|
1
|
Forner A, Llovet JM and Bruix J:
Hepatocellular carcinoma. Lancet. 379:1245–1255. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Schwartz M, Roayaie S and Konstadoulakis
M: Strategies for the management of hepatocellular carcinoma. Nat
Clin Pract Oncol. 4:424–432. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Poon RT and Fan ST: Hepatectomy for
hepatocellular carcinoma: Patient selection and postoperative
outcome. Liver Transpl. 10(2 Suppl 1): S39–S45. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
He L and Hannon GJ: MicroRNAs: Small RNAs
with a big role in gene regulation. Nat Rev Genet. 5:522–531. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Kloosterman WP and Plasterk RH: The
diverse functions of microRNAs in animal development and disease.
Dev Cell. 11:441–450. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
D'Anzeo M, Faloppi L, Scartozzi M,
Giampieri R, Bianconi M, Del Prete M, Silvestris N and Cascinu S:
The role of micro-RNAs in hepatocellular carcinoma: From molecular
biology to treatment. Molecules. 19:6393–6406. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Carthew RW and Sontheimer EJ: Origins and
mechanisms of miRNAs and siRNAs. Cell. 136:642–655. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Garajová I, Le Large TY, Frampton AE,
Rolfo C, Voortman J and Giovannetti E: Molecular mechanisms
underlying the role of microRNAs in the chemoresistance of
pancreatic cancer. Biomed Res Int. 2014:6784012014. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Ambros V: The functions of animal
microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Han J, Lee Y, Yeom KH, Kim YK, Jin H and
Kim VN: The Drosha-DGCR8 complex in primary microRNA processing.
Genes Dev. 18:3016–3027. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J,
Lee J, Provost P, Rådmark O, Kim S, et al: The nuclear RNase III
Drosha initiates microRNA processing. Nature. 425:415–419. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Yi R, Qin Y, Macara IG and Cullen BR:
Exportin-5 mediates the nuclear export of pre-microRNAs and short
hairpin RNAs. Genes Dev. 17:3011–3016. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Denli AM, Tops BB, Plasterk RH, Ketting RF
and Hannon GJ: Processing of primary microRNAs by the
microprocessor complex. Nature. 432:231–235. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Borchert GM, Lanier W and Davidson BL: RNA
polymerase III transcribes human microRNAs. Nat Struct Mol Biol.
13:1097–1101. 2006. View
Article : Google Scholar : PubMed/NCBI
|
|
15
|
Cai X, Hagedorn CH and Cullen BR: Human
microRNAs are processed from capped, polyadenylated transcripts
that can also function as mRNAs. RNA. 10:1957–1966. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Weber B, Stresemann C, Brueckner B and
Lyko F: Methylation of human microRNA genes in normal and
neoplastic cells. Cell Cycle. 6:1001–1005. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Scott GK, Mattie MD, Berger CE, Benz SC
and Benz CC: Rapid alteration of microRNA levels by histone
deacetylase inhibition. Cancer Res. 66:1277–1281. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Klein U, Lia M, Crespo M, Siegel R, Shen
Q, Mo T, Ambesi-Impiombato A, Califano A, Migliazza A, Bhagat G, et
al: The DLEU2/miR-15a/16-1 cluster controls B cell proliferation
and its deletion leads to chronic lymphocytic leukemia. Cancer
Cell. 17:28–40. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Costinean S, Zanesi N, Pekarsky Y, Tili E,
Volinia S, Heerema N and Croce CM: Pre-B cell proliferation and
lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155
transgenic mice. Proc Natl Acad Sci USA. 103:7024–7029. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Chen KJ, Hou Y, Wang K, Li J, Xia Y, Yang
XY, Lv G, Xing XL and Shen F: Reexpression of Let-7g microRNA
inhibits the proliferation and migration via K-Ras/HMGA2/snail axis
in hepatocellular carcinoma. Biomed Res Int.
