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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October-2015 Volume 34 Issue 4

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

The complex liaison between cachexia and tumor burden (Review)

Andrea De Lerma Barbaro
Pages: 1635-1649
Published online on: 31 July 2015

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Article Open Access

NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells

Yoshihiro Hayashi, Makoto Osanai, Gang-Hong Lee
Pages: 1650-1658
Published online on: 04 August 2015

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Article Open Access

Selective induction of apoptosis in human gastric cancer cells by Lactobacillus kefiri (PFT), a novel kefir product

Mamdooh Ghoneum, Nouran Felo
Pages: 1659-1666
Published online on: 06 August 2015

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Article Open Access

Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder

Mariana Chantre-Justino, Gilda Alves, Constança Britto, Angélica Cardoso, Luciano Scherrer, Aline dos Santos Moreira, Raul Quirino, Antonio Ornellas, Alvaro Leitão, Claudia Lage
Pages: 1667-1674
Published online on: 24 July 2015

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Article Open Access

Differential crosstalk between the AMPK and PI3K/Akt pathways in breast cancer cells of differing genotypes: Leptin inhibits the effectiveness of AMPK activation

Omar S. El-Masry, Kaltoom Al-Sakkaf, Barry L. Brown, Pauline R.M. Dobson
Pages: 1675-1680
Published online on: 11 August 2015

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Article Open Access

HOXD10 acts as a tumor-suppressive factor via inhibition of the RHOC/AKT/MAPK pathway in human cholangiocellular carcinoma

Haixia Yang, Jiupeng Zhou, Jianqiang Mi, Ke Ma, Yangwei Fan, Jing Ning, Chuying Wang, Xin Wei, Huadong Zhao, Enxiao Li
Pages: 1681-1691
Published online on: 10 August 2015

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Article Open Access

Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity

Yee-Lin Voon, Munirah Ahmad, Pooi-Fong Wong, Roslina Husaini, Wayne Tiong-Weng Ng, Chee-Onn Leong, David Philip Lane, Alan Soo-Beng Khoo
Pages: 1692-1700
Published online on: 05 August 2015

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Article Open Access

Acquirement of DNA copy number variations in non‑small cell lung cancer metastasis to the brain

Fang Li, Libo Sun, Sixun Zhang
Pages: 1701-1707
Published online on: 10 August 2015

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Article

The novel mTOR inhibitor Torin-2 induces autophagy and downregulates the expression of UHRF1 to suppress hepatocarcinoma cell growth

Congren Wang, Xuejin Wang, Zijian Su, Hongjiang Fei, Xiaoyu Liu, Qunxiong Pan
Pages: 1708-1716
Published online on: 23 July 2015

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Article

Significance of expression of glucagon-like peptide 1 receptor in pancreatic cancer

Ana Ines Cases, Takao Ohtsuka, Hideyo Kimura, Biao Zheng, Koji Shindo, Yoshinao Oda, Kazuhiro Mizumoto, Masafumi Nakamura, Masao Tanaka
Pages: 1717-1725
Published online on: 20 July 2015

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Article

Inhibition of NADPH oxidase 4 induces apoptosis in malignant mesothelioma: Role of reactive oxygen species

Motoya Tanaka, Yuji Miura, Hiroki Numanami, Sivasundaram Karnan, Akinobu Ota, Hiroyuki Konishi, Yoshitaka Hosokawa, Masayuki Hanyuda
Pages: 1726-1732
Published online on: 27 July 2015

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Article

Dual effects of human adipose tissue-derived mesenchymal stem cells in human lung adenocarcinoma A549 xenografts and colorectal adenocarcinoma HT-29 xenografts in mice

Jung Joo Rhyu, Jun-Won Yun, Euna Kwon, Jeong-Hwan Che, Byeong-Cheol Kang
Pages: 1733-1744
Published online on: 07 August 2015

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Article

Subpath analysis of each subtype of head and neck cancer based on the regulatory relationship between miRNAs and biological pathways

Fengwei An, Zhiqiang Zhang, Ming Xia, Lijun Xing
Pages: 1745-1754
Published online on: 24 July 2015

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Article

12-Deoxyphorbol 13-palmitate inhibits the expression of VEGF and HIF-1α in MCF-7 cells by blocking the PI3K/Akt/mTOR signaling pathway

Ying Yang, Huan Cong, Cuicui Han, Liling Yue, Haiying Dong, Jicheng Liu
Pages: 1755-1760
Published online on: 31 July 2015

