Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
August-2015 Volume 34 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2015 Volume 34 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Telomere shortening in breast cancer correlates with the pathological features of tumor progression

  • Authors:
    • Makoto Kammori
    • Yoshiyuki Sugishita
    • Takahiro Okamoto
    • Makio Kobayashi
    • Kazuko Yamazaki
    • Emiko Yamada
    • Tetsu Yamada
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Kanaji Thyroid Hospital, Kita-ku, Tokyo 114‑0015, Japan, Department of Laboratory, Kanaji Thyroid Hospital, Kita-ku, Tokyo 114‑0015, Japan, Department of Surgery, Division of Surgical Endocrinology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo 162-0054, Japan, Department of Pathology 1, Tokyo Women's Medical University, Shinjuku-ku, Tokyo 162-0054, Japan, Department of Medicine, Kanaji Thyroid Hospital, Kita-ku, Tokyo 114‑0015, Japan
  • Pages: 627-632
    |
    Published online on: June 15, 2015
       https://doi.org/10.3892/or.2015.4063
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Telomeres are involved in the maintenance of genomic stability. Telomere alteration has been observed in most human cancer types, and is known to be a feature of malignancy. The aim of the present study was to evaluate whether the telomere length of breast cancer cells correlates with TNM stage and several pathological features. We investigated a total of 44 breast cancers, including 17 scirrhous, 15 papillotubular and 12 solid-tubular carcinomas. Telomere lengths were determined by tissue quantitative fluorescence in situ hybridization (Q-FISH), and compared according to the TNM stage, histological tumor size, lymph node metastases, vascular invasion and immunohistochemical status (ER, PR, HER2 status and Ki67 labeling index). In all histological types, telomeres of cancer cells were significantly shorter than those of normal epithelial cells. Mean telomere length was significantly less in patients with TNM stage III, and in those with large tumors, lymph node metastases and vascular invasion. Our results suggest that the telomere length of cancer cells is strongly correlated with the degree of cancer progression.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Deng Y, Chan SS and Chang S: Telomere dysfunction and tumour suppression: The senescence connection. Nat Rev Cancer. 8:450–458. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Palm W and de Lange T: How shelterin protects mammalian telomeres. Annu Rev Genet. 42:301–334. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Stewart SA and Weinberg RA: Telomeres: Cancer to human aging. Annu Rev Cell Dev Biol. 22:531–557. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Harley CB, Futcher AB and Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature. 345:458–460. 1990. View Article : Google Scholar : PubMed/NCBI

5 

von Zglinicki T: Oxidative stress shortens telomeres. Trends Biochem Sci. 27:339–344. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Harley CB and Villeponteau B: Telomeres and telomerase in aging and cancer. Curr Opin Genet Dev. 5:249–255. 1995. View Article : Google Scholar : PubMed/NCBI

7 

de Lange T: Telomeres and senescence: Ending the debate. Science. 279:334–335. 1998. View Article : Google Scholar : PubMed/NCBI

8 

DePinho RA: The age of cancer. Nature. 408:248–254. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Artandi SE and DePinho RA: Telomeres and telomerase in cancer. Carcinogenesis. 31:9–18. 2010. View Article : Google Scholar :

10 

Blasco MA: Telomeres and human disease: Ageing, cancer and beyond. Nat Rev Genet. 6:611–622. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Prescott J, Wentzensen IM, Savage SA and De Vivo I: Epidemiologic evidence for a role of telomere dysfunction in cancer etiology. Mutat Res. 730:75–84. 2012. View Article : Google Scholar

12 

Svenson U and Roos G: Telomere length as a biological marker in malignancy. Biochim Biophys Acta. 1792:317–323. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Kurabayashi R, Takubo K, Aida J, Honma N, Poon SS, Kammori M, Izumiyama-Shimomura N, Nakamura K, Tsuji E, Matsuura M, et al: Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts. Hum Pathol. 39:1647–1655. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Meeker AK, Hicks JL, Iacobuzio-Donahue CA, Montgomery EA, Westra WH, Chan TY, Ronnett BM and De Marzo AM: Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis. Clin Cancer Res. 10:3317–3326. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Meeker AK and Argani P: Telomere shortening occurs early during breast tumorigenesis: A cause of chromosome destabilization underlying malignant transformation? J Mammary Gland Biol Neoplasia. 9:285–296. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Meeker AK, Hicks JL, Gabrielson E, Strauss WM, De Marzo AM and Argani P: Telomere shortening occurs in subsets of normal breast epithelium as well as in situ and invasive carcinoma. Am J Pathol. 164:925–935. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Chin K, de Solorzano CO, Knowles D, Jones A, Chou W, Rodriguez EG, Kuo WL, Ljung BM, Chew K, Myambo K, et al: In situ analyses of genome instability in breast cancer. Nat Genet. 36:984–988. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Odagiri E, Kanada N, Jibiki K, Demura R, Aikawa E and Demura H: Reduction of telomeric length and c-erbB-2 gene amplification in human breast cancer, fibroadenoma, and gynecomastia. Relationship to histologic grade and clinical parameters. Cancer. 73:2978–2984. 1994. View Article : Google Scholar : PubMed/NCBI

