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Review

MicroRNAs involved with hepatocellular carcinoma (Review)

  • Authors:
    • Bijing Mao
    • Ge Wang
  • View Affiliations / Copyright

    Affiliations: Cancer Center, Institute of Surgical Research, Daping Hospital, Third Military Medical University, Yuzhong, Chongqing 400042, P.R. China
  • Pages: 2811-2820
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    Published online on: September 15, 2015
       https://doi.org/10.3892/or.2015.4275
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Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies, which accounts for 90% of primary liver cancer. HCC usually presents with poor outcomes due to the high rates of tumor recurrence and widespread metastasis. However, the underlying mechanism of HCC initiation and progression, which significantly hindered the development of valid approaches for early detection and treatment remain to be elucidated. As a group of small non-coding RNAs, microRNAs (miRNAs) have been demonstrated to be involved in many types of diseases especially human malignancies. Numerous miRNAs are deregulated in HCC, which may shed some light on current investigations. Since miRNAs are stable and detected easily, their ectopic expression has been reported in HCC tissues, serum/plasma and cell lines. As previously described, miRNAs serve as tumor suppressors or oncogenes, indicating that miRNAs may be useful as diagnostic, therapeutic and prognostic markers of HCC. In the present review, we assessed the latest data regarding dysregulated miRNAs in HCC and reviewed the reported functions of these miRNAs as they apply to the diagnosis and prognosis of HCC.
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1 

Forner A, Llovet JM and Bruix J: Hepatocellular carcinoma. Lancet. 379:1245–1255. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Schwartz M, Roayaie S and Konstadoulakis M: Strategies for the management of hepatocellular carcinoma. Nat Clin Pract Oncol. 4:424–432. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Poon RT and Fan ST: Hepatectomy for hepatocellular carcinoma: Patient selection and postoperative outcome. Liver Transpl. 10(2 Suppl 1): S39–S45. 2004. View Article : Google Scholar : PubMed/NCBI

4 

He L and Hannon GJ: MicroRNAs: Small RNAs with a big role in gene regulation. Nat Rev Genet. 5:522–531. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Kloosterman WP and Plasterk RH: The diverse functions of microRNAs in animal development and disease. Dev Cell. 11:441–450. 2006. View Article : Google Scholar : PubMed/NCBI

6 

D'Anzeo M, Faloppi L, Scartozzi M, Giampieri R, Bianconi M, Del Prete M, Silvestris N and Cascinu S: The role of micro-RNAs in hepatocellular carcinoma: From molecular biology to treatment. Molecules. 19:6393–6406. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Carthew RW and Sontheimer EJ: Origins and mechanisms of miRNAs and siRNAs. Cell. 136:642–655. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Garajová I, Le Large TY, Frampton AE, Rolfo C, Voortman J and Giovannetti E: Molecular mechanisms underlying the role of microRNAs in the chemoresistance of pancreatic cancer. Biomed Res Int. 2014:6784012014. View Article : Google Scholar : PubMed/NCBI

9 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Han J, Lee Y, Yeom KH, Kim YK, Jin H and Kim VN: The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev. 18:3016–3027. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, Rådmark O, Kim S, et al: The nuclear RNase III Drosha initiates microRNA processing. Nature. 425:415–419. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Yi R, Qin Y, Macara IG and Cullen BR: Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17:3011–3016. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Denli AM, Tops BB, Plasterk RH, Ketting RF and Hannon GJ: Processing of primary microRNAs by the microprocessor complex. Nature. 432:231–235. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Borchert GM, Lanier W and Davidson BL: RNA polymerase III transcribes human microRNAs. Nat Struct Mol Biol. 13:1097–1101. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Cai X, Hagedorn CH and Cullen BR: Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA. 10:1957–1966. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Weber B, Stresemann C, Brueckner B and Lyko F: Methylation of human microRNA genes in normal and neoplastic cells. Cell Cycle. 6:1001–1005. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Scott GK, Mattie MD, Berger CE, Benz SC and Benz CC: Rapid alteration of microRNA levels by histone deacetylase inhibition. Cancer Res. 66:1277–1281. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Klein U, Lia M, Crespo M, Siegel R, Shen Q, Mo T, Ambesi-Impiombato A, Califano A, Migliazza A, Bhagat G, et al: The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell. 17:28–40. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Costinean S, Zanesi N, Pekarsky Y, Tili E, Volinia S, Heerema N and Croce CM: Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci USA. 103:7024–7029. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Chen KJ, Hou Y, Wang K, Li J, Xia Y, Yang XY, Lv G, Xing XL and Shen F: Reexpression of Let-7g microRNA inhibits the proliferation and migration via K-Ras/HMGA2/snail axis in hepatocellular carcinoma. Biomed Res Int. 2014:7424172014.PubMed/NCBI