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Article

Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest

Kiyoyuki Kobayashi, Asahiro Morishita, Hisakazu Iwama, Koji Fujita, Ryoichi Okura, Shintaro Fujihara, Takuma Yamashita, Takayuki Fujimori, Kiyohito Kato, Hideki Kamada, Toshiro Niki, Mitsuomi Hirashima, Keiichi Okano, Yasuyuki Suzuki, Tsutomu Masaki
Pages: 1761-1770
Published online on: 10 August 2015

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Article

microRNA-22 downregulation of galectin-9 influences lymphocyte apoptosis and tumor cell proliferation in liver cancer

Qianqian Yang, Weichao Jiang, Chunbo Zhuang, Zhi Geng, Chen Hou, Da Huang, Lihua Hu, Xiaobei Wang
Pages: 1771-1778
Published online on: 31 July 2015

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Article

Expression profile analysis of microRNAs and downregulated miR-486-5p and miR-30a-5p in non-small cell lung cancer

Jianjie Zhu, Yuanyuan Zeng, Chun Xu, Hualong Qin, Zhe Lei, Dan Shen, Zeyi Liu, Jian-An Huang
Pages: 1779-1786
Published online on: 21 July 2015

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Article

Twist induces epithelial-mesenchymal transition in cervical carcinogenesis by regulating the TGF-β/Smad3 signaling pathway Retraction in /10.3892/or.2025.8960

Qiong Fan, Mei-Ting Qiu, Zhu Zhu, Jin-Hua Zhou, Limo Chen, Ye Zhou, Wei Gu, Li‑Hua Wang, Zhu-Nan Li, Ying Xu, Wei-Wei Cheng, Dan Wu, Wei Bao
Pages: 1787-1794
Published online on: 22 July 2015

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Article

Enhanced therapeutic effects against murine colon carcinoma induced by a Colon 26/Ag85A-CD226 tumor cell vaccine

Yan Li, Fangli Yang, Lixuan Sang, Junfeng Zhu, Xue Han, Fengping Shan, Shengjun Li, Jingbo Zhai, Danan Wang, Changlong Lu, Xun Sun
Pages: 1795-1804
Published online on: 20 July 2015

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Article

Inhibiting GLUT-1 expression and PI3K/Akt signaling using apigenin improves the radiosensitivity of laryngeal carcinoma in vivo

Yang‑Yang Bao, Shui‑Hong Zhou, Zhong‑Jie Lu, Jun Fan, Ya‑Ping Huang
Pages: 1805-1814
Published online on: 28 July 2015

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Article

Expression of cortactin in human gliomas and its effect on migration and invasion of glioma cells

Leilei Wang, Kai Zhao, Bingcheng Ren, Meng Zhu, Chen Zhang, Pengfei Zhao, Hua Zhou, Lei Chen, Shenping Yu, Xuejun Yang
Pages: 1815-1824
Published online on: 28 July 2015

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Article

Targeting effect of PEGylated liposomes modified with the Arg-Gly-Asp sequence on gastric cancer

Jie Ding, Min Feng, Feng Wang, Hao Wang, Wenxian Guan
Pages: 1825-1834
Published online on: 22 July 2015

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Article

Effect of Rab23 on the proliferation and apoptosis in breast cancer

Yali Liu, Chao Zeng, Nandi Bao, Jie Zhao, Yuzhen Hu, Chengxin Li, Sumin Chi
Pages: 1835-1844
Published online on: 24 July 2015

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Article

MicroRNA-144 affects radiotherapy sensitivity by promoting proliferation, migration and invasion of breast cancer cells

Lei Yu, Yanming Yang, Jiguang Hou, Chengwei Zhai, Yunhao Song, Zhiliang Zhang, Ling Qiu, Xiaojing Jia
Pages: 1845-1852
Published online on: 05 August 2015

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Article

Curcumin alters gene expression-associated DNA damage, cell cycle, cell survival and cell migration and invasion in NCI-H460 human lung cancer cells in vitro

I-Tsang Chiang, Wei-Shu Wang, Hsin-Chung Liu, Su-Tso Yang, Nou-Ying Tang, Jing-Gung Chung
Pages: 1853-1874
Published online on: 29 July 2015

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Article

Novel quinazoline derivatives exhibit antitumor activity by inhibiting JAK2/STAT3

