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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September-2015 Volume 34 Issue 3

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Genetics, diagnosis and management of colorectal cancer (Review)

Marina De Rosa, Ugo Pace, Daniela Rega, Valeria Costabile, Francesca Duraturo, Paola Izzo, Paolo Delrio
Pages: 1087-1096
Published online on: 03 July 2015

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Review

Nanotechnology applications in hematological malignancies (Review)

Ahmed Samir, Basma M. Elgamal, Hala Gabr, Hatem E. Sabaawy
Pages: 1097-1105
Published online on: 02 July 2015

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Review Open Access

Natural and adaptive IgM antibodies in the recognition of tumor-associated antigens of breast cancer (Review)

Mariana Díaz-Zaragoza, Ricardo Hernández-Ávila, Rubí Viedma‑Rodríguez, Diego Arenas-Aranda, Pedro Ostoa-Saloma
Pages: 1106-1114
Published online on: 30 June 2015

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Article Open Access

Effects of daidzein in regards to cytotoxicity in vitro, apoptosis, reactive oxygen species level, cell cycle arrest and the expression of caspase and Bcl-2 family proteins

Bing-Jie Han, Wei Li, Guang-Bin Jiang, Shang-Hai Lai, Cheng Zhang, Chuan-Chuan Zeng, Yun-Jun Liu
Pages: 1115-1120
Published online on: 14 July 2015

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Article Open Access

Knockdown of SOX18 inhibits the proliferation, migration and invasion of hepatocellular carcinoma cells

Guiming Wang, Zhigang Wei, Hongyan Jia, Wenbo Zhao, Gaochao Yang, Haoliang Zhao
Pages: 1121-1128
Published online on: 07 July 2015

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Article Open Access

Celastrol induces apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway

Xiaolong Yu, Xin Zhou, Changlin Fu, Qiang Wang, Tao Nie, Fan Zou, Runsheng Guo, Hucheng Liu, Bin Zhang, Min Dai
Pages: 1129-1136
Published online on: 13 July 2015

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Article Open Access

Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer

Takashi Sato, Kenzo Soejima, Eri Arai, Junko Hamamoto, Hiroyuki Yasuda, Daisuke Arai, Kota Ishioka, Keiko Ohgino, Katsuhiko Naoki, Takashi Kohno, Koji Tsuta, Shun-Ichi Watanabe, Yae Kanai, Tomoko Betsuyaku
Pages: 1137-1145
Published online on: 25 June 2015

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Article Open Access

Trastuzumab and docetaxel in a preclinical organotypic breast cancer model using tissue slices from mammary fat pad: Translational relevance Corrigendum in /or/35/1/602

Loredana Vesci, Valeria Carollo, Giuseppe Roscilli, Luigi Aurisicchio, Fabiana Fosca Ferrara, Luigi Spagnoli, Rita De Santis
Pages: 1146-1152
Published online on: 24 June 2015

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Article Open Access

miR-130a acts as a potential diagnostic biomarker and promotes gastric cancer migration, invasion and proliferation by targeting RUNX3

Hong Jiang, Wei-Wei Yu, Lu-Lu Wang, Yang Peng
Pages: 1153-1161
Published online on: 01 July 2015

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Article Open Access

Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells

Yuhui Huang, Motofumi Kumazoe, Jaehoon Bae, Shuhei Yamada, Mika Takai, Shiori Hidaka, Shuya Yamashita, Yoonhee Kim, Yeongseon Won, Motoki Murata, Shuntaro Tsukamoto, Hirofumi Tachibana
Pages: 1162-1168
Published online on: 26 June 2015

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Article Open Access

Hepatic stellate cells promote upregulation of epithelial cell adhesion molecule and epithelial-mesenchymal transition in hepatic cancer cells

Teruya Nagahara, Hidenori Shiraha, Hiroaki Sawahara, Daisuke Uchida, Yasuto Takeuchi, Masaya Iwamuro, Junro Kataoka, Shigeru Horiguchi, Takeshi Kuwaki, Hideki Onishi, Shinichiro Nakamura, Akinobu Takaki, Kazuhiro Nouso, Kazuhide Yamamoto
Pages: 1169-1177
Published online on: 13 July 2015

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Article

Widdrol, a sesquiterpene isolated from Juniperus chinensis, inhibits angiogenesis by targeting vascular endothelial growth factor receptor 2 signaling

Soojung Jin, Hee Jung Yun, Hyun Young Jeong, You Na Oh, Hyun‑Jin Park, Seung-Geun Yun, Byung Woo Kim, Hyun Ju Kwon
Pages: 1178-1184
Published online on: 24 June 2015

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Article

Inhibitory effects of valproic acid in DNA double-strand break repair after irradiation in esophageal squamous carcinoma cells

