1
|
Mendelsohn J and Baselga J: Status of
epidermal growth factor receptor antagonists in the biology and
treatment of cancer. J Clin Oncol. 21:2787–2799. 2003. View Article : Google Scholar : PubMed/NCBI
|
2
|
Chong CR and Jänne PA: The quest to
overcome resistance to EGFR-targeted therapies in cancer. Nat Med.
19:1389–1400. 2013. View
Article : Google Scholar : PubMed/NCBI
|
3
|
Nyati MK, Morgan MA, Feng FY and Lawrence
TS: Integration of EGFR inhibitors with radiochemotherapy. Nat Rev
Cancer. 6:876–885. 2006. View
Article : Google Scholar : PubMed/NCBI
|
4
|
Bonner JA, Harari PM, Giralt J, Cohen RB,
Jones CU, Sur RK, Raben D, Baselga J, Spencer SA, Zhu J, et al:
Radiotherapy plus cetuximab for locoregionally advanced head and
neck cancer: 5-year survival data from a phase 3 randomised trial,
and relation between cetuximab-induced rash and survival. Lancet
Oncol. 11:21–28. 2010. View Article : Google Scholar
|
5
|
Caudell JJ, Sawrie SM, Spencer SA, Desmond
RA, Carroll WR, Peters GE, Nabell LM, Meredith RF and Bonner JA:
Locoregionally advanced head and neck cancer treated with primary
radiotherapy: A comparison of the addition of cetuximab or
chemotherapy and the impact of protocol treatment. Int J Radiat
Oncol Biol Phys. 71:676–681. 2008. View Article : Google Scholar : PubMed/NCBI
|
6
|
Yamada KM and Even-Ram S: Integrin
regulation of growth factor receptors. Nat Cell Biol. 4:E75–E76.
2002. View Article : Google Scholar : PubMed/NCBI
|
7
|
Cabodi S, Moro L, Bergatto E, Boeri Erba
E, Di Stefano P, Turco E, Tarone G and Defilippi P: Integrin
regulation of epidermal growth factor (EGF) receptor and of
EGF-dependent responses. Biochem Soc Trans. 32:438–442. 2004.
View Article : Google Scholar : PubMed/NCBI
|
8
|
Eke I, Storch K, Krause M and Cordes N:
Cetuximab attenuates its cytotoxic and radiosensitizing potential
by inducing fibronectin biosynthesis. Cancer Res. 73:5869–5879.
2013. View Article : Google Scholar : PubMed/NCBI
|
9
|
Hehlgans S, Haase M and Cordes N:
Signalling via integrins: Implications for cell survival and
anticancer strategies. Biochim Biophys Acta. 1775:163–180.
2007.
|
10
|
Braverman LE and Quilliam LA:
Identification of Grb4/Nckbeta, a src homology 2 and 3
domain-containing adapter protein having similar binding and
biological properties to Nck. J Biol Chem. 274:5542–5549. 1999.
View Article : Google Scholar : PubMed/NCBI
|
11
|
Chiswell BP, Zhang R, Murphy JW, Boggon TJ
and Calderwood DA: The structural basis of integrin-linked
kinase-PINCH interactions. Proc Natl Acad Sci USA. 105:20677–20682.
2008. View Article : Google Scholar : PubMed/NCBI
|
12
|
Tu Y, Li F and Wu C: Nck-2, a novel Src
homology2/3-containing adaptor protein that interacts with the
LIM-only protein PINCH and components of growth factor receptor
kinase-signaling pathways. Mol Biol Cell. 9:3367–3382. 1998.
View Article : Google Scholar : PubMed/NCBI
|
13
|
Vaynberg J, Fukuda T, Chen K, Vinogradova
O, Velyvis A, Tu Y, Ng L, Wu C and Qin J: Structure of an ultraweak
protein-protein complex and its crucial role in regulation of cell
morphology and motility. Mol Cell. 17:513–523. 2005. View Article : Google Scholar : PubMed/NCBI
|
14
|
Legate KR, Montañez E, Kudlacek O and
Fässler R: ILK, PINCH and parvin: The tIPP of integrin signalling.
Nat Rev Mol Cell Biol. 7:20–31. 2006. View
Article : Google Scholar : PubMed/NCBI
|
15
|
Xu Z, Fukuda T, Li Y, Zha X, Qin J and Wu
C: Molecular dissection of PINCH-1 reveals a mechanism of coupling
and uncoupling of cell shape modulation and survival. J Biol Chem.
280:27631–27637. 2005. View Article : Google Scholar : PubMed/NCBI
|
16
|
Eke I and Cordes N: Dual targeting of EGFR
and focal adhesion kinase in 3D grown HNSCC cell cultures.