Haishi Qiao, Dan Zhao, Hengfei Shi, Ke Ren, Jianxin Li, Erguang Li
Pages: 1875-1882
Published online on: 21 July 2015

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Article

RRM1, TUBB3, TOP2A, CYP19A1, CYP2D6: Difference between mRNA and protein expression in predicting prognosis of breast cancer patients

Ying-Chun Xu, Feng-Chun Zhang, Jun-Jian Li, Jia-Qi Dai, Qiang Liu, Lei Tang, Yue Ma, Qi Xu, Xiao-Lin Lin, Hong-Bin Fan, Hong-Xia Wang
Pages: 1883-1894
Published online on: 07 August 2015

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Article

Inhibitory effects of 3-bromopyruvate in human nasopharyngeal carcinoma cells

Xue Zou, Mengxiao Zhang, Yiming Sun, Surong Zhao, Yingmei Wei, Xudong Zhang, Chenchen Jiang, Hao Liu
Pages: 1895-1904
Published online on: 23 July 2015

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Article

Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer

Emre Gerçeker, Seda Orenay Boyacıoglu, Elmas Kasap, Ahmed Baykan, Hakan Yuceyar, Hatice Yıldırım, Semin Ayhan, Ender Ellidokuz, Mehmet Korkmaz
Pages: 1905-1914
Published online on: 10 August 2015

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Article

Bone marrow-derived mesenchymal stem cells co‑expressing interleukin-18 and interferon-β exhibit potent antitumor effect against intracranial glioma in rats

Gang Xu, Yanwu Guo, Zhiyuan Seng, Gang Cui, Jianqiang Qu
Pages: 1915-1922
Published online on: 05 August 2015

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Article

miR-219-5p plays a tumor suppressive role in colon cancer by targeting oncogene Sall4

Ji Cheng, Rui Deng, Peng Zhang, Chuanqing Wu, Ke Wu, Liang Shi, Xinghua Liu, Jie Bai, Meizhou Deng, Xiaoming Shuai, Jinbo Gao, Guobin Wang, Kaixiong Tao
Pages: 1923-1932
Published online on: 04 August 2015

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Article

Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cells

Parunya Chaiyawat, Daranee Chokchaichamnankit, Kriengsak Lirdprapamongkol, Chantragan Srisomsap, Jisnuson Svasti, Voraratt Champattanachai
Pages: 1933-1942
Published online on: 05 August 2015

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Article

MicroRNA-338 inhibits migration and proliferation by targeting hypoxia-induced factor 1α in nasopharyngeal carcinoma Corrigendum in /10.3892/or.2022.8358

Ying Shan, Xingyu Li, Bo You, Si Shi, Qicheng Zhang, Yiwen You
Pages: 1943-1952
Published online on: 10 August 2015

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Article

Targeted delivery of doxorubicin to breast cancer cells by aptamer functionalized DOTAP/DOPE liposomes

Xingli Song, Yi Ren, Jing Zhang, Gang Wang, Xuedong Han, Wei Zheng, Linlin Zhen
Pages: 1953-1960
Published online on: 17 July 2015

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Article

Prediction of response to preoperative chemoradiotherapy and establishment of individualized therapy in advanced rectal cancer

Toshihiro Nakao, Takashi Iwata, Masanori Hotchi, Kozo Yoshikawa, Jun Higashijima, Masaaki Nishi, Chie Takasu, Shohei Eto, Hiroki Teraoku, Mitsuo Shimada
Pages: 1961-1967
Published online on: 10 August 2015

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Article

Inhibition of carbonic anhydrase IX (CA9) sensitizes renal cell carcinoma to ionizing radiation

Wilhelmina C.M. Duivenvoorden, Sarah N. Hopmans, Daniel Gallino, Thomas Farrell, Carrie Gerdes, Diana Glennie, Himu Lukka, Jehonathan H. Pinthus
Pages: 1968-1976
Published online on: 07 August 2015

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Article

Inhibition of sphingosine-1-phosphate phosphatase 1 promotes cancer cells migration in gastric cancer: Clinical implications Corrigendum in /10.3892/or.2018.6269

Xiang Y. Gao, Lin Li, Xiao H. Wang, Xian Z. Wen, Ke Ji, Lin Ye, Jun Cai, Wen G. Jiang, Jia F. Ji
Pages: 1977-1987
Published online on: 30 July 2015

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Article

MicroRNA-374a promotes esophageal cancer cell proliferation via Axin2 suppression