21 

Nassirpour R, Mehta PP and Yin MJ: miR-122 regulates tumori-genesis in hepatocellular carcinoma by targeting AKT3. PLoS One. 8:e796552013. View Article : Google Scholar

22 

Wang SC, Lin XL, Li J, Zhang TT, Wang HY, Shi JW, Yang S, Zhao WT, Xie RY, Wei F, et al: MicroRNA-122 triggers mesenchymal-epithelial transition and suppresses hepatocellular carcinoma cell motility and invasion by targeting RhoA. PLoS One. 9:e1013302014. View Article : Google Scholar : PubMed/NCBI

23 

Jin JC, Zhang X, Jin XL, Qian CS, Jiang H and Ruan Y: Micro-RNA-122 regulation of the morphology and cytoarchitecture of hepatoma carcinoma cells. Mol Med Rep. 9:1376–1380. 2014.PubMed/NCBI

24 

Xing TJ, Xu HT, Yu WQ and Jiang DF: Methylation regulation of liver-specific microRNA-122 expression and its effects on the proliferation and apoptosis of hepatocellular carcinoma cells. Genet Mol Res. 12:3588–3597. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Lee JM, Heo MJ, Lee CG, Yang YM and Kim SG: Increase of miR-199a-5p by protoporphyrin IX, a photocatalyzer, directly inhibits E2F3, sensitizing mesenchymal tumor cells to anticancer agents. Oncotarget. 6:3918–3931. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Xu N, Zhang J, Shen C, Luo Y, Xia L, Xue F and Xia Q: Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell. Biochem Biophys Res Commun. 423:826–831. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Peveling-Oberhag J, Seiz A, Döring C, Hartmann S, Köberle V, Liese J, Zeuzem S, Hansmann ML and Piiper A: MicroRNA profiling of laser-microdissected hepatocellular carcinoma reveals an oncogenic phenotype of the tumor capsule. Transl Oncol. 7:672–680. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Wang CX, Song W, Li ZJ, Song B, Wu DH, Sun AM and Chen LH: MicroRNA profiling in patients with hepatocellular carcinoma. Nan Fang Yi Ke Da Xue Xue Bao. 30:976–977. 2010.In Chinese. PubMed/NCBI

29 

Zhang J, Zhang D, Wu GQ, Feng ZY and Zhu SM: Propofol inhibits the adhesion of hepatocellular carcinoma cells by upreg-ulating microRNA-199a and downregulating MMP-9 expression. Hepatobiliary Pancreat Dis Int. 12:305–309. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Fornari F, Milazzo M, Chieco P, Negrini M, Calin GA, Grazi GL, Pollutri D, Croce CM, Bolondi L and Gramantieri L: MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res. 70:5184–5193. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Henry JC, Park JK, Jiang J, Kim JH, Nagorney DM, Roberts LR, Banerjee S and Schmittgen TD: miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines. Biochem Biophys Res Commun. 403:120–125. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Jia XQ, Cheng HQ, Qian X, Bian CX, Shi ZM, Zhang JP, Jiang BH and Feng ZQ: Lentivirus-mediated overexpression of microRNA-199a inhibits cell proliferation of human hepatocellular carcinoma. Cell Biochem Biophys. 62:237–244. 2012. View Article : Google Scholar

33 

Shen Q, Cicinnati VR, Zhang X, Iacob S, Weber F, Sotiropoulos GC, Radtke A, Lu M, Paul A, Gerken G, et al: Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion. Mol Cancer. 9:2272010. View Article : Google Scholar : PubMed/NCBI

34 

Song J, Gao L, Yang G, Tang S, Xie H, Wang Y, Wang J, Zhang Y, Jin J, Gou Y, et al: MiR-199a regulates cell proliferation and survival by targeting FZD7. PLoS One. 9:e1100742014. View Article : Google Scholar : PubMed/NCBI

35 

Otsuka M, Kishikawa T, Yoshikawa T, Ohno M, Takata A, Shibata C and Koike K: The role of microRNAs in hepato-carcinogenesis: Current knowledge and future prospects. J Gastroenterol. 49:173–184. 2014. View Article : Google Scholar

