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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2015 Volume 34 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

MicroRNAs involved with hepatocellular carcinoma (Review)

Bijing Mao, Ge Wang
Pages: 2811-2820
Published online on: 15 September 2015

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Review

Role of the LKB1/AMPK pathway in tumor invasion and metastasis of cancer cells (Review)

Nianshuang Li, Deqiang Huang, Nonghua Lu, Lingyu Luo
Pages: 2821-2826
Published online on: 18 September 2015

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Article Open Access

Targeting cryptic epitope with modified antigen coupled to the surface of liposomes induces strong antitumor CD8 T-cell immune responses in vivo

Yutaka Horiuchi, Akira Takagi, Tetsuya Uchida, Toshitaka Akatsuka
Pages: 2827-2836
Published online on: 21 September 2015

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Article Open Access

Surgical cytoreduction of the primary tumor reduces metastatic progression in a mouse model of prostate cancer

Federico F. Cifuentes, Rodrigo H. Valenzuela, Héctor R. Contreras, Enrique A. Castellón
Pages: 2837-2844
Published online on: 01 October 2015

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Article Open Access

Trichosanthin suppresses the proliferation of glioma cells by inhibiting LGR5 expression and the Wnt/β-catenin signaling pathway

Junjie Miao, Yilin Jiang, Dongliang Wang, Jingru Zhou, Cungang Fan, Feng Jiao, Bo Liu, Jun Zhang, Yangshuo Wang, Qingjun Zhang
Pages: 2845-2852
Published online on: 18 September 2015

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Article Open Access

CMTM8 inhibits the carcinogenesis and progression of bladder cancer

Denghui Gao, Hao Hu, Ying Wang, Weidong Yu, Jianhua Zhou, Xiaofeng Wang, Weiping Wang, Chunyan Zhou, Kexin Xu
Pages: 2853-2863
Published online on: 24 September 2015

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Article Open Access

Lapatinib enhances trastuzumab-mediated antibody-dependent cellular cytotoxicity via upregulation of HER2 in malignant mesothelioma cells

Riki Okita, Katsuhiko Shimizu, Yuji Nojima, Takuro Yukawa, Ai Maeda, Shinsuke Saisho, Masao Nakata
Pages: 2864-2870
Published online on: 28 September 2015

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Article Open Access

Phloretin induces apoptosis of non-small cell lung carcinoma A549 cells via JNK1/2 and p38 MAPK pathways

Jie Min, Xu Li, Kenan Huang, Hua Tang, Xinyu Ding, Chen Qi, Xiong Qin, Zhifei Xu
Pages: 2871-2879
Published online on: 02 October 2015

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Article

A CXCR4 antagonist leads to tumor suppression by activation of immune cells in a leukemia-induced microenvironment

A-Reum Han, Ji Yoon Lee, Hee-Je Kim, Woo-Sung Min, Gyeongsin Park, Se-Hoon Kim
Pages: 2880-2888
Published online on: 21 September 2015

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Article

Benzyl butyl phthalate increases the chemoresistance to doxorubicin/cyclophosphamide by increasing breast cancer-associated dendritic cell-derived CXCL1/GROα and S100A8/A9

Ya-Ling Hsu, Jen-Yu Hung, Eing-Mei Tsai, Cheng-Ying Wu, Ya-Wen Ho, Shu-Fang Jian, Meng-Chi Yen, Wei-An Chang, Ming-Feng Hou, Po-Lin Kuo
Pages: 2889-2900
Published online on: 23 September 2015

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Article

Isothiocyanates inhibit the invasion and migration of C6 glioma cells by blocking FAK/JNK-mediated MMP-9 expression

Chang-Su Lee, Hyun-Ji Cho, Yun-Jeong Jeong, Jae-Moon Shin, Kwan-Kyu Park, Yoon-Yub Park, Young-Seuk Bae, Il-Kyung Chung, Mihyun Kim, Cheorl-Ho Kim, Fansi Jin, Hyeun-Wook Chang, Young-Chae Chang
Pages: 2901-2908
Published online on: 18 September 2015

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Article

Antitumor effect of COOH-terminal polypeptide of human TERT is associated with the declined expression of hTERT and NF-κB p65 in HeLa cells

Xian Wu, Jiasheng Chen, Ying Cao, Baoping Xie, Hongwei Li, Pingzheng Zhou, Yuchang Qiu, Jianxin Pang
Pages: 2909-2916
Published online on: 21 September 2015