Yue Wang, Hua Xin, Zhifeng Han, Hongbing Sun, Nan Gao, Haixiang Yu
Pages: 1988-1994
Published online on: 07 August 2015

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Article

Dendritic cells combined with anti-GITR antibody produce antitumor effects in osteosarcoma

Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Tatsuya Iwasaki, Masashi Miyazaki, Shinichi Ikeda, Hiroshi Tsumura
Pages: 1995-2001
Published online on: 29 July 2015

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Article

Mechanisms and in vitro effects of cepharanthine hydrochloride: Classification analysis of the drug-induced differentially-expressed genes of human nasopharyngeal carcinoma cells

Guanjun Liu, Dongmei Wu, Xinqiang Liang, Huifen Yue, Ying Cui
Pages: 2002-2010
Published online on: 10 August 2015

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Article

NOV inhibits proliferation while promoting apoptosis and migration in osteosarcoma cell lines through p38/MAPK and JNK/MAPK pathways

Juan Yao, Yaguang Weng, Shujuan Yan, Mengyi Hou, Hao Wang, Qiong Shi, Guowei Zuo
Pages: 2011-2021
Published online on: 24 July 2015

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Article

Fusion of cancer stem cells and mesenchymal stem cells contributes to glioma neovascularization

Chao Sun, Dongliang Zhao, Xingliang Dai, Jinsheng Chen, Xiaoci Rong, Haiyang Wang, Aidong Wang, Ming Li, Jun Dong, Qiang Huang, Qing Lan
Pages: 2022-2030
Published online on: 16 July 2015

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Article

Protective effect of neutralizing anti-IL-18α monoclonal antibody on a mouse model of acute graft-versus-host disease

Xiaocui Li, Cuiping Zhang, Wei Chen, Bin Pan, Fanyun Kong, Kuiyang Zheng, Renxian Tang, Lingyu Zeng
Pages: 2031-2039
Published online on: 05 August 2015

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Article

Aqueous extract of Psoralea corylifolia L. inhibits lipopolysaccharide-induced endothelial-mesenchymal transition via downregulation of the NF-κB-SNAIL signaling pathway

Bom Jung, Eun Hyang Jang, Darong Hong, In Hye Cho, Min-Ju Park, Jong-Ho Kim
Pages: 2040-2046
Published online on: 27 July 2015

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Article

Clinicopathological significance of N-cadherin and VEGF in advanced gastric cancer brain metastasis and the effects of metformin in preclinical models

Kyong-Hwa Jun, Jung Eun Lee, Se Hoon Kim, Ji-Han Jung, Hyun‑Joo Choi, Young Il Kim, Hyung-Min Chin, Seung-Ho Yang
Pages: 2047-2053
Published online on: 10 August 2015

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Article

MicroRNA-122 affects cell aggressiveness and apoptosis by targeting PKM2 in human hepatocellular carcinoma Corrigendum in /10.3892/or.2021.8073 Retraction in /10.3892/or.2023.8475

Qiuran Xu, Meiqi Zhang, Jianfeng Tu, Linxiao Pang, Wenwei Cai, Xin Liu
Pages: 2054-2064
Published online on: 05 August 2015

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Article

Valproic acid suppresses the self-renewal and proliferation of head and neck cancer stem cells

Sang Hyuk Lee, Hyo Jung Nam, Hyun Jung Kang, Tina L. Samuels, Nikki Johnston, Young Chang Lim
Pages: 2065-2071
Published online on: 23 July 2015

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Article

Gene expression profiling in myelodysplastic syndrome after SPARC overexpression associated with Ara-C

Qing Nian, Zhiqiang Zhang, Chunmei Wei, Xingyi Kuang, Xingyong Wang, Li Wang
Pages: 2072-2082
Published online on: 20 July 2015

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Article

MG132 enhances the radiosensitivity of lung cancer cells in vitro and in vivo

Wei Zhu, Jing Liu, Jihua Nie, Wenjiong Sheng, Han Cao, Wenhao Shen, Aijing Dong, Jundong Zhou, Yang Jiao, Shuyu Zhang, Jianping Cao
Pages: 2083-2089
Published online on: 04 August 2015

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Article

Hepatitis B virus X protein modifies invasion, proliferation and the inflammatory response in an HTR-8/SVneo cell model

Hong Cui, Qiu-Ling Li, Jing Chen, Quan Na, Cai-Xia Liu
Pages: 2090-2098
Published online on: 05 August 2015

