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Article

Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis

  • Authors:
    • Jingtao Zhong
    • Peng Xiu
    • Xiaofeng Dong
    • Fuhai Wang
    • Honglong Wei
    • Xin Wang
    • Zongzhen Xu
    • Feng Liu
    • Tao Li
    • Yong Wang
    • Jie Li
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Qianfoshan Hospital, Shandong University, Jinan, Shandong, P.R. China, Department of General Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, P.R. China
  • Pages: 2142-2150
    |
    Published online on: August 6, 2015
       https://doi.org/10.3892/or.2015.4181
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Abstract

Sorafenib (SOR) is a promising treatment for advanced hepatocellular carcinoma (HCC). However, the precise mechanisms of toxicity and drug resistance have not been fully explored and new strategies are urgently needed for HCC therapy. Meloxicam (MEL) is a selective cyclooxygenase-2 (COX-2) inhibitor which elicits antitumor effects in human HCC cells. In the present study, we investigated the interaction between MEL and SOR in human SMMC‑7721 cells and the role endoplasmic reticulum (ER) stress exerts in the combination of SOR with MEL treatment-induced cytotoxicity. Our results revealed that the combination treatment synergistically inhibited cell proliferation and enhanced apoptosis. Furthermore, the combination treatment enhanced ER stress-related molecules which involved in SMMC-7721 cell apoptosis. GRP78 knockdown by siRNA or co-treatment with MG132 significantly increased this combination treatment-induced apoptosis. In addition, we found that the combination treatment suppressed tumor growth by way of activation of ER stress in in vivo models. We concluded that the combination of SOR with MEL treatment-induced ER stress, and eventually apoptosis in human SMMC-7721 cells. Knockdown of GRP78 using siRNA or proteosome inhibitor enhanced the cytotoxicity of the combination of SOR with MEL-treatment in SMMC-7721 cells. These findings provided a new potential treatment strategy against HCC.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Asghar U and Meyer T: Are there opportunities for chemotherapy in the treatment of hepatocellular cancer? J Hepatol. 56:686–695. 2012. View Article : Google Scholar

3 

Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, et al: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64:7099–7109. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Liu L, Cao Y, Chen C, Zhang X, McNabola A, Wilkie D, Wilhelm S, Lynch M and Carter C: Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res. 66:11851–11858. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, et al SHARP Investigators Study Group: Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 359:378–390. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Thun MJ, Henley SJ and Patrono C: Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues. J Natl Cancer Inst. 94:252–266. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Lönnroth C, Andersson M, Asting AG, Nordgren S and Lundholm K: Preoperative low dose NSAID treatment influences the genes for stemness, growth, invasion and metastasis in colorectal cancer. Int J Oncol. 45:2208–2220. 2014.PubMed/NCBI

8 

Ding N, Cui XX, Gao Z, Huang H, Wei X, Du Z, Lin Y, Shih WJ, Rabson AB, Conney AH, et al: A triple combination of atorvastatin, celecoxib and tipifarnib strongly inhibits pancreatic cancer cells and xenograft pancreatic tumors. Int J Oncol. 44:2139–2145. 2014.PubMed/NCBI

9 

Zhivkova T, Alexandrova R, Dyakova L, Georgieva M, Miloshev G, Culita DC, Marinescu G, Patron L and Alexandrov M: P7.05. Metal complexes of meloxicam and isoxicam decrease viability and proliferation of virus-transformed cancer cells. Ann Oncol. 26(Suppl 2): ii322015. View Article : Google Scholar

10 

Hassan MH, El-Beshbishy HA, Aly H, Attia SM, Bahashwan SA and Ghobara MM: Modulatory effects of meloxicam on cardiotoxicity and antitumor activity of doxorubicin in mice. Cancer Chemother Pharmacol. 74:559–569. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Arantes-Rodrigues R, Pinto-Leite R, Ferreira R, Neuparth MJ, Pires MJ, Gaivão I, Palmeira C, Santos L, Colaço A and Oliveira P: Meloxicam in the treatment of in vitro and in vivo models of urinary bladder cancer. Biomed Pharmacother. 67:277–284. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Li J, Chen X, Dong X, Xu Z, Jiang H and Sun X: Specific COX-2 inhibitor, meloxicam, suppresses proliferation and induces apoptosis in human HepG2 hepatocellular carcinoma cells. J Gastroenterol Hepatol. 21:1814–1820. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Dong X, Li R, Xiu P, Dong X, Xu Z, Zhai B, Liu F, Jiang H, Sun X, Li J, et al: Meloxicam executes its antitumor effects against hepatocellular carcinoma in COX-2-dependent and -independent pathways. PLoS One. 9:e928642014. View Article : Google Scholar

