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Article

Clinical significance and therapeutic potential of prostate cancer antigen-1/ALKBH3 in human renal cell carcinoma

  • Authors:
    • Kiyohiko Hotta
    • Masayuki Sho
    • Kiyohide Fujimoto
    • Keiji Shimada
    • Ichiro Yamato
    • Satoshi Anai
    • Hiroshi Harada
    • Kazutake Tsujikawa
    • Noboru Konishi
    • Nobuo Shinohara
    • Yoshiyuki Nakajima
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Nara Medical University, Kashihara, Nara, Japan, Department of Urology, Nara Medical University, Kashihara, Nara, Japan, Department of Pathology, Nara Medical University, Kashihara, Nara, Japan, Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan, Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan, Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • Pages: 648-654
    |
    Published online on: May 29, 2015
       https://doi.org/10.3892/or.2015.4017
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Abstract

Prostate cancer antigen-1 (PCA-1)/ALKBH3 has been recently identified in human prostate cancer and its expression is correlated with disease progression and prognosis. However, the precise role and function of PCA-1/ALKBH3 in human malignancies are largely unknown. In the present study, we investigated the clinical significance and therapeutic potential of PCA-1/ALKBH3 in renal cell carcinoma (RCC). PCA-1/ALKBH3 expression was examined by immunohistochemistry in 101 RCC patients who underwent radical or partial nephrectomy. Its expression was positively correlated with advanced pathological T- and M-factors and TNM stage (T, P<0.05; M, P<0.01; TNM, P<0.01, respectively). In the prognostic analysis, PCA-1/ALKBH3-negative patients with RCC had a significantly better prognosis than PCA-1/ALKBH3-positive patients (5-year survival rate, 92.9 vs. 75.9%, respectively; P<0.05). Next, the therapeutic potential of targeting PCA-1/ALKBH3 was further evaluated by small interfering RNA method using a human RCC cell line (CAKI‑1). We found that PCA-1/ALKBH3 knockdown significantly inhibited the growth of CAKI-1 cells compared with the control (P<0.001). Furthermore, knockdown of PCA-1 induced apoptosis in CAKI-1 cells, as assessed by poly(ADP-ribose) polymerase‑cleavage assays. We demonstrated for the first time that PCA-1/ALKBH3 expression has a significant prognostic impact on patient prognosis in RCC. Furthermore, its knockdown has a therapeutic efficacy on RCC. Taken together, both our clinical and experimental data strongly suggest that PCA-1/ALKBH3 may be functionally important and a novel molecular target for human RCC.
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View References

1 

Motzer RJ, Mazumdar M, Bacik J, Berg W, Amsterdam A and Ferrara J: Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol. 17:2530–2540. 1999.PubMed/NCBI

2 

Cohen HT and McGovern FJ: Renal-cell carcinoma. N Engl J Med. 353:2477–2490. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Yang JC, Sherry RM, Steinberg SM, Topalian SL, Schwartzentruber DJ, Hwu P, Seipp CA, Rogers-Freezer L, Morton KE, White DE, et al: Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer. J Clin Oncol. 21:3127–3132. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, Grünwald V, Thompson JA, Figlin RA, Hollaender N, et al RECORD-1 Study Group: Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial. Lancet. 372:449–456. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, Negrier S, Szczylik C, Pili R, Bjarnason GA, et al: Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol. 27:3584–3590. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Rini BI, Escudier B, Tomczak P, Kaprin A, Szczylik C, Hutson TE, Michaelson MD, Gorbunova VA, Gore ME, Rusakov IG, et al: Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): A randomised phase 3 trial. Lancet. 378:1931–1939. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Staehler M, Negrier S, Chevreau C, Desai AA, Rolland F, et al: Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol. 27:3312–3318. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Escudier B, Pluzanska A, Koralewski P, Ravaud A, Bracarda S, Szczylik C, Chevreau C, Filipek M, Melichar B, Bajetta E, et al AVOREN Trial investigators: Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial. Lancet. 370:2103–2111. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A, Staroslawska E, Sosman J, McDermott D, Bodrogi I, et al: Global ARCC Trial: Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med. 356:2271–2281. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, Barrios CH, Salman P, Gladkov OA, Kavina A, et al: Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial. J Clin Oncol. 28:1061–1068. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Albiges L, Choueiri T, Escudier B, Galsky M, George D, Hofmann F, Lam T, Motzer R, Mulders P, Porta C, et al: A systematic review of sequencing and combinations of systemic therapy in metastatic renal cancer. Eur Urol. 67:100–110. 2015. View Article : Google Scholar

12 

Shimada K, Nakamura M, Ishida E, Higuchi T, Yamamoto H, Tsujikawa K and Konishi N: Prostate cancer antigen-1 contributes to cell survival and invasion though discoidin receptor 1 in human prostate cancer. Cancer Sci. 99:39–45. 2008.