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Article

USP14 activation promotes tumor progression in hepatocellular carcinoma

Gang Huang, Limei Li, Weiping Zhou
Pages: 2917-2924
Published online on: 21 September 2015

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Article

Early and delayed intervention with Rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice

Jagan M.R. Patlolla, Levy Kopelovich, Li Qian, Yuting Zhang, Gaurav Kumar, Venkateshwar Madka, Altaf Mohammed, Laura Biddick, Michael Sadeghi, Stan Lightfoot, Chinthalapally V. Rao
Pages: 2925-2934
Published online on: 16 September 2015

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Article

SIRT1 downregulation enhances chemosensitivity and survival of adult T-cell leukemia-lymphoma cells by reducing DNA double-strand repair

Liang Li, Shiguang Ye, Meng Yang, Wenlei Yu, Zhuoyi Fan, Hong Zhang, Jiong Hu, Aibin Liang, Wenjun Zhang
Pages: 2935-2942
Published online on: 18 September 2015

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Article

OCT4B1 promotes cell growth, migration and invasion suppressing sensitivity to οxaliplatin in colon cancer

Kun-Ming Wen, Gui-Hai Zhang, Jiang Li, Zheng-Quan Chen, Yi-Lin Cheng, Xuan Su, Qing-Liang Zeng
Pages: 2943-2952
Published online on: 17 September 2015

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Article

ABL-N may induce apoptosis of human prostate cancer cells through suppression of KLF5, ICAM-1 and Stat5b, and upregulation of Bax/Bcl-2 ratio: An in vitro and in vivo study

Yanping Zhang, Kailong Liu, Yong Zhang, Jinchun Qi, Baosai Lu, Chongjun Shi, Yuewei Yin, Wenqing Cai, Wei Li
Pages: 2953-2960
Published online on: 18 September 2015

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Article

MicroRNA-92b promotes tumor growth and activation of NF-κB signaling via regulation of NLK in oral squamous cell carcinoma Retraction in /10.3892/or.2025.9019

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Pages: 2961-2968
Published online on: 02 October 2015

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Article

High mobility group box 1-mediated autophagy promotes neuroblastoma cell chemoresistance

Li Wang, Huiping Zhang, Min Sun, Zhanghua Yin, Jihong Qian
Pages: 2969-2976
Published online on: 16 September 2015

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Article

Ultrasound-targeted microbubble destruction-mediated downregulation of CD133 inhibits epithelial-mesenchymal transition, stemness and migratory ability of liver cancer stem cells

Yan-Min Liu, Xuan-Fei Li, Hao Liu, Xiao-Ling Wu
Pages: 2977-2986
Published online on: 11 September 2015

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Article

Antitumor effect of metformin on cholangiocarcinoma: In vitro and in vivo studies

Takayuki Fujimori, Kiyohito Kato, Shintaro Fujihara, Hisakazu Iwama, Takuma Yamashita, Kiyoyuki Kobayashi, Hideki Kamada, Asahiro Morishita, Hideki Kobara, Hirohito Mori, Keiichi Okano, Yasuyuki Suzuki, Tsutomu Masaki
Pages: 2987-2996
Published online on: 17 September 2015

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Article

Malignant transformation of host stromal fibroblasts derived from the bone marrow traced in a dual-color fluorescence xenograft tumor model

Xingliang Dai, Hua Chen, Yanming Chen, Jinding Wu, Haiyang Wang, Jia Shi, Xifeng Fei, Zhimin Wang, Aidong Wang, Jun Dong, Qing Lan, Qiang Huang
Pages: 2997-3006
Published online on: 17 September 2015

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Article

RANKL/RANK interaction promotes the growth of cervical cancer cells by strengthening the dialogue between cervical cancer cells and regulation of IL-8 secretion

Wen-Qing Shang, Hui Li, Li-Bing Liu, Kai-Kai Chang, Jia‑Jun Yu, Feng Xie, Ming-Qing Li, Jin-Jin Yu
Pages: 3007-3016
Published online on: 22 September 2015

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Article

Upregulation of BTG1 enhances the radiation sensitivity of human breast cancer in vitro and in vivo

Ran Zhu, Wei Li, Yan Xu, Jianmei Wan, Zengli Zhang
Pages: 3017-3024
Published online on: 25 September 2015

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Article

Berberine-induced anticancer activities in FaDu head and neck squamous cell carcinoma cells