36 

Fan MQ, Huang CB, Gu Y, Xiao Y, Sheng JX and Zhong L: Decrease expression of microRNA-20a promotes cancer cell proliferation and predicts poor survival of hepatocellular carcinoma. J Exp Clin Cancer Res. 32:212013. View Article : Google Scholar : PubMed/NCBI

37 

Xiao F, Zhang W, Chen L, Chen F, Xie H, Xing C, Yu X, Ding S, Chen K, Guo H, et al: MicroRNA-503 inhibits the G1/S transition by downregulating cyclin D3 and E2F3 in hepatocellular carcinoma. J Transl Med. 11:1952013. View Article : Google Scholar : PubMed/NCBI

38 

Chen J and Wang X: MicroRNA-21 in breast cancer: Diagnostic and prognostic potential. Clin Transl Oncol. 16:225–233. 2014. View Article : Google Scholar

39 

Huang Y, Yang YB, Zhang XH, Yu XL, Wang ZB and Cheng XC: MicroRNA-21 gene and cancer. Med Oncol. 30:3762013. View Article : Google Scholar : PubMed/NCBI

40 

Pan X, Wang ZX and Wang R: MicroRNA-21: A novel therapeutic target in human cancer. Cancer Biol Ther. 10:1224–1232. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Zhou L, Yang ZX, Song WJ, Li QJ, Yang F, Wang DS, Zhang N and Dou KF: MicroRNA-21 regulates the migration and invasion of a stem-like population in hepatocellular carcinoma. Int J Oncol. 43:661–669. 2013.PubMed/NCBI

42 

Bao L, Yan Y, Xu C, Ji W, Shen S, Xu G, Zeng Y, Sun B, Qian H, Chen L, et al: MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways. Cancer Lett. 337:226–236. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Hu S, Tao R, Wang S, Wang C, Zhao X, Zhao H, Li L, Zhu S, He Y, Jiang X, et al: MicroRNA-21 promotes cell proliferation in human hepatocellular carcinoma partly by targeting HEPN1. Tumour Biol. Feb 17–2015.Epub ahead of print. View Article : Google Scholar

44 

Xu G, Zhang Y, Wei J, Jia W, Ge Z, Zhang Z and Liu X: MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3. BMC Cancer. 13:4692013. View Article : Google Scholar : PubMed/NCBI

45 

Gramantieri L, Fornari F, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Croce CM, Bolondi L and Negrini M: MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality. Clin Cancer Res. 15:5073–5081. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Ma D, Tao X, Gao F, Fan C and Wu D: miR-224 functions as an onco-miRNA in hepatocellular carcinoma cells by activating AKT signaling. Oncol Lett. 4:483–488. 2012.

47 

Li Q, Ding C, Chen C, Zhang Z, Xiao H, Xie F, Lei L, Chen Y, Mao B, Jiang M, et al: miR-224 promotion of cell migration and invasion by targeting Homeobox D 10 gene in human hepatocel-lular carcinoma. J Gastroenterol Hepatol. 29:835–842. 2014. View Article : Google Scholar

48 

Zhou J, Lu S, Yang S, Chen H, Shi H, Miao M and Jiao B: MicroRNA-127 post-transcriptionally downregulates Sept7 and suppresses cell growth in hepatocellular carcinoma cells. Cell Physiol Biochem. 33:1537–1546. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Callegari E, Elamin BK, Sabbioni S, Gramantieri L and Negrini M: Role of microRNAs in hepatocellular carcinoma: A clinical perspective. Onco Targets Ther. 6:1167–1178. 2013.PubMed/NCBI

50 

Anwar SL and Lehmann U: DNA methylation, microRNAs, and their crosstalk as potential biomarkers in hepatocellular carcinoma. World J Gastroenterol. 20:7894–7913. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Zhou L, He J and Zhang Y: MicroRNA-22 expression in hepatocellular carcinoma and its correlation with ezrin protein. J Int Med Res. 41:1009–1016. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Bae HJ, Noh JH, Kim JK, Eun JW, Jung KH, Kim MG, Chang YG, Shen Q, Kim SJ, Park WS, et al: MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepato-cellular carcinoma. Oncogene. 33:2557–2567. 2014. View Article : Google Scholar