13 

Konishi N, Nakamura M, Ishida E, Shimada K, Mitsui E, Yoshikawa R, Yamamoto H and Tsujikawa K: High expression of a new marker PCA-1 in human prostate carcinoma. Clin Cancer Res. 11:5090–5097. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Aas PA, Otterlei M, Falnes PO, Vågbø CB, Skorpen F, Akbari M, Sundheim O, Bjørås M, Slupphaug G, Seeberg E, et al: Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature. 421:859–863. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Falnes PO, Johansen RF and Seeberg E: AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature. 419:178–182. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Dinglay S, Trewick SC, Lindahl T and Sedgwick B: Defective processing of methylated single-stranded DNA by E. coli AlkB mutants. Genes Dev. 14:2097–2105. 2000.PubMed/NCBI

17 

Tsujikawa K, Koike K, Kitae K, Shinkawa A, Arima H, Suzuki T, Tsuchiya M, Makino Y, Furukawa T, Konishi N, et al: Expression and sub-cellular localization of human ABH family molecules. J Cell Mol Med. 11:1105–1116. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Chen B, Liu H, Sun X and Yang CG: Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3. Mol Biosyst. 6:2143–2149. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, et al: The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science. 318:1469–1472. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Kurowski MA, Bhagwat AS, Papaj G and Bujnicki JM: Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB. BMC Genomics. 4:482003. View Article : Google Scholar : PubMed/NCBI

21 

Ougland R, Zhang CM, Liiv A, Johansen RF, Seeberg E, Hou YM, Remme J and Falnes PO: AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation. Mol Cell. 16:107–116. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Sundheim O, Vågbø CB, Bjørås M, Sousa MM, Talstad V, Aas PA, Drabløs F, Krokan HE, Tainer JA and Slupphaug G: Human ABH3 structure and key residues for oxidative demeth-ylation to reverse DNA/RNA damage. EMBO J. 25:3389–3397. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Yu B, Edstrom WC, Benach J, Hamuro Y, Weber PC, Gibney BR and Hunt JF: Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB. Nature. 439:879–884. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Hausinger RP: FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes. Crit Rev Biochem Mol Biol. 39:21–68. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Yamato I, Sho M, Shimada K, Hotta K, Ueda Y, Yasuda S, Shigi N, Konishi N, Tsujikawa K and Nakajima Y: PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis. Cancer Res. 72:4829–4839. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Tasaki M, Shimada K, Kimura H, Tsujikawa K and Konishi N: ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer. Br J Cancer. 104:700–706. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Guinan P, Sobin LH, Algaba F, Badellino F, Kameyama S, MacLennan G and Novick A; Union International Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC): TNM staging of renal cell carcinoma: Workgroup No 3. Cancer. 80:992–993. 1997. View Article : Google Scholar : PubMed/NCBI

28 

Fuhrman SA, Lasky LC and Limas C: Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol. 6:655–663. 1982. View Article : Google Scholar : PubMed/NCBI

29 

Motzer RJ, Bacik J, Murphy BA, Russo P and Mazumdar M: Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol. 20:289–296. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Shimada K, Nakamura M, Anai S, De Velasco M, Tanaka M, Tsujikawa K, Ouji Y and Konishi N: A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression. Cancer Res. 69:3157–3164. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Wu SS, Xu W, Liu S, Chen B, Wang XL, Wang Y, Liu SF and Wu JQ: Down-regulation of ALKBH2 increases cisplatin sensitivity in H1299 lung cancer cells. Acta Pharmacol Sin. 32:393–398. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Gao W, Li L, Xu P, Fang J, Xiao S and Chen S: Frequent down-regulation of hABH2 in gastric cancer and its involvement in growth of cancer cells. J Gastroenterol Hepatol. 26:577–584. 2011. View Article : Google Scholar

33 

Neta G, Brenner AV, Sturgis EM, Pfeiffer RM, Hutchinson AA, Aschebrook-Kilfoy B, Yeager M, Xu L, Wheeler W, Abend M, et al: Common genetic variants related to genomic integrity and risk of papillary thyroid cancer. Carcinogenesis. 32:1231–1237. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Calvo JA, Meira LB, Lee CY, Moroski-Erkul CA, Abolhassani N, Taghizadeh K, Eichinger LW, Muthupalani S, Nordstrand LM, Klungland A, et al: DNA repair is indispensable for survival after acute inflammation. J Clin Invest. 122:2680–2689. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Shimada K, Fujii T, Tsujikawa K, Anai S, Fujimoto K and Konishi N: ALKBH3 contributes to survival and angiogenesis of human urothelial carcinoma cells through NADPH oxidase and tweak/Fn14/VEGF signals. Clin Cancer Res. 18:5247–5255. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Casamassima A, Picciariello M, Quaranta M, Berardino R, Ranieri C, Paradiso A, Lorusso V and Guida M: C-reactive protein: A biomarker of survival in patients with metastatic renal cell carcinoma treated with subcutaneous interleukin-2 based immunotherapy. J Urol. 173:52–55. 2005. View Article : Google Scholar