2014:7424172014.PubMed/NCBI
|
|
21
|
Nassirpour R, Mehta PP and Yin MJ: miR-122
regulates tumori-genesis in hepatocellular carcinoma by targeting
AKT3. PLoS One. 8:e796552013. View Article : Google Scholar
|
|
22
|
Wang SC, Lin XL, Li J, Zhang TT, Wang HY,
Shi JW, Yang S, Zhao WT, Xie RY, Wei F, et al: MicroRNA-122
triggers mesenchymal-epithelial transition and suppresses
hepatocellular carcinoma cell motility and invasion by targeting
RhoA. PLoS One. 9:e1013302014. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Jin JC, Zhang X, Jin XL, Qian CS, Jiang H
and Ruan Y: Micro-RNA-122 regulation of the morphology and
cytoarchitecture of hepatoma carcinoma cells. Mol Med Rep.
9:1376–1380. 2014.PubMed/NCBI
|
|
24
|
Xing TJ, Xu HT, Yu WQ and Jiang DF:
Methylation regulation of liver-specific microRNA-122 expression
and its effects on the proliferation and apoptosis of
hepatocellular carcinoma cells. Genet Mol Res. 12:3588–3597. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Lee JM, Heo MJ, Lee CG, Yang YM and Kim
SG: Increase of miR-199a-5p by protoporphyrin IX, a photocatalyzer,
directly inhibits E2F3, sensitizing mesenchymal tumor cells to
anticancer agents. Oncotarget. 6:3918–3931. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Xu N, Zhang J, Shen C, Luo Y, Xia L, Xue F
and Xia Q: Cisplatin-induced downregulation of miR-199a-5p
increases drug resistance by activating autophagy in HCC cell.
Biochem Biophys Res Commun. 423:826–831. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Peveling-Oberhag J, Seiz A, Döring C,
Hartmann S, Köberle V, Liese J, Zeuzem S, Hansmann ML and Piiper A:
MicroRNA profiling of laser-microdissected hepatocellular carcinoma
reveals an oncogenic phenotype of the tumor capsule. Transl Oncol.
7:672–680. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Wang CX, Song W, Li ZJ, Song B, Wu DH, Sun
AM and Chen LH: MicroRNA profiling in patients with hepatocellular
carcinoma. Nan Fang Yi Ke Da Xue Xue Bao. 30:976–977. 2010.In
Chinese. PubMed/NCBI
|
|
29
|
Zhang J, Zhang D, Wu GQ, Feng ZY and Zhu
SM: Propofol inhibits the adhesion of hepatocellular carcinoma
cells by upreg-ulating microRNA-199a and downregulating MMP-9
expression. Hepatobiliary Pancreat Dis Int. 12:305–309. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Fornari F, Milazzo M, Chieco P, Negrini M,
Calin GA, Grazi GL, Pollutri D, Croce CM, Bolondi L and Gramantieri
L: MiR-199a-3p regulates mTOR and c-Met to influence the
doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res.
70:5184–5193. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Henry JC, Park JK, Jiang J, Kim JH,
Nagorney DM, Roberts LR, Banerjee S and Schmittgen TD: miR-199a-3p
targets CD44 and reduces proliferation of CD44 positive
hepatocellular carcinoma cell lines. Biochem Biophys Res Commun.
403:120–125. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Jia XQ, Cheng HQ, Qian X, Bian CX, Shi ZM,
Zhang JP, Jiang BH and Feng ZQ: Lentivirus-mediated overexpression
of microRNA-199a inhibits cell proliferation of human
hepatocellular carcinoma. Cell Biochem Biophys. 62:237–244. 2012.
View Article : Google Scholar
|
|
33
|
Shen Q, Cicinnati VR, Zhang X, Iacob S,
Weber F, Sotiropoulos GC, Radtke A, Lu M, Paul A, Gerken G, et al:
Role of microRNA-199a-5p and discoidin domain receptor 1 in human
hepatocellular carcinoma invasion. Mol Cancer. 9:2272010.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Song J, Gao L, Yang G, Tang S, Xie H, Wang
Y, Wang J, Zhang Y, Jin J, Gou Y, et al: MiR-199a regulates cell
proliferation and survival by targeting FZD7. PLoS One.