Naoki Makita, Itasu Ninomiya, Tomoya Tsukada, Koichi Okamoto, Shinichi Harada, Shinichi Nakanuma, Seisho Sakai, Isamu Makino, Jun Kinoshita, Hironori Hayashi, Katsunobu Oyama, Hisatoshi Nakagawara, Tomoharu Miyashita, Hidehiro Tajima, Hiroyuki Takamura, Sachio Fushida, Tetsuo Ohta
Pages: 1185-1192
Published online on: 26 June 2015

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Article

Activation of ARK5/miR-1181/HOXA10 axis promotes epithelial-mesenchymal transition in ovarian cancer

Hai-Yan Zhang, Jian-Hua Li, Guang Li, Su-Rong Wang
Pages: 1193-1202
Published online on: 07 July 2015

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Article

HOXA1 enhances the cell proliferation, invasion and metastasis of prostate cancer cells

Haitao Wang, Guanzhong Liu, Dan Shen, Huamao Ye, Jinming Huang, Li Jiao, Yinghao Sun
Pages: 1203-1210
Published online on: 26 June 2015

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Article

Expression of DNA ligase IV is linked to poor prognosis and characterizes a subset of prostate cancers harboring TMPRSS2:ERG fusion and PTEN deletion

Katharina Grupp, Laura Roettger, Martina Kluth, Claudia Hube-Magg, Ronald Simon, Patrick Lebok, Sarah Minner, Maria Christina Tsourlakis, Christina Koop, Markus Graefen, Meike Adam, Alexander Haese, Corinna Wittmer, Guido Sauter, Waldemar Wilczak, Hartwig Huland, Thorsten Schlomm, Stefan Steurer, Till Krech
Pages: 1211-1220
Published online on: 25 June 2015

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Article

Suppression of KLF8 induces cell differentiation and sensitizes colorectal cancer to 5-fluorouracil

Xinpeng Shi, Xiaoyong Luo, Qingqing Yan, Wenjing Zhang, Yao Wu, Mengnan Zhang, Jinjun Zhao, Ying Peng, Ye Chen, Yali Zhang, Cunlong Chen, Tianming Cheng, Chudi Chen, Side Liu, Yang Bai, Jide Wang
Pages: 1221-1230
Published online on: 30 June 2015

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Article

CD44 alternative splicing and hnRNP A1 expression are associated with the metastasis of breast cancer

Tiing Jen Loh, Heegyum Moon, Sunghee Cho, Hana Jang, Yong Chao Liu, Hongmei Tai, Da-Woon Jung, Darren R. Williams, Hey-Ran Kim, Myung-Geun Shin, D. Joshua Liao, Jianhua Zhou, Wei Shi, Xuexiu Zheng, Haihong Shen
Pages: 1231-1238
Published online on: 06 July 2015

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Article

ZGDHu-1 and fludarabine have a synergistic effect on apoptosis of chronic lymphocytic leukemia cells

Liannv Qiu, Jinlin Liu, Zhenni Wang, Weixiao Hu, Qiang Huang, Yonglie Zhou
Pages: 1239-1248
Published online on: 08 July 2015

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Article

A secretomic study on human hepatocellular carcinoma multiple drug-resistant cell lines

Yi Xiang, Yi Liu, Yixuan Yang, Huaidong Hu, Peng Hu, Hong Ren, Dazhi Zhang
Pages: 1249-1260
Published online on: 03 July 2015

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Article

Ursodeoxycholic acid effectively kills drug-resistant gastric cancer cells through induction of autophagic death

Sung-Chul Lim, Song Iy Han
Pages: 1261-1268
Published online on: 24 June 2015

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Article

Circulating classical CD14++CD16- monocytes predict shorter time to initial treatment in chronic lymphocytic leukemia patients: Differential effects of immune chemotherapy on monocyte-related membrane and soluble forms of CD163

Izabela Lapuc, Lukasz Bolkun, Andrzej Eljaszewicz, Malgorzata Rusak, Ewa Luksza, Paulina Singh, Paula Miklasz, Jaroslaw Piszcz, Katarzyna Ptaszynska‑Kopczynska, Malgorzata Jasiewicz, Karol Kaminski, Milena Dabrowska, Anna Bodzenta-Lukaszyk, Janusz Kloczko, Marcin Moniuszko
Pages: 1269-1278
Published online on: 26 June 2015

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Article

RITA enhances irradiation-induced apoptosis in p53-defective cervical cancer cells via upregulation of IRE1α/XBP1 signaling

Hong Zhu, Muyasha Abulimiti, Huan Liu, Xiang-Jiang Su, Cai-Hong Liu, Hai-Ping Pei
Pages: 1279-1288
Published online on: 25 June 2015

