Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
November-2015 Volume 34 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2015 Volume 34 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Identification of biomarkers with a tumor stage-dependent expression and exploration of the mechanism involved in laryngeal squamous cell carcinoma

  • Authors:
    • Lian Hui
    • Ning Yang
    • Huijun Yang
    • Xing Guo
    • Xuejun Jang
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 2627-2635
    |
    Published online on: August 27, 2015
       https://doi.org/10.3892/or.2015.4230
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of this study was to identify biomarkers with a tumor stage-dependent expression manner and explore the regulatory mechanisms of laryngeal squamous cell carcinoma (LSCC) progression. Microarray data GSE59102 was used for differential analysis using a limma package. Enrichment analyses were performed for the differentially expressed genes (DEGs) between tumor tissues and normal tissues at different stages. A co-expressed network involving the overlapped DEGs in two stages was established based on Pearson's correlation coefficients. Furthermore, for the tumor stage‑dependent expressed DEGs, a protein‑protein interaction (PPI) network was constructed by mapping the genes using the STRING database. Transcription factors (TFs), oncogenes and tumor‑associated genes (TSGs) among the DEGs were predicted, following a search of the TRANSFAC, tumor-associated gene (TAG) and TSG databases. The CDT database was used to identify LSCC‑associated genes. In total, 696 DEGs from early stage and control samples and 622 DEGs from advanced sttage and control samples were selected, which were mainly enriched in the cell cycle pathway. In the co-expressed network, BUB1, TTK, E2F1 and CEP55 were prominent, with E2F1 being predicted as a TSG and CEP55 as an oncogene. The HOX family members were predicted as TFs. MMP1, MMP9, MMP3 and PLAU were the most evident nodes in the PPI network, where MMP3 was connected with MMP1. The ADH family was correlated with LSCC. Several biomarkers with tumor stage-dependent expression were identified including MMP1, MMP3, MMP9, PLAU and ADHs. Additionally, the dysregulated cell cycle pathway involving BUB1, TTK, E2F1 and CEP55, and the mediation of MMP1 by MMP3 as well as the predicted TF HOX, may all play significant roles in LSCC progression.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Hui AB, Lenarduzzi M, Krushel T, Waldron L, Pintilie M, Shi W, Perez-Ordonez B, Jurisica I, O'Sullivan B, Waldron J, et al: Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas. Clin Cancer Res. 16:1129–1139. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Wang W, Lin P, Han C, Cai W, Zhao X and Sun B: Vasculogenic mimicry contributes to lymph node metastasis of laryngeal squamous cell carcinoma. J Exp Clin Cancer Res. 29:602010. View Article : Google Scholar : PubMed/NCBI

3 

Zhang S-Y, Lu Z-M, Luo X-N, Chen LS, Ge PJ, Song XH, Chen SH and Wu YL: Retrospective analysis of prognostic factors in 205 patients with laryngeal squamous cell carcinoma who underwent surgical treatment. PLoS One. 8:e601572013. View Article : Google Scholar : PubMed/NCBI

4 

Li D, Feng J, Wu T, Wang Y, Sun Y, Ren J and Liu M: Long intergenic noncoding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma. Am J Pathol. 182:64–70. 2013. View Article : Google Scholar

5 

Karatas OF, Yuceturk B, Suer I, Yilmaz M, Cansiz H, Solak M, Ittmann M and Ozen M: The role of miR-145 in Human Laryngeal Squamous Cell Carcinoma. Head Neck n/a. 2014.

