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Article

High IGF2 expression is associated with poor clinical outcome in human ovarian cancer

  • Authors:
    • Yan Dong
    • Jianjun Li
    • Fei Han
    • Hongqiang Chen
    • Xiaoxin Zhao
    • Qin Qin
    • Ronghui Shi
    • Jinyi Liu
  • View Affiliations / Copyright

    Affiliations: Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing, P.R. China, Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing, P.R. China
  • Pages: 936-942
    |
    Published online on: June 10, 2015
       https://doi.org/10.3892/or.2015.4048
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Abstract

Ovarian cancer is one of the most common types of cancer in females and is the leading cause of death among gynaecological cancers in women worldwide. In the present study, we identified insulin-like growth factor 2 (IGF2) as a differentially expressed gene between cancerous and non-cancerous ovarian tissues. IGF2 was frequently increased in the human ovarian cancers when compared to the frequency in the non-cancerous ovarian tissues both at the mRNA (30/35) and protein level (61/72). The mean level of IGF2 in the tumor tissues was markedly higher than that in the non-cancerous tissues (nearly 3-fold change) (P=0.000). There was a significant correlation of IGF2 expression with histological grade (P=0.047). Kaplan‑Meier analysis indicated that the ovarian cancer patients with high IGF2 expression showed a poorer prognosis both in regards to overall survival (OS) and progression-free survival (PFS) (n=1,648, P=0.000). Further analysis revealed that high expression of IGF2 was an unfavorable factor for the prognosis of the ovarian cancer patients at clinical stage I + II, stage III, histological grade 2, grade 3 or those treated with chemotherapy containing platin and Taxol. Our data provide evidence that IGF2 expression is frequently increased in ovarian cancer tissues, and high expression of IGF2 may be a significant prognostic factor for poor survival in ovarian cancer patients.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Chen YL, Cheng WF, Chang MC, Lin HW, Huang CT, Chien CL and Chen CA: Interferon-gamma in ascites could be a predictive biomarker of outcome in ovarian carcinoma. Gynecol Oncol. 131:63–68. 2013. View Article : Google Scholar : PubMed/NCBI

4 

White KL, Schildkraut JM, Palmieri RT, Iversen ES Jr, Berchuck A, Vierkant RA, Rider DN, Charbonneau B, Cicek MS, Sutphen R, et al Ovarian Cancer Association Consortium: Ovarian cancer risk associated with inherited inflammation-related variants. Cancer Res. 72:1064–1069. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Koyanagi T, Suzuki Y, Saga Y, Machida S, Takei Y, Fujiwara H, Suzuki M and Sato Y: In vivo delivery of siRNA targeting vasohibin-2 decreases tumor angiogenesis and suppresses tumor growth in ovarian cancer. Cancer Sci. 104:1705–1710. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Vaughan S, Coward JI, Bast RC Jr, Berchuck A, Berek JS, Brenton JD, Coukos G, Crum CC, Drapkin R, Etemadmoghadam D, et al: Rethinking ovarian cancer: Recommendations for improving outcomes. Nat Rev Cancer. 11:719–725. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Tsofack SP, Meunier L, Sanchez L, Madore J, Provencher D, Mes-Masson AM and Lebel M: Low expression of the X-linked ribosomal protein S4 in human serous epithelial ovarian cancer is associated with a poor prognosis. BMC Cancer. 13:3032013. View Article : Google Scholar : PubMed/NCBI

8 

Marsh S: Pharmacogenomics of taxane/platinum therapy in ovarian cancer. Int J Gynecol Cancer. 19(Suppl 2): S30–S34. 2009. View Article : Google Scholar

9 

Kartalou M and Essigmann JM: Mechanisms of resistance to cisplatin. Mutat Res. 478:23–43. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Livingstone C: IGF2 and cancer. Endocr Relat Cancer. 20:R321–R339. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Yu H, Mistry J, Nicar MJ, Khosravi MJ, Diamandis A, van Doorn J and Juul A: Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation. J Clin Lab Anal. 13:166–172. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Raynaud-Simon A: Levels of plasma insulin-like growth factor I (IGF I), IGF II, IGF binding proteins, type 1 IGF receptor and growth hormone binding protein in community-dwelling elderly subjects with no malnutrition and no inflammation. J Nutr Health Aging. 7:267–273. 2003.PubMed/NCBI

13 

O’Dell SD and Day IN: Insulin-like growth factor II (IGF-II). Int J Biochem Cell Biol. 30:767–771. 1998. View Article : Google Scholar