9:e1100742014. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Otsuka M, Kishikawa T, Yoshikawa T, Ohno
M, Takata A, Shibata C and Koike K: The role of microRNAs in
hepato-carcinogenesis: Current knowledge and future prospects. J
Gastroenterol. 49:173–184. 2014. View Article : Google Scholar
|
|
36
|
Fan MQ, Huang CB, Gu Y, Xiao Y, Sheng JX
and Zhong L: Decrease expression of microRNA-20a promotes cancer
cell proliferation and predicts poor survival of hepatocellular
carcinoma. J Exp Clin Cancer Res. 32:212013. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Xiao F, Zhang W, Chen L, Chen F, Xie H,
Xing C, Yu X, Ding S, Chen K, Guo H, et al: MicroRNA-503 inhibits
the G1/S transition by downregulating cyclin D3 and E2F3 in
hepatocellular carcinoma. J Transl Med. 11:1952013. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Chen J and Wang X: MicroRNA-21 in breast
cancer: Diagnostic and prognostic potential. Clin Transl Oncol.
16:225–233. 2014. View Article : Google Scholar
|
|
39
|
Huang Y, Yang YB, Zhang XH, Yu XL, Wang ZB
and Cheng XC: MicroRNA-21 gene and cancer. Med Oncol. 30:3762013.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Pan X, Wang ZX and Wang R: MicroRNA-21: A
novel therapeutic target in human cancer. Cancer Biol Ther.
10:1224–1232. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Zhou L, Yang ZX, Song WJ, Li QJ, Yang F,
Wang DS, Zhang N and Dou KF: MicroRNA-21 regulates the migration
and invasion of a stem-like population in hepatocellular carcinoma.
Int J Oncol. 43:661–669. 2013.PubMed/NCBI
|
|
42
|
Bao L, Yan Y, Xu C, Ji W, Shen S, Xu G,
Zeng Y, Sun B, Qian H, Chen L, et al: MicroRNA-21 suppresses PTEN
and hSulf-1 expression and promotes hepatocellular carcinoma
progression through AKT/ERK pathways. Cancer Lett. 337:226–236.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Hu S, Tao R, Wang S, Wang C, Zhao X, Zhao
H, Li L, Zhu S, He Y, Jiang X, et al: MicroRNA-21 promotes cell
proliferation in human hepatocellular carcinoma partly by targeting
HEPN1. Tumour Biol. Feb 17–2015.Epub ahead of print. View Article : Google Scholar
|
|
44
|
Xu G, Zhang Y, Wei J, Jia W, Ge Z, Zhang Z
and Liu X: MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell
proliferation through repression of mitogen-activated protein
kinase-kinase 3. BMC Cancer. 13:4692013. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Gramantieri L, Fornari F, Ferracin M,
Veronese A, Sabbioni S, Calin GA, Grazi GL, Croce CM, Bolondi L and
Negrini M: MicroRNA-221 targets Bmf in hepatocellular carcinoma and
correlates with tumor multifocality. Clin Cancer Res. 15:5073–5081.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Ma D, Tao X, Gao F, Fan C and Wu D:
miR-224 functions as an onco-miRNA in hepatocellular carcinoma
cells by activating AKT signaling. Oncol Lett. 4:483–488. 2012.
|
|
47
|
Li Q, Ding C, Chen C, Zhang Z, Xiao H, Xie
F, Lei L, Chen Y, Mao B, Jiang M, et al: miR-224 promotion of cell
migration and invasion by targeting Homeobox D 10 gene in human
hepatocel-lular carcinoma. J Gastroenterol Hepatol. 29:835–842.
2014. View Article : Google Scholar
|
|
48
|
Zhou J, Lu S, Yang S, Chen H, Shi H, Miao
M and Jiao B: MicroRNA-127 post-transcriptionally downregulates
Sept7 and suppresses cell growth in hepatocellular carcinoma cells.
Cell Physiol Biochem. 33:1537–1546. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Callegari E, Elamin BK, Sabbioni S,
Gramantieri L and Negrini M: Role of microRNAs in hepatocellular
carcinoma: A clinical perspective. Onco Targets Ther. 6:1167–1178.
