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Article

MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT

Retraction in: /10.3892/or.2021.8199
  • Authors:
    • Qiang Zhao
    • Ying-Xian Zhai
    • Huan-Qiu Liu
    • Ying-Ai Shi
    • Xin-Bai Li
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Surgery, The First Hospital, Jilin University, Chaoyang, Changchun, Jilin 130021, P.R. China, Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Chaoyang, Changchun, Jilin 130021, P.R. China, Department of Anesthesiology, The First Hospital, Jilin University, Chaoyang, Changchun, Jilin 130021, P.R. China
  • Pages: 979-986
    |
    Published online on: May 28, 2015
       https://doi.org/10.3892/or.2015.4013
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Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that have been shown to regulate a variety of biological processes by targeting messenger RNA. MicroRNA-491-5p (miR-491-5p), an important miRNA, has been demonstrated to be involved in the processes of initiation and progression in several tumors. However, the precise biological function of miR-491-5p and its molecular mechanism in cervical cancer cells remain elusive. The present study was carried out to investigate the clinical significance and prognostic value of miR-491-5p expression in cervical cancer, and to evaluate the role of miR-491-5p and the underlying molecular mechanisms involved in cervical cancer. The results showed that miR-491-5p expression was significantly downregulated in cervical cancer tissues when compared with the corresponding adjacent normal tissues (P<0.001), and the value was negatively associated with advanced International Federation of Gynecology and Obstetrics (FIGO) stage, high histological grading and lymph node metastasis (P<0.01). The enforced expression of miR-491-5p in cervical cancer cells significantly inhibited proliferation, migration and invasion, induced cell apoptosis, and suppressed the tumor growth of the mouse model of HeLa cells. In addition, the dual-luciferase reporter assay revealed that human telomerase reverse transcriptase (hTERT) was identified as a novel target gene of miR-491-5p. Notably, it was found that miR-491-5p regulated the PI3K/AKT signaling pathway. These results suggested that targeting miR-491-5p is a strategy for blocking the development of cervical cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao Q, Zhai Y, Liu H, Shi Y and Li X: MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT Retraction in /10.3892/or.2021.8199. Oncol Rep 34: 979-986, 2015.
APA
Zhao, Q., Zhai, Y., Liu, H., Shi, Y., & Li, X. (2015). MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT Retraction in /10.3892/or.2021.8199. Oncology Reports, 34, 979-986. https://doi.org/10.3892/or.2015.4013
MLA
Zhao, Q., Zhai, Y., Liu, H., Shi, Y., Li, X."MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT Retraction in /10.3892/or.2021.8199". Oncology Reports 34.2 (2015): 979-986.
Chicago
Zhao, Q., Zhai, Y., Liu, H., Shi, Y., Li, X."MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT Retraction in /10.3892/or.2021.8199". Oncology Reports 34, no. 2 (2015): 979-986. https://doi.org/10.3892/or.2015.4013
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Q, Zhai Y, Liu H, Shi Y and Li X: MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT Retraction in /10.3892/or.2021.8199. Oncol Rep 34: 979-986, 2015.
APA
Zhao, Q., Zhai, Y., Liu, H., Shi, Y., & Li, X. (2015). MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT Retraction in /10.3892/or.2021.8199. Oncology Reports, 34, 979-986. https://doi.org/10.3892/or.2015.4013
MLA
Zhao, Q., Zhai, Y., Liu, H., Shi, Y., Li, X."MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT Retraction in /10.3892/or.2021.8199". Oncology Reports 34.2 (2015): 979-986.
Chicago
Zhao, Q., Zhai, Y., Liu, H., Shi, Y., Li, X."MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT Retraction in /10.3892/or.2021.8199". Oncology Reports 34, no. 2 (2015): 979-986. https://doi.org/10.3892/or.2015.4013
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