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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September-2015 Volume 34 Issue 3

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Genetics, diagnosis and management of colorectal cancer (Review)

Marina De Rosa, Ugo Pace, Daniela Rega, Valeria Costabile, Francesca Duraturo, Paola Izzo, Paolo Delrio
Pages: 1087-1096
Published online on: 03 July 2015

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Review

Nanotechnology applications in hematological malignancies (Review)

Ahmed Samir, Basma M. Elgamal, Hala Gabr, Hatem E. Sabaawy
Pages: 1097-1105
Published online on: 02 July 2015

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Review Open Access

Natural and adaptive IgM antibodies in the recognition of tumor-associated antigens of breast cancer (Review)

Mariana Díaz-Zaragoza, Ricardo Hernández-Ávila, Rubí Viedma‑Rodríguez, Diego Arenas-Aranda, Pedro Ostoa-Saloma
Pages: 1106-1114
Published online on: 30 June 2015

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Article Open Access

Effects of daidzein in regards to cytotoxicity in vitro, apoptosis, reactive oxygen species level, cell cycle arrest and the expression of caspase and Bcl-2 family proteins

Bing-Jie Han, Wei Li, Guang-Bin Jiang, Shang-Hai Lai, Cheng Zhang, Chuan-Chuan Zeng, Yun-Jun Liu
Pages: 1115-1120
Published online on: 14 July 2015

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Article Open Access

Knockdown of SOX18 inhibits the proliferation, migration and invasion of hepatocellular carcinoma cells

Guiming Wang, Zhigang Wei, Hongyan Jia, Wenbo Zhao, Gaochao Yang, Haoliang Zhao
Pages: 1121-1128
Published online on: 07 July 2015

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Article Open Access

Celastrol induces apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway

Xiaolong Yu, Xin Zhou, Changlin Fu, Qiang Wang, Tao Nie, Fan Zou, Runsheng Guo, Hucheng Liu, Bin Zhang, Min Dai
Pages: 1129-1136
Published online on: 13 July 2015

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Article Open Access

Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer

Takashi Sato, Kenzo Soejima, Eri Arai, Junko Hamamoto, Hiroyuki Yasuda, Daisuke Arai, Kota Ishioka, Keiko Ohgino, Katsuhiko Naoki, Takashi Kohno, Koji Tsuta, Shun-Ichi Watanabe, Yae Kanai, Tomoko Betsuyaku
Pages: 1137-1145
Published online on: 25 June 2015

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Article Open Access

Trastuzumab and docetaxel in a preclinical organotypic breast cancer model using tissue slices from mammary fat pad: Translational relevance Corrigendum in /or/35/1/602

Loredana Vesci, Valeria Carollo, Giuseppe Roscilli, Luigi Aurisicchio, Fabiana Fosca Ferrara, Luigi Spagnoli, Rita De Santis
Pages: 1146-1152
Published online on: 24 June 2015

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Article Open Access

miR-130a acts as a potential diagnostic biomarker and promotes gastric cancer migration, invasion and proliferation by targeting RUNX3

Hong Jiang, Wei-Wei Yu, Lu-Lu Wang, Yang Peng
Pages: 1153-1161
Published online on: 01 July 2015

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Article Open Access

Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells

Yuhui Huang, Motofumi Kumazoe, Jaehoon Bae, Shuhei Yamada, Mika Takai, Shiori Hidaka, Shuya Yamashita, Yoonhee Kim, Yeongseon Won, Motoki Murata, Shuntaro Tsukamoto, Hirofumi Tachibana
Pages: 1162-1168
Published online on: 26 June 2015

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Article Open Access

Hepatic stellate cells promote upregulation of epithelial cell adhesion molecule and epithelial-mesenchymal transition in hepatic cancer cells

Teruya Nagahara, Hidenori Shiraha, Hiroaki Sawahara, Daisuke Uchida, Yasuto Takeuchi, Masaya Iwamuro, Junro Kataoka, Shigeru Horiguchi, Takeshi Kuwaki, Hideki Onishi, Shinichiro Nakamura, Akinobu Takaki, Kazuhiro Nouso, Kazuhide Yamamoto
Pages: 1169-1177
Published online on: 13 July 2015