2013.PubMed/NCBI
|
|
50
|
Anwar SL and Lehmann U: DNA methylation,
microRNAs, and their crosstalk as potential biomarkers in
hepatocellular carcinoma. World J Gastroenterol. 20:7894–7913.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Zhou L, He J and Zhang Y: MicroRNA-22
expression in hepatocellular carcinoma and its correlation with
ezrin protein. J Int Med Res. 41:1009–1016. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Bae HJ, Noh JH, Kim JK, Eun JW, Jung KH,
Kim MG, Chang YG, Shen Q, Kim SJ, Park WS, et al: MicroRNA-29c
functions as a tumor suppressor by direct targeting oncogenic SIRT1
in hepato-cellular carcinoma. Oncogene. 33:2557–2567. 2014.
View Article : Google Scholar
|
|
53
|
Xie K, Liu J, Chen J, Dong J, Ma H, Liu Y
and Hu Z: Methylation-associated silencing of microRNA-34b in
hepatocellular carcinoma cancer. Gene. 543:101–107. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Shen Q, Bae HJ, Eun JW, Kim HS, Park SJ,
Shin WC, Lee EK, Park S, Park WS, Lee JY, et al: MiR-101 functions
as a tumor suppressor by directly targeting nemo-like kinase in
liver cancer. Cancer Lett. 344:204–211. 2014. View Article : Google Scholar
|
|
55
|
Lu Y, Yue X, Cui Y, Zhang J and Wang K:
MicroRNA-124 suppresses growth of human hepatocellular carcinoma by
targeting STAT3. Biochem Biophys Res Commun. 441:873–879. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Tsang FH, Au V, Lu WJ, Shek FH, Liu AM,
Luk JM, Fan ST, Poon RT and Lee NP: Prognostic marker microRNA-125b
inhibits tumorigenic properties of hepatocellular carcinoma cells
via suppressing tumorigenic molecule eIF5A2. Dig Dis Sci.
59:2477–2487. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Liu LL, Lu SX, Li M, Li LZ, Fu J, Hu W,
Yang YZ, Luo RZ, Zhang CZ and Yun JP: FoxD3-regulated microRNA-137
suppresses tumour growth and metastasis in human hepatocellular
carcinoma by targeting AKT2. Oncotarget. 5:5113–5124. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Long XR, He Y, Huang C and Li J:
MicroRNA-148a is silenced by hypermethylation and interacts with
DNA methyltransferase 1 in hepatocellular carcinogenesis. Int J
Oncol. 44:1915–1922. 2014.PubMed/NCBI
|
|
59
|
Zhang Z, Zheng W and Hai J: MicroRNA-148b
expression is decreased in hepatocellular carcinoma and associated
with prognosis. Med Oncol. 31:9842014. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Zhi Q, Zhu J, Guo X, He S, Xue X, Zhou J,
Hu B, Li H, Chen S, Zhao H, et al: MMetastasis-related miR-185 is a
potential prognostic biomarker for hepatocellular carcinoma in
early stage. Biomed Pharmacother. 67:393–398. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Qadir XV, Han C, Lu D, Zhang J and Wu T:
miR-185 inhibits hepatocellular carcinoma growth by targeting the
DNMT1/PTEN/Akt pathway. Am J Pathol. 184:2355–2364. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Xiao F, Zhang W, Zhou L, Xie H, Xing C,
Ding S, Chen K and Zheng S: microRNA-200a is an independent
prognostic factor of hepatocellular carcinoma and induces cell
cycle arrest by targeting CDK6. Oncol Rep. 30:2203–2210.
2013.PubMed/NCBI
|
|
63
|
Zhang Y, Zheng D, Xiong Y, Xue C, Chen G,
Yan B and Ye Q: miR-202 suppresses cell proliferation in human
hepatocellular carcinoma by downregulating LRP6
post-transcriptionally. FEBS Lett. 588:1913–1920. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Wang J, Li J, Wang X, Zheng C and Ma W:
Downregulation of microRNA-214 and overexpression of FGFR-1
contribute to hepatocellular carcinoma metastasis. Biochem Biophys
Res Commun. 439:47–53. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Yu L, Ding GF, He C, Sun L, Jiang Y and
Zhu L: MicroRNA-424 is down-regulated in hepatocellular carcinoma
and suppresses cell migration and invasion through c-Myb. PLoS One.
