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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
August-2015 Volume 34 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

The emerging role of astrocyte-elevated gene-1 in hepatocellular carcinoma (Review)

Hai Dan Zhu, Jia Zhi Liao, Xing Xing He, Pei Yuan Li
Pages: 539-546
Published online on: 29 May 2015

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Review

The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review)

Xiangjian Luo, Xinfang Yu, Sufang Liu, Qipan Deng, Xiaolan Liu, Songling Peng, Hongde Li, Jikai Liu, Ya Cao
Pages: 547-554
Published online on: 04 June 2015

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Article Open Access

HtrA1: Its future potential as a novel biomarker for cancer

Emma Altobelli, Daniela Marzioni, Amedeo Lattanzi, Paolo Matteo Angeletti
Pages: 555-566
Published online on: 28 May 2015

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Article Open Access

A novel method to identify pathways associated with renal cell carcinoma based on a gene co-expression network

Xiyun Ruan, Hongyun Li, Bo Liu, Jie Chen, Shibao Zhang, Zeqiang Sun, Shuangqing Liu, Fahai Sun, Qingyong Liu
Pages: 567-576
Published online on: 08 June 2015

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Article Open Access

Rearrangement of chromosome bands 12q14~15 causing HMGA2-SOX5 gene fusion and HMGA2 expression in extraskeletal osteochondroma

Ioannis Panagopoulos, Bodil Bjerkehagen, Ludmila Gorunova, Ingeborg Taksdal, Sverre Heim
Pages: 577-584
Published online on: 05 June 2015

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Article Open Access

Integrated analysis of DNA methylation and microRNA regulation of the lung adenocarcinoma transcriptome

Jiang Du, Lin Zhang
Pages: 585-594
Published online on: 29 May 2015

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Article Open Access

MicroRNA-153 is a prognostic marker and inhibits cell migration and invasion by targeting SNAI1 in human pancreatic ductal adenocarcinoma Retraction in /10.3892/or.2022.8444

Zhenghai Bai, Jiangli Sun, Xiaobo Wang, Hai Wang, Honghong Pei, Zhengliang Zhang
Pages: 595-602
Published online on: 11 June 2015

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Article Open Access

Activated protein C upregulates ovarian cancer cell migration and promotes unclottability of the cancer cell microenvironment

Hamda Althawadi, Halema Alfarsi, Samaher Besbes, Shahsoltan Mirshahi, Elodie Ducros, Arash Rafii, Marc Pocard, Amu Therwath, Jeannette Soria, Massoud Mirshahi
Pages: 603-609
Published online on: 15 June 2015

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Article Open Access

Adrenomedullin promotes intrahepatic cholangiocellular carcinoma metastasis and invasion by inducing epithelial-mesenchymal transition

Chuang Zhou, Yan Zheng, Lin Li, Wenlong Zhai, Renfeng Li, Zhiwen Liang, Longshuan Zhao
Pages: 610-616
Published online on: 05 June 2015

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Article

Syringetin suppresses osteoclastogenesis mediated by osteoblasts in human lung adenocarcinoma

Ying-Ming Tsai, Inn-Wen Chong, Jen-Yu Hung, Wei-An Chang, Po-Lin Kuo, Ming-Ju Tsai, Ya-Ling Hsu
Pages: 617-626
Published online on: 04 June 2015

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Article

Telomere shortening in breast cancer correlates with the pathological features of tumor progression

Makoto Kammori, Yoshiyuki Sugishita, Takahiro Okamoto, Makio Kobayashi, Kazuko Yamazaki, Emiko Yamada, Tetsu Yamada
Pages: 627-632
Published online on: 15 June 2015

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Article

Combinatorial anti-angiogenic gene therapy in a human malignant mesothelioma model

Shuji Kubo, Misato Takagi-Kimura, Noriyuki Kasahara
Pages: 633-638
Published online on: 12 June 2015

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Article

Alteration of CD4 T cell subsets in metastatic lymph nodes of human gastric cancer

Yoshihiro Okita, Masaichi Ohira, Hiroaki Tanaka, Mao Tokumoto, Yukie Go, Katsunobu Sakurai, Takahiro Toyokawa, Naoshi Kubo, Kazuya Muguruma, Tetsuji Sawada, Kiyoshi Maeda, Kosei Hirakawa
Pages: 639-647
Published online on: 15 June 2015

