Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
November-2015 Volume 34 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2015 Volume 34 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Immunotherapy for Lewis lung carcinoma utilizing dendritic cells infected with CK19 gene recombinant adenoviral vectors

  • Authors:
    • Q. F. Sun
    • X. N. Zhao
    • C. L. Peng
    • Y. T. Hao
    • Y. P. Zhao
    • N. Jiang
    • H. Xue
    • J. Z. Guo
    • C. H. Yun
    • B. Cong
    • X. G. Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Second Hospital of Shandong University, Jinan, Shandong, P.R. China, Department of Comprehensive Health Ⅱ, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2289-2295
    |
    Published online on: August 27, 2015
       https://doi.org/10.3892/or.2015.4231
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Dendritic cells (DCs) as ʻprofessionalʼ antigen-presenting cells (APCs) initiate and regulate immune responses to various antigens. DC-based vaccines have become a promising modality in cancer immunotherapy. Cytokeratin 19 (CK19) protein is expressed at high levels in lung cancer and many other tumor cells, suggesting CK19 as a potential tumor‑specific target for cancer immune therapy. We constructed a recombinant adenoviral vector containing the CK19 gene (rAd-CK19). DCs transfected with rAd-CK19 were used to vaccinate C57BL/6 mice bearing xenografts derived from Lewis lung carcinoma (LLC) cells. The transfected DCs gave rise to potent CK19-specific cytotoxic T lymphocytes (CTLs) capable of lysing LLC cells. Mice immunized with the rAd‑CK19-DCs exhibited significantly attenuated tumor growth (including tumor volume and weight) when compared to the tumor growth of mice immunized with rAd-c DCs or DCs during the 24-day observation period (P<0.05). The results revealed that the mice vaccinated with the rAd-CK19-DCs exhibited a potent protective and therapeutic antitumor immunity to LLC cells in the subcutaneous model along with an inhibitive effect on tumor growth compared to the mice vaccinated with the rAd-c DCs or DCs alone. The present study proposes a meaningful mode of action utilizing rAd-CK19 DCs in lung cancer immunotherapy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLoBoCAn 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar

2 

Collins LG, Haines C, Perkel R and Enck RE: Lung cancer: Diagnosis and management. Am Fam Physician. 75:56–63. 2007.PubMed/NCBI

3 

Moscatello DK, Ramirez G and Wong AJ: A naturally occurring mutant human epidermal growth factor receptor as a target for peptide vaccine immunotherapy of tumors. Cancer Res. 57:1419–1424. 1997.PubMed/NCBI

4 

Heimberger AB, Crotty LE, Archer GE, et al: Epidermal growth factor receptor VIII peptide vaccination is efficacious against established intracerebral tumors. Clin Cancer Res. 9:4247–4254. 2003.PubMed/NCBI

5 

Ciesielski MJ, Kazim AL, Barth RF and Fenstermaker RA: Cellular antitumor immune response to a branched lysine multiple antigenic peptide containing epitopes of a common tumor-specific antigen in a rat glioma model. Cancer Immunol Immunother. 54:107–119. 2005. View Article : Google Scholar

6 

Paine R, Gaposchkin D, Kelly C and Wilcoxen SE: Regulation of cytokeratin expression in rat lung alveolar epithelial cells in vitro. Am J Physiol. 269:L536–L544. 1995.PubMed/NCBI

7 

Kosacka M and Jankowska R: The prognostic value of cytokeratin 19 expression in non-small cell lung cancer. Pneumonol Alergol Pol. 75:317–323. 2007.In Polish.

8 

Overwijk WW, Tsung A, Irvine KR, et al: gp100/pmel 17 is a murine tumor rejection antigen: Induction of 'self'-reactive, tumoricidal T cells using high-affinity, altered peptide ligand. J Exp Med. 188:277–286. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Banchereau J and Steinman RM: Dendritic cells and the control of immunity. Nature. 392:245–252. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Steinman RM and Dhodapkar M: Active immunization against cancer with dendritic cells: The near future. Int J Cancer. 94:459–473. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Nyberg-Hoffman C, Shabram P, Li W, Giroux D and Aguilar-Cordova E: Sensitivity and reproducibility in adenoviral infectious titer determination. Nat Med. 3:808–811. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Morelli AE, Larregina AT, Ganster RW, et al: Recombinant adenovirus induces maturation of dendritic cells via an NF-kappaB-dependent pathway. J Virol. 74:9617–9628. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Huang AY, Golumbek P, Ahmadzadeh M, et al: Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science. 264:961–965. 1994. View Article : Google Scholar : PubMed/NCBI