53 

Xie K, Liu J, Chen J, Dong J, Ma H, Liu Y and Hu Z: Methylation-associated silencing of microRNA-34b in hepatocellular carcinoma cancer. Gene. 543:101–107. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Shen Q, Bae HJ, Eun JW, Kim HS, Park SJ, Shin WC, Lee EK, Park S, Park WS, Lee JY, et al: MiR-101 functions as a tumor suppressor by directly targeting nemo-like kinase in liver cancer. Cancer Lett. 344:204–211. 2014. View Article : Google Scholar

55 

Lu Y, Yue X, Cui Y, Zhang J and Wang K: MicroRNA-124 suppresses growth of human hepatocellular carcinoma by targeting STAT3. Biochem Biophys Res Commun. 441:873–879. 2013. View Article : Google Scholar : PubMed/NCBI

56 

Tsang FH, Au V, Lu WJ, Shek FH, Liu AM, Luk JM, Fan ST, Poon RT and Lee NP: Prognostic marker microRNA-125b inhibits tumorigenic properties of hepatocellular carcinoma cells via suppressing tumorigenic molecule eIF5A2. Dig Dis Sci. 59:2477–2487. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Liu LL, Lu SX, Li M, Li LZ, Fu J, Hu W, Yang YZ, Luo RZ, Zhang CZ and Yun JP: FoxD3-regulated microRNA-137 suppresses tumour growth and metastasis in human hepatocellular carcinoma by targeting AKT2. Oncotarget. 5:5113–5124. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Long XR, He Y, Huang C and Li J: MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in hepatocellular carcinogenesis. Int J Oncol. 44:1915–1922. 2014.PubMed/NCBI

59 

Zhang Z, Zheng W and Hai J: MicroRNA-148b expression is decreased in hepatocellular carcinoma and associated with prognosis. Med Oncol. 31:9842014. View Article : Google Scholar : PubMed/NCBI

60 

Zhi Q, Zhu J, Guo X, He S, Xue X, Zhou J, Hu B, Li H, Chen S, Zhao H, et al: MMetastasis-related miR-185 is a potential prognostic biomarker for hepatocellular carcinoma in early stage. Biomed Pharmacother. 67:393–398. 2013. View Article : Google Scholar : PubMed/NCBI

61 

Qadir XV, Han C, Lu D, Zhang J and Wu T: miR-185 inhibits hepatocellular carcinoma growth by targeting the DNMT1/PTEN/Akt pathway. Am J Pathol. 184:2355–2364. 2014. View Article : Google Scholar : PubMed/NCBI

62 

Xiao F, Zhang W, Zhou L, Xie H, Xing C, Ding S, Chen K and Zheng S: microRNA-200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6. Oncol Rep. 30:2203–2210. 2013.PubMed/NCBI

63 

Zhang Y, Zheng D, Xiong Y, Xue C, Chen G, Yan B and Ye Q: miR-202 suppresses cell proliferation in human hepatocellular carcinoma by downregulating LRP6 post-transcriptionally. FEBS Lett. 588:1913–1920. 2014. View Article : Google Scholar : PubMed/NCBI

64 

Wang J, Li J, Wang X, Zheng C and Ma W: Downregulation of microRNA-214 and overexpression of FGFR-1 contribute to hepatocellular carcinoma metastasis. Biochem Biophys Res Commun. 439:47–53. 2013. View Article : Google Scholar : PubMed/NCBI

65 

Yu L, Ding GF, He C, Sun L, Jiang Y and Zhu L: MicroRNA-424 is down-regulated in hepatocellular carcinoma and suppresses cell migration and invasion through c-Myb. PLoS One. 9:e916612014. View Article : Google Scholar : PubMed/NCBI

66 

Miao HL, Lei CJ, Qiu ZD, Liu ZK, Li R, Bao ST and Li MY: MicroRNA-520c-3p inhibits hepatocellular carcinoma cell proliferation and invasion through induction of cell apoptosis by targeting glypican-3. Hepatol Res. 44:338–348. 2014. View Article : Google Scholar

67 

Sun Z, Han Q, Zhou N, Wang S, Lu S, Bai C and Zhao RC: MicroRNA-9 enhances migration and invasion through KLF17 in hepatocellular carcinoma. Mol Oncol. 7:884–894. 2013. View Article : Google Scholar : PubMed/NCBI

