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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-2015 Volume 34 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells

  • Authors:
    • Sangmin Kim
    • Jeongmin Lee
    • Soo Jin Oh
    • Seok Jin Nam
    • Jeong Eon Lee
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Republic of Korea
  • Pages: 1613-1619
    |
    Published online on: July 8, 2015
       https://doi.org/10.3892/or.2015.4116
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Abstract

Although tamoxifen is the most common and effective therapy for treatment of estrogen receptor-α (ER-α) breast cancer patients, resistance of endocrine therapy occurs, either de novo or acquired during therapy. Here, we investigated the clinical value of epidermal growth factor receptor (EGFR) in tamoxifen-resistant (TamR) patients and the differential effect of EGFR inhibitors, neratinib and gefitinib, on TamR breast cancer cell model. The morphology of TamR MCF7 cells showed mesenchymal phenotypes and did not induce cell death by tamoxifen treatment compared with tamoxifen‑sensitive (TamS) MCF7 cells. In addition, mesenchymal marker proteins, including N-cadherin (N-cad), fibronectin (FN), and Slug, significantly increased in TamR cells. In contrast, ER-α and E-cadherin (E-cad) were greatly decreased. We also found that the levels of EGFR and HER2 expression were increased in TamR cells. Furthermore, we observed that EGFR expression was directly involved with poor prognosis of tamoxifen-treated breast cancer patients using the GSE1378 date set. Thus, we treated TamR and TamS cells with EGFR inhibitors, neratinib and gefitinib, respectively. Interestingly, neratinib induced apoptotic cell death of TamR but not gefitinib. Cleaved PARP-1 expression was also increased by neratinib treatment in TamR cells. Therefore, we suggest that neratinib may be a potential therapeutic drug for treating TamR breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Kim S, Lee J, Oh SJ, Nam SJ and Lee JE: Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells. Oncol Rep 34: 1613-1619, 2015.
APA
Kim, S., Lee, J., Oh, S.J., Nam, S.J., & Lee, J.E. (2015). Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells. Oncology Reports, 34, 1613-1619. https://doi.org/10.3892/or.2015.4116
MLA
Kim, S., Lee, J., Oh, S. J., Nam, S. J., Lee, J. E."Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells". Oncology Reports 34.3 (2015): 1613-1619.
Chicago
Kim, S., Lee, J., Oh, S. J., Nam, S. J., Lee, J. E."Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells". Oncology Reports 34, no. 3 (2015): 1613-1619. https://doi.org/10.3892/or.2015.4116
Copy and paste a formatted citation
x
Spandidos Publications style
Kim S, Lee J, Oh SJ, Nam SJ and Lee JE: Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells. Oncol Rep 34: 1613-1619, 2015.
APA
Kim, S., Lee, J., Oh, S.J., Nam, S.J., & Lee, J.E. (2015). Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells. Oncology Reports, 34, 1613-1619. https://doi.org/10.3892/or.2015.4116
MLA
Kim, S., Lee, J., Oh, S. J., Nam, S. J., Lee, J. E."Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells". Oncology Reports 34.3 (2015): 1613-1619.
Chicago
Kim, S., Lee, J., Oh, S. J., Nam, S. J., Lee, J. E."Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells". Oncology Reports 34, no. 3 (2015): 1613-1619. https://doi.org/10.3892/or.2015.4116
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