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Article

Clinical significance and therapeutic potential of prostate cancer antigen-1/ALKBH3 in human renal cell carcinoma

Kiyohiko Hotta, Masayuki Sho, Kiyohide Fujimoto, Keiji Shimada, Ichiro Yamato, Satoshi Anai, Hiroshi Harada, Kazutake Tsujikawa, Noboru Konishi, Nobuo Shinohara, Yoshiyuki Nakajima
Pages: 648-654
Published online on: 29 May 2015

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Article

miR-153 inhibits epithelial-to-mesenchymal transition in hepatocellular carcinoma by targeting Snail

Wenfei Xia, Xiaopeng Ma, Xingrui Li, Hong Dong, Jilin Yi, Weixia Zeng, Zhifang Yang
Pages: 655-662
Published online on: 28 May 2015

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Article

Depletion of histone deacetylase 1 inhibits metastatic abilities of gastric cancer cells by regulating the miR-34a/CD44 pathway

Lele Lin, Hongpeng Jiang, Mingkui Huang, Xu Hou, Xuepu Sun, Xian Jiang, Xuesong Dong, Xueying Sun, Baoguo Zhou, Haiquan Qiao
Pages: 663-672
Published online on: 28 May 2015

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Article

Anti-oxidative and hepatoprotective effects of lithospermic acid against carbon tetrachloride-induced liver oxidative damage in vitro and in vivo

Ka Woon Karen Chan, Wing Shing Ho
Pages: 673-680
Published online on: 16 June 2015

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Article

Claudin-4 controls the proliferation, apoptosis, migration and in vivo growth of MCF-7 breast cancer cells

Xiaotang Ma, Huilai Miao, Baoguo Jing, Qunwen Pan, Huiting Zhang, Yanfang Chen, Dan Zhang, Zhongzeng Liang, Zhili Wen, Mingyi Li
Pages: 681-690
Published online on: 05 June 2015

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Article

Curcumin inhibits the invasion of lung cancer cells by modulating the PKCα/Nox-2/ROS/ATF-2/MMP-9 signaling pathway

Zhigang Fan, Xiaoyi Duan, Hui Cai, Li Wang, Min Li, Jingkun Qu, Wanjun Li, Yongheng Wang, Jiansheng Wang
Pages: 691-698
Published online on: 09 June 2015

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Article

U0126 inhibits pancreatic cancer progression via the KRAS signaling pathway in a zebrafish xenotransplantation model

Meng Guo, Huanhuan Wei, Jingying Hu, Shaoyang Sun, Jiang Long, Xu Wang
Pages: 699-706
Published online on: 29 May 2015

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Article

MicroRNA-429 inhibits the migration and invasion of colon cancer cells by targeting PAK6/cofilin signaling

Xiangyang Tian, Zibai Wei, Jia Wang, Ping Liu, Yijun Qin, Meizuo Zhong
Pages: 707-714
Published online on: 08 June 2015

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Article

Prostaglandin E2 promotes human cholangiocarcinoma cell proliferation, migration and invasion through the upregulation of β-catenin expression via EP3-4 receptor

Mingzhan Du, Feng Shi, Hai Zhang, Shukai Xia, Min Zhang, Juan Ma, Xiaoming Bai, Li Zhang, Yipin Wang, Shanyu Cheng, Qinyi Yang, Jing Leng
Pages: 715-726
Published online on: 09 June 2015

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Article

SASS6 overexpression is associated with mitotic chromosomal abnormalities and a poor prognosis in patients with colorectal cancer

Kazuya Shinmura, Hisami Kato, Yuichi Kawanishi, Kiyoko Nagura, Takaharu Kamo, Yusuke Okubo, Yusuke Inoue, Nobuya Kurabe, Chunping Du, Moriya Iwaizumi, Kiyotaka Kurachi, Toshio Nakamura, Haruhiko Sugimura
Pages: 727-738
Published online on: 28 May 2015

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Article

Downregulation of miR-19a exhibits inhibitory effects on metastatic renal cell carcinoma by targeting PIK3CA and inactivating Notch signaling in vitro

Wei Xiao, Zhiyong Gao, Yixing Duan, Wuxiong Yuan, Yang Ke
Pages: 739-746
Published online on: 08 June 2015

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Article

PCDH10 inhibits cell proliferation of multiple myeloma via the negative regulation of the Wnt/β-catenin/BCL-9 signaling pathway