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Article

Honokiol exhibits enhanced antitumor effects with chloroquine by inducing cell death and inhibiting autophagy in human non-small cell lung cancer cells

Xiaoqin Lv, Fang Liu, Yue Shang, Shu-Zhen Chen
Pages: 1289-1300
Published online on: 29 June 2015

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Article

Identification of genes and long non-coding RNAs associated with the pathogenesis of gastric cancer

Zhiwei Zhao, Yan Song, Daxun Piao, Tianyou Liu, Liangliang Zhao
Pages: 1301-1310
Published online on: 14 July 2015

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Article

Antitumor activity of a 2-pyridinecarboxaldehyde 2-pyridinecarboxylic acid hydrazone copper complex and the related mechanism

Yingli Yang, Tengfei Huang, Sufeng Zhou, Yun Fu, Youxun Liu, Yanbin Yuan, Qiongqing Zhang, Shaoshan Li, Changzheng Li
Pages: 1311-1318
Published online on: 26 June 2015

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Article

Astrocyte elevated gene-1 regulates CCL3/CCR5-induced epithelial-to-mesenchymal transition via Erk1/2 and Akt signaling in cardiac myxoma

Ping Shi, Changcun Fang, Xinyan Pang
Pages: 1319-1326
Published online on: 25 June 2015

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Article

Nuclear vasohibin-2 promotes cell proliferation by inducing G0/G1 to S phase progression

Qianqian Ge, Jia Zhou, Min Tu, Xiaofeng Xue, Zhanjun Li, Zipeng Lu, Jishu Wei, Guoxin Song, Jianmin Chen, Feng Guo, Kuirong Jiang, Yi Miao, Wentao Gao
Pages: 1327-1336
Published online on: 13 July 2015

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Article

Expression and activity analysis of a new fusion protein targeting ovarian cancer cells

Manman Su, Weiqin Chang, Dingding Wang, Manhua Cui, Yang Lin, Shuying Wu, Tianmin Xu
Pages: 1337-1344
Published online on: 09 July 2015

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Article

Binding of MMP-9-degraded fibronectin to β6 integrin promotes invasion via the FAK-Src-related Erk1/2 and PI3K/Akt/Smad-1/5/8 pathways in breast cancer

Wentong Li, Zhijun Liu, Chunling Zhao, Limin Zhai
Pages: 1345-1352
Published online on: 02 July 2015

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Article

The tumor-suppressive role of BATF2 in esophageal squamous cell carcinoma

Tianci Han, Zhiyong Wang, Yang Yang, Tianci Shu, Weinan Li, Dali Liu, Peiwen Li, Ruiqun Qi, Yi Ren, Li Li, Hong Liu, Shuguang Zhang, Lin Zhang
Pages: 1353-1360
Published online on: 26 June 2015

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Article

Concentration-dependent differential effects of an epothilone analog on cell cycle and p53 signaling

Fan An, Wei-Jie Zhao, Li Tang, Rong-Guo Qiu
Pages: 1361-1368
Published online on: 14 July 2015

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Article

GALC gene is downregulated by promoter hypermethylation in Epstein-Barr virus-associated nasopharyngeal carcinoma

Yinghai Zhao, Ying Guo, Zhijing Wang, Zebin Xiao, Rong Li, Aihua Luo, Changli Wu, Zhiliang Jing, Ning Sun, Xiaoyi Chen, Haijun Du, Yi Zeng
Pages: 1369-1378
Published online on: 14 July 2015

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Article

A limited overlap between intratumoral distribution of 1-(5-fluoro-5-deoxy-α-D-arabinofuranosyl)-2-nitroimidazole and copper-diacetyl-bis[N(4)-methylthiosemicarbazone]

Takako Furukawa, Qinghua Yuan, Zhao-Hui Jin, Winn Aung, Yukie Yoshii, Sumitaka Hasegawa, Hiroko Endo, Masahiro Inoue, Ming‑Rong Zhang, Yasuhisa Fujibayashi, Tsuneo Saga
Pages: 1379-1387
Published online on: 25 June 2015

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Article

Evodiamine inhibits the proliferation of human osteosarcoma cells by blocking PI3K/Akt signaling

Zi-Jun Meng, Nian Wu, Yang Liu, Ke-Jie Shu, Xiang Zou, Ran-Xi Zhang, Chang-Jun Pi, Bai-Cheng He, Zhen-Yong Ke, Liang Chen, Zhong-Liang Deng, Liang-Jun Yin
Pages: 1388-1396
Published online on: 25 June 2015

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Article

High expression of transforming acidic coiled coil-containing protein 3 strongly correlates with aggressive characteristics and poor prognosis of gastric cancer