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Article

Widdrol, a sesquiterpene isolated from Juniperus chinensis, inhibits angiogenesis by targeting vascular endothelial growth factor receptor 2 signaling

Soojung Jin, Hee Jung Yun, Hyun Young Jeong, You Na Oh, Hyun‑Jin Park, Seung-Geun Yun, Byung Woo Kim, Hyun Ju Kwon
Pages: 1178-1184
Published online on: 24 June 2015

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Article

Inhibitory effects of valproic acid in DNA double-strand break repair after irradiation in esophageal squamous carcinoma cells

Naoki Makita, Itasu Ninomiya, Tomoya Tsukada, Koichi Okamoto, Shinichi Harada, Shinichi Nakanuma, Seisho Sakai, Isamu Makino, Jun Kinoshita, Hironori Hayashi, Katsunobu Oyama, Hisatoshi Nakagawara, Tomoharu Miyashita, Hidehiro Tajima, Hiroyuki Takamura, Sachio Fushida, Tetsuo Ohta
Pages: 1185-1192
Published online on: 26 June 2015

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Article

Activation of ARK5/miR-1181/HOXA10 axis promotes epithelial-mesenchymal transition in ovarian cancer

Hai-Yan Zhang, Jian-Hua Li, Guang Li, Su-Rong Wang
Pages: 1193-1202
Published online on: 07 July 2015

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Article

HOXA1 enhances the cell proliferation, invasion and metastasis of prostate cancer cells

Haitao Wang, Guanzhong Liu, Dan Shen, Huamao Ye, Jinming Huang, Li Jiao, Yinghao Sun
Pages: 1203-1210
Published online on: 26 June 2015

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Article

Expression of DNA ligase IV is linked to poor prognosis and characterizes a subset of prostate cancers harboring TMPRSS2:ERG fusion and PTEN deletion

Katharina Grupp, Laura Roettger, Martina Kluth, Claudia Hube-Magg, Ronald Simon, Patrick Lebok, Sarah Minner, Maria Christina Tsourlakis, Christina Koop, Markus Graefen, Meike Adam, Alexander Haese, Corinna Wittmer, Guido Sauter, Waldemar Wilczak, Hartwig Huland, Thorsten Schlomm, Stefan Steurer, Till Krech
Pages: 1211-1220
Published online on: 25 June 2015

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Article

Suppression of KLF8 induces cell differentiation and sensitizes colorectal cancer to 5-fluorouracil

Xinpeng Shi, Xiaoyong Luo, Qingqing Yan, Wenjing Zhang, Yao Wu, Mengnan Zhang, Jinjun Zhao, Ying Peng, Ye Chen, Yali Zhang, Cunlong Chen, Tianming Cheng, Chudi Chen, Side Liu, Yang Bai, Jide Wang
Pages: 1221-1230
Published online on: 30 June 2015

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Article

CD44 alternative splicing and hnRNP A1 expression are associated with the metastasis of breast cancer

Tiing Jen Loh, Heegyum Moon, Sunghee Cho, Hana Jang, Yong Chao Liu, Hongmei Tai, Da-Woon Jung, Darren R. Williams, Hey-Ran Kim, Myung-Geun Shin, D. Joshua Liao, Jianhua Zhou, Wei Shi, Xuexiu Zheng, Haihong Shen
Pages: 1231-1238
Published online on: 06 July 2015

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Article

ZGDHu-1 and fludarabine have a synergistic effect on apoptosis of chronic lymphocytic leukemia cells

Liannv Qiu, Jinlin Liu, Zhenni Wang, Weixiao Hu, Qiang Huang, Yonglie Zhou
Pages: 1239-1248
Published online on: 08 July 2015

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Article

A secretomic study on human hepatocellular carcinoma multiple drug-resistant cell lines