37 

Lamb GW, McMillan DC, Ramsey S and Aitchison M: The relationship between the preoperative systemic inflammatory response and cancer-specific survival in patients undergoing potentially curative resection for renal clear cell cancer. Br J Cancer. 94:781–784. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Karakiewicz PI, Hutterer GC, Trinh QD, Jeldres C, Perrotte P, Gallina A, Tostain J and Patard JJ: C-reactive protein is an informative predictor of renal cell carcinoma-specific mortality: A European study of 313 patients. Cancer. 110:1241–1247. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Yang J, Wezeman M, Zhang X, Lin P, Wang M, Qian J, Wan B, Kwak LW, Yu L and Yi Q: Human C-reactive protein binds activating Fcgamma receptors and protects myeloma tumor cells from apoptosis. Cancer Cell. 12:252–265. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Secchiero P, Rimondi E, di Iasio MG, Agnoletto C, Melloni E, Volpi I and Zauli G: C-Reactive protein downregulates TRAIL expression in human peripheral monocytes via an Egr-1-dependent pathway. Clin Cancer Res. 19:1949–1959. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hotta K, Sho M, Fujimoto K, Shimada K, Yamato I, Anai S, Harada H, Tsujikawa K, Konishi N, Shinohara N, Shinohara N, et al: Clinical significance and therapeutic potential of prostate cancer antigen-1/ALKBH3 in human renal cell carcinoma. Oncol Rep 34: 648-654, 2015.
APA
Hotta, K., Sho, M., Fujimoto, K., Shimada, K., Yamato, I., Anai, S. ... Nakajima, Y. (2015). Clinical significance and therapeutic potential of prostate cancer antigen-1/ALKBH3 in human renal cell carcinoma. Oncology Reports, 34, 648-654. https://doi.org/10.3892/or.2015.4017
MLA
Hotta, K., Sho, M., Fujimoto, K., Shimada, K., Yamato, I., Anai, S., Harada, H., Tsujikawa, K., Konishi, N., Shinohara, N., Nakajima, Y."Clinical significance and therapeutic potential of prostate cancer antigen-1/ALKBH3 in human renal cell carcinoma". Oncology Reports 34.2 (2015): 648-654.
Chicago
Hotta, K., Sho, M., Fujimoto, K., Shimada, K., Yamato, I., Anai, S., Harada, H., Tsujikawa, K., Konishi, N., Shinohara, N., Nakajima, Y."Clinical significance and therapeutic potential of prostate cancer antigen-1/ALKBH3 in human renal cell carcinoma". Oncology Reports 34, no. 2 (2015): 648-654. https://doi.org/10.3892/or.2015.4017
Copy and paste a formatted citation
x
Spandidos Publications style
Hotta K, Sho M, Fujimoto K, Shimada K, Yamato I, Anai S, Harada H, Tsujikawa K, Konishi N, Shinohara N, Shinohara N, et al: Clinical significance and therapeutic potential of prostate cancer antigen-1/ALKBH3 in human renal cell carcinoma. Oncol Rep 34: 648-654, 2015.
APA
Hotta, K., Sho, M., Fujimoto, K., Shimada, K., Yamato, I., Anai, S. ... Nakajima, Y. (2015). Clinical significance and therapeutic potential of prostate cancer antigen-1/ALKBH3 in human renal cell carcinoma. Oncology Reports, 34, 648-654. https://doi.org/10.3892/or.2015.4017
MLA
Hotta, K., Sho, M., Fujimoto, K., Shimada, K., Yamato, I., Anai, S., Harada, H., Tsujikawa, K., Konishi, N., Shinohara, N., Nakajima, Y."Clinical significance and therapeutic potential of prostate cancer antigen-1/ALKBH3 in human renal cell carcinoma". Oncology Reports 34.2 (2015): 648-654.
Chicago
Hotta, K., Sho, M., Fujimoto, K., Shimada, K., Yamato, I., Anai, S., Harada, H., Tsujikawa, K., Konishi, N., Shinohara, N., Nakajima, Y."Clinical significance and therapeutic potential of prostate cancer antigen-1/ALKBH3 in human renal cell carcinoma". Oncology Reports 34, no. 2 (2015): 648-654. https://doi.org/10.3892/or.2015.4017
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