Miao Yun, Jian Rong, Zhi-Rui Lin, Yu-Long He, Jia-Xing Zhang, Zhen-Wei Peng, Lin-Quan Tang, Mu-Sheng Zeng, Qian Zhong, Sheng Ye
Pages: 1397-1405
Published online on: 30 June 2015

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Article

SPARC ectopic overexpression inhibits growth and promotes programmed cell death in acute myeloid leukemia transformed from myelodysplastic syndrome cells, alone and in combination with Ara-C treatment

Qing Nian, Jianxiang Chi, Qing Xiao, Chunmei Wei, Paul Costeas, Zesong Yang, Lin Liu, Li Wang
Pages: 1406-1414
Published online on: 08 July 2015

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Article

miR-99b promotes metastasis of hepatocellular carcinoma through inhibition of claudin 11 expression and may serve as a prognostic marker

Jianhui Yang, Xiwu Liu, Xiaohua Yuan, Zhiming Wang
Pages: 1415-1423
Published online on: 02 July 2015

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Article

PIG3 plays an oncogenic role in papillary thyroid cancer by activating the PI3K/AKT/PTEN pathway

Jinye Xu, Junbo Cai, Xiaoyan Jin, Jingjin Yang, Qinyan Shen, Xiaofei Ding, Yong Liang
Pages: 1424-1430
Published online on: 30 June 2015

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Article

Knockdown of zinc transporter ZIP5 (SLC39A5) expression significantly inhibits human esophageal cancer progression

Jing Jin, Zhongxin Li, Jianghui Liu, Yan Wu, Xing Gao, Yutong He
Pages: 1431-1439
Published online on: 01 July 2015

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Article

Aquaporin 1 promotes the proliferation and migration of lung cancer cell in vitro

Xiaobai Wei, Jingcheng Dong
Pages: 1440-1448
Published online on: 03 July 2015

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Article

Topical treatment with Xiaozheng Zhitong Paste alleviates bone cancer pain by inhibiting proteinase-activated receptor 2 signaling pathway

Yanju Bao, Gaimei Wang, Yebo Gao, Maobo Du, Liping Yang, Xiangying Kong, Honggang Zheng, Wei Hou, Baojin Hua
Pages: 1449-1459
Published online on: 24 June 2015

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Article

REV3L modulates cisplatin sensitivity of non-small cell lung cancer H1299 cells

Wenjie Wang, Wenjiong Sheng, Chenxiao Yu, Jianping Cao, Jundong Zhou, Jinchang Wu, Huojun Zhang, Shuyu Zhang
Pages: 1460-1468
Published online on: 09 July 2015

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Article

Umbilical cord-derived mesenchymal stem cells promote proliferation and migration in MCF-7 and MDA-MB-231 breast cancer cells through activation of the ERK pathway Corrigendum in /10.3892/or.2025.8933

Tao Li, Chunfu Zhang, Yanling Ding, Wei Zhai, Kui Liu, Fan Bu, Tao Tu, Lingxian Sun, Wei Zhu, Fangfang Zhou, Wenkai Qi, Jiabo Hu, Huabiao Chen, Xiaochun Sun
Pages: 1469-1477
Published online on: 03 July 2015

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Article

Low-dose UVB irradiation prevents MMP2-induced skin hyperplasia by inhibiting inflammation and ROS

Lin Dang, Yan Wang, Yadong Xue, Lei He, Yuzhen Li, Jikui Xiong
Pages: 1478-1486
Published online on: 24 June 2015

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Article

Tanshinone IIA enhances bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in nuclei and mitochondria

Haiyang Jiang, Lei Zhao, Xiaoshen Dong, Anning He, Caiwei Zheng, Magnus Johansson, Anna Karlsson, Xinyu Zheng
Pages: 1487-1493
Published online on: 02 July 2015

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Article

STC2 overexpression mediated by HMGA2 is a biomarker for aggressiveness of high-grade serous ovarian cancer

Jingjing Wu, Maode Lai, Changshun Shao, Jian Wang, Jian-Jun Wei
Pages: 1494-1502
Published online on: 09 July 2015

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Article

Hypomethylated Rab27b is a progression-associated prognostic biomarker of glioma regulating MMP-9 to promote invasion

Hongjun Wang, Yongzhi Wang, Zhaoshi Bao, Chuanbao Zhang, Yanwei Liu, Jinquan Cai, Chuanlu Jiang
Pages: 1503-1509
Published online on: 13 July 2015

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Article

Lentivirus-mediated gene silencing of NOB1 suppresses non-small cell lung cancer cell proliferation

Weiyi Huang, Weiqing Zhong, Jun Xu, Benhua Su, Guanghui Huang, Jiajun Du, Qi Liu
Pages: 1510-1516
Published online on: 14 July 2015