14 

Liu L, Greenberg S, Russell SM and Nicoll CS: Effects of insulin-like growth factors I and II on growth and differentiation of transplanted rat embryos and fetal tissues. Endocrinology. 124:3077–3082. 1989. View Article : Google Scholar : PubMed/NCBI

15 

Yu H and Rohan T: Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst. 92:1472–1489. 2000. View Article : Google Scholar : PubMed/NCBI

16 

El Tayebi HM, Salah W, El Sayed IH, Salam EM, Zekri AR, Zayed N, Salem ES, Esmat G and Abdelaziz AI: Expression of insulin-like growth factor-II, matrix metalloproteinases, and their tissue inhibitors as predictive markers in the peripheral blood of HCC patients. Biomarkers. 16:346–354. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Zhao R, DeCoteau JF, Geyer CR, Gao M, Cui H and Casson AG: Loss of imprinting of the insulin-like growth factor II (IGF2) gene in esophageal normal and adenocarcinoma tissues. Carcinogenesis. 30:2117–2122. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Kalla Singh S, Tan QW, Brito C, De León M, Garberoglio C and De León D: Differential insulin-like growth factor II (IGF-II) expression: A potential role for breast cancer survival disparity. Growth Horm IGF Res. 20:162–170. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Deng J, Dong Y, Li C, Zuo W, Meng G, Xu C and Li J: Decreased expression of C10orf10 and its prognostic significance in human breast cancer. PLoS One. 9:e997302014. View Article : Google Scholar : PubMed/NCBI

20 

Gao Q, Qiu SJ, Fan J, Zhou J, Wang XY, Xiao YS, Xu Y, Li YW and Tang ZY: Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol. 25:2586–2593. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Han F, Liu W, Jiang X, Shi X, Yin L, Ao L, Cui Z, Li Y, Huang C, Cao J, et al: SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer. Oncogene. Dec 1–2014.Epub ahead of print. View Article : Google Scholar

22 

Han F, Dong Y, Liu W, Ma X, Shi R, Chen H, Cui Z, Ao L, Zhang H, Cao J, et al: Epigenetic regulation of sox30 is associated with testis development in mice. PLoS One. 9:e972032014. View Article : Google Scholar : PubMed/NCBI

23 

Gyorffy B, Lánczky A and Szállási Z: Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients. Endocr Relat Cancer. 19:197–208. 2012. View Article : Google Scholar : PubMed/NCBI

24 

El-Badry OM, Romanus JA, Helman LJ, Cooper MJ, Rechler MM and Israel MA: Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II. J Clin Invest. 84:829–839. 1989. View Article : Google Scholar : PubMed/NCBI

25 

Zhan S, Shapiro DN and Helman LJ: Activation of an imprinted allele of the insulin-like growth factor II gene implicated in rhabdomyosarcoma. J Clin Invest. 94:445–448. 1994. View Article : Google Scholar : PubMed/NCBI

26 

Tricoli JV, Rall LB, Karakousis CP, Herrera L, Petrelli NJ, Bell GI and Shows TB: Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas. Cancer Res. 46:6169–6173. 1986.PubMed/NCBI

27 

Cariani E, Lasserre C, Seurin D, Hamelin B, Kemeny F, Franco D, Czech MP, Ullrich A and Brechot C: Differential expression of insulin-like growth factor II mRNA in human primary liver cancers, benign liver tumors, and liver cirrhosis. Cancer Res. 48:6844–6849. 1988.PubMed/NCBI

28 

Gicquel C, Bertagna X, Schneid H, Francillard-Leblond M, Luton JP, Girard F and Le Bouc Y: Rearrangements at the 11p15 locus and overexpression of insulin-like growth factor-II gene in sporadic adrenocortical tumors. J Clin Endocrinol Metab. 78:1444–1453. 1994.PubMed/NCBI

29 

Yoon AJ, Zavras AI, Chen MK, Lin CW and Yang SF: Association between Gly1619ARG polymorphism of IGF2R domain 11 (rs629849) and advanced stage of oral cancer. Med Oncol. 29:682–685. 2012. View Article : Google Scholar

