and Chung IK: Nuclear
import of hTERT requires a bipartite nuclear localization signal
and Akt-mediated phosphorylation. J Cell Sci. 125:2684–2697. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Meeran SM, Ahmed A and Tollefsbol TO:
Epigenetic targets of bioactive dietary components for cancer
prevention and therapy. Clin Epigenetics. 1:101–116. 2010.
View Article : Google Scholar
|