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Article

Flavonoids isolated from Citrus platymamma induce mitochondrial-dependent apoptosis in AGS cells by modulation of the PI3K/AKT and MAPK pathways

Ho Jeong Lee, Arulkumar Nagappan, Hyeon Soo Park, Gyeong Eun Hong, Silvia Yumnam, Suchismita Raha, Venu Venkatarame Gowda Saralamma, Won Sup Lee, Eun Hee Kim, Gon Sup Kim
Pages: 1517-1525
Published online on: 10 July 2015

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Article

Dicer ablation promotes a mesenchymal and invasive phenotype in bladder cancer cells

Alan P. Lombard, Rebecca M. Lim, Rachel M. Nakagawa, Kathleen D. Vidallo, Stephen J. Libertini, Alexander J. Platero, Maria Mudryj
Pages: 1526-1532
Published online on: 09 July 2015

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Article

Antitumor effects of a drug combination targeting glycolysis, glutaminolysis and de novo synthesis of fatty acids

Diana Cervantes-Madrid, Alfonso Dueñas-González
Pages: 1533-1542
Published online on: 24 June 2015

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Article

ERK/GSK3β signaling is involved in atractylenolide I-induced apoptosis and cell cycle arrest in melanoma cells

Yan Ye, Xiao-Juan Chao, Jin-Feng Wu, Brian Chi-Yan Cheng, Tao Su, Xiu-Qiong Fu, Ting Li, Hui Guo, Anfernee Kai-Wing Tse, Hiu-Yee Kwan, Juan Du, Gui-Xin Chou, Zhi-Ling Yu
Pages: 1543-1548
Published online on: 06 July 2015

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Article

Roscovitine has anti-proliferative and pro-apoptotic effects on glioblastoma cell lines: A pilot study

M. Kolodziej, C. Goetz, P. Di Fazio, R. Montalbano, M. Ocker, H. Strik, K. Quint
Pages: 1549-1556
Published online on: 03 July 2015

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Article

MicroRNA-216a enhances the radiosensitivity of pancreatic cancer cells by inhibiting beclin-1-mediated autophagy

Xiangliang Zhang, Huijuan Shi, Shengqv Lin, Mingchen Ba, Shuzhong Cui
Pages: 1557-1564
Published online on: 25 June 2015

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Article

Sulforaphane inhibits invasion by phosphorylating ERK1/2 to regulate E-cadherin and CD44v6 in human prostate cancer DU145 cells

Xiaohui Peng, Yan Zhou, Hua Tian, Gaoxiang Yang, Chunliu Li, Yang Geng, Sai Wu, Wei Wu
Pages: 1565-1572
Published online on: 01 July 2015

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Article

miR-133a inhibits cervical cancer growth by targeting EGFR Retraction in /10.3892/or.2021.8103

Xuesong Song, Bo Shi, Kexin Huang, Wenjie Zhang
Pages: 1573-1580
Published online on: 02 July 2015

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Article

ERK5 positively regulates cigarette smoke-induced urocystic epithelial-mesenchymal transition in SV‑40 immortalized human urothelial cells

Hao Geng, Li Zhao, Zhaofeng Liang, Zhiqiang Zhang, Dongdong Xie, Liangkuan Bi, Yi Wang, Tao Zhang, Lei Cheng, Dexin Yu, Caiyun Zhong
Pages: 1581-1588
Published online on: 14 July 2015

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Article

Enhanced cytotoxicity in triple-negative and estrogen receptor‑positive breast adenocarcinoma cells due to inhibition of the transient receptor potential melastatin-2 channel

David W. Koh, Daniel P. Powell, Steven D. Blake, Joy L. Hoffman, Mandi M. Hopkins, Xiaoxing Feng
Pages: 1589-1598
Published online on: 14 July 2015

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Article

Suppression of casein kinase 2 sensitizes tumor cells to antitumor TRAIL therapy by regulating the phosphorylation and localization of p65 in prostate cancer

Xiaokun Gang, Yao Wang, Yingdi Wang, Yu Zhao, Liya Ding, Jingwen Zhao, Lin Sun, Guixia Wang
Pages: 1599-1604
Published online on: 13 July 2015

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Article

MicroRNA-20b inhibits the proliferation, migration and invasion of bladder cancer EJ cells via the targeting of cell cycle regulation and Sp-1-mediated MMP-2 expression

Sung Lyea Park, Tae-Min Cho, Se Yeon Won, Jun-Hui Song, Dae‑Hwa Noh, Wun-Jae Kim, Sung-Kwon Moon
Pages: 1605-1612
Published online on: 09 July 2015