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Article

Expression of immune checkpoint molecules of T cell immunoglobulin and mucin protein 3/galectin-9 for NK cell suppression in human gastrointestinal stromal tumors

Hideo Komita, Shigeo Koido, Kazumi Hayashi, Shin Kan, Masaki Ito, Yuko Kamata, Masafumi Suzuki, Sadamu Homma
Pages: 2099-2105
Published online on: 24 July 2015

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Article

Effect of Raf kinase inhibitor protein expression on malignant biological behavior and progression of colorectal cancer

Yun Wang, Ling-Yun Wang, Fen Feng, Yang Zhao, Ma-Yan Huang, Qiong Shao, Cui Chen, Hui Sheng, Dong-Liang Chen, Zhao-Lei Zeng, Rui-Hua Xu, Yu-Hong Li
Pages: 2106-2114
Published online on: 28 July 2015

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Article

Effect of DR4 promoter methylation on the TRAIL‑induced apoptosis in lung squamous carcinoma cell

Wenwu Wang, Xiaoyan Qi, Minghua Wu
Pages: 2115-2125
Published online on: 04 August 2015

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Article

Enrichment and characterization of cancer stem cells from a human non-small cell lung cancer cell line

Changhong Zhao, Sarra Setrerrahmane, Hanmei Xu
Pages: 2126-2132
Published online on: 30 July 2015

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Article

Simvastatin protects Sertoli cells against cisplatin cytotoxicity through enhanced gap junction intercellular communication

Lingzhi Wang, Jianxin Peng, Huansen Huang, Qin Wang, Meiling Yu, Liang Tao
Pages: 2133-2141
Published online on: 10 August 2015

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Article

Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis

Jingtao Zhong, Peng Xiu, Xiaofeng Dong, Fuhai Wang, Honglong Wei, Xin Wang, Zongzhen Xu, Feng Liu, Tao Li, Yong Wang, Jie Li
Pages: 2142-2150
Published online on: 06 August 2015

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Article

A genetic polymorphism (rs17251221) in the calcium-sensing receptor is associated with ovarian cancer susceptibility

Shi Yan, Cunzhong Yuan, Qifeng Yang, Xiaoyan Li, Ning Yang, Xiaoyan Liu, Ruihua Dong, Xi Zhang, Zeng Yuan, Ning Zhang, Beihua Kong
Pages: 2151-2155
Published online on: 05 August 2015

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Article

Gentian violet inhibits MDA-MB-231 human breast cancer cell proliferation, and reverses the stimulation of osteoclastogenesis and suppression of osteoblast activity induced by cancer cells

Masayoshi Yamaguchi, Tatyana Vikulina, M. Neale Weitzmann
Pages: 2156-2162
Published online on: 10 August 2015

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Article

MicroRNA-205 inhibits the proliferation and invasion of breast cancer by regulating AMOT expression

Haige Zhang, Qingxia Fan
Pages: 2163-2170
Published online on: 23 July 2015

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Article

miR-138 suppresses the proliferation of oral squamous cell carcinoma cells by targeting Yes-associated protein 1

Ran Xu, Guang Zeng, Jing Gao, Yue Ren, Zhe Zhang, Qingna Zhang, Jinxiu Zhao, Hong Tao, Daxu Li
Pages: 2171-2178
Published online on: 23 July 2015

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Article

HGF mediated upregulation of lipocalin 2 regulates MMP9 through nuclear factor-κB activation

Sung Ae Koh, Kyung Hee Lee
Pages: 2179-2187
Published online on: 10 August 2015

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Article

miR-519d-mediated downregulation of STAT3 suppresses breast cancer progression

Xin Deng, Yi Zhao, Baosheng Wang
Pages: 2188-2194
Published online on: 29 July 2015

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Article

MicroRNA-124 suppresses the migration and invasion of osteosarcoma cells via targeting ROR2-mediated non-canonical Wnt signaling Retraction in /10.3892/or.2021.8107

Can Zhang, Yihe Hu, Jun Wan, Hongbo He
Pages: 2195-2201
Published online on: 10 August 2015

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Article

miR-126 inhibits papillary thyroid carcinoma growth by targeting LRP6 Retraction in /10.3892/or.2021.8097

Qiang Wen, Jie Zhao, Lin Bai, Tongtong Wang, Haishan Zhang, Qingjie Ma
Pages: 2202-2210
Published online on: 31 July 2015

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Article Open Access

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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