9:e916612014. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Miao HL, Lei CJ, Qiu ZD, Liu ZK, Li R, Bao
ST and Li MY: MicroRNA-520c-3p inhibits hepatocellular carcinoma
cell proliferation and invasion through induction of cell apoptosis
by targeting glypican-3. Hepatol Res. 44:338–348. 2014. View Article : Google Scholar
|
|
67
|
Sun Z, Han Q, Zhou N, Wang S, Lu S, Bai C
and Zhao RC: MicroRNA-9 enhances migration and invasion through
KLF17 in hepatocellular carcinoma. Mol Oncol. 7:884–894. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Murakami Y, Tamori A, Itami S, Tanahashi
T, Toyoda H, Tanaka M, Wu W, Brojigin N, Kaneoka Y, Maeda A, et al:
The expression level of miR-18b in hepatocellular carcinoma is
associated with the grade of malignancy and prognosis. BMC Cancer.
13:992013. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Su ZX, Zhao J, Rong ZH, Geng WM, Wu YG and
Qin CK: Upregulation of microRNA-25 associates with prognosis in
hepatocellular carcinoma. Diagn Pathol. 9:472014. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Yang H, Zheng W, Zhao W, Guan C and An J:
Roles of miR-590-5p and miR-590-3p in the development of
hepatocellular carcinoma. Nan Fang Yi Ke Da Xue Xue Bao.
33:804–811. 2013.In Chinese. PubMed/NCBI
|
|
71
|
Jiang L, Cheng Q, Zhang BH and Zhang MZ:
Circulating microRNAs as biomarkers in hepatocellular carcinoma
screening: A validation set from China. Medicine. 94:e6032015.
View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Wen Y, Han J, Chen J, Dong J, Xia Y, Liu
J, Jiang Y, Dai J, Lu J, Jin G, et al: Plasma miRNAs as early
biomarkers for detecting hepatocellular carcinoma. Int J Cancer.
37:1679–1690. 2015. View Article : Google Scholar
|
|
73
|
Zhang X, Hu S, Zhang X, Wang L, Zhang X,
Yan B, Zhao J, Yang A and Zhang R: MicroRNA-7 arrests cell cycle in
G1 phase by directly targeting CCNE1 in human hepatocellular
carcinoma cells. Biochem Biophys Res Commun. 443:1078–1084. 2014.
View Article : Google Scholar
|
|
74
|
Wang N, Zhu M, Tsao SW, Man K, Zhang Z and
Feng Y: MiR-23a-mediated inhibition of topoisomerase 1 expression
potentiates cell response to etoposide in human hepatocellular
carcinoma. Mol Cancer. 12:1192013. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Chai ZT, Kong J, Zhu XD, Zhang YY, Lu L,
Zhou JM, Wang LR, Zhang KZ, Zhang QB, Ao JY, et al: MicroRNA-26a
inhibits angiogenesis by down-regulating VEGFA through the
PIK3C2α/Akt/HIF-1α pathway in hepatocellular carcinoma. PLoS One.
8:e779572013. View Article : Google Scholar
|
|
76
|
Shen G, Lin Y, Yang X, Zhang J, Xu Z and
Jia H: MicroRNA-26b inhibits epithelial-mesenchymal transition in
hepatocellular carcinoma by targeting USP9X. BMC Cancer.
14:3932014. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Zhao N, Wang R, Zhou L, Zhu Y, Gong J and
Zhuang SM: MicroRNA-26b suppresses the NF-κB signaling and enhances
the chemosensitivity of hepatocellular carcinoma cells by targeting
TAK1 and TAB3. Mol Cancer. 13:352014. View Article : Google Scholar
|
|
78
|
Chen Z, Ma T, Huang C, Zhang L, Lv X, Xu
T, Hu T and Li J: MiR-27a modulates the MDR1/P-glycoprotein
expression by inhibiting FZD7/β-catenin pathway in hepatocellular
carcinoma cells. Cell Signal. 25:2693–2701. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Yang F, Li QJ, Gong ZB, Zhou L, You N,
Wang S, Li XL, Li JJ, An JZ, Wang DS, et al: MicroRNA-34a targets
Bcl-2 and sensitizes human hepatocellular carcinoma cells to
sorafenib treatment. Technol Cancer Res Treat. 13:77–86. 2014.
|
|
80
|
Dang Y, Luo D, Rong M and Chen G:
Underexpression of miR-34a in hepatocellular carcinoma and its
contribution towards enhancement of proliferating inhibitory
effects of agents targeting c-MET. PLoS One. 8:e610542013.