30 

Hoyo C, Murphy SK, Schildkraut JM, Vidal AC, Skaar D, Millikan RC, Galanko J, Sandler RS, Jirtle R and Keku T: IGF2R genetic variants, circulating IGF2 concentrations and colon cancer risk in African Americans and Whites. Dis Markers. 32:133–141. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Couvert P, Carrié A, Tezenas du Montcel S, Vaysse J, Sutton A, Barget N, Trinchet JC, Beaugrand M, Ganne N, Giral P, et al: Insulin-like growth factor 2 gene methylation in peripheral blood mononuclear cells of patients with hepatitis C related cirrhosis or hepatocellular carcinoma. Clin Res Hepatol Gastroenterol. 36:345–351. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Randhawa GS, Cui H, Barletta JA, Strichman-Almashanu LZ, Talpaz M, Kantarjian H, Deisseroth AB, Champlin RC and Feinberg AP: Loss of imprinting in disease progression in chronic myelogenous leukemia. Blood. 91:3144–3147. 1998.PubMed/NCBI

33 

Bates P, Fisher R, Ward A, Richardson L, Hill DJ and Graham CF: Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II). Br J Cancer. 72:1189–1193. 1995. View Article : Google Scholar : PubMed/NCBI

34 

Moorehead RA, Sanchez OH, Baldwin RM and Khokha R: Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma. Oncogene. 22:853–857. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Rogler CE, Yang D, Rossetti L, Donohoe J, Alt E, Chang CJ, Rosenfeld R, Neely K and Hintz R: Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice. J Biol Chem. 269:13779–13784. 1994.PubMed/NCBI

36 

Pravtcheva DD and Wise TL: Metastasizing mammary carcinomas in H19 enhancers-Igf2 transgenic mice. J exp Zool. 281:43–57. 1998. View Article : Google Scholar : PubMed/NCBI

37 

Bartke A, Chandrashekar V, Bailey B, Zaczek D and Turyn D: Consequences of growth hormone (GH) overexpression and GH resistance. Neuropeptides. 36:201–208. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Huang GS, Brouwer-visser J, Ramirez MJ, Kim CH, Hebert TM, Lin J, Arias-Pulido H, Qualls CR, Prossnitz ER, Goldberg GL, et al: Insulin-like growth factor 2 expression modulates Taxol resistance and is a candidate biomarker for reduced disease-free survival in ovarian cancer. Clin Cancer Res. 16:2999–3010. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Brouwer-Visser J, Lee J, McCullagh K, Cossio MJ, Wang Y and Huang GS: Insulin-like growth factor 2 silencing restores taxol sensitivity in drug resistant ovarian cancer. PLoS One. 9:e1001652014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dong Y, Li J, Han F, Chen H, Zhao X, Qin Q, Shi R and Liu J: High IGF2 expression is associated with poor clinical outcome in human ovarian cancer. Oncol Rep 34: 936-942, 2015.
APA
Dong, Y., Li, J., Han, F., Chen, H., Zhao, X., Qin, Q. ... Liu, J. (2015). High IGF2 expression is associated with poor clinical outcome in human ovarian cancer. Oncology Reports, 34, 936-942. https://doi.org/10.3892/or.2015.4048
MLA
Dong, Y., Li, J., Han, F., Chen, H., Zhao, X., Qin, Q., Shi, R., Liu, J."High IGF2 expression is associated with poor clinical outcome in human ovarian cancer". Oncology Reports 34.2 (2015): 936-942.
Chicago
Dong, Y., Li, J., Han, F., Chen, H., Zhao, X., Qin, Q., Shi, R., Liu, J."High IGF2 expression is associated with poor clinical outcome in human ovarian cancer". Oncology Reports 34, no. 2 (2015): 936-942. https://doi.org/10.3892/or.2015.4048
Copy and paste a formatted citation
x
Spandidos Publications style
Dong Y, Li J, Han F, Chen H, Zhao X, Qin Q, Shi R and Liu J: High IGF2 expression is associated with poor clinical outcome in human ovarian cancer. Oncol Rep 34: 936-942, 2015.
APA
Dong, Y., Li, J., Han, F., Chen, H., Zhao, X., Qin, Q. ... Liu, J. (2015). High IGF2 expression is associated with poor clinical outcome in human ovarian cancer. Oncology Reports, 34, 936-942. https://doi.org/10.3892/or.2015.4048
MLA
Dong, Y., Li, J., Han, F., Chen, H., Zhao, X., Qin, Q., Shi, R., Liu, J."High IGF2 expression is associated with poor clinical outcome in human ovarian cancer". Oncology Reports 34.2 (2015): 936-942.
Chicago
Dong, Y., Li, J., Han, F., Chen, H., Zhao, X., Qin, Q., Shi, R., Liu, J."High IGF2 expression is associated with poor clinical outcome in human ovarian cancer". Oncology Reports 34, no. 2 (2015): 936-942. https://doi.org/10.3892/or.2015.4048
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