Radiother Oncol. 99:279–286. 2011. View Article : Google Scholar : PubMed/NCBI
|
17
|
Eke I, Sandfort V, Storch K, Baumann M,
Röper B and Cordes N: Pharmacological inhibition of EGFR tyrosine
kinase affects ILK-mediated cellular radiosensitization in vitro.
Int J Radiat Biol. 83:793–802. 2007. View Article : Google Scholar : PubMed/NCBI
|
18
|
Morello V, Cabodi S, Sigismund S,
Camacho-Leal MP, Repetto D, Volante M, Papotti M, Turco E and
Defilippi P: β1 integrin controls EGFR signaling and tumorigenic
properties of lung cancer cells. Oncogene. 30:4087–4096. 2011.
View Article : Google Scholar : PubMed/NCBI
|
19
|
Wang F, Weaver VM, Petersen OW, Larabell
CA, Dedhar S, Briand P, Lupu R and Bissell MJ: Reciprocal
interactions between beta1-integrin and epidermal growth factor
receptor in three-dimensional basement membrane breast cultures: A
different perspective in epithelial biology. Proc Natl Acad Sci
USA. 95:14821–14826. 1998. View Article : Google Scholar : PubMed/NCBI
|
20
|
Eke I, Sandfort V, Mischkus A, Baumann M
and Cordes N: Antiproliferative effects of EGFR tyrosine kinase
inhibition and radiation-induced genotoxic injury are attenuated by
adhesion to fibronectin. Radiother Oncol. 80:178–184. 2006.
View Article : Google Scholar : PubMed/NCBI
|
21
|
Rodemann HP, Dittmann K and Toulany M:
Radiation-induced EGFR-signaling and control of DNA-damage repair.
Int J Radiat Biol. 83:781–791. 2007. View Article : Google Scholar : PubMed/NCBI
|
22
|
Huang S, Peet CR, Saker J, Li C, Armstrong
EA, Kragh M, Pedersen MW and Harari PM: Sym004, a novel anti-EGFR
antibody mixture, augments radiation response in human lung and
head and neck cancers. Mol Cancer Ther. 12:2772–2781. 2013.
View Article : Google Scholar : PubMed/NCBI
|
23
|
Eke I, Zscheppang K, Dickreuter E,
Hickmann L, Mazzeo E, Unger K, Krause M and Cordes N: Simultaneous
β1 integrin-EGFR targeting and radiosensitization of human head and
neck cancer. J Natl Cancer Inst. 107:1072015. View Article : Google Scholar
|
24
|
Eke I, Deuse Y, Hehlgans S, Gurtner K,
Krause M, Baumann M, Shevchenko A, Sandfort V and Cordes N:
β1Integrin/FAK/cortactin signaling is essential for
human head and neck cancer resistance to radiotherapy. J Clin
Invest. 122:1529–1540. 2012. View
Article : Google Scholar : PubMed/NCBI
|
25
|
Storch K and Cordes N: Focal
adhesion-chromatin linkage controls tumor cell resistance to radio-
and chemotherapy. Chemother Res Pract. 2012:3192872012.PubMed/NCBI
|
26
|
Eke I, Schneider L, Förster C, Zips D,
Kunz-Schughart LA and Cordes N: EGFR/JIP-4/JNK2 signaling
attenuates cetuximab-mediated radiosensitization of squamous cell
carcinoma cells. Cancer Res. 73:297–306. 2013. View Article : Google Scholar
|
27
|
Cordes N and Meineke V: Cell
adhesion-mediated radioresistance (CAM-RR). Extracellular
matrix-dependent improvement of cell survival in human tumor and
normal cells in vitro. Strahlenther Onkol. 179:337–344. 2003.
View Article : Google Scholar : PubMed/NCBI
|
28
|
Cordes N, Seidler J, Durzok R, Geinitz H
and Brakebusch C: beta1-integrin-mediated signaling essentially
contributes to cell survival after radiation-induced genotoxic
injury. Oncogene. 25:1378–1390. 2006. View Article : Google Scholar
|
29
|
Storch K, Eke I, Borgmann K, Krause M,
Richter C, Becker K, Schröck E and Cordes N: Three-dimensional cell
growth confers radioresistance by chromatin density modification.
Cancer Res. 70:3925–3934. 2010. View Article : Google Scholar : PubMed/NCBI
|
30
|
Sandfort V, Eke I and Cordes N: The role
of the focal adhesion protein PINCH1 for the radiosensitivity of
adhesion and suspension cell cultures. PLoS One. 5:e130562010.
View Article : Google Scholar : PubMed/NCBI
|
31
|
Estrugo D, Fischer A, Hess F, Scherthan H,
Belka C and Cordes N: Ligand bound beta1 integrins inhibit
procaspase-8 for mediating cell adhesion-mediated drug and
radiation resistance in human leukemia cells. PLoS One. 2:e2692007.