View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Zhang J, Jin H, Liu H, Lv S, Wang B, Wang
R, Liu H, Ding M, Yang Y, Li L, et al: MiRNA-99a directly regulates
AGO2 through translational repression in hepatocellular carcinoma.
Oncogenesis. 3:e972014. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Chen P, Zhao X and Ma L: Downregulation of
microRNA-100 correlates with tumor progression and poor prognosis
in hepatocellular carcinoma. Mol Cell Biochem. 383:49–58. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Zha R, Guo W, Zhang Z, Qiu Z, Wang Q, Ding
J, Huang S, Chen T, Gu J, Yao M, et al: Genome-wide screening
identified that miR-134 acts as a metastasis suppressor by
targeting integrin β1 in hepatocellular carcinoma. PLoS One.
9:e876652014. View Article : Google Scholar
|
|
84
|
Duan X, Hu J, Wang Y, Gao J, Peng D and
Xia L: MicroRNA-145: A promising biomarker for hepatocellular
carcinoma (HCC). Gene. 541:67–68. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Liu Y, Wu C, Wang Y, Wen S, Wang J, Chen
Z, He Q and Feng D: MicroRNA-145 inhibits cell proliferation by
directly targeting ADAM17 in hepatocellular carcinoma. Oncol Rep.
32:1923–1930. 2014.PubMed/NCBI
|
|
86
|
Wang Y, Hu C, Cheng J, Chen B, Ke Q, Lv Z,
Wu J and Zhou Y: MicroRNA-145 suppresses hepatocellular carcinoma
by targeting IRS1 and its downstream Akt signaling. Biochem Biophys
Res Commun. 446:1255–1260. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Noh JH, Chang YG, Kim MG, Jung KH, Kim JK,
Bae HJ, Eun JW, Shen Q, Kim SJ, Kwon SH, et al: MiR-145 functions
as a tumor suppressor by directly targeting histone deacetylase 2
in liver cancer. Cancer Lett. 335:455–462. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Amer M, Elhefnawi M, El-Ahwany E, Awad AF,
Gawad NA, Zada S and Tawab FM: Hsa-miR-195 targets PCMT1 in
hepa-tocellular carcinoma that increases tumor life span. Tumour
Biol. 35:11301–11309. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Yang Y, Li M, Chang S, Wang L, Song T, Gao
L, Hu L, Li Z, Liu L, Yao J, et al: MicroRNA-195 acts as a tumor
suppressor by directly targeting Wnt3a in HepG2 hepatocellular
carcinoma cells. Mol Med Rep. 10:2643–2648. 2014.PubMed/NCBI
|
|
90
|
Yang T, Zheng ZM, Li XN, Li ZF, Wang Y,
Geng YF, Bai L and Zhang XB: MiR-223 modulates multidrug resistance
via down-regulation of ABCB1 in hepatocellular carcinoma cells. Exp
Biol Med. 238:1024–1032. 2013. View Article : Google Scholar
|
|
91
|
Yao J, Liang LH, Zhang Y, Ding J, Tian Q,
Li JJ and He XH: GNAI1 suppresses tumor cell migration and invasion
and is post-transcriptionally regulated by mir-320a/c/d in
hepatocellular carcinoma. Cancer Biol Med. 9:234–241. 2012.
|
|
92
|
Zhou P, Huang G, Zhao Y, Zhong D, Xu Z,
Zeng Y, Zhang Y, Li S and He F: MicroRNA-363-mediated
downregulation of S1PR1 suppresses the proliferation of
hepatocellular carcinoma cells. Cell Signal. 26:1347–1354. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Vaira V, Roncalli M, Carnaghi C, Faversani
A, Maggioni M, Augello C, Rimassa L, Pressiani T, Spagnuolo G, Di
Tommaso L, et al: MicroRNA-425-3p predicts response to sorafenib
therapy in patients with hepatocellular carcinoma. Liver Int.