Yonghui Xu, Zesong Yang, Haiting Yuan, Zhen Li, Ying Li, Qiong Liu, Jianbin Chen
Pages: 747-754
Published online on: 11 June 2015

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Article

Butorphanol, a synthetic opioid, sensitizes ABCB1-mediated multidrug resistance via inhibition of the efflux function of ABCB1 in leukemia cells

Jing Wen, Tao Zhang, Zhi-Ming Shan, Min-Yue Qi, Huan-Huan Xiu, Lei Liu, Shi-Zhe Wu, Zhen Jia, Kang-Qing Xu
Pages: 755-762
Published online on: 11 June 2015

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Article

Growth inhibitory effect of adenovirus-mediated tissue-targeted expression of ribosomal protein L23 on human colorectal carcinoma cells

Henghu Fang, Jingbo Kang, Rui Du, Xiangfei Zhao, Xinhong Zhang, Dongqing Ren, Yafei Zhang, Zejun Lu, Shanshan Wu, Wei Zheng, Juyi Wen
Pages: 763-770
Published online on: 04 June 2015

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Article

Expression of BMI1 and ZEB1 in epithelial-mesenchymal transition of tongue squamous cell carcinoma

Kinue Kurihara, Tomohide Isobe, Gou Yamamoto, Yoichi Tanaka, Akira Katakura, Tetsuhiko Tachikawa
Pages: 771-778
Published online on: 05 June 2015

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Article

Integrin α4 is involved in the regulation of glioma-induced motility of bone marrow mesenchymal stem cells

Jiang-Chun Ma, Peng Cheng, Yi Hu, Yi-Xue Xue, Yun-Hui Liu
Pages: 779-786
Published online on: 28 May 2015

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Article

Hypoxia-induced apoptosis is blocked by adrenomedullin via upregulation of Bcl-2 in human osteosarcoma cells

Xue-Yuan Wu, Cui-Pei Hao, Ming Ling, Chi-Hua Guo, Wei Ma
Pages: 787-794
Published online on: 28 May 2015

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Article

High expression of IL-9R promotes the progression of human hepatocellular carcinoma and indicates a poor clinical outcome

Hong-Jun Li, Qi-Man Sun, Long-Zi Liu, Jun Zhang, Jun Huang, Cheng-Hong Wang, Rui Ding, Kang Song, Zhong Tong
Pages: 795-802
Published online on: 15 June 2015

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Article

Aurora kinases are essential for PKC-induced invasion and matrix metalloproteinase-9 expression in MCF-7 breast cancer cells

Eun-Mi Noh, Young-Rae Lee, On-Yu Hong, Sung Hoo Jung, Hyun Jo Youn, Jong-Suk Kim
Pages: 803-810
Published online on: 04 June 2015

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Article

Inhibition of skin squamous cell carcinoma proliferation and promote apoptosis by dual silencing of NET-1 and survivin

Zhou-Jing Ji, Jian-Li Wang, Li Chen
Pages: 811-822
Published online on: 15 June 2015

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Article

USP39 promotes the growth of human hepatocellular carcinoma in vitro and in vivo

Xianwen Yuan, Xitai Sun, Xiaolei Shi, Chunping Jiang, Decai Yu, Weiwei Zhang, Wenxian Guan, Jianxin Zhou, Yafu Wu, Yudong Qiu, Yitao Ding
Pages: 823-832
Published online on: 15 June 2015

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Article

Podoplanin is involved in the prognosis of head and neck squamous cell carcinoma through interaction with VEGF-C

Hyun-Yi Kim, Ki-Sang Rha, Geun Ae Shim, Ju-Hee Kim, Jin‑Man Kim, Song Mei Huang, Bon Seok Koo
Pages: 833-842
Published online on: 16 June 2015

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Article

DBC1 promotes anoikis resistance of gastric cancer cells by regulating NF-κB activity

Yongwei Huan, Deping Wu, Dayong Zhou, Bo Sun, Guoxin Li
Pages: 843-849
Published online on: 28 May 2015

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Article

The retinoic acid-metabolizing enzyme CYP26A1 upregulates fascin and promotes the malignant behavior of breast carcinoma cells

Makoto Osanai, Gang-Hong Lee
Pages: 850-858
Published online on: 08 June 2015

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Article

Lentiviral vector-mediated survivin shRNA delivery in gastric cancer cell lines significantly inhibits cell proliferation and tumor growth

