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RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells

  • Authors:
    • Hui Liu
    • Shaohua Liang
    • Xi Yang
    • Zhaoning Ji
    • Wenying Zhao
    • Xiaobing Ye
    • Jing Rui
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Wannan Medical College, Wuhu, Anhui 241001, P.R. China, Department of Medical Oncology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2267-2272
    |
    Published online on: August 21, 2015
       https://doi.org/10.3892/or.2015.4219
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Abstract

An increasing body of evidence suggests that ribosomal proteins may have ribosome-independent functions and may be involved in various physiological and pathological processes. To examine the role of ribosomal protein L34 (RPL34) in cancer transformation, we assessed its expression in gastric cancer cell lines and found it highly expressed. We further used lentivirus-mediated small interfering RNAs (siRNAs) to knockdown RPL34 expression in the human gastric cancer cell line SGC-7901. RNA interference (RNAi)-mediated inhibition of RPL34 expression in SGC-7901 cells significantly suppressed cell proliferation, increased apoptosis and arrested cells in the S phase. The results of the present study suggest that RPL34 plays a critical role in cell proliferation, cell cycle distribution and apoptosis of human malignant gastric cells.
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Copy and paste a formatted citation
Spandidos Publications style
Liu H, Liang S, Yang X, Ji Z, Zhao W, Ye X and Rui J: RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells. Oncol Rep 34: 2267-2272, 2015.
APA
Liu, H., Liang, S., Yang, X., Ji, Z., Zhao, W., Ye, X., & Rui, J. (2015). RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells. Oncology Reports, 34, 2267-2272. https://doi.org/10.3892/or.2015.4219
MLA
Liu, H., Liang, S., Yang, X., Ji, Z., Zhao, W., Ye, X., Rui, J."RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells". Oncology Reports 34.5 (2015): 2267-2272.
Chicago
Liu, H., Liang, S., Yang, X., Ji, Z., Zhao, W., Ye, X., Rui, J."RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells". Oncology Reports 34, no. 5 (2015): 2267-2272. https://doi.org/10.3892/or.2015.4219
Copy and paste a formatted citation
x
Spandidos Publications style
Liu H, Liang S, Yang X, Ji Z, Zhao W, Ye X and Rui J: RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells. Oncol Rep 34: 2267-2272, 2015.
APA
Liu, H., Liang, S., Yang, X., Ji, Z., Zhao, W., Ye, X., & Rui, J. (2015). RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells. Oncology Reports, 34, 2267-2272. https://doi.org/10.3892/or.2015.4219
MLA
Liu, H., Liang, S., Yang, X., Ji, Z., Zhao, W., Ye, X., Rui, J."RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells". Oncology Reports 34.5 (2015): 2267-2272.
Chicago
Liu, H., Liang, S., Yang, X., Ji, Z., Zhao, W., Ye, X., Rui, J."RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells". Oncology Reports 34, no. 5 (2015): 2267-2272. https://doi.org/10.3892/or.2015.4219
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