14 

Sharma S, Stolina M, Luo J, et al: Secondary lymphoid tissue chemokine mediates T cell-dependent antitumor responses in vivo. J Immunol. 164:4558–4563. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Fields RC, Shimizu K and Mulé JJ: Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo. Proc Natl Acad Sci USA. 95:9482–9487. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Schnurr M, Galambos P, Scholz C, et al: Tumor cell lysate-pulsed human dendritic cells induce a T-cell response against pancreatic carcinoma cells: An in vitro model for the assessment of tumor vaccines. Cancer Res. 61:6445–6450. 2001.PubMed/NCBI

17 

Mitchell MS, Harel W, Kan-Mitchell J, et al: Active specific immunotherapy of melanoma with allogeneic cell lysates. Rationale, results, and possible mechanisms of action. Ann NY Acad Sci. 690:153–166. 1993. View Article : Google Scholar : PubMed/NCBI

18 

Kirk CJ and Mulé JJ: Gene-modified dendritic cells for use in tumor vaccines. Hum Gene Ther. 11:797–806. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Klein C, Bueler H and Mulligan RC: Comparative analysis of genetically modified dendritic cells and tumor cells as therapeutic cancer vaccines. J Exp Med. 191:1699–1708. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Kim S, Lee JB, Lee GK and Chang J: Vaccination with recombinant adenoviruses and dendritic cells expressing prostate-specific antigens is effective in eliciting CTL and suppresses tumor growth in the experimental prostate cancer. Prostate. 69:938–948. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Song W, Kong HL, Carpenter H, Torii H, Granstein R, Rafii S, Moore MA and Crystal RG: Dendritic cells genetically modified with an adenovirus vector encoding the cDnA for a model antigen induce protective and therapeutic antitumor immunity. J Exp Med. 186:1247–1256. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Ribas A, Butterfield LH, Hu B, et al: Generation of T-cell immunity to a murine melanoma using MART-1-engineered dendritic cells. J Immunother. 23:59–66. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Kaplan JM, Yu Q, Piraino ST, et al: Induction of antitumor immunity with dendritic cells transduced with adenovirus vector-encoding endogenous tumor-associated antigens. J Immunol. 163:699–707. 1999.PubMed/NCBI

24 

Cho HI, Kim HJ, Oh ST and Kim TG: In vitro induction of carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes by dendritic cells transduced with recombinant adenoviruses. Vaccine. 22:224–236. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Zhou Q, Guo AL, Xu CR, An SJ, Wang Z, Yang SQ and Wu YL: A dendritic cell-based tumour vaccine for lung cancer: Full-length XAGE-1b protein-pulsed dendritic cells induce specific cytotoxic T lymphocytes in vitro. Clin Exp Immunol. 153:392–400. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Xie J, Xiong L, Tao X, Li X, Su Y, Hou X and Shi H: Antitumor effects of murine bone marrow-derived dendritic cells infected with xenogeneic livin alpha recombinant adenoviral vectors against Lewis lung carcinoma. Lung Cancer. 68:338–345. 2010. View Article : Google Scholar

27 

Rea D, Schagen FH, Hoeben RC, et al: Adenoviruses activate human dendritic cells without polarization toward a T-helper type 1-inducing subset. J Virol. 73:10245–10253. 1999.PubMed/NCBI

28 

Jonuleit H, Tüting T, Steitz J, et al: Efficient transduction of mature CD83+ dendritic cells using recombinant adenovirus suppressed T cell stimulatory capacity. Gene Ther. 7:249–254. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Miller G, Lahrs S, Shah AB and DeMatteo RP: Optimization of dendritic cell maturation and gene transfer by recombinant adenovirus. Cancer Immunol Immunother. 52:347–358. 2003.PubMed/NCBI

30 

Yang Y, Li Q, Ertl HC and Wilson JM: Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J Virol. 69:2004–2015. 1995.PubMed/NCBI

31 

Zhong LP, Zhao SF, Chen GF, Ping FY, Xu ZF and Hu JA: Increased levels of CK19 mRnA in oral squamous cell carcinoma tissue detected by relative quantification with real-time polymerase chain reaction. Arch Oral Biol. 51:1112–1119. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Galus R and Wodarski K: Importance of the cytokeratins in cancer diagnosis. Pol Merk Lek. 135:209–211. 2007.

