MicroRNA-374a promotes esophageal cancer cell proliferation via Axin2 suppression

  • Authors:
    • Yue Wang
    • Hua Xin
    • Zhifeng Han
    • Hongbing Sun
    • Nan Gao
    • Haixiang Yu
  • View Affiliations

  • Published online on: August 7, 2015     https://doi.org/10.3892/or.2015.4182
  • Pages: 1988-1994
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Abstract

MicroRNA-374a (miR-374a) is involved in the progress of various types of cancer, and may indicate a poor prognosis. However, its role in esophageal cancer remains to be determined. In the present study, the role of miR-374a in esophageal cancers and cancer cell growth was examined using miR-374a overexpression and underexpression models. The results showed that miR-374a was markedly increased in esophageal cancer cell lines and tumor samples from patients with esophageal cancer. In esophageal cancer Eca109 cells, the ectopic overexpression of miR-374a promoted cell growth. Additionally, cell growth was reduced by miR‑374a inhibition. The mechanisms underlying the promotive role were examined and it was found that miR-374a significantly decreased the expression and transcription activity of axis inhibition protein 2 (Axin2). Axin2, a tumor suppressor, exhibited a marked inhibitory effect on Eca109 cell growth. The results identified a new role of miR-374a in esophageal cancer involving Axin2 suppression.
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October-2015
Volume 34 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wang Y, Xin H, Han Z, Sun H, Gao N and Yu H: MicroRNA-374a promotes esophageal cancer cell proliferation via Axin2 suppression. Oncol Rep 34: 1988-1994, 2015
APA
Wang, Y., Xin, H., Han, Z., Sun, H., Gao, N., & Yu, H. (2015). MicroRNA-374a promotes esophageal cancer cell proliferation via Axin2 suppression. Oncology Reports, 34, 1988-1994. https://doi.org/10.3892/or.2015.4182
MLA
Wang, Y., Xin, H., Han, Z., Sun, H., Gao, N., Yu, H."MicroRNA-374a promotes esophageal cancer cell proliferation via Axin2 suppression". Oncology Reports 34.4 (2015): 1988-1994.
Chicago
Wang, Y., Xin, H., Han, Z., Sun, H., Gao, N., Yu, H."MicroRNA-374a promotes esophageal cancer cell proliferation via Axin2 suppression". Oncology Reports 34, no. 4 (2015): 1988-1994. https://doi.org/10.3892/or.2015.4182