68 

Murakami Y, Tamori A, Itami S, Tanahashi T, Toyoda H, Tanaka M, Wu W, Brojigin N, Kaneoka Y, Maeda A, et al: The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis. BMC Cancer. 13:992013. View Article : Google Scholar : PubMed/NCBI

69 

Su ZX, Zhao J, Rong ZH, Geng WM, Wu YG and Qin CK: Upregulation of microRNA-25 associates with prognosis in hepatocellular carcinoma. Diagn Pathol. 9:472014. View Article : Google Scholar : PubMed/NCBI

70 

Yang H, Zheng W, Zhao W, Guan C and An J: Roles of miR-590-5p and miR-590-3p in the development of hepatocellular carcinoma. Nan Fang Yi Ke Da Xue Xue Bao. 33:804–811. 2013.In Chinese. PubMed/NCBI

71 

Jiang L, Cheng Q, Zhang BH and Zhang MZ: Circulating microRNAs as biomarkers in hepatocellular carcinoma screening: A validation set from China. Medicine. 94:e6032015. View Article : Google Scholar : PubMed/NCBI

72 

Wen Y, Han J, Chen J, Dong J, Xia Y, Liu J, Jiang Y, Dai J, Lu J, Jin G, et al: Plasma miRNAs as early biomarkers for detecting hepatocellular carcinoma. Int J Cancer. 37:1679–1690. 2015. View Article : Google Scholar

73 

Zhang X, Hu S, Zhang X, Wang L, Zhang X, Yan B, Zhao J, Yang A and Zhang R: MicroRNA-7 arrests cell cycle in G1 phase by directly targeting CCNE1 in human hepatocellular carcinoma cells. Biochem Biophys Res Commun. 443:1078–1084. 2014. View Article : Google Scholar

74 

Wang N, Zhu M, Tsao SW, Man K, Zhang Z and Feng Y: MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma. Mol Cancer. 12:1192013. View Article : Google Scholar : PubMed/NCBI

75 

Chai ZT, Kong J, Zhu XD, Zhang YY, Lu L, Zhou JM, Wang LR, Zhang KZ, Zhang QB, Ao JY, et al: MicroRNA-26a inhibits angiogenesis by down-regulating VEGFA through the PIK3C2α/Akt/HIF-1α pathway in hepatocellular carcinoma. PLoS One. 8:e779572013. View Article : Google Scholar

76 

Shen G, Lin Y, Yang X, Zhang J, Xu Z and Jia H: MicroRNA-26b inhibits epithelial-mesenchymal transition in hepatocellular carcinoma by targeting USP9X. BMC Cancer. 14:3932014. View Article : Google Scholar : PubMed/NCBI

77 

Zhao N, Wang R, Zhou L, Zhu Y, Gong J and Zhuang SM: MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3. Mol Cancer. 13:352014. View Article : Google Scholar

78 

Chen Z, Ma T, Huang C, Zhang L, Lv X, Xu T, Hu T and Li J: MiR-27a modulates the MDR1/P-glycoprotein expression by inhibiting FZD7/β-catenin pathway in hepatocellular carcinoma cells. Cell Signal. 25:2693–2701. 2013. View Article : Google Scholar : PubMed/NCBI

79 

Yang F, Li QJ, Gong ZB, Zhou L, You N, Wang S, Li XL, Li JJ, An JZ, Wang DS, et al: MicroRNA-34a targets Bcl-2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment. Technol Cancer Res Treat. 13:77–86. 2014.

80 

Dang Y, Luo D, Rong M and Chen G: Underexpression of miR-34a in hepatocellular carcinoma and its contribution towards enhancement of proliferating inhibitory effects of agents targeting c-MET. PLoS One. 8:e610542013. View Article : Google Scholar : PubMed/NCBI

81 

Zhang J, Jin H, Liu H, Lv S, Wang B, Wang R, Liu H, Ding M, Yang Y, Li L, et al: MiRNA-99a directly regulates AGO2 through translational repression in hepatocellular carcinoma. Oncogenesis. 3:e972014. View Article : Google Scholar : PubMed/NCBI

82 

Chen P, Zhao X and Ma L: Downregulation of microRNA-100 correlates with tumor progression and poor prognosis in hepatocellular carcinoma. Mol Cell Biochem. 383:49–58. 2013. View Article : Google Scholar : PubMed/NCBI