Yi Xiang, Yi Liu, Yixuan Yang, Huaidong Hu, Peng Hu, Hong Ren, Dazhi Zhang
Pages: 1249-1260
Published online on: 03 July 2015

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Article

Ursodeoxycholic acid effectively kills drug-resistant gastric cancer cells through induction of autophagic death

Sung-Chul Lim, Song Iy Han
Pages: 1261-1268
Published online on: 24 June 2015

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Article

Circulating classical CD14++CD16- monocytes predict shorter time to initial treatment in chronic lymphocytic leukemia patients: Differential effects of immune chemotherapy on monocyte-related membrane and soluble forms of CD163

Izabela Lapuc, Lukasz Bolkun, Andrzej Eljaszewicz, Malgorzata Rusak, Ewa Luksza, Paulina Singh, Paula Miklasz, Jaroslaw Piszcz, Katarzyna Ptaszynska‑Kopczynska, Malgorzata Jasiewicz, Karol Kaminski, Milena Dabrowska, Anna Bodzenta-Lukaszyk, Janusz Kloczko, Marcin Moniuszko
Pages: 1269-1278
Published online on: 26 June 2015

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Article

RITA enhances irradiation-induced apoptosis in p53-defective cervical cancer cells via upregulation of IRE1α/XBP1 signaling

Hong Zhu, Muyasha Abulimiti, Huan Liu, Xiang-Jiang Su, Cai-Hong Liu, Hai-Ping Pei
Pages: 1279-1288
Published online on: 25 June 2015

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Article

Honokiol exhibits enhanced antitumor effects with chloroquine by inducing cell death and inhibiting autophagy in human non-small cell lung cancer cells

Xiaoqin Lv, Fang Liu, Yue Shang, Shu-Zhen Chen
Pages: 1289-1300
Published online on: 29 June 2015

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Article

Identification of genes and long non-coding RNAs associated with the pathogenesis of gastric cancer

Zhiwei Zhao, Yan Song, Daxun Piao, Tianyou Liu, Liangliang Zhao
Pages: 1301-1310
Published online on: 14 July 2015

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Article

Antitumor activity of a 2-pyridinecarboxaldehyde 2-pyridinecarboxylic acid hydrazone copper complex and the related mechanism

Yingli Yang, Tengfei Huang, Sufeng Zhou, Yun Fu, Youxun Liu, Yanbin Yuan, Qiongqing Zhang, Shaoshan Li, Changzheng Li
Pages: 1311-1318
Published online on: 26 June 2015

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Article

Astrocyte elevated gene-1 regulates CCL3/CCR5-induced epithelial-to-mesenchymal transition via Erk1/2 and Akt signaling in cardiac myxoma

Ping Shi, Changcun Fang, Xinyan Pang
Pages: 1319-1326
Published online on: 25 June 2015

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Article

Nuclear vasohibin-2 promotes cell proliferation by inducing G0/G1 to S phase progression

Qianqian Ge, Jia Zhou, Min Tu, Xiaofeng Xue, Zhanjun Li, Zipeng Lu, Jishu Wei, Guoxin Song, Jianmin Chen, Feng Guo, Kuirong Jiang, Yi Miao, Wentao Gao
Pages: 1327-1336
Published online on: 13 July 2015

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Article

Expression and activity analysis of a new fusion protein targeting ovarian cancer cells

Manman Su, Weiqin Chang, Dingding Wang, Manhua Cui, Yang Lin, Shuying Wu, Tianmin Xu
Pages: 1337-1344
Published online on: 09 July 2015

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Article

Binding of MMP-9-degraded fibronectin to β6 integrin promotes invasion via the FAK-Src-related Erk1/2 and PI3K/Akt/Smad-1/5/8 pathways in breast cancer

Wentong Li, Zhijun Liu, Chunling Zhao, Limin Zhai
Pages: 1345-1352
Published online on: 02 July 2015