33 

Xenidis N, Ignatiadis M, Apostolaki S, et al: Cytokeratin-19 mRnA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer. J Clin Oncol. 27:2177–2184. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Van Trappen Po, Gyselman VG, Lowe DG, et al: Molecular quantification and mapping of lymph-node micrometastases in cervical cancer. Lancet. 357:15–20. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Visser M, Jiwa M, Horstman A, et al: Intra-operative rapid diagnostic method based on CK19 mRnA expression for the detection of lymph node metastases in breast cancer. Int J Cancer. 122:2562–2567. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Chen TF, Jiang GL, Fu XL, Wang LJ, Qian H, Wu KL and Zhao S: CK19 mRnA expression measured by reverse-transcription polymerase chain reaction (RT-PCR) in the peripheral blood of patients with non-small cell lung cancer treated by chemoradiation: An independent prognostic factor. Lung Cancer. 56:105–114. 2007. View Article : Google Scholar

37 

van Sprundel RG, van den Ingh TS, Desmet VJ, et al: Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours. Comp Hepatol. 9:42010. View Article : Google Scholar : PubMed/NCBI

38 

Ohshio G, Imamura T, Okada N, Yamaki K, Suwa H, Imamura M and Sakahara H: Cytokeratin 19 fragment in serum and tissues of patients with pancreatic diseases. Int J Pancreatol. 21:235–241. 1997. View Article : Google Scholar : PubMed/NCBI

39 

Steitz J, Brück J, Steinbrink K, Enk A, Knop J and Tüting T: Genetic immunization of mice with human tyrosinase-related protein 2: Implications for the immunotherapy of melanoma. Int J Cancer. 86:89–94. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Fenstermaker RA and Ciesielski MJ: Immunotherapeutic strategies for malignant glioma. Cancer Control. 11:181–191. 2004.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun QF, Zhao XN, Peng CL, Hao YT, Zhao YP, Jiang N, Xue H, Guo JZ, Yun CH, Cong B, Cong B, et al: Immunotherapy for Lewis lung carcinoma utilizing dendritic cells infected with CK19 gene recombinant adenoviral vectors. Oncol Rep 34: 2289-2295, 2015.
APA
Sun, Q.F., Zhao, X.N., Peng, C.L., Hao, Y.T., Zhao, Y.P., Jiang, N. ... Zhao, X.G. (2015). Immunotherapy for Lewis lung carcinoma utilizing dendritic cells infected with CK19 gene recombinant adenoviral vectors. Oncology Reports, 34, 2289-2295. https://doi.org/10.3892/or.2015.4231
MLA
Sun, Q. F., Zhao, X. N., Peng, C. L., Hao, Y. T., Zhao, Y. P., Jiang, N., Xue, H., Guo, J. Z., Yun, C. H., Cong, B., Zhao, X. G."Immunotherapy for Lewis lung carcinoma utilizing dendritic cells infected with CK19 gene recombinant adenoviral vectors". Oncology Reports 34.5 (2015): 2289-2295.
Chicago
Sun, Q. F., Zhao, X. N., Peng, C. L., Hao, Y. T., Zhao, Y. P., Jiang, N., Xue, H., Guo, J. Z., Yun, C. H., Cong, B., Zhao, X. G."Immunotherapy for Lewis lung carcinoma utilizing dendritic cells infected with CK19 gene recombinant adenoviral vectors". Oncology Reports 34, no. 5 (2015): 2289-2295. https://doi.org/10.3892/or.2015.4231
Copy and paste a formatted citation
x
Spandidos Publications style
Sun QF, Zhao XN, Peng CL, Hao YT, Zhao YP, Jiang N, Xue H, Guo JZ, Yun CH, Cong B, Cong B, et al: Immunotherapy for Lewis lung carcinoma utilizing dendritic cells infected with CK19 gene recombinant adenoviral vectors. Oncol Rep 34: 2289-2295, 2015.
APA
Sun, Q.F., Zhao, X.N., Peng, C.L., Hao, Y.T., Zhao, Y.P., Jiang, N. ... Zhao, X.G. (2015). Immunotherapy for Lewis lung carcinoma utilizing dendritic cells infected with CK19 gene recombinant adenoviral vectors. Oncology Reports, 34, 2289-2295. https://doi.org/10.3892/or.2015.4231
MLA
Sun, Q. F., Zhao, X. N., Peng, C. L., Hao, Y. T., Zhao, Y. P., Jiang, N., Xue, H., Guo, J. Z., Yun, C. H., Cong, B., Zhao, X. G."Immunotherapy for Lewis lung carcinoma utilizing dendritic cells infected with CK19 gene recombinant adenoviral vectors". Oncology Reports 34.5 (2015): 2289-2295.
Chicago
Sun, Q. F., Zhao, X. N., Peng, C. L., Hao, Y. T., Zhao, Y. P., Jiang, N., Xue, H., Guo, J. Z., Yun, C. H., Cong, B., Zhao, X. G."Immunotherapy for Lewis lung carcinoma utilizing dendritic cells infected with CK19 gene recombinant adenoviral vectors". Oncology Reports 34, no. 5 (2015): 2289-2295. https://doi.org/10.3892/or.2015.4231
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team