20 

Griffith JK, Bryant JE, Fordyce CA, Gilliland FD, Joste NE and Moyzis RK: Reduced telomere DNA content is correlated with genomic instability and metastasis in invasive human breast carcinoma. Breast Cancer Res Treat. 54:59–64. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Radpour R, Barekati Z, Haghighi MM, Kohler C, Asadollahi R, Torbati PM, Holzgreve W and Zhong XY: Correlation of telomere length shortening with promoter methylation profile of p16/Rb and p53/p21 pathways in breast cancer. Mod Pathol. 23:763–772. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Fordyce CA, Heaphy CM, Bisoffi M, Wyaco JL, Joste NE, Mangalik A, Baumgartner KB, Baumgartner RN, Hunt WC and Griffith JK: Telomere content correlates with stage and prognosis in breast cancer. Breast Cancer Res Treat. 99:193–202. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Rogalla P, Rohen C, Bonk U and Bullerdiek J: Telomeric repeat fragment lengths are not correlated to histological grading in 85 breast cancers. Cancer Lett. 106:155–161. 1996. View Article : Google Scholar : PubMed/NCBI

24 

Sugishita Y, Kammori M, Yamada O, Yamazaki K, Ito K, Fukumori T, Yoshikawa K and Yamada T: Biological differential diagnosis of follicular thyroid tumor and Hürthle cell tumor on the basis of telomere length and hTERT expression. Ann Surg Oncol. 21:2318–2325. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Aida J, Izumiyama-Shimomura N, Nakamura K, Ishii A, Ishikawa N, Honma N, Kurabayashi R, Kammori M, Poon SS, Arai T, et al: Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method. Hum Pathol. 38:1192–1200. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Kammori M, Izumiyama N, Nakamura K, Kurabayashi R, Kashio M, Aida J, Poon SS and Kaminishi M: Telomere metabolism and diagnostic demonstration of telomere measurement in the human esophagus for distinguishing benign from malignant tissue by tissue quantitative fluorescence in situ hybridization. Oncology. 71:430–436. 2006. View Article : Google Scholar

27 

Ahlin C, Aaltonen K, Amini RM, Nevanlinna H, Fjällskog ML and Blomqvist C: Ki67 and cyclin A as prognostic factors in early breast cancer. What are the optimal cut-off values? Histopathology. 51:491–498. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Cheang MC, Chia SK, Voduc D, Gao D, Leung S, Snider J, Watson M, Davies S, Bernard PS, Parker JS, et al: Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J Natl Cancer Inst. 101:736–750. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thürlimann B and Senn HJ; Panel members: Strategies for subtypes - dealing with the diversity of breast cancer: Highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol. 22:1736–1747. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Knutsvik G, Stefansson IM, Aziz S, Arnes J, Eide J, Collett K and Akslen LA: Evaluation of Ki67 expression across distinct categories of breast cancer specimens: A population-based study of matched surgical specimens, core needle biopsies and tissue microarrays. PLoS One. 9:e1121212014. View Article : Google Scholar : PubMed/NCBI

31 

Donaldson L, Fordyce C, Gilliland F, Smith A, Feddersen R, Joste N, Moyzis R and Griffith J: Association between outcome and telomere DNA content in prostate cancer. J Urol. 162:1788–1792. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Frías C, García-Aranda C, De Juan C, Morán A, Ortega P, Gómez A, Hernando F, López-Asenjo JA, Torres AJ, Benito M, et al: Telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer. Lung Cancer. 60:416–425. 2008. View Article : Google Scholar

33 

Bisoffi M, Heaphy CM and Griffith JK: Telomeres: Prognostic markers for solid tumors. Int J Cancer. 119:2255–2260. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Heaphy CM, Baumgartner KB, Bisoffi M, Baumgartner RN and Griffith JK: Telomere DNA content predicts breast cancer-free survival interval. Clin Cancer Res. 13:7037–7043. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Diehl MC, Idowu MO, Kimmelshue KN, York TP, Jackson-Cook CK, Turner KC, Holt SE and Elmore LW: Elevated TRF2 in advanced breast cancers with short telomeres. Breast Cancer Res Treat. 127:623–630. 2011. View Article : Google Scholar

