Open Access

RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells

  • Authors:
    • Hui Liu
    • Shaohua Liang
    • Xi Yang
    • Zhaoning Ji
    • Wenying Zhao
    • Xiaobing Ye
    • Jing Rui
  • View Affiliations

  • Published online on: August 21, 2015     https://doi.org/10.3892/or.2015.4219
  • Pages: 2267-2272
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

An increasing body of evidence suggests that ribosomal proteins may have ribosome-independent functions and may be involved in various physiological and pathological processes. To examine the role of ribosomal protein L34 (RPL34) in cancer transformation, we assessed its expression in gastric cancer cell lines and found it highly expressed. We further used lentivirus-mediated small interfering RNAs (siRNAs) to knockdown RPL34 expression in the human gastric cancer cell line SGC-7901. RNA interference (RNAi)-mediated inhibition of RPL34 expression in SGC-7901 cells significantly suppressed cell proliferation, increased apoptosis and arrested cells in the S phase. The results of the present study suggest that RPL34 plays a critical role in cell proliferation, cell cycle distribution and apoptosis of human malignant gastric cells.
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November-2015
Volume 34 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Liu H, Liang S, Yang X, Ji Z, Zhao W, Ye X and Rui J: RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells. Oncol Rep 34: 2267-2272, 2015
APA
Liu, H., Liang, S., Yang, X., Ji, Z., Zhao, W., Ye, X., & Rui, J. (2015). RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells. Oncology Reports, 34, 2267-2272. https://doi.org/10.3892/or.2015.4219
MLA
Liu, H., Liang, S., Yang, X., Ji, Z., Zhao, W., Ye, X., Rui, J."RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells". Oncology Reports 34.5 (2015): 2267-2272.
Chicago
Liu, H., Liang, S., Yang, X., Ji, Z., Zhao, W., Ye, X., Rui, J."RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells". Oncology Reports 34, no. 5 (2015): 2267-2272. https://doi.org/10.3892/or.2015.4219