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Article

The tumor-suppressive role of BATF2 in esophageal squamous cell carcinoma

Tianci Han, Zhiyong Wang, Yang Yang, Tianci Shu, Weinan Li, Dali Liu, Peiwen Li, Ruiqun Qi, Yi Ren, Li Li, Hong Liu, Shuguang Zhang, Lin Zhang
Pages: 1353-1360
Published online on: 26 June 2015

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Article

Concentration-dependent differential effects of an epothilone analog on cell cycle and p53 signaling

Fan An, Wei-Jie Zhao, Li Tang, Rong-Guo Qiu
Pages: 1361-1368
Published online on: 14 July 2015

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Article

GALC gene is downregulated by promoter hypermethylation in Epstein-Barr virus-associated nasopharyngeal carcinoma

Yinghai Zhao, Ying Guo, Zhijing Wang, Zebin Xiao, Rong Li, Aihua Luo, Changli Wu, Zhiliang Jing, Ning Sun, Xiaoyi Chen, Haijun Du, Yi Zeng
Pages: 1369-1378
Published online on: 14 July 2015

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Article

A limited overlap between intratumoral distribution of 1-(5-fluoro-5-deoxy-α-D-arabinofuranosyl)-2-nitroimidazole and copper-diacetyl-bis[N(4)-methylthiosemicarbazone]

Takako Furukawa, Qinghua Yuan, Zhao-Hui Jin, Winn Aung, Yukie Yoshii, Sumitaka Hasegawa, Hiroko Endo, Masahiro Inoue, Ming‑Rong Zhang, Yasuhisa Fujibayashi, Tsuneo Saga
Pages: 1379-1387
Published online on: 25 June 2015

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Article

Evodiamine inhibits the proliferation of human osteosarcoma cells by blocking PI3K/Akt signaling

Zi-Jun Meng, Nian Wu, Yang Liu, Ke-Jie Shu, Xiang Zou, Ran-Xi Zhang, Chang-Jun Pi, Bai-Cheng He, Zhen-Yong Ke, Liang Chen, Zhong-Liang Deng, Liang-Jun Yin
Pages: 1388-1396
Published online on: 25 June 2015

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Article

High expression of transforming acidic coiled coil-containing protein 3 strongly correlates with aggressive characteristics and poor prognosis of gastric cancer

Miao Yun, Jian Rong, Zhi-Rui Lin, Yu-Long He, Jia-Xing Zhang, Zhen-Wei Peng, Lin-Quan Tang, Mu-Sheng Zeng, Qian Zhong, Sheng Ye
Pages: 1397-1405
Published online on: 30 June 2015

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Article

SPARC ectopic overexpression inhibits growth and promotes programmed cell death in acute myeloid leukemia transformed from myelodysplastic syndrome cells, alone and in combination with Ara-C treatment

Qing Nian, Jianxiang Chi, Qing Xiao, Chunmei Wei, Paul Costeas, Zesong Yang, Lin Liu, Li Wang
Pages: 1406-1414
Published online on: 08 July 2015

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Article

miR-99b promotes metastasis of hepatocellular carcinoma through inhibition of claudin 11 expression and may serve as a prognostic marker

Jianhui Yang, Xiwu Liu, Xiaohua Yuan, Zhiming Wang
Pages: 1415-1423
Published online on: 02 July 2015

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Article

PIG3 plays an oncogenic role in papillary thyroid cancer by activating the PI3K/AKT/PTEN pathway

Jinye Xu, Junbo Cai, Xiaoyan Jin, Jingjin Yang, Qinyan Shen, Xiaofei Ding, Yong Liang
Pages: 1424-1430
Published online on: 30 June 2015

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Article

Knockdown of zinc transporter ZIP5 (SLC39A5) expression significantly inhibits human esophageal cancer progression

Jing Jin, Zhongxin Li, Jianghui Liu, Yan Wu, Xing Gao, Yutong He
Pages: 1431-1439
Published online on: 01 July 2015

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Article

Aquaporin 1 promotes the proliferation and migration of lung cancer cell in vitro

