Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
October-2015 Volume 34 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2015 Volume 34 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

A genetic polymorphism (rs17251221) in the calcium-sensing receptor is associated with ovarian cancer susceptibility

  • Authors:
    • Shi Yan
    • Cunzhong Yuan
    • Qifeng Yang
    • Xiaoyan Li
    • Ning Yang
    • Xiaoyan Liu
    • Ruihua Dong
    • Xi Zhang
    • Zeng Yuan
    • Ning Zhang
    • Beihua Kong
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji'nan, Shandong, P.R. China, Department of Breast Surgery, Qilu Hospital of Shandong University, Ji'nan, Shandong, P.R. China
  • Pages: 2151-2155
    |
    Published online on: August 5, 2015
       https://doi.org/10.3892/or.2015.4179
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Calcium-sensing receptor (CaSR) is a G-protein‑ coupled receptor that senses blood calcium. In vivo, CaSR is required for normal epidermal differentiation by mediating calcium signaling. CaSR was confirmed to be a tumor suppressor in colon and breast cancer. The single-nucleotide polymorphism (SNP) rs17251221, located on the intron, is a genetic variation of the CaSR gene. We analyzed rs17251221 in ovarian cancer using an allelic discrimination assay. Cycling probes were used for genotyping 290 ovarian cancer patients and 312 age-matched cancer-free females. rs17251221 and clinicopathological characteristics of ovarian cancer were analyzed statistically. The AG and GG genotypes were confirmed to appear in fewer cancer cases than in controls and the genotype distribution between cases and controls was statistically significant. The AG+GG genotype was correlated with low ovarian cancer risk, while rs17251221 was not associated with clinicopathological variables including age at diagnosis, tumor size, histologic type, pathological subtype, lymph node metastasis, CA-125 expression, clinical stage, or degree of differentiation. The rs17251221 polymorphism genotype was not correlated with survival in ovarian cancer. These results suggest that the G allele of the CaSR rs17251221 polymorphism is protective against ovarian cancer and the homozygous GG genotype may be a protective genotype as well. The rs17251221 may play an important role in the development of ovarian cancer and could be used as a biomarker for predicting ovarian cancer.
View Figures

Figure 1

Figure 2

View References

1 

Smith RA, Manassaram-Baptiste D, Brooks D, Doroshenk M, Fedewa S, Saslow D, Brawley OW and Wender R: Cancer screening in the United States, 2015: A review of current American cancer society guidelines and current issues in cancer screening. CA Cancer J Clin. 65:30–54. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Wang M, He Y, Shi L and Shi C: Multivariate analysis by Cox proportional hazard model on prognosis of patient with epithelial ovarian cancer. Eur J Gynaecol Oncol. 32:171–177. 2011.PubMed/NCBI

4 

American College of Obstetricians and Gynecologists Committee on Gynecologic Practice: Committee opinion no. 477: The role of the obstetrician-gynecologist in the early detection of epithelial ovarian cancer. Obstet Gynecol. 117:742–746. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Sueblinvong T and Carney ME: Current understanding of risk factors for ovarian cancer. Curr Treat Options Oncol. 10:67–81. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Zheng L, Song A, Ruan Y, Chen L, Liu D, Li X, Guo H, Han J, Li Y, Tian X, et al: Genetic polymorphisms in AURKA, BRCA1, CCNE1 and CDK2 are associated with ovarian cancer susceptibility among Chinese Han women. Cancer Epidemiol. 37:639–646. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Mostowska A, Pawlik P, Sajdak S, Markowska J, Pawałowska M, Lianeri M and Jagodzinski PP: An analysis of polymorphisms within the Wnt signaling pathway in relation to ovarian cancer risk in a Polish population. Mol Diagn Ther. 18:85–91. 2014. View Article : Google Scholar :

8 

Brown EM, Gamba G, Riccardi D, Lombardi M, Butters R, Kifor O, Sun A, Hediger MA, Lytton J and Hebert SC: Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature. 366:575–580. 1993. View Article : Google Scholar : PubMed/NCBI