6 

Rudolph E, Dyckhoff G, Becher H, Dietz A and Ramroth H: Effects of tumour stage, comorbidity and therapy on survival of laryngeal cancer patients: A systematic review and a meta-analysis. Eur Arch Otorhinolaryngol. 268:165–179. 2011. View Article : Google Scholar

7 

Liu WW, Zeng ZY, Wu QL, Hou JH and Chen YY: Overexpression of MMP-2 in laryngeal squamous cell carcinoma: A potential indicator for poor prognosis. Otolaryngol Head Neck Surg. 132:395–400. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Shi Y, Gong H-L, Zhou L, Tian J and Wang Y: CD24: A novel cancer biomarker in laryngeal squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec. 74:78–85. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Chen K, Cornejo KM, Ye W, Wu Q, Liang J and Jiang Z: Oncofetal protein IMP3: A new diagnostic biomarker for laryngeal carcinoma. Hum Pathol. 44:2126–2131. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Geomela P-A, Kontos CK, Yiotakis I, Fragoulis EG and Scorilas A: L-DOPA decarboxylase mRNA expression is associated with tumor stage and size in head and neck squamous cell carcinoma: A retrospective cohort study. BMC Cancer. 12:4842012. View Article : Google Scholar : PubMed/NCBI

11 

Saglam O, Shah V and Worsham MJ: Molecular differentiation of early and late stage laryngeal squamous cell carcinoma: An exploratory analysis. Diagn Mol Pathol. 16:218–221. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Plaça JR, Pinheiro DG, Panepucci RA, et al: Gene expression analysis of laryngeal squamous cell carcinoma. Genomics Data. 5:9–12. 2015. View Article : Google Scholar

13 

Smyth GK: Limma: Linear models for microarray data. Bioinformatics and Computational Biology Solutions using R and Bioconductor. Springer; New York, NY: pp. 397–420. 2005, View Article : Google Scholar

14 

Blake JA, Dolan M, Drabkin H, Hill DP, Li N, Sitnikov D, Bridges S, Burgess S, Buza T, McCarthy F, et al Gene Ontology Consortium: Gene Ontology annotations and resources. Nucleic Acids Res. 41(D1): D530–D535. 2013. View Article : Google Scholar

15 

Kanehisa M, Goto S, Sato Y, Furumichi M and Tanabe M: KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res. 40:D109–D114. 2012. View Article : Google Scholar :

16 

Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC and Lempicki RA: DAVID: Database for annotation, visualization, and integrated discovery. Genome Biol. 4:32003. View Article : Google Scholar

17 

Matys V, Kel-Margoulis OV, Fricke E, Liebich I, Land S, Barre-Dirrie A, Reuter I, Chekmenev D, Krull M, Hornischer K, et al: TRANSFAC and its module TRANSCompel: Transcriptional gene regulation in eukaryotes. Nucleic Acids Res. 34:D108–D110. 2006. View Article : Google Scholar

18 

Zhao M, Sun J and Zhao Z: TSGene: A web resource for tumor suppressor genes. Nucleic Acids Res. 41:D970–D976. 2013. View Article : Google Scholar :

19 

Szklarczyk D, Franceschini A, Kuhn M, Simonovic M, Roth A, Minguez P, Doerks T, Stark M, Muller J, Bork P, et al: The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 39:D561–D568. 2011. View Article : Google Scholar :

20 

Kohl M, Wiese S and Warscheid B: Cytoscape: Software for Visualization and Analysis of Biological Networks. Data Mining in Proteomics. Springer; pp. 291–303. 2011

21 

Mattingly C, Rosenstein M, Colby G, Forrest J Jr and Boyer J: The Comparative Toxicogenomics Database (CTD): A resource for comparative toxicological studies. J Exp Zool A Comp Exp Biol. 305:689–692. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Johnson VL, Scott MI, Holt SV, Hussein D and Taylor SS: Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. J Cell Sci. 117:1577–1589. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Ma HF, Guo X and Li XY: Expression and Interaction between STK15 and BUBR1 in Human Laryngeal Squamous Cell Carcinoma. J China Med Univ. 7:0172011.

24 

Li Z, Chen Y, Yan F, Zhang Q, Zhou J and Yang J: The expression of BUB1 in laryngeal squamous cell carcinoma and its clinical significance. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 27:1184–1187. 2013.In Chinese.