Xiaobai Wei, Jingcheng Dong
Pages: 1440-1448
Published online on: 03 July 2015

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Article

Topical treatment with Xiaozheng Zhitong Paste alleviates bone cancer pain by inhibiting proteinase-activated receptor 2 signaling pathway

Yanju Bao, Gaimei Wang, Yebo Gao, Maobo Du, Liping Yang, Xiangying Kong, Honggang Zheng, Wei Hou, Baojin Hua
Pages: 1449-1459
Published online on: 24 June 2015

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Article

REV3L modulates cisplatin sensitivity of non-small cell lung cancer H1299 cells

Wenjie Wang, Wenjiong Sheng, Chenxiao Yu, Jianping Cao, Jundong Zhou, Jinchang Wu, Huojun Zhang, Shuyu Zhang
Pages: 1460-1468
Published online on: 09 July 2015

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Article

Umbilical cord-derived mesenchymal stem cells promote proliferation and migration in MCF-7 and MDA-MB-231 breast cancer cells through activation of the ERK pathway Corrigendum in /10.3892/or.2025.8933

Tao Li, Chunfu Zhang, Yanling Ding, Wei Zhai, Kui Liu, Fan Bu, Tao Tu, Lingxian Sun, Wei Zhu, Fangfang Zhou, Wenkai Qi, Jiabo Hu, Huabiao Chen, Xiaochun Sun
Pages: 1469-1477
Published online on: 03 July 2015

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Article

Low-dose UVB irradiation prevents MMP2-induced skin hyperplasia by inhibiting inflammation and ROS

Lin Dang, Yan Wang, Yadong Xue, Lei He, Yuzhen Li, Jikui Xiong
Pages: 1478-1486
Published online on: 24 June 2015

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Article

Tanshinone IIA enhances bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in nuclei and mitochondria

Haiyang Jiang, Lei Zhao, Xiaoshen Dong, Anning He, Caiwei Zheng, Magnus Johansson, Anna Karlsson, Xinyu Zheng
Pages: 1487-1493
Published online on: 02 July 2015

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Article

STC2 overexpression mediated by HMGA2 is a biomarker for aggressiveness of high-grade serous ovarian cancer

Jingjing Wu, Maode Lai, Changshun Shao, Jian Wang, Jian-Jun Wei
Pages: 1494-1502
Published online on: 09 July 2015

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Article

Hypomethylated Rab27b is a progression-associated prognostic biomarker of glioma regulating MMP-9 to promote invasion

Hongjun Wang, Yongzhi Wang, Zhaoshi Bao, Chuanbao Zhang, Yanwei Liu, Jinquan Cai, Chuanlu Jiang
Pages: 1503-1509
Published online on: 13 July 2015

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Article

Lentivirus-mediated gene silencing of NOB1 suppresses non-small cell lung cancer cell proliferation

Weiyi Huang, Weiqing Zhong, Jun Xu, Benhua Su, Guanghui Huang, Jiajun Du, Qi Liu
Pages: 1510-1516
Published online on: 14 July 2015

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Article

Flavonoids isolated from Citrus platymamma induce mitochondrial-dependent apoptosis in AGS cells by modulation of the PI3K/AKT and MAPK pathways

Ho Jeong Lee, Arulkumar Nagappan, Hyeon Soo Park, Gyeong Eun Hong, Silvia Yumnam, Suchismita Raha, Venu Venkatarame Gowda Saralamma, Won Sup Lee, Eun Hee Kim, Gon Sup Kim
Pages: 1517-1525
Published online on: 10 July 2015

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Article

Dicer ablation promotes a mesenchymal and invasive phenotype in bladder cancer cells

Alan P. Lombard, Rebecca M. Lim, Rachel M. Nakagawa, Kathleen D. Vidallo, Stephen J. Libertini, Alexander J. Platero, Maria Mudryj
Pages: 1526-1532
Published online on: 09 July 2015

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Article

Antitumor effects of a drug combination targeting glycolysis, glutaminolysis and de novo synthesis of fatty acids

Diana Cervantes-Madrid, Alfonso Dueñas-González
Pages: 1533-1542
Published online on: 24 June 2015

