Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer

  • Authors:
    • Emre Gerçeker
    • Seda Orenay Boyacıoglu
    • Elmas Kasap
    • Ahmed Baykan
    • Hakan Yuceyar
    • Hatice Yıldırım
    • Semin Ayhan
    • Ender Ellidokuz
    • Mehmet Korkmaz
  • View Affiliations

  • Published online on: August 10, 2015     https://doi.org/10.3892/or.2015.4187
  • Pages: 1905-1914
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Abstract

Ulcerative colitis (UC) is an important risk factor for colorectal cancer (CRC). Histone modifications are one of the epigenetic mechanisms that may have key roles in the carcinogenesis of CRC. At present, there are no studies comparing histone modification patterns of UC and CRC in the literature. Therefore the aim of the present study was to investigate whether genes, particularly those involved in histone modification, have value in patient monitoring with regards to CRC development in UC. Key gene expressions of the histone modification enzyme were assessed and compared in CRC, UC and control groups using the RT-PCR array technique. Patients were divided into subgroups based on the extent and duration of the disease and inflammatory burden, which are considered risk factors for CRC development in UC patients. In UC and CRC groups, a significantly higher overexpression of the NEK6 and AURKA genes compared to the control group was identified. In addition, there was a significantly higher overexpression of HDAC1 and PAK1 genes in the UC group, and of HDAC1, HDAC7, PAK1 and AURKB genes in the CRC group. NEK6, AURKA, HDAC1 and PAK1 were significantly overexpressed in patients with a longer UC duration. Overexpression of AURKA and NEK6 genes was significantly more pronounced in UC patients with more extensive colon involvement. HDAC1, HDAC7, PAK1, NEK6, AURKA and AURKB are important diagnostic and prognostic markers involved in the carcinogenesis of CRC. HDAC1, PAK1, NEK6 and AURKA may be considered as diagnostic markers to be used in CRC screening for UC patients.
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October-2015
Volume 34 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Gerçeker E, Boyacıoglu SO, Kasap E, Baykan A, Yuceyar H, Yıldırım H, Ayhan S, Ellidokuz E and Korkmaz M: Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer. Oncol Rep 34: 1905-1914, 2015
APA
Gerçeker, E., Boyacıoglu, S.O., Kasap, E., Baykan, A., Yuceyar, H., Yıldırım, H. ... Korkmaz, M. (2015). Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer. Oncology Reports, 34, 1905-1914. https://doi.org/10.3892/or.2015.4187
MLA
Gerçeker, E., Boyacıoglu, S. O., Kasap, E., Baykan, A., Yuceyar, H., Yıldırım, H., Ayhan, S., Ellidokuz, E., Korkmaz, M."Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer". Oncology Reports 34.4 (2015): 1905-1914.
Chicago
Gerçeker, E., Boyacıoglu, S. O., Kasap, E., Baykan, A., Yuceyar, H., Yıldırım, H., Ayhan, S., Ellidokuz, E., Korkmaz, M."Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer". Oncology Reports 34, no. 4 (2015): 1905-1914. https://doi.org/10.3892/or.2015.4187