35:1077–1086. 2015. View Article : Google Scholar
|
|
94
|
Zhang H, Feng Z, Huang R, Xia Z, Xiang G
and Zhang J: MicroRNA-449 suppresses proliferation of hepatoma cell
lines through blockade lipid metabolic pathway related to SIRT1.
Int J Oncol. 45:2143–2152. 2014.PubMed/NCBI
|
|
95
|
Zhou Y, Li Y, Ye J, Jiang R, Yan H, Yang
X, Liu Q and Zhang J: MicroRNA-491 is involved in metastasis of
hepatocellular carcinoma by inhibitions of matrix metalloproteinase
and epithelial to mesenchymal transition. Liver Int. 33:1271–1280.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Tang J, Tao ZH, Wen D, Wan JL, Liu DL,
Zhang S, Cui JF, Sun HC, Wang L, Zhou J, et al: MiR-612 suppresses
the stemness of liver cancer via Wnt/β-catenin signaling. Biochem
Biophys Res Commun. 447:210–215. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Lin F, Ding R, Zheng S, Xing D, Hong W,
Zhou Z and Shen J: Decrease expression of microRNA-744 promotes
cell proliferation by targeting c-Myc in human hepatocellular
carcinoma. Cancer Cell Int. 14:582014. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Zhu K, Pan Q, Zhang X, Kong LQ, Fan J, Dai
Z, Wang L, Yang XR, Hu J, Wan JL, et al: MiR-146a enhances
angiogenic activity of endothelial cells in hepatocellular
carcinoma by promoting PDGFRA expression. Carcinogenesis.
34:2071–2079. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Qin J, Luo M, Qian H and Chen W:
Upregulated miR-182 increases drug resistance in cisplatin-treated
HCC cell by regulating TP53INP1. Gene. 538:342–347. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Gao B, Gao K, Li L, Huang Z and Lin L:
miR-184 functions as an oncogenic regulator in hepatocellular
carcinoma (HCC). Biomed Pharmacother. 68:143–148. 2014. View Article : Google Scholar
|
|
101
|
Wu GG, Li WH, He WG, Jiang N, Zhang GX,
Chen W, Yang HF, Liu QL, Huang YN, Zhang L, et al: Mir-184
post-transcriptionally regulates SOX7 expression and promotes cell
proliferation in human hepatocellular carcinoma. PLoS One.
9:e887962014. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Hung TM, Ho CM, Liu YC, Lee JL, Liao YR,
Wu YM, Ho MC, Chen CH, Lai HS and Lee PH: Up-regulation of
microRNA-190b plays a role for decreased IGF-1 that induces insulin
resistance in human hepatocellular carcinoma. PLoS One.
9:e894462014. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Ren J, Chu Y, Ma H, Zhang Y, Zhang X, Zhao
D, Li Z, Wang J, Gao YE, Xiao L, et al: Epigenetic interventions
increase the radiation sensitivity of cancer cells. Curr Pharm Des.
20:1857–1865. 2014. View Article : Google Scholar
|
|
104
|
Zhou S, Ye W, Ren J, Shao Q, Qi Y, Liang J
and Zhang M: MicroRNA-381 increases radiosensitivity in esophageal
squamous cell carcinoma. Am J Cancer Res. 5:267–277.
2015.PubMed/NCBI
|
|
105
|
Ye C, Sun NX, Ma Y, Zhao Q, Zhang Q, Xu C,
Wang SB, Sun SH, Wang F and Li W: MicroRNA-145 contributes to
enhancing radiosensitivity of cervical cancer cells. FEBS Lett.
589:702–709. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Li T, Yin J, Yuan L, Wang S, Yang L, Du X
and Lu J: Downregulation of microRNA-139 is associated with
hepato-cellular carcinoma risk and short-term survival. Oncol Rep.