83 

Zha R, Guo W, Zhang Z, Qiu Z, Wang Q, Ding J, Huang S, Chen T, Gu J, Yao M, et al: Genome-wide screening identified that miR-134 acts as a metastasis suppressor by targeting integrin β1 in hepatocellular carcinoma. PLoS One. 9:e876652014. View Article : Google Scholar

84 

Duan X, Hu J, Wang Y, Gao J, Peng D and Xia L: MicroRNA-145: A promising biomarker for hepatocellular carcinoma (HCC). Gene. 541:67–68. 2014. View Article : Google Scholar : PubMed/NCBI

85 

Liu Y, Wu C, Wang Y, Wen S, Wang J, Chen Z, He Q and Feng D: MicroRNA-145 inhibits cell proliferation by directly targeting ADAM17 in hepatocellular carcinoma. Oncol Rep. 32:1923–1930. 2014.PubMed/NCBI

86 

Wang Y, Hu C, Cheng J, Chen B, Ke Q, Lv Z, Wu J and Zhou Y: MicroRNA-145 suppresses hepatocellular carcinoma by targeting IRS1 and its downstream Akt signaling. Biochem Biophys Res Commun. 446:1255–1260. 2014. View Article : Google Scholar : PubMed/NCBI

87 

Noh JH, Chang YG, Kim MG, Jung KH, Kim JK, Bae HJ, Eun JW, Shen Q, Kim SJ, Kwon SH, et al: MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer. Cancer Lett. 335:455–462. 2013. View Article : Google Scholar : PubMed/NCBI

88 

Amer M, Elhefnawi M, El-Ahwany E, Awad AF, Gawad NA, Zada S and Tawab FM: Hsa-miR-195 targets PCMT1 in hepa-tocellular carcinoma that increases tumor life span. Tumour Biol. 35:11301–11309. 2014. View Article : Google Scholar : PubMed/NCBI

89 

Yang Y, Li M, Chang S, Wang L, Song T, Gao L, Hu L, Li Z, Liu L, Yao J, et al: MicroRNA-195 acts as a tumor suppressor by directly targeting Wnt3a in HepG2 hepatocellular carcinoma cells. Mol Med Rep. 10:2643–2648. 2014.PubMed/NCBI

90 

Yang T, Zheng ZM, Li XN, Li ZF, Wang Y, Geng YF, Bai L and Zhang XB: MiR-223 modulates multidrug resistance via down-regulation of ABCB1 in hepatocellular carcinoma cells. Exp Biol Med. 238:1024–1032. 2013. View Article : Google Scholar

91 

Yao J, Liang LH, Zhang Y, Ding J, Tian Q, Li JJ and He XH: GNAI1 suppresses tumor cell migration and invasion and is post-transcriptionally regulated by mir-320a/c/d in hepatocellular carcinoma. Cancer Biol Med. 9:234–241. 2012.

92 

Zhou P, Huang G, Zhao Y, Zhong D, Xu Z, Zeng Y, Zhang Y, Li S and He F: MicroRNA-363-mediated downregulation of S1PR1 suppresses the proliferation of hepatocellular carcinoma cells. Cell Signal. 26:1347–1354. 2014. View Article : Google Scholar : PubMed/NCBI

93 

Vaira V, Roncalli M, Carnaghi C, Faversani A, Maggioni M, Augello C, Rimassa L, Pressiani T, Spagnuolo G, Di Tommaso L, et al: MicroRNA-425-3p predicts response to sorafenib therapy in patients with hepatocellular carcinoma. Liver Int. 35:1077–1086. 2015. View Article : Google Scholar

94 

Zhang H, Feng Z, Huang R, Xia Z, Xiang G and Zhang J: MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1. Int J Oncol. 45:2143–2152. 2014.PubMed/NCBI

95 

Zhou Y, Li Y, Ye J, Jiang R, Yan H, Yang X, Liu Q and Zhang J: MicroRNA-491 is involved in metastasis of hepatocellular carcinoma by inhibitions of matrix metalloproteinase and epithelial to mesenchymal transition. Liver Int. 33:1271–1280. 2013. View Article : Google Scholar : PubMed/NCBI

96 

Tang J, Tao ZH, Wen D, Wan JL, Liu DL, Zhang S, Cui JF, Sun HC, Wang L, Zhou J, et al: MiR-612 suppresses the stemness of liver cancer via Wnt/β-catenin signaling. Biochem Biophys Res Commun. 447:210–215. 2014. View Article : Google Scholar : PubMed/NCBI