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Article

Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells

Sangmin Kim, Jeongmin Lee, Soo Jin Oh, Seok Jin Nam, Jeong Eon Lee
Pages: 1613-1619
Published online on: 08 July 2015

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Article

Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs

Chia-Chi Hsu, Ling-Chia Wu, Cheng-Yuan Hsia, Pen-Hui Yin, Chin‑Wen Chi, Tien-Shun Yeh, Hsin-Chen Lee
Pages: 1620-1628
Published online on: 30 June 2015

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Journal Cover
May-2026 Volume 55 Issue 5

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

ZBTB7A promotes malignant phenotypes in ovarian cancer through transcriptional activation of CRLF1

Xiaobai Hao, Yu Chen
Article Number: 102
Published online on: 24 March 2026

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Article Open Access

MS4322 is a selective protein arginine methyltransferase 5 degrader with antitumor effects in cervical cancer cells

Rui Luo, Jingping Chen, Zhaojie Chen, Surong Wang, Tianfeng Liu, Yang Xu
Article Number: 101
Published online on: 24 March 2026

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Retraction Open Access

[Retracted] Roles of the SNHG7/microRNA‑9‑5p/DPP4 ceRNA network in the growth and 131I resistance of thyroid carcinoma cells through PI3K/Akt activation

Wanzhi Chen, Jichun Yu, Rong Xie, Tao Zhou, Chengfeng Xiong, Shuyong Zhang, Meijun Zhong
Article Number: 100
Published online on: 23 March 2026

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Article Open Access

Andrographis exerts antitumor effects and enhances 5‑FU efficacy via the alteration of ferroptosis‑related genes in esophageal squamous cell carcinoma

Kosuke Yoshimura, Tadanobu Shimura, Ruiya Ma, Yaxuan Huang, Takahito Kitajima, Shinji Yamashita, Yuki Sato, Koki Higashi, Mikio Kawamura, Hiromi Yasuda, Yuhki Koike, Yoshiki Okita, Shigeyuki Yoshiyama, Minako Kobayashi, Masaki Ohi, Hiroki Ohge, Shinya Takahashi, Ajay Goel, Yoshinaga Okugawa, Yuji Toiyama
Article Number: 99
Published online on: 20 March 2026

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Article Open Access

Sphingosine‑1‑phosphate receptor 1 enhances olfactory receptor 51E1‑mediated inhibition of proliferation via Src/JNK signaling in prostate cancer cells

Kiheon Kim, Jinwoo Lee, Chulwon Choi, Jungnam Bae, Hee-Jung Choi, Won-Ki Huh
Article Number: 98
Published online on: 19 March 2026

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Review Open Access

Mechanistic insights into the roles of astragalosides and Astragalus polysaccharides in gynecological and breast cancers (Review)

Ruixin Liu, Zhanyu Lin, Yuelin Li, Yuetong Ci, Zhengqi Guo, Zhenguo Xu
Article Number: 97
Published online on: 19 March 2026

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Retraction Open Access

[Retracted] Inhibition of tankyrase 1 in human gastric cancer cells enhances telomere shortening by telomerase inhibitors 

Hao Zhang, Meng-Hua Yang, Jing-Jing Zhao, Ling Chen, Song-Tao Yu, Xu-Dong Tang, Dian-Chun Fang, Shi-Ming Yang
Article Number: 96
Published online on: 16 March 2026

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Article Open Access

Silencing of SIVA‑1 promotes cisplatin resistance in gastric cancer via the Bcl‑2/BAX‑mediated mitochondria‑dependent apoptosis pathway

Zheng-Yi Shi, Zheng-Rong Ding, Yu-Liang Huang, Yuan-Rui Lei, Hai-Bin Huang, Yan Qing, Miao-Ren Deng, Xu-Man Lu, Xu-Dong Dong, Long-Jie Xia, Sheng Xu, Xiao-Gang Zhong, Lei Li, Fan-Biao Kong, Xiao-Tong Wang
Article Number: 95
Published online on: 13 March 2026

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Article Open Access

Depleting HIF‑1α attenuates the progression of osteosarcoma, but tumorigenicity is sustained through HIF‑independent pathways

Ayaka Kunishima, Takatsune Shimizu, Tetsuya Takimoto, Atsunobu Sagara, Hiroyuki Nobusue, Hidetoshi Hasuwa, Shinya Hasegawa, Yuka Tamaoki, Hitomi Miyake, Yumi Fukuchi, Hideyuki Saya, Akihiro Muto
Article Number: 94
Published online on: 12 March 2026

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Article Open Access

Unveiling the role of ANGPT2 in esophageal cancer: A prognostic factor and potential oncogene