View Article : Google Scholar : PubMed/NCBI
|
32
|
Ito S, Takahara Y, Hyodo T, Hasegawa H,
Asano E, Hamaguchi M and Senga T: The roles of two distinct regions
of PINCH-1 in the regulation of cell attachment and spreading. Mol
Biol Cell. 21:4120–4129. 2010. View Article : Google Scholar : PubMed/NCBI
|
33
|
Fukuda T, Chen K, Shi X and Wu C: PINCH-1
is an obligate partner of integrin-linked kinase (ILK) functioning
in cell shape modulation, motility, and survival. J Biol Chem.
278:51324–51333. 2003. View Article : Google Scholar : PubMed/NCBI
|
34
|
Eke I, Koch U, Hehlgans S, Sandfort V,
Stanchi F, Zips D, Baumann M, Shevchenko A, Pilarsky C, Haase M, et
al: PINCH1 regulates Akt1 activation and enhances radioresistance
by inhibiting PP1alpha. J Clin Invest. 120:2516–2527. 2010.
View Article : Google Scholar : PubMed/NCBI
|
35
|
Funasaka K, Ito S, Hasegawa H, Goldberg
GS, Hirooka Y, Goto H, Hamaguchi M and Senga T: Cas utilizes Nck2
to activate Cdc42 and regulate cell polarization during cell
migration in response to wound healing. FEBS J. 277:3502–3513.
2010. View Article : Google Scholar : PubMed/NCBI
|
36
|
Labelle-Côté M, Dusseault J, Ismaïl S,
Picard-Cloutier A, Siegel PM and Larose L: Nck2 promotes human
melanoma cell proliferation, migration and invasion in vitro and
primary melanoma-derived tumor growth in vivo. BMC Cancer.
11:4432011. View Article : Google Scholar : PubMed/NCBI
|
37
|
Errington TM and Macara IG: Depletion of
the adaptor protein NCK increases uV-induced p53 phosphorylation
and promotes apoptosis. PLoS One. 8:e762042013. View Article : Google Scholar : PubMed/NCBI
|
38
|
Chen K, Tu Y, Zhang Y, Blair HC, Zhang L
and Wu C: PINCH-1 regulates the ERK-Bim pathway and contributes to
apoptosis resistance in cancer cells. J Biol Chem. 283:2508–2517.
2008. View Article : Google Scholar
|
39
|
Gonzalez-Nieves R, Desantis AI and Cutler
ML: Rsu1 contributes to regulation of cell adhesion and spreading
by PINCH1-dependent and -independent mechanisms. J Cell Commun
Signal. 7:279–293. 2013. View Article : Google Scholar : PubMed/NCBI
|
40
|
Stanchi F, Grashoff C, Nguemeni Yonga CF,
Grall D, Fässler R and Van Obberghen-Schilling E: Molecular
dissection of the ILK-PINCH-parvin triad reveals a fundamental role
for the ILK kinase domain in the late stages of focal-adhesion
maturation. J Cell Sci. 122:1800–1811. 2009. View Article : Google Scholar : PubMed/NCBI
|
41
|
Montanez E, Karaköse E, Tischner D,
Villunger A and Fässler R: PINCH-1 promotes Bcl-2-dependent
survival signalling and inhibits JNK-mediated apoptosis in the
primitive endoderm. J Cell Sci. 125:5233–5240. 2012. View Article : Google Scholar : PubMed/NCBI
|
42
|
Rea K, Sensi M, Anichini A, Canevari S and
Tomassetti A: EGFR/MEK/ERK/CDK5-dependent integrin-independent FAK
phosphorylated on serine 732 contributes to microtubule
depolymerization and mitosis in tumor cells. Cell Death Dis.
4:e8152013. View Article : Google Scholar : PubMed/NCBI
|
43
|
Wang D, Li Y, Wu C and Liu Y: PINCH1 is
transcriptional regulator in podocytes that interacts with WT1 and
represses podocalyxin expression. PLoS One. 6:e170482011.
View Article : Google Scholar : PubMed/NCBI
|
44
|
Kremer BE, Adang LA and Macara IG: Septins
regulate actin organization and cell-cycle arrest through nuclear
accumulation of NCK mediated by SOCS7. Cell. 130:837–850. 2007.
View Article : Google Scholar : PubMed/NCBI
|
45
|
Jahn T, Seipel P, Coutinho S, Miething C,
Peschel C and Duyster J: Grb4/Nckbeta acts as a nuclear repressor
of v-Abl-induced transcription from c-jun/c-fos promoter elements.
J Biol Chem. 276:43419–43427. 2001. View Article : Google Scholar : PubMed/NCBI
|