31:1699–1706. 2014.PubMed/NCBI
|
|
107
|
Gu W, Li X and Wang J: miR-139 regulates
the proliferation and invasion of hepatocellular carcinoma through
the WNT/TCF-4 pathway. Oncol Rep. 31:397–404. 2014.
|
|
108
|
Liang X, Zeng J, Wang L, Fang M, Wang Q,
Zhao M, Xu X, Liu Z, Li W, Liu S, et al: Histone demethylase
retinoblastoma binding protein 2 is overexpressed in hepatocellular
carcinoma and negatively regulated by hsa-miR-212. PLoS One.
8:e697842013. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Ma Y, She XG, Ming YZ and Wan QQ: miR-24
promotes the proliferation and invasion of HCC cells by targeting
SOX7. Tumour Biol. 35:10731–10736. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Dai W, Wang C, Wang F, Wang Y, Shen M,
Chen K, Cheng P, Zhang Y, Yang J, Zhu R, et al: Anti-miR-197
inhibits migration in HCC cells by targeting KAI 1/CD82. Biochem
Biophys Res Commun. 446:541–548. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Yang YF, Wang F, Xiao JJ, Song Y, Zhao YY,
Cao Y, Bei YH and Yang CQ: MiR-222 overexpression promotes
proliferation of human hepatocellular carcinoma HepG2 cells by
downregulating p27. Int J Clin Exp Med. 7:893–902. 2014.PubMed/NCBI
|
|
112
|
Pang F, Zha R, Zhao Y, Wang Q, Chen D,
Zhang Z, Chen T, Yao M, Gu J and He X: MiR-525-3p enhances the
migration and invasion of liver cancer cells by downregulating
ZNF395. PLoS One. 9:e908672014. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Sun Z, Meng C, Wang S, Zhou N, Guan M, Bai
C, Lu S, Han Q and Zhao RC: MicroRNA-1246 enhances migration and
invasion through CADM1 in hepatocellular carcinoma. BMC Cancer.
14:6162014. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Köberle V, Kronenberger B, Pleli T, Trojan
J, Imelmann E, Peveling-Oberhag J, Welker MW, Elhendawy M, Zeuzem
S, Piiper A, et al: Serum microRNA-1 and microRNA-122 are
prognostic markers in patients with hepatocellular carcinoma. Eur J
Cancer. 49:3442–3449. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Ge W, Yu DC, Li QG, Chen X, Zhang CY and
Ding YT: Expression of serum miR-16, let-7f, and miR-21 in patients
with hepatocellular carcinoma and their clinical significances.
Clin Lab. 60:427–434. 2014.PubMed/NCBI
|
|
116
|
Meng FL, Wang W and Jia WD: Diagnostic and
prognostic significance of serum miR-24-3p in HBV-related
hepatocellular carcinoma. Med Oncol. 31:1772014. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Luo J, Chen M, Huang H, Yuan T, Zhang M,
Zhang K and Deng S: Circulating microRNA-122a as a diagnostic
marker for hepatocellular carcinoma. Onco Targets Ther. 6:577–583.
2013.PubMed/NCBI
|
|
118
|
Zhang ZQ, Meng H, Wang N, Liang LN, Liu
LN, Lu SM and Luan Y: Serum microRNA 143 and microRNA 215 as
potential biomarkers for the diagnosis of chronic hepatitis and
hepatocel-lular carcinoma. Diagn Pathol. 9:1352014. View Article : Google Scholar
|
|
119
|
Li J, Wang Y, Yu W, Chen J and Luo J:
Expression of serum miR-221 in human hepatocellular carcinoma and
its prognostic significance. Biochem Biophys Res Commun. 406:70–73.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Zhan MX, Li Y, Hu BS, Shao PJ, Meng QW, He
X, Huang JW and Lu LG: Expression of serum microRNAs (miR-222,
miR-181, miR-216) in human hepatocellular carcinoma and its
clinical significance. Zhonghua Yi Xue Za Zhi. 93:1830–1832.
2013.In Chinese. PubMed/NCBI
|