Zhigang Zhai, Zhenyu Xue, Yuan Fang, Yixu Fan, Shijiao Li, Yunpeng Yu, Chuansheng Chen, Kaijun Zhang, Deyu Chen, Xiang Tang, Rui Ling
Article Number: 93
Published online on: 12 March 2026

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Article Open Access

POLQ promotes tumor progression and immunosuppression via ATM‑P53 signaling in endometrial cancer

Ningning Zhu, Juanjuan Wang, Xiaoli Zhang, Kai Tang, Lei Gong, Yi Hu
Article Number: 92
Published online on: 11 March 2026

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Correction Open Access

[Corrigendum] 3‑Bromopyruvate and sodium citrate target glycolysis, suppress survivin, and induce mitochondrial‑mediated apoptosis in gastric cancer cells and inhibit gastric orthotopic transplantation tumor growth

Ting-An Wang, Xiao-Dong Zhang, Xing-Yu Guo, Shu-Lin Xian, Yun-Fei Lu
Article Number: 91
Published online on: 11 March 2026

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Review Open Access

Unveiling the molecular landscape: Long non-coding RNAs in neuroblastoma (Review)

Zidong Xia, Huishan Zhai, Lei Zheng, Cheng Wang
Article Number: 90
Published online on: 09 March 2026

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Retraction Open Access

[Retracted] Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine‑γ‑lyase function

Liangyu Chen, Xinxing Li, Libo Liu, Bo Yu, Yixue Xue, Yunhui Liu
Article Number: 89
Published online on: 09 March 2026

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Review Open Access

Advances in the application of frailty scoring in the diagnosis and management of elderly patients with multiple myeloma (Review)

Junlun Liu, Danyu Li, Chao Li, Zhuoren Chen
Article Number: 88
Published online on: 06 March 2026

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Expression of Concern Open Access

[Expression of Concern] c‑Fos/ERK promotes the progression from pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma 

Lei You, Xiaoxia Ren, Yongxing Du, Wenjing Zhao, Ming Cui, Ge Chen, Yupei Zhao
Article Number: 87
Published online on: 05 March 2026

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Review Open Access

CXCL1 in triple‑negative breast cancer: Mechanisms, challenges, and therapeutic opportunities (Review)

Hiba Al Sayegh, Zahraa Assi, Amjad Kanaan, Mirvat El Sibai
Article Number: 86
Published online on: 03 March 2026

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Article Open Access

Cellular and inflammatory characteristics of patient‑derived glioblastoma organoids during in vitro cultivation

Jessica Nojszewski, Nils Oliver Schröder, Jacqueline Clüver, Jonna Holler, Hajrullah Ahmeti, Michael Synowitz, Janka Held-Feindt
Article Number: 85
Published online on: 02 March 2026

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Retraction Open Access

[Retracted] Growth and differentiation factor‑9 promotes adhesive and motile capacity of prostate cancer cells by up‑regulating FAK and Paxillin via Smad dependent pathway 

Sivan M. Bokobza, Lin Ye, Howard G. Kynaston, Wen G. Jiang
Article Number: 84
Published online on: 02 March 2026

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Article Open Access

Platycodin D sensitizes head and neck squamous cell carcinoma to cisplatin by inducing autophagy arrest

Minji Bae, Min Kyeong Lee, Mi Gyeong Jeong, Yeonseo Lee, Harim Joo, Young Chan Lee, Jung Woo Lee, Su Il Kim, Seong-Gyu Ko, Young-Gyu Eun
Article Number: 83
Published online on: 27 February 2026

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Article Open Access

ACSBG1‑driven lipid reprogramming unveiled: A fatty acid metabolism‑associated prognostic model for lung adenocarcinoma

Panxin Hu, Anan Li
Article Number: 82
Published online on: 27 February 2026

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Article Open Access

Knockdown of CCT2 inhibits the malignant progression of hepatocellular carcinoma cells by impairing STAT3 activation

Chao Li, Lei Yang, Yudong Zhang, Baocheng Zhao, Hao Qu
Article Number: 81
Published online on: 25 February 2026

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Retraction Open Access

[Retracted] Songorine suppresses cell growth and metastasis in epithelial ovarian cancer via the Bcl‑2/Bax and GSK3β/β‑catenin signaling pathways

Hongxia Zhang, Ruifeng Dong, Ping Zhang, Yankui Wang
Article Number: 80
Published online on: 25 February 2026

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Journal Cover
June-2026 Volume 55 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Expression of Concern Open Access

[Expression of Concern] Adenovirus‑mediated truncated Bid overexpression induced by the Cre/LoxP system promotes the cell apoptosis of CD133+ ovarian cancer stem cells