Raees Habib, Javed Akhtar, Mohammad Taqi, Che Yu, Chunqing Zhang
Pages: 859-867
Published online on: 05 June 2015

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Article

FUS1 acts as a tumor-suppressor gene by upregulating miR-197 in human glioblastoma

Jun Xin, Xue-Kui Zhang, De-You Xin, Xian-Feng Li, De‑Ke Sun, Yue-Ye Ma, Li-Qiang Tian
Pages: 868-876
Published online on: 16 June 2015

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Article

MicroRNA-196a post-transcriptionally upregulates the UBE2C proto-oncogene and promotes cell proliferation in breast cancer

Qinglin Han, Chun Zhou, Fan Liu, Guanghuan Xu, Rui Zheng, Xin Zhang
Pages: 877-883
Published online on: 11 June 2015

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Article

Lapatinib sensitizes quiescent MDA-MB-231 breast cancer cells to doxorubicin by inhibiting the expression of multidrug resistance-associated protein-1

Yun-Suk Kwon, So-Young Chun, Kyung-Soo Nam, Soyoung Kim
Pages: 884-890
Published online on: 10 June 2015

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Article

Knockdown of RhoA expression alters ovarian cancer biological behavior in vitro and in nude mice

Xiaoxia Wang, Wenyan Jiang, Jiali Kang, Qicai Liu, Miaoling Nie
Pages: 891-899
Published online on: 28 May 2015

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Article

The novel herbal cocktail MA128 suppresses tumor growth and the metastatic potential of highly malignant tumor cells

Aeyung Kim, Minju Im, Nam-Hiu Yim, Youn-Hwan Hwang, Hye Jin Yang, Jin Yeul Ma
Pages: 900-912
Published online on: 29 May 2015

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Article

Sanguinarine-induced apoptosis in lung adenocarcinoma cells is dependent on reactive oxygen species production and endoplasmic reticulum stress

Shuang Gu, Xiao-Chun Yang, Xi-Yan Xiang, Yao Wu, Yu Zhang, Xiao-Yu Yan, Ya-Nan Xue, Lian-Kun Sun, Guo-Guang Shao
Pages: 913-919
Published online on: 11 June 2015

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Article

Enhancement of SOX-2 expression and ROS accumulation by culture of A172 glioblastoma cells under non-adherent culture conditions

Chang-Nim Im, Hye Hyeon Yun, Hyung Jae Yoo, Myung-Jin Park, Jeong-Hwa Lee
Pages: 920-928
Published online on: 29 May 2015

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Article

Side population cells separated from A549 lung cancer cell line possess cancer stem cell-like properties and inhibition of autophagy potentiates the cytotoxic effect of cisplatin

Yang Yang, Yuxia Fan, Yu Qi, Donglei Liu, Kai Wu, Fengbiao Wen, Song Zhao
Pages: 929-935
Published online on: 12 June 2015

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Article

High IGF2 expression is associated with poor clinical outcome in human ovarian cancer

Yan Dong, Jianjun Li, Fei Han, Hongqiang Chen, Xiaoxin Zhao, Qin Qin, Ronghui Shi, Jinyi Liu
Pages: 936-942
Published online on: 10 June 2015

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Article

β-elemene enhances both radiosensitivity and chemosensitivity of glioblastoma cells through the inhibition of the ATM signaling pathway

Siwei Liu, Lei Zhou, Yongshun Zhao, Yuhui Yuan
Pages: 943-951
Published online on: 11 June 2015

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Article

Effects of Slit3 silencing on the invasive ability of lung carcinoma A549 cells

Chao Zhang, Hui Guo, Bin Li, Chengzhi Sui, Yuan Zhang, Xianyuan Xia, Ying Qin, Liying Ye, Fu'an Xie, Heng Wang, Mingjing Yuan, Li Yuan, Jun Ye
Pages: 952-960
Published online on: 05 June 2015

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Article

Differential roles of Bcl2L12 and its short variant in breast cancer lymph node metastasis

Shang-Tao Chien, Tzu-Feng Yang, Ming-Chang Yang, Ching-Mei Hsu, Yi-Ren Hong, Tai-Min Lee
Pages: 961-971
Published online on: 16 June 2015

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Article

OSTP as a novel peptide specifically targeting human ovarian cancer

Chen Yang, Xiaojuan He, Xiaomin Liu, Zheng Tang, Xiaoqiu Liang
Pages: 972-978
Published online on: 15 June 2015