9 

Vezzoli G, Terranegra A, Arcidiacono T, Gambaro G, Milanesi L, Mosca E and Soldati L; GENIAL network (Genetics and Environment in Nephrolithiasis Italian Alliance): Calcium kidney stones are associated with a haplotype of the calcium-sensing receptor gene regulatory region. Nephrol Dial Transplant. 25:2245–2252. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Pearce SH and Thakker RV: The calcium-sensing receptor: Insights into extracellular calcium homeostasis in health and disease. J Endocrinol. 154:371–378. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Brown EM and Hebert SC: Calcium-receptor-regulated parathyroid and renal function. Bone. 20:303–309. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Tu CL, Oda Y, Komuves L and Bikle DD: The role of the calcium-sensing receptor in epidermal differentiation. Cell Calcium. 35:265–273. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Hendy GN, D'Souza-Li L, Yang B, Canaff L and Cole DE: Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. Hum Mutat. 16:281–296. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Rodland KD: The role of the calcium-sensing receptor in cancer. Cell Calcium. 35:291–295. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Jorde R, Schirmer H, Njølstad I, Løchen ML, Bøgeberg Mathiesen E, Kamycheva E, Figenschau Y and Grimnes G: Serum calcium and the calcium-sensing receptor polymorphism rs17251221 in relation to coronary heart disease, type 2 diabetes, cancer and mortality: The Tromsø Study. Eur J Epidemiol. 28:569–578. 2013. View Article : Google Scholar : PubMed/NCBI

16 

O'Seaghdha CM, Yang Q, Glazer NL, Leak TS, Dehghan A, Smith AV, Kao WH, Lohman K, Hwang SJ, Johnson AD, et al GEFOS Consortium: Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. Hum Mol Genet. 19:4296–4303. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Chou YH, Woon PY, Chen WC, Hsu YW, Chang JM, Hwang DY, Chiu YC, Kuo HC, Chang WP, Hou MF, et al: A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis. PLoS One. 6:e252272011. View Article : Google Scholar : PubMed/NCBI

18 

Tang Q, Zhao Y, Wang Y and Wei M: A genetic variant (rs17251221) in the calcium-sensing receptor relates to hepatocellular carcinoma susceptibility and clinical outcome treated by transcatheter hepatic arterial chemoembolization (TACE) therapy. Med Oncol. 31:2672014. View Article : Google Scholar : PubMed/NCBI

19 

Li X, Kong X, Jiang L, Ma T, Yan S, Yuan C and Yang Q: A genetic polymorphism (rs17251221) in the calcium-sensing receptor is associated with breast cancer susceptibility and prognosis. Cell Physiol Biochem. 33:165–172. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Liu X, Zhang N, Li X, Moran MS, Yuan C, Yan S, Jiang L, Ma T, Haffty BG and Yang Q: Identification of novel variants of metadherin in breast cancer. PLoS One. 6:e175822011. View Article : Google Scholar : PubMed/NCBI

21 

Zhang N, Li X, Tao K, Jiang L, Ma T, Yan S, Yuan C, Moran MS, Liang F, Haffty BG, et al: BCL-2 (−938C > A) polymorphism is associated with breast cancer susceptibility. BMC Med Genet. 12:482011. View Article : Google Scholar

22 

Rodriguez S, Gaunt TR and Day IN: Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am J Epidemiol. 169:505–514. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Meng QH, Xu E, Hildebrandt MA, Liang D, Lu K, Ye Y, Wagar EA and Wu X: Genetic variants in the fibroblast growth factor pathway as potential markers of ovarian cancer risk, therapeutic response, and clinical outcome. Clin Chem. 60:222–232. 2014. View Article : Google Scholar