36 

Carter CL, Allen C and Henson DE: Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases. Cancer. 63:181–187. 1989. View Article : Google Scholar : PubMed/NCBI

37 

Leitner SP, Swern AS, Weinberger D, Duncan LJ and Hutter RV: Predictors of recurrence for patients with small (one centimeter or less) localized breast cancer (T1a,b N0 M0). Cancer. 76:2266–2274. 1995. View Article : Google Scholar : PubMed/NCBI

38 

Gebauer G, Fehm T, Lang N and Jäger W: Tumor size, axillary lymph node status and steroid receptor expression in breast cancer: Prognostic relevance 5 years after surgery. Breast Cancer Res Treat. 75:167–173. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 98:10869–10874. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, et al: Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA. 100:8418–8423. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Sotiriou C and Pusztai L: Gene-expression signatures in breast cancer. N Engl J Med. 360:790–800. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Voduc KD, Cheang MC, Tyldesley S, Gelmon K, Nielsen TO and Kennecke H: Breast cancer subtypes and the risk of local and regional relapse. J Clin Oncol. 28:1684–1691. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Heaphy CM, Subhawong AP, Gross AL, Konishi Y, Kouprina N, Argani P, Visvanathan K and Meeker AK: Shorter telomeres in luminal B, HER-2 and triple-negative breast cancer subtypes. Mod Pathol. 24:194–200. 2011. View Article : Google Scholar

45 

Martinez-Delgado B, Gallardo M, Tanic M, Yanowsky K, Inglada-Perez L, Barroso A, Rodriguez-Pinilla M, Cañamero M, Blasco MA and Benitez J: Short telomeres are frequent in hereditary breast tumors and are associated with high tumor grade. Breast Cancer Res Treat. 141:231–242. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kammori M, Sugishita Y, Okamoto T, Kobayashi M, Yamazaki K, Yamada E and Yamada T: Telomere shortening in breast cancer correlates with the pathological features of tumor progression. Oncol Rep 34: 627-632, 2015.
APA
Kammori, M., Sugishita, Y., Okamoto, T., Kobayashi, M., Yamazaki, K., Yamada, E., & Yamada, T. (2015). Telomere shortening in breast cancer correlates with the pathological features of tumor progression. Oncology Reports, 34, 627-632. https://doi.org/10.3892/or.2015.4063
MLA
Kammori, M., Sugishita, Y., Okamoto, T., Kobayashi, M., Yamazaki, K., Yamada, E., Yamada, T."Telomere shortening in breast cancer correlates with the pathological features of tumor progression". Oncology Reports 34.2 (2015): 627-632.
Chicago
Kammori, M., Sugishita, Y., Okamoto, T., Kobayashi, M., Yamazaki, K., Yamada, E., Yamada, T."Telomere shortening in breast cancer correlates with the pathological features of tumor progression". Oncology Reports 34, no. 2 (2015): 627-632. https://doi.org/10.3892/or.2015.4063
Copy and paste a formatted citation
x
Spandidos Publications style
Kammori M, Sugishita Y, Okamoto T, Kobayashi M, Yamazaki K, Yamada E and Yamada T: Telomere shortening in breast cancer correlates with the pathological features of tumor progression. Oncol Rep 34: 627-632, 2015.
APA
Kammori, M., Sugishita, Y., Okamoto, T., Kobayashi, M., Yamazaki, K., Yamada, E., & Yamada, T. (2015). Telomere shortening in breast cancer correlates with the pathological features of tumor progression. Oncology Reports, 34, 627-632. https://doi.org/10.3892/or.2015.4063
MLA
Kammori, M., Sugishita, Y., Okamoto, T., Kobayashi, M., Yamazaki, K., Yamada, E., Yamada, T."Telomere shortening in breast cancer correlates with the pathological features of tumor progression". Oncology Reports 34.2 (2015): 627-632.
Chicago
Kammori, M., Sugishita, Y., Okamoto, T., Kobayashi, M., Yamazaki, K., Yamada, E., Yamada, T."Telomere shortening in breast cancer correlates with the pathological features of tumor progression". Oncology Reports 34, no. 2 (2015): 627-632. https://doi.org/10.3892/or.2015.4063
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team