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Article

HOXA1 enhances the cell proliferation, invasion and metastasis of prostate cancer cells

  • Authors:
    • Haitao Wang
    • Guanzhong Liu
    • Dan Shen
    • Huamao Ye
    • Jinming Huang
    • Li Jiao
    • Yinghao Sun
  • View Affiliations / Copyright

    Affiliations: Department of E.N.T., Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China, Department of Radiology Imaging, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China, Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China, Department of Urologic Surgery, The 85th Hospital of PLA, Shanghai 200052, P.R. China
  • Pages: 1203-1210
    |
    Published online on: June 26, 2015
       https://doi.org/10.3892/or.2015.4085
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Abstract

HOXA1, a member of the HOX gene family, has been implicated in tumor progression. However, the role of HOXA1 in prostate cancer is not well-established. In the present study, we found that HOXA1 was highly expressed in prostate cancer cells. We then repressed the expression of HOXA1 by short hairpin RNA (shRNA) to investigate the function of HOXA1 in prostate cancer cells. Our in vitro data showed that knockdown of HOXA1 attenuated the growth, invasion and migration of prostate cancer DU-145 and PC-3 cells. Furthermore, knockdown of HOXA1 resulted in an increased E-cadherin level and decreased Snail and MMP-3 levels in the DU-145 cells. In addition, knockdown of HOXA1 inhibited activation of ERK1/2 and AKT in the DU-145 cells. Our in vivo data revealed that knockdown of HOXA1 suppressed the growth and metastasis of prostate cancer cells. Collectively, our findings suggest that HOXA1 is involved in the regulation of prostate cancer progression, including cell growth, migration, invasion and metastasis. Thus, downregulation of HOXA1 may be a novel approach for the treatment of prostate cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Liu G, Shen D, Ye H, Huang J, Jiao L and Sun Y: HOXA1 enhances the cell proliferation, invasion and metastasis of prostate cancer cells. Oncol Rep 34: 1203-1210, 2015.
APA
Wang, H., Liu, G., Shen, D., Ye, H., Huang, J., Jiao, L., & Sun, Y. (2015). HOXA1 enhances the cell proliferation, invasion and metastasis of prostate cancer cells. Oncology Reports, 34, 1203-1210. https://doi.org/10.3892/or.2015.4085
MLA
Wang, H., Liu, G., Shen, D., Ye, H., Huang, J., Jiao, L., Sun, Y."HOXA1 enhances the cell proliferation, invasion and metastasis of prostate cancer cells". Oncology Reports 34.3 (2015): 1203-1210.
Chicago
Wang, H., Liu, G., Shen, D., Ye, H., Huang, J., Jiao, L., Sun, Y."HOXA1 enhances the cell proliferation, invasion and metastasis of prostate cancer cells". Oncology Reports 34, no. 3 (2015): 1203-1210. https://doi.org/10.3892/or.2015.4085
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Liu G, Shen D, Ye H, Huang J, Jiao L and Sun Y: HOXA1 enhances the cell proliferation, invasion and metastasis of prostate cancer cells. Oncol Rep 34: 1203-1210, 2015.
APA
Wang, H., Liu, G., Shen, D., Ye, H., Huang, J., Jiao, L., & Sun, Y. (2015). HOXA1 enhances the cell proliferation, invasion and metastasis of prostate cancer cells. Oncology Reports, 34, 1203-1210. https://doi.org/10.3892/or.2015.4085
MLA
Wang, H., Liu, G., Shen, D., Ye, H., Huang, J., Jiao, L., Sun, Y."HOXA1 enhances the cell proliferation, invasion and metastasis of prostate cancer cells". Oncology Reports 34.3 (2015): 1203-1210.
Chicago
Wang, H., Liu, G., Shen, D., Ye, H., Huang, J., Jiao, L., Sun, Y."HOXA1 enhances the cell proliferation, invasion and metastasis of prostate cancer cells". Oncology Reports 34, no. 3 (2015): 1203-1210. https://doi.org/10.3892/or.2015.4085
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