25 

Liu Y, Sun W, Zhang K, Zheng H, Ma Y, Lin D, Zhang X, Feng L, Lei W, Zhang Z, et al: Identification of genes differentially expressed in human primary lung squamous cell carcinoma. Lung Cancer. 56:307–317. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Dou Z, Ding X, Zereshki A, Zhang Y, Zhang J, Wang F, Sun J, Huang H and Yao X: TTK kinase is essential for the centrosomal localization of TACC2. FEBS Lett. 572:51–56. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Ahmed AA, Lu Z, Jennings NB, Etemadmoghadam D, Capalbo L, Jacamo RO, Barbosa-Morais N, Le XF, Vivas-Mejia P, Lopez-Berestein G, et al Australian Ovarian Cancer Study Group: SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer. Cancer Cell. 18:109–121. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Sen S, Ateeq B, Sharma H, Datta P, Gupta SD, Bal S, Kumar A and Singh N: Identification of differentially expressed genes in human lung squamous cell carcinoma in Asian Indians using suppression subtractive hybridization. Clin Cancer Res. 12:A71. 2006.

29 

Pi J-T, Lin Y, Quan Q, Chen LL, Jiang LZ, Chi W and Chen HY: Overexpression of UHRF1 is significantly associated with poor prognosis in laryngeal squamous cell carcinoma. Med Oncol. 30:6132013. View Article : Google Scholar : PubMed/NCBI

30 

Fabbro M, Zhou B-B, Takahashi M, et al: Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Dev Cell. 9:477–488. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Waseem A, Ali M, Odell EW, Fortune F and Teh MT: Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma. Oral Oncol. 46:536–542. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Sun X, Liu B, Ji W, Ma X, Wang X and Gu H: The role of HOXA9 in human laryngeal squamous cell carcinoma. Oncol Res. 20:467–472. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Krecicki T, Fraczek M, Jelen M, Podhorska M, Szkudlarek T and Zatonski T: Expression of collagenase-1 (MMP-1), collagenase-3 (MMP-13) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in laryngeal squamous cell carcinomas. Eur Arch Otorhinolaryngol. 260:494–497. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Cao X-L, Xu R-J, Zheng YY, Liu J, Teng YS, Li Y and Zhu J: Expression of type IV collagen, metalloproteinase-2, metallopro-teinase-9 and tissue inhibitor of metalloproteinase-1 in laryngeal squamous cell carcinomas. Asian Pac J Cancer Prev. 12:3245–3249. 2011.

35 

Qin G, Li W, Sun X, Zhu L and Chen Z: Expression and significance of CD44v6 and MMP-9 in laryngeal squamous cell carcinoma. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 19:688–691. 2005.PubMed/NCBI

36 

Papadas TA, Naxakis SS, Mastronikolis NS, Stathas T, Karabekos NCh and Tsiambas E: Determination of matrix metalloproteinase 9 (MMP-9) protein expression in laryngeal squamous cell carcinomas based on digital image analysis. J BUON. 18:977–981. 2013.PubMed/NCBI

37 

Nagaraj NS: Evolving 'omics' technologies for diagnostics of head and neck cancer. Brief Funct Genomics. 8:49–59. 2009. View Article : Google Scholar

38 

Xavier FCA, Rodini CO, Ramalho LMP, Mantesso A and Nunes FD: WNT-5A, but not matrix metalloproteinase 3 or β-catenin protein, expression is related to early stages of lip carcinogenesis. J Oral Pathol Med. 38:708–715. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Bogner W, Gruber S, Pinker K, Grabner G, Stadlbauer A, Weber M, Moser E, Helbich TH and Trattnig S: Diffusion-weighted MR for differentiation of breast lesions at 3.0 T: How does selection of diffusion protocols affect diagnosis? Radiology. 253:341–351. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Vachani A, Nebozhyn M, Singhal S, Alila L, Wakeam E, Muschel R, Powell CA, Gaffney P, Singh B, Brose MS, et al: A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and lung squamous cell carcinoma. Clin Cancer Res. 13:2905–2915. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Hashibe M, McKay JD, Curado MP, Oliveira JC, Koifman S, Koifman R, Zaridze D, Shangina O, Wünsch-Filho V, Eluf-Neto J, et al: Multiple ADH genes are associated with upper aerodigestive cancers. Nat Genet. 40:707–709. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Duell EJ, Sala N, Travier N, Muñoz X, Boutron-Ruault MC, Clavel-Chapelon F, Barricarte A, Arriola L, Navarro C, Sánchez- Cantalejo E, et al: Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Carcinogenesis. 33:361–367. 2012. View Article : Google Scholar