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Article

MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT Retraction in /10.3892/or.2021.8199

Qiang Zhao, Ying-Xian Zhai, Huan-Qiu Liu, Ying-Ai Shi, Xin-Bai Li
Pages: 979-986
Published online on: 28 May 2015

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Article

Visfatin promotes osteosarcoma cell migration and invasion via induction of epithelial-mesenchymal transition

Gong Cheng, Changying Liu, Xiujiang Sun, Lei Zhang, Lifang Liu, Jun Ouyang, Bo Li
Pages: 987-994
Published online on: 11 June 2015

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Article

miRNA-24-3p promotes cell proliferation and inhibits apoptosis in human breast cancer by targeting p27Kip1

Kangping Lu, Jingxuan Wang, Ying Song, Shu Zhao, Hang Liu, Dabei Tang, Bo Pan, Hong Zhao, Qingyuan Zhang
Pages: 995-1002
Published online on: 04 June 2015

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Article

miR-494 promotes cell proliferation, migration and invasion, and increased sorafenib resistance in hepatocellular carcinoma by targeting PTEN Retraction in /10.3892/or.2021.8236

Kai Liu, Songyang Liu, Wei Zhang, Baoxing Jia, Ludong Tan, Zhe Jin, Yahui Liu
Pages: 1003-1010
Published online on: 04 June 2015

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Article

Myeloid cell leukemia-1 promotes epithelial-mesenchymal transition of human gastric cancer cells

Wan-Sik Lee, Nuri Kim, Young-Ran Park, Hyung-Hoon Oh, Eun Myung, Seung-Hun Kim, Hyung-Min Yu, Mi-Young Kim, Chan-Young Oak, Cho-Yun Chung, Hyung‑Chul Park, Dae-Seong Myung, Sung-Bum Cho, Young-Eun Joo
Pages: 1011-1016
Published online on: 08 June 2015

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Article

Epigenetically silenced microRNAs in gastric cancer: Functional analysis and identification of their target genes

Jin-Han Bae, Myoung Joo Kang, Kwang-Mo Yang, Tae-Oh Kim, Joo Mi Yi
Pages: 1017-1026
Published online on: 05 June 2015

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Article

Capsaicin causes inactivation and degradation of the androgen receptor by inducing the restoration of miR-449a in prostate cancer

Long Zheng, Jiaqi Chen, Zhenkun Ma, Wei Liu, Fei Yang, Zhao Yang, Ke Wang, Xinyang Wang, Dalin He, Lei Li
Pages: 1027-1034
Published online on: 11 June 2015

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Article

Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway

Xiaofeng Liu, Liubing Li, Ling Lv, Dongmei Chen, Liqin Shen, Zonggang Xie
Pages: 1035-1041
Published online on: 29 May 2015

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Article

Comparative evaluation of 111In-labeled NOTA‑conjugated affibody molecules for visualization of HER3 expression in malignant tumors

Ken G. Andersson, Maria Rosestedt, Zohreh Varasteh, Magdalena Malm, Mattias Sandström, Vladimir Tolmachev, John Löfblom, Stefan Ståhl, Anna Orlova
Pages: 1042-1048
Published online on: 09 June 2015

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Reduced expression of semaphorin 4D and plexin-B in breast cancer is associated with poorer prognosis and the potential linkage with oestrogen receptor

Muhammad Faraz Arshad Malik, Lin Ye, Wen G. Jiang
Pages: 1049-1057
Published online on: 28 May 2015

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Induction of apoptotic cell death by betulin in multidrug-resistant human renal carcinoma cells

Nam-Hui Yim, Young Pil Jung, Aeyung Kim, Taesoo Kim, Jin Yeul Ma
Pages: 1058-1064
Published online on: 09 June 2015

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Selective enhancement of hypoxic cell killing by tempol-regulated suicide gene expression

Go Kagiya, Ryohei Ogawa, Rajani Choudhuri, John A. Cook, Masanori Hatashita, Yoshikazu Tanaka, Kana Koda, Kei Yamashita, Makoto Kubo, Fumitaka Kawakami, James B. Mitchell
Pages: 1065-1073
Published online on: 29 May 2015

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YM155 exerts a growth inhibitory effect on human osteosarcoma in vitro and in vivo

Zhuo Zhang, Lianjun Ma, Jincheng Wang
Pages: 1074-1080
Published online on: 15 June 2015

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Journal Cover
January-2026 Volume 55 Issue 1

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Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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