14 

Tabas I and Ron D: Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol. 13:184–190. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Zhu J, Chen M, Chen N, Ma A, Zhu C, Zhao R, Jiang M, Zhou J, Ye L, Fu H, et al: Glycyrrhetinic acid induces G1-phase cell cycle arrest in human non-small cell lung cancer cells through endoplasmic reticulum stress pathway. Int J Oncol. 46:981–988. 2015.PubMed/NCBI

16 

Xu C, Bailly-Maitre B and Reed JC: Endoplasmic reticulum stress: Cell life and death decisions. J Clin Invest. 115:2656–2664. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Meusser B, Hirsch C, Jarosch E and Sommer T: ERAD: The long road to destruction. Nat Cell Biol. 7:766–772. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Cao SS and Zhen YS: Potentiation of antimetabolite antitumor activity in vivo by dipyridamole and amphotericin B. Cancer Chemother Pharmacol. 24:181–186. 1989. View Article : Google Scholar : PubMed/NCBI

19 

Inamoto T and Azuma H: Sorafenib increases endoplasmic reticulum (ER) stress in concert with vorinostat. Cancer Biol Ther. 12:10182011. View Article : Google Scholar : PubMed/NCBI

20 

Shi YH, Ding ZB, Zhou J, Hui B, Shi GM, Ke AW, Wang XY, Dai Z, Peng YF, Gu CY, et al: Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis. Autophagy. 7:1159–1172. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Suzuki K, Gerelchuluun A, Hong Z, Sun L, Zenkoh J, Moritake T and Tsuboi K: Celecoxib enhances radiosensitivity of hypoxic glioblastoma cells through endoplasmic reticulum stress. Neurooncol. 15:1186–1199. 2013.

22 

Kim SJ, Ha GH, Bae JH, Kim GR, Son CH, Park YS, Yang K, Oh SO, Kim SH and Kang CD: COX-2- and endoplasmic reticulum stress-independent induction of ULBP-1 and enhancement of sensitivity to NK cell-mediated cytotoxicity by celecoxib in colon cancer cells. Exp Cell Res. 330:451–459. 2015. View Article : Google Scholar

23 

Momoi T: Caspases involved in ER stress-mediated cell death. J Chem Neuroanat. 28:101–105. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Virrey JJ, Dong D, Stiles C, Patterson JB, Pen L, Ni M, Schönthal AH, Chen TC, Hofman FM and Lee AS: Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells. Mol Cancer Res. 6:1268–1275. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Egger L, Madden DT, Rhême C, Rao RV and Bredesen DE: Endoplasmic reticulum stress-induced cell death mediated by the proteasome. Cell Death Differ. 14:1172–1180. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Komatsu S, Miyazawa K, Moriya S, Takase A, Naito M, Inazu M, Kohno N, Itoh M and Tomoda A: Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells. Int J Oncol. 40:1029–1039. 2012.

27 

Dupuy E, Hainaud P, Villemain A, Bodevin-Phèdre E, Brouland JP, Briand P and Tobelem G: Tumoral angiogenesis and tissue factor expression during hepatocellular carcinoma progression in a transgenic mouse model. J Hepatol. 38:793–802. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Geis T, Döring C, Popp R, Grossmann N, Fleming I, Hansmann ML, Dehne N and Brüne B: HIF-2alpha-dependent PAI-1 induction contributes to angiogenesis in hepatocellular carcinoma. Exp Cell Res. 331:46–57. 2015. View Article : Google Scholar

