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August-2015 Volume 34 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway

  • Authors:
    • Xiaofeng Liu
    • Liubing Li
    • Ling Lv
    • Dongmei Chen
    • Liqin Shen
    • Zonggang Xie
  • View Affiliations

    Affiliations: Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China, Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China
  • Published online on: May 29, 2015     https://doi.org/10.3892/or.2015.4022
  • Pages: 1035-1041
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Abstract

Osteosarcoma (OS) is the most common type of bone cancer. Even with early diagnosis and aggressive treatment, the prognosis for OS is poor. In the present study, we investigated the proliferation and invasion inhibitory effect of apigenin on human OS cells and the possible molecular mechanisms involved. The cell viability of U2OS and MG63 human OS cell lines was detected by MTT assay. Cell cycle progression and invasion were assessed by flow cytometry and the Matrigel Boyden chamber assay, respectively, and the involvement of molecular mechanisms was examined by western blot analysis. We demonstrated that apigenin inhibited proliferation and reduced invasion in human OS cells, and downregulated the expression of β-catenin in OS cells. Furthermore, the inhibitory effect of apigenin on OS cells was reversed by overexpression of β-catenin, but enhanced by knockdown of β-catenin. Collectively, our results showed that apigenin inhibits the tumor growth of OS cells by inactivating Wnt/β-catenin signaling. Therefore, apigenin is a promising chemotherapeutic agent that may be used in the treatment of human OS.
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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Li L, Lv L, Chen D, Shen L and Xie Z: Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway. Oncol Rep 34: 1035-1041, 2015.
APA
Liu, X., Li, L., Lv, L., Chen, D., Shen, L., & Xie, Z. (2015). Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway. Oncology Reports, 34, 1035-1041. https://doi.org/10.3892/or.2015.4022
MLA
Liu, X., Li, L., Lv, L., Chen, D., Shen, L., Xie, Z."Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway". Oncology Reports 34.2 (2015): 1035-1041.
Chicago
Liu, X., Li, L., Lv, L., Chen, D., Shen, L., Xie, Z."Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway". Oncology Reports 34, no. 2 (2015): 1035-1041. https://doi.org/10.3892/or.2015.4022
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Li L, Lv L, Chen D, Shen L and Xie Z: Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway. Oncol Rep 34: 1035-1041, 2015.
APA
Liu, X., Li, L., Lv, L., Chen, D., Shen, L., & Xie, Z. (2015). Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway. Oncology Reports, 34, 1035-1041. https://doi.org/10.3892/or.2015.4022
MLA
Liu, X., Li, L., Lv, L., Chen, D., Shen, L., Xie, Z."Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway". Oncology Reports 34.2 (2015): 1035-1041.
Chicago
Liu, X., Li, L., Lv, L., Chen, D., Shen, L., Xie, Z."Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway". Oncology Reports 34, no. 2 (2015): 1035-1041. https://doi.org/10.3892/or.2015.4022
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