24 

Johnson CC, Kessel B, Riley TL, Ragard LR, Williams CR, Xu JL and Buys SS; Prostate, Lung Colorectal and Ovarian Cancer Project Team: The epidemiology of CA-125 in women without evidence of ovarian cancer in the Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) Screening Trial. Gynecol Oncol. 110:383–389. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Duffy MJ, Bonfrer JM, Kulpa J, Rustin GJ, Soletormos G, Torre GC, Tuxen MK and Zwirner M: CA125 in ovarian cancer: European Group on Tumor Markers guidelines for clinical use. Int J Gynecol Cancer. 15:679–691. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Aggarwal A, Prinz-Wohlgenannt M, Tennakoon S, Höbaus J, Boudot C, Mentaverri R, Brown EM, Baumgartner-Parzer S and Kállay E: Calcium-sensing receptor: A promising target for prevention of colorectal cancer. Biochim Biophys Acta. Feb 18–2015.Epub ahead of print. View Article : Google Scholar

27 

Liu G, Hu X and Chakrabarty S: Calcium sensing receptor down-regulates malignant cell behavior and promotes chemosensitivity in human breast cancer cells. Cell Calcium. 45:216–225. 2009. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yan S, Yuan C, Yang Q, Li X, Yang N, Liu X, Dong R, Zhang X, Yuan Z, Zhang N, Zhang N, et al: A genetic polymorphism (rs17251221) in the calcium-sensing receptor is associated with ovarian cancer susceptibility. Oncol Rep 34: 2151-2155, 2015.
APA
Yan, S., Yuan, C., Yang, Q., Li, X., Yang, N., Liu, X. ... Kong, B. (2015). A genetic polymorphism (rs17251221) in the calcium-sensing receptor is associated with ovarian cancer susceptibility. Oncology Reports, 34, 2151-2155. https://doi.org/10.3892/or.2015.4179
MLA
Yan, S., Yuan, C., Yang, Q., Li, X., Yang, N., Liu, X., Dong, R., Zhang, X., Yuan, Z., Zhang, N., Kong, B."A genetic polymorphism (rs17251221) in the calcium-sensing receptor is associated with ovarian cancer susceptibility". Oncology Reports 34.4 (2015): 2151-2155.
Chicago
Yan, S., Yuan, C., Yang, Q., Li, X., Yang, N., Liu, X., Dong, R., Zhang, X., Yuan, Z., Zhang, N., Kong, B."A genetic polymorphism (rs17251221) in the calcium-sensing receptor is associated with ovarian cancer susceptibility". Oncology Reports 34, no. 4 (2015): 2151-2155. https://doi.org/10.3892/or.2015.4179
Copy and paste a formatted citation
x
Spandidos Publications style
Yan S, Yuan C, Yang Q, Li X, Yang N, Liu X, Dong R, Zhang X, Yuan Z, Zhang N, Zhang N, et al: A genetic polymorphism (rs17251221) in the calcium-sensing receptor is associated with ovarian cancer susceptibility. Oncol Rep 34: 2151-2155, 2015.
APA
Yan, S., Yuan, C., Yang, Q., Li, X., Yang, N., Liu, X. ... Kong, B. (2015). A genetic polymorphism (rs17251221) in the calcium-sensing receptor is associated with ovarian cancer susceptibility. Oncology Reports, 34, 2151-2155. https://doi.org/10.3892/or.2015.4179
MLA
Yan, S., Yuan, C., Yang, Q., Li, X., Yang, N., Liu, X., Dong, R., Zhang, X., Yuan, Z., Zhang, N., Kong, B."A genetic polymorphism (rs17251221) in the calcium-sensing receptor is associated with ovarian cancer susceptibility". Oncology Reports 34.4 (2015): 2151-2155.
Chicago
Yan, S., Yuan, C., Yang, Q., Li, X., Yang, N., Liu, X., Dong, R., Zhang, X., Yuan, Z., Zhang, N., Kong, B."A genetic polymorphism (rs17251221) in the calcium-sensing receptor is associated with ovarian cancer susceptibility". Oncology Reports 34, no. 4 (2015): 2151-2155. https://doi.org/10.3892/or.2015.4179
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team