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HOXD10 acts as a tumor-suppressive factor via inhibition of the RHOC/AKT/MAPK pathway in human cholangiocellular carcinoma

  • Authors:
    • Haixia Yang
    • Jiupeng Zhou
    • Jianqiang Mi
    • Ke Ma
    • Yangwei Fan
    • Jing Ning
    • Chuying Wang
    • Xin Wei
    • Huadong Zhao
    • Enxiao Li
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710062, P.R. China, Department of Medical Oncology, Xi'an Chest Hospital of Shaanxi, Xi'an, Shaanxi 710061, P.R. China, Department of Pathology, The First Affiliated Hospital of Henan Science and Technology University, Luoyang, Henan 471003, P.R. China, Department of General Surgery, Tangdu Hospital, Xi'an, Shaanxi 710038, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1681-1691
    |
    Published online on: August 10, 2015
       https://doi.org/10.3892/or.2015.4194
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Abstract

HOXD10, a key regulator of cell-differentiated phenotype maintainence, has been demonstrated to be involved in the tumorigenesis of many human malignacies. However, the status of HOXD10 expression and its biological function in cholangiocellular carcinoma (CCC) remain to be clarified. In the present study, we investigated the clinical significance and biological functions of HOXD10 in CCC and found that the expression of HOXD10 and its downstream effector RHOC was significantly different in well-differentiated CCC tissues compared with poorly-differentiated lesions. We also observed a significant correlation between low HOXD10 and high RHOC expression levels and worse prognosis. The stable overexpression of HOXD10 by lentivirus vector significantly inhibited cell invasion partly by downregulating the expression of MMP2 and MMP9, and significantly increased early apoptosis in CCC cell lines and induced G1 phase cell cycle arrest, contributing to the inhibition of cell proliferation in vitro. Additionally, we demonstrated that the inactivation of the RHOC/AKT/MAPK pathway was involved in the tumor‑suppressive functions of HOXD10 in CCC. These results suggested that HOXD10 may be a putative suppressor gene and can act as a prognostic marker and potentially a novel therapeutic target for CCC.
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Copy and paste a formatted citation
Spandidos Publications style
Yang H, Zhou J, Mi J, Ma K, Fan Y, Ning J, Wang C, Wei X, Zhao H, Li E, Li E, et al: HOXD10 acts as a tumor-suppressive factor via inhibition of the RHOC/AKT/MAPK pathway in human cholangiocellular carcinoma. Oncol Rep 34: 1681-1691, 2015.
APA
Yang, H., Zhou, J., Mi, J., Ma, K., Fan, Y., Ning, J. ... Li, E. (2015). HOXD10 acts as a tumor-suppressive factor via inhibition of the RHOC/AKT/MAPK pathway in human cholangiocellular carcinoma. Oncology Reports, 34, 1681-1691. https://doi.org/10.3892/or.2015.4194
MLA
Yang, H., Zhou, J., Mi, J., Ma, K., Fan, Y., Ning, J., Wang, C., Wei, X., Zhao, H., Li, E."HOXD10 acts as a tumor-suppressive factor via inhibition of the RHOC/AKT/MAPK pathway in human cholangiocellular carcinoma". Oncology Reports 34.4 (2015): 1681-1691.
Chicago
Yang, H., Zhou, J., Mi, J., Ma, K., Fan, Y., Ning, J., Wang, C., Wei, X., Zhao, H., Li, E."HOXD10 acts as a tumor-suppressive factor via inhibition of the RHOC/AKT/MAPK pathway in human cholangiocellular carcinoma". Oncology Reports 34, no. 4 (2015): 1681-1691. https://doi.org/10.3892/or.2015.4194
Copy and paste a formatted citation
x
Spandidos Publications style
Yang H, Zhou J, Mi J, Ma K, Fan Y, Ning J, Wang C, Wei X, Zhao H, Li E, Li E, et al: HOXD10 acts as a tumor-suppressive factor via inhibition of the RHOC/AKT/MAPK pathway in human cholangiocellular carcinoma. Oncol Rep 34: 1681-1691, 2015.
APA
Yang, H., Zhou, J., Mi, J., Ma, K., Fan, Y., Ning, J. ... Li, E. (2015). HOXD10 acts as a tumor-suppressive factor via inhibition of the RHOC/AKT/MAPK pathway in human cholangiocellular carcinoma. Oncology Reports, 34, 1681-1691. https://doi.org/10.3892/or.2015.4194
MLA
Yang, H., Zhou, J., Mi, J., Ma, K., Fan, Y., Ning, J., Wang, C., Wei, X., Zhao, H., Li, E."HOXD10 acts as a tumor-suppressive factor via inhibition of the RHOC/AKT/MAPK pathway in human cholangiocellular carcinoma". Oncology Reports 34.4 (2015): 1681-1691.
Chicago
Yang, H., Zhou, J., Mi, J., Ma, K., Fan, Y., Ning, J., Wang, C., Wei, X., Zhao, H., Li, E."HOXD10 acts as a tumor-suppressive factor via inhibition of the RHOC/AKT/MAPK pathway in human cholangiocellular carcinoma". Oncology Reports 34, no. 4 (2015): 1681-1691. https://doi.org/10.3892/or.2015.4194
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