43 

Chang JS, Straif K and Guha N: The role of alcohol dehydrogenase genes in head and neck cancers: A systematic review and meta-analysis of ADH1B and ADH1C. Mutagenesis. 27:275–286. 2012. View Article : Google Scholar

44 

Jiang J, Loganathan J, Eliaz I, Terry C, Sandusky GE and Sliva D: ProstaCaid inhibits tumor growth in a xenograft model of human prostate cancer. Int J Oncol. 40:1339–1344. 2012.PubMed/NCBI

45 

Iliopoulos D, Rotem A and Struhl K: Inhibition of miR-193a expression by Max and RXRα activates K-Ras and PLAU to mediate distinct aspects of cellular transformation. Cancer Res. 71:5144–5153. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Bloch M, Ousingsawat J, Simon R, Schraml P, Gasser TC, Mihatsch MJ, Kunzelmann K and Bubendorf L: KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer. Oncogene. 26:2525–2534. 2007. View Article : Google Scholar

47 

Tomlins SA, Laxman B, Varambally S, Cao X, Yu J, Helgeson BE, Cao Q, Prensner JR, Rubin MA, Shah RB, et al: Role of the TMPRSS2-ERG gene fusion in prostate cancer. Neoplasia. 10:177–188. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hui L, Yang N, Yang H, Guo X and Jang X: Identification of biomarkers with a tumor stage-dependent expression and exploration of the mechanism involved in laryngeal squamous cell carcinoma. Oncol Rep 34: 2627-2635, 2015.
APA
Hui, L., Yang, N., Yang, H., Guo, X., & Jang, X. (2015). Identification of biomarkers with a tumor stage-dependent expression and exploration of the mechanism involved in laryngeal squamous cell carcinoma. Oncology Reports, 34, 2627-2635. https://doi.org/10.3892/or.2015.4230
MLA
Hui, L., Yang, N., Yang, H., Guo, X., Jang, X."Identification of biomarkers with a tumor stage-dependent expression and exploration of the mechanism involved in laryngeal squamous cell carcinoma". Oncology Reports 34.5 (2015): 2627-2635.
Chicago
Hui, L., Yang, N., Yang, H., Guo, X., Jang, X."Identification of biomarkers with a tumor stage-dependent expression and exploration of the mechanism involved in laryngeal squamous cell carcinoma". Oncology Reports 34, no. 5 (2015): 2627-2635. https://doi.org/10.3892/or.2015.4230
Copy and paste a formatted citation
x
Spandidos Publications style
Hui L, Yang N, Yang H, Guo X and Jang X: Identification of biomarkers with a tumor stage-dependent expression and exploration of the mechanism involved in laryngeal squamous cell carcinoma. Oncol Rep 34: 2627-2635, 2015.
APA
Hui, L., Yang, N., Yang, H., Guo, X., & Jang, X. (2015). Identification of biomarkers with a tumor stage-dependent expression and exploration of the mechanism involved in laryngeal squamous cell carcinoma. Oncology Reports, 34, 2627-2635. https://doi.org/10.3892/or.2015.4230
MLA
Hui, L., Yang, N., Yang, H., Guo, X., Jang, X."Identification of biomarkers with a tumor stage-dependent expression and exploration of the mechanism involved in laryngeal squamous cell carcinoma". Oncology Reports 34.5 (2015): 2627-2635.
Chicago
Hui, L., Yang, N., Yang, H., Guo, X., Jang, X."Identification of biomarkers with a tumor stage-dependent expression and exploration of the mechanism involved in laryngeal squamous cell carcinoma". Oncology Reports 34, no. 5 (2015): 2627-2635. https://doi.org/10.3892/or.2015.4230
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team