Qifang Long, Ru Yang, Weixian Lu, Weipei Zhu, Jundong Zhou, Cui Zheng, Dongmei Zhou, Ling Yu, Jinchang Wu
Article Number: 116
Published online on: 15 April 2026

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Review Open Access

Incorporating artificial intelligence into morphological diagnosis of acute leukemias: Current landscape, challenges and prospects (Review)

Hui Cheng, Guodong Zheng, Yuanyuan Yang, Chun Xu, Gusheng Tang, Chongmei Huang
Article Number: 115
Published online on: 15 April 2026

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Article Open Access

Mechanistic study of MUC3A in promoting progression of clear cell renal cell carcinoma via the JAK‑STAT pathway

Yongyang Yun, Xing Ji, Shuai Hu, Tianyu Wu, Yixiao Liu, Zheng Li, Zhoujie Sun, Peimin Zhou, Lei Yang, Wei Yu
Article Number: 114
Published online on: 14 April 2026

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Article Open Access

Perturbation of BRD4 and p300 activity suppresses super enhancer‑driven KLF6 expression in renal carcinoma

Nurul Nadia Mohamad Zamberi, Asmaa Y. Abuhamad, Siti Nur Hasanah Mohd Yusuf, Nur Qurratu Athirah A. Rahman, Mohamad Aimanuddin Mohtar, Saiful Effendi Syafruddin
Article Number: 113
Published online on: 14 April 2026

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Article Open Access

PINK1‑mediated mitophagy enhances breast cancer proliferation through metabolic reprogramming

Zong Jin Guo, Qian Yu, Rui Sha, Wei Li, Hui Juan Dai
Article Number: 112
Published online on: 14 April 2026

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Expression of Concern Open Access

[Expression of Concern] Metformin inhibits growth and sensitizes osteosarcoma cell lines to cisplatin through cell cycle modulation

Irene Quattrini, Amalia Conti, Laura Pazzaglia, Chiara Novello, Stefano Ferrari, Piero Picci, Maria Serena Benassi
Article Number: 111
Published online on: 08 April 2026

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Article Open Access

NF‑κB‑driven LUZP1 promotes metastasis and chemoresistance in head and neck squamous cell carcinoma

Chen-Yuan Lin, Ching-Yun Hsieh, Hsin-Chi Lan, Ching-Chan Lin, Tzu-Ting Chen, Wei-Chi Tseng, Yung-An Tsou, Wei-Chao Chang
Article Number: 110
Published online on: 07 April 2026

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Article Open Access

Hypoxic CAF studies unveil PTHrP‑vitamin D‑RAS axis as pivotal in the CAF

Shoichiro Nakajo, Mamoru Uemura, Hiroshi Kusafuka, Mao Osaki, Chikako Kusunoki, Nobuo Takiguchi, Mitsunobu Takeda, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, Takayuki Ogino, Norikatsu Miyoshi, Mitsuyoshi Tei, Yoshinori Kagawa, Hirofumi Yamamoto, Yuichiro Doki, Hidetoshi Eguchi
Article Number: 109
Published online on: 07 April 2026

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Retraction Open Access

[Retracted] miR‑24‑3p regulates bladder cancer cell proliferation, migration, invasion and autophagy by targeting DEDD

Guoqiang Yu, Zhaohui Jia, Zhongling Dou
Article Number: 108
Published online on: 06 April 2026

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Review Open Access

Role of CHD4 in tumor progression, DNA damage response and treatment resistance (Review)

Shuo Li, Quan Ma, Keying Lian, Zhisheng Jiang, Yun Ma
Article Number: 107
Published online on: 02 April 2026

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Review Open Access

T cell fate regulation in EBV‑associated nasopharyngeal carcinoma (Review)

Liuyang Zhang, Shun Ding, Dongzhui Chen, Benchi Cai, Zhonglin Mu
Article Number: 106
Published online on: 02 April 2026

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Retraction Open Access

[Retracted] Ultrasound‑targeted microbubble destruction‑mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer

Li Cheng, Dongmei Zhang, Wei Yan
Article Number: 105
Published online on: 02 April 2026

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Review Open Access

HMGB3: A pivotal orchestrator of therapy resistance and cancer stemness in human malignancies (Review)

Ju Zhang, Yifan Sun, Lanyu Wang, Jiayu Gu, Ye Hua, Jianfeng Shao, Ninghan Feng
Article Number: 104
Published online on: 01 April 2026

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Expression of Concern Open Access

[Expression of Concern] 5‑Azacytidine inhibits the proliferation of bladder cancer cells via reversal of the aberrant hypermethylation of the hepaCAM gene

Xiaorong Wang, E. Chen, Xue Yang, Yin Wang, Zhen Quan, Xiaohou Wu, Chunli Luo
Article Number: 103
Published online on: 30 March 2026

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