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Article

Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death

  • Authors:
    • Ji-Hong Moon
    • Seong Kug Eo
    • John Hwa Lee
    • Sang-Youel Park
  • View Affiliations / Copyright

    Affiliations: Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea
  • Pages: 375-381
    |
    Published online on: May 19, 2015
       https://doi.org/10.3892/or.2015.3991
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Abstract

Quercetin is a potent cancer therapeutic agent and dietary antioxidant present in fruit and vegetables. Quercetin prevents tumor proliferation by inducing cell cycle arrest and is a well known cancer therapeutic agent and autophagy mediator. We investigated whether quercetin enhances TRAIL-induced tumor cell death and the possible mechanism in human lung cancer cells. We identified that quercetin markedly enhanced TRAIL-mediated lung cancer cell death. Quercetin treatment dose-dependently decreased the p62 protein expression and increased GFP-LC3B. Autophagy flux inhibitor, chloroquine treatment blocked the enhancing effects of TRAIL-induced apoptosis by quercetin. Our results indicated that quercetin enhanced TRAIL-induced cell death via autophagy flux activation, and also suggest that quercetin may be a therapeutic agent against human lung cancer via combination therapy with many anticancer drugs including TRAIL.
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Copy and paste a formatted citation
Spandidos Publications style
Moon J, Eo SK, Lee JH and Park S: Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death. Oncol Rep 34: 375-381, 2015.
APA
Moon, J., Eo, S.K., Lee, J.H., & Park, S. (2015). Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death. Oncology Reports, 34, 375-381. https://doi.org/10.3892/or.2015.3991
MLA
Moon, J., Eo, S. K., Lee, J. H., Park, S."Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death". Oncology Reports 34.1 (2015): 375-381.
Chicago
Moon, J., Eo, S. K., Lee, J. H., Park, S."Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death". Oncology Reports 34, no. 1 (2015): 375-381. https://doi.org/10.3892/or.2015.3991
Copy and paste a formatted citation
x
Spandidos Publications style
Moon J, Eo SK, Lee JH and Park S: Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death. Oncol Rep 34: 375-381, 2015.
APA
Moon, J., Eo, S.K., Lee, J.H., & Park, S. (2015). Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death. Oncology Reports, 34, 375-381. https://doi.org/10.3892/or.2015.3991
MLA
Moon, J., Eo, S. K., Lee, J. H., Park, S."Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death". Oncology Reports 34.1 (2015): 375-381.
Chicago
Moon, J., Eo, S. K., Lee, J. H., Park, S."Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death". Oncology Reports 34, no. 1 (2015): 375-381. https://doi.org/10.3892/or.2015.3991
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