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Article

ERK/GSK3β signaling is involved in atractylenolide I-induced apoptosis and cell cycle arrest in melanoma cells

Yan Ye, Xiao-Juan Chao, Jin-Feng Wu, Brian Chi-Yan Cheng, Tao Su, Xiu-Qiong Fu, Ting Li, Hui Guo, Anfernee Kai-Wing Tse, Hiu-Yee Kwan, Juan Du, Gui-Xin Chou, Zhi-Ling Yu
Pages: 1543-1548
Published online on: 06 July 2015

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Article

Roscovitine has anti-proliferative and pro-apoptotic effects on glioblastoma cell lines: A pilot study

M. Kolodziej, C. Goetz, P. Di Fazio, R. Montalbano, M. Ocker, H. Strik, K. Quint
Pages: 1549-1556
Published online on: 03 July 2015

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MicroRNA-216a enhances the radiosensitivity of pancreatic cancer cells by inhibiting beclin-1-mediated autophagy

Xiangliang Zhang, Huijuan Shi, Shengqv Lin, Mingchen Ba, Shuzhong Cui
Pages: 1557-1564
Published online on: 25 June 2015

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Article

Sulforaphane inhibits invasion by phosphorylating ERK1/2 to regulate E-cadherin and CD44v6 in human prostate cancer DU145 cells

Xiaohui Peng, Yan Zhou, Hua Tian, Gaoxiang Yang, Chunliu Li, Yang Geng, Sai Wu, Wei Wu
Pages: 1565-1572
Published online on: 01 July 2015

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Article

miR-133a inhibits cervical cancer growth by targeting EGFR Retraction in /10.3892/or.2021.8103

Xuesong Song, Bo Shi, Kexin Huang, Wenjie Zhang
Pages: 1573-1580
Published online on: 02 July 2015

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Article

ERK5 positively regulates cigarette smoke-induced urocystic epithelial-mesenchymal transition in SV‑40 immortalized human urothelial cells

Hao Geng, Li Zhao, Zhaofeng Liang, Zhiqiang Zhang, Dongdong Xie, Liangkuan Bi, Yi Wang, Tao Zhang, Lei Cheng, Dexin Yu, Caiyun Zhong
Pages: 1581-1588
Published online on: 14 July 2015

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Article

Enhanced cytotoxicity in triple-negative and estrogen receptor‑positive breast adenocarcinoma cells due to inhibition of the transient receptor potential melastatin-2 channel

David W. Koh, Daniel P. Powell, Steven D. Blake, Joy L. Hoffman, Mandi M. Hopkins, Xiaoxing Feng
Pages: 1589-1598
Published online on: 14 July 2015

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Article

Suppression of casein kinase 2 sensitizes tumor cells to antitumor TRAIL therapy by regulating the phosphorylation and localization of p65 in prostate cancer

Xiaokun Gang, Yao Wang, Yingdi Wang, Yu Zhao, Liya Ding, Jingwen Zhao, Lin Sun, Guixia Wang
Pages: 1599-1604
Published online on: 13 July 2015

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Article

MicroRNA-20b inhibits the proliferation, migration and invasion of bladder cancer EJ cells via the targeting of cell cycle regulation and Sp-1-mediated MMP-2 expression

Sung Lyea Park, Tae-Min Cho, Se Yeon Won, Jun-Hui Song, Dae‑Hwa Noh, Wun-Jae Kim, Sung-Kwon Moon
Pages: 1605-1612
Published online on: 09 July 2015

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Article

Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells

Sangmin Kim, Jeongmin Lee, Soo Jin Oh, Seok Jin Nam, Jeong Eon Lee
Pages: 1613-1619
Published online on: 08 July 2015

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Article

Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs

Chia-Chi Hsu, Ling-Chia Wu, Cheng-Yuan Hsia, Pen-Hui Yin, Chin‑Wen Chi, Tien-Shun Yeh, Hsin-Chen Lee
Pages: 1620-1628
Published online on: 30 June 2015

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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