97 

Lin F, Ding R, Zheng S, Xing D, Hong W, Zhou Z and Shen J: Decrease expression of microRNA-744 promotes cell proliferation by targeting c-Myc in human hepatocellular carcinoma. Cancer Cell Int. 14:582014. View Article : Google Scholar : PubMed/NCBI

98 

Zhu K, Pan Q, Zhang X, Kong LQ, Fan J, Dai Z, Wang L, Yang XR, Hu J, Wan JL, et al: MiR-146a enhances angiogenic activity of endothelial cells in hepatocellular carcinoma by promoting PDGFRA expression. Carcinogenesis. 34:2071–2079. 2013. View Article : Google Scholar : PubMed/NCBI

99 

Qin J, Luo M, Qian H and Chen W: Upregulated miR-182 increases drug resistance in cisplatin-treated HCC cell by regulating TP53INP1. Gene. 538:342–347. 2014. View Article : Google Scholar : PubMed/NCBI

100 

Gao B, Gao K, Li L, Huang Z and Lin L: miR-184 functions as an oncogenic regulator in hepatocellular carcinoma (HCC). Biomed Pharmacother. 68:143–148. 2014. View Article : Google Scholar

101 

Wu GG, Li WH, He WG, Jiang N, Zhang GX, Chen W, Yang HF, Liu QL, Huang YN, Zhang L, et al: Mir-184 post-transcriptionally regulates SOX7 expression and promotes cell proliferation in human hepatocellular carcinoma. PLoS One. 9:e887962014. View Article : Google Scholar : PubMed/NCBI

102 

Hung TM, Ho CM, Liu YC, Lee JL, Liao YR, Wu YM, Ho MC, Chen CH, Lai HS and Lee PH: Up-regulation of microRNA-190b plays a role for decreased IGF-1 that induces insulin resistance in human hepatocellular carcinoma. PLoS One. 9:e894462014. View Article : Google Scholar : PubMed/NCBI

103 

Ren J, Chu Y, Ma H, Zhang Y, Zhang X, Zhao D, Li Z, Wang J, Gao YE, Xiao L, et al: Epigenetic interventions increase the radiation sensitivity of cancer cells. Curr Pharm Des. 20:1857–1865. 2014. View Article : Google Scholar

104 

Zhou S, Ye W, Ren J, Shao Q, Qi Y, Liang J and Zhang M: MicroRNA-381 increases radiosensitivity in esophageal squamous cell carcinoma. Am J Cancer Res. 5:267–277. 2015.PubMed/NCBI

105 

Ye C, Sun NX, Ma Y, Zhao Q, Zhang Q, Xu C, Wang SB, Sun SH, Wang F and Li W: MicroRNA-145 contributes to enhancing radiosensitivity of cervical cancer cells. FEBS Lett. 589:702–709. 2015. View Article : Google Scholar : PubMed/NCBI

106 

Li T, Yin J, Yuan L, Wang S, Yang L, Du X and Lu J: Downregulation of microRNA-139 is associated with hepato-cellular carcinoma risk and short-term survival. Oncol Rep. 31:1699–1706. 2014.PubMed/NCBI

107 

Gu W, Li X and Wang J: miR-139 regulates the proliferation and invasion of hepatocellular carcinoma through the WNT/TCF-4 pathway. Oncol Rep. 31:397–404. 2014.

108 

Liang X, Zeng J, Wang L, Fang M, Wang Q, Zhao M, Xu X, Liu Z, Li W, Liu S, et al: Histone demethylase retinoblastoma binding protein 2 is overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212. PLoS One. 8:e697842013. View Article : Google Scholar : PubMed/NCBI

109 

Ma Y, She XG, Ming YZ and Wan QQ: miR-24 promotes the proliferation and invasion of HCC cells by targeting SOX7. Tumour Biol. 35:10731–10736. 2014. View Article : Google Scholar : PubMed/NCBI

110 

Dai W, Wang C, Wang F, Wang Y, Shen M, Chen K, Cheng P, Zhang Y, Yang J, Zhu R, et al: Anti-miR-197 inhibits migration in HCC cells by targeting KAI 1/CD82. Biochem Biophys Res Commun. 446:541–548. 2014. View Article : Google Scholar : PubMed/NCBI