29 

Yusup G, Akutsu Y, Mutallip M, Qin W, Hu X, Komatsu-Akimoto A, Hoshino I, Hanari N, Mori M, Akanuma N, et al: A COX-2 inhibitor enhances the antitumor effects of chemotherapy and radiotherapy for esophageal squamous cell carcinoma. Int J Oncol. 44:1146–1152. 2014.PubMed/NCBI

30 

Agarwal V, Hodgkinson VC, Eagle GL, Scaife L, Lind MJ and Cawkwell L: Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697. Int J Oncol. 42:1088–1092. 2013.PubMed/NCBI

31 

Rutkowski DT and Kaufman RJ: A trip to the ER: Coping with stress. Trends Cell Biol. 14:20–28. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Dolai S, Pal S, Yadav RK and Adak S: Endoplasmic reticulum stress-induced apoptosis in Leishmania through Ca2+-dependent and caspase-independent mechanism. J Biol Chem. 286:13638–13646. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Fribley AM, Miller JR, Brownell AL, Garshott DM, Zeng Q, Reist TE, Narula N, Cai P, Xi Y, Callaghan MU, et al: Celastrol induces unfolded protein response-dependent cell death in head and neck cancer. Exp Cell Res. 330:412–422. 2015. View Article : Google Scholar

34 

Li J and Lee AS: Stress induction of GRP78/BiP and its role in cancer. Curr Mol Med. 6:45–54. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Kulkarni P, Rajagopalan K, Yeater D and Getzenberg RH: Protein folding and the order/disorder paradox. J Cell Biochem. 112:1949–1952. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Wu J and Kaufman RJ: From acute ER stress to physiological roles of the Unfolded Protein Response. Cell Death Differ. 13:374–384. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Lee AS: GRP78 induction in cancer: Therapeutic and prognostic implications. Cancer Res. 67:3496–3499. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Ermakova SP, Kang BS, Choi BY, Choi HS, Schuster TF, Ma WY, Bode AM and Dong Z: (−)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78. Cancer Res. 66:9260–9269. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhong J, Xiu P, Dong X, Wang F, Wei H, Wang X, Xu Z, Liu F, Li T, Wang Y, Wang Y, et al: Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis. Oncol Rep 34: 2142-2150, 2015.
APA
Zhong, J., Xiu, P., Dong, X., Wang, F., Wei, H., Wang, X. ... Li, J. (2015). Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis. Oncology Reports, 34, 2142-2150. https://doi.org/10.3892/or.2015.4181
MLA
Zhong, J., Xiu, P., Dong, X., Wang, F., Wei, H., Wang, X., Xu, Z., Liu, F., Li, T., Wang, Y., Li, J."Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis". Oncology Reports 34.4 (2015): 2142-2150.
Chicago
Zhong, J., Xiu, P., Dong, X., Wang, F., Wei, H., Wang, X., Xu, Z., Liu, F., Li, T., Wang, Y., Li, J."Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis". Oncology Reports 34, no. 4 (2015): 2142-2150. https://doi.org/10.3892/or.2015.4181
Copy and paste a formatted citation
x
Spandidos Publications style
Zhong J, Xiu P, Dong X, Wang F, Wei H, Wang X, Xu Z, Liu F, Li T, Wang Y, Wang Y, et al: Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis. Oncol Rep 34: 2142-2150, 2015.
APA
Zhong, J., Xiu, P., Dong, X., Wang, F., Wei, H., Wang, X. ... Li, J. (2015). Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis. Oncology Reports, 34, 2142-2150. https://doi.org/10.3892/or.2015.4181
MLA
Zhong, J., Xiu, P., Dong, X., Wang, F., Wei, H., Wang, X., Xu, Z., Liu, F., Li, T., Wang, Y., Li, J."Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis". Oncology Reports 34.4 (2015): 2142-2150.
Chicago
Zhong, J., Xiu, P., Dong, X., Wang, F., Wei, H., Wang, X., Xu, Z., Liu, F., Li, T., Wang, Y., Li, J."Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis". Oncology Reports 34, no. 4 (2015): 2142-2150. https://doi.org/10.3892/or.2015.4181
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