111 

Yang YF, Wang F, Xiao JJ, Song Y, Zhao YY, Cao Y, Bei YH and Yang CQ: MiR-222 overexpression promotes proliferation of human hepatocellular carcinoma HepG2 cells by downregulating p27. Int J Clin Exp Med. 7:893–902. 2014.PubMed/NCBI

112 

Pang F, Zha R, Zhao Y, Wang Q, Chen D, Zhang Z, Chen T, Yao M, Gu J and He X: MiR-525-3p enhances the migration and invasion of liver cancer cells by downregulating ZNF395. PLoS One. 9:e908672014. View Article : Google Scholar : PubMed/NCBI

113 

Sun Z, Meng C, Wang S, Zhou N, Guan M, Bai C, Lu S, Han Q and Zhao RC: MicroRNA-1246 enhances migration and invasion through CADM1 in hepatocellular carcinoma. BMC Cancer. 14:6162014. View Article : Google Scholar : PubMed/NCBI

114 

Köberle V, Kronenberger B, Pleli T, Trojan J, Imelmann E, Peveling-Oberhag J, Welker MW, Elhendawy M, Zeuzem S, Piiper A, et al: Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma. Eur J Cancer. 49:3442–3449. 2013. View Article : Google Scholar : PubMed/NCBI

115 

Ge W, Yu DC, Li QG, Chen X, Zhang CY and Ding YT: Expression of serum miR-16, let-7f, and miR-21 in patients with hepatocellular carcinoma and their clinical significances. Clin Lab. 60:427–434. 2014.PubMed/NCBI

116 

Meng FL, Wang W and Jia WD: Diagnostic and prognostic significance of serum miR-24-3p in HBV-related hepatocellular carcinoma. Med Oncol. 31:1772014. View Article : Google Scholar : PubMed/NCBI

117 

Luo J, Chen M, Huang H, Yuan T, Zhang M, Zhang K and Deng S: Circulating microRNA-122a as a diagnostic marker for hepatocellular carcinoma. Onco Targets Ther. 6:577–583. 2013.PubMed/NCBI

118 

Zhang ZQ, Meng H, Wang N, Liang LN, Liu LN, Lu SM and Luan Y: Serum microRNA 143 and microRNA 215 as potential biomarkers for the diagnosis of chronic hepatitis and hepatocel-lular carcinoma. Diagn Pathol. 9:1352014. View Article : Google Scholar

119 

Li J, Wang Y, Yu W, Chen J and Luo J: Expression of serum miR-221 in human hepatocellular carcinoma and its prognostic significance. Biochem Biophys Res Commun. 406:70–73. 2011. View Article : Google Scholar : PubMed/NCBI

120 

Zhan MX, Li Y, Hu BS, Shao PJ, Meng QW, He X, Huang JW and Lu LG: Expression of serum microRNAs (miR-222, miR-181, miR-216) in human hepatocellular carcinoma and its clinical significance. Zhonghua Yi Xue Za Zhi. 93:1830–1832. 2013.In Chinese. PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mao B and Wang G: MicroRNAs involved with hepatocellular carcinoma (Review). Oncol Rep 34: 2811-2820, 2015.
APA
Mao, B., & Wang, G. (2015). MicroRNAs involved with hepatocellular carcinoma (Review). Oncology Reports, 34, 2811-2820. https://doi.org/10.3892/or.2015.4275
MLA
Mao, B., Wang, G."MicroRNAs involved with hepatocellular carcinoma (Review)". Oncology Reports 34.6 (2015): 2811-2820.
Chicago
Mao, B., Wang, G."MicroRNAs involved with hepatocellular carcinoma (Review)". Oncology Reports 34, no. 6 (2015): 2811-2820. https://doi.org/10.3892/or.2015.4275
Copy and paste a formatted citation
x
Spandidos Publications style
Mao B and Wang G: MicroRNAs involved with hepatocellular carcinoma (Review). Oncol Rep 34: 2811-2820, 2015.
APA
Mao, B., & Wang, G. (2015). MicroRNAs involved with hepatocellular carcinoma (Review). Oncology Reports, 34, 2811-2820. https://doi.org/10.3892/or.2015.4275
MLA
Mao, B., Wang, G."MicroRNAs involved with hepatocellular carcinoma (Review)". Oncology Reports 34.6 (2015): 2811-2820.
Chicago
Mao, B., Wang, G."MicroRNAs involved with hepatocellular carcinoma (Review)". Oncology Reports 34, no. 6 (2015): 2811-2820. https://doi.org/10.3892/or.2015.4275
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