Yo-Seob Seo, Min-Ji Yim, Bok-Hee Kim, Kyung-Rok Kang, Sook-Young Lee, Ji-Su Oh, Jae-Seek You, Su-Gwan Kim, Sang-Joun Yu, Gyeong-Je Lee, Do Kyung Kim, Chun Sung Kim, Jin-Soo Kim, Jae-Sung Kim
Pages: 3025-3034
Published online on: 25 September 2015

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Article

Polyphenol mixtures of Euphorbia supina the inhibit invasion and metastasis of highly metastatic breast cancer MDA-MB-231 cells

Young Shin Ko, Won Sup Lee, Young Nak Joo, Yung Hyun Choi, Gon Sup Kim, Jin-Myung Jung, Chung Ho Ryu, Sung Chul Shin, Hye Jung Kim
Pages: 3035-3042
Published online on: 22 September 2015

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Article

β-asarone inhibits gastric cancer cell proliferation

Jian Wu, Xing-Xing Zhang, Qing-Min Sun, Min Chen, Sheng‑Lin Liu, Xiang Zhang, Jin-Yong Zhou, Xi Zou
Pages: 3043-3050
Published online on: 30 September 2015

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Article

Tolerance to endoplasmic reticulum stress mediates cisplatin resistance in human ovarian cancer cells by maintaining endoplasmic reticulum and mitochondrial homeostasis

Ye Xu, Chunyan Wang, Jing Su, Qi Xie, Liwei Ma, Linchuan Zeng, Yang Yu, Shibing Liu, Songyan Li, Zhixin Li, Liankun Sun
Pages: 3051-3060
Published online on: 17 September 2015

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Article

Frizzled2 mediates the migration and invasion of human oral squamous cell carcinoma cells through the regulation of the signal transducer and activator of transcription-3 signaling pathway

Enjiao Zhang, Zhenning Li, Zhongfei Xu, Weiyi Duan, Changfu Sun, Li Lu
Pages: 3061-3067
Published online on: 17 September 2015

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Article

Tetraspanin 1 is involved in survival, proliferation and carcinogenesis of pancreatic cancer

Feng-Qiang Hou, Xi-Feng Lei, Jian-Long Yao, Yi-Jin Wang, Wei Zhang
Pages: 3068-3076
Published online on: 14 September 2015

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Article

Downregulation of NOB1 inhibits proliferation and promotes apoptosis in human oral squamous cell carcinoma

Jirong Yin, Juncheng Wang, Yi Jiang, Lili Wang, Hao Wu, Hongchen Liu
Pages: 3077-3087
Published online on: 11 September 2015

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Article

miR-130a regulates macrophage polarization and is associated with non-small cell lung cancer

Lin Lin, Haibo Lin, Lin Wang, Bin Wang, Xuezhi Hao, Yuankai Shi
Pages: 3088-3096
Published online on: 22 September 2015

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Article

Screening and verification of proteins that interact with HSPC238

Jia-Yu Tan, Jing-Lin Chen, Xiang Huang, Chun-Lei Yuan
Pages: 3097-3103
Published online on: 18 September 2015

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Article

MicroRNA-205 suppresses the growth of adrenocortical carcinoma SW-13 cells via targeting Bcl-2

Yigao Wu, Wei Wang, Weilie Hu, Wenqing Xu, Ge Xiao, Qiwei Nie, Keyu Ouyang, Shuai Chen
Pages: 3104-3110
Published online on: 21 September 2015

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Article

Downregulation of Notch1 induces apoptosis and inhibits cell proliferation and metastasis in laryngeal squamous cell carcinoma Corrigendum in /10.3892/or.2023.8581

Meng-Yuan Dai, Fang Fang, You Zou, Xing Yi, Yong-Jun Ding, Chen Chen, Ze-Zhang Tao, Shi-Ming Chen
Pages: 3111-3119
Published online on: 15 September 2015

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Article

Autocrine interferon-γ may affect malignant behavior and sensitivity to tamoxifen of MCF-7 via estrogen receptor β subtype

Xiu Long Niu, Yue Wang, Zhi Yao, Hongjie Duan, Zhijun Li, Wenxing Liu, Hongjian Zhang, Wei Min Deng
Pages: 3120-3130
Published online on: 18 September 2015

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Article

Argininosuccinate lyase is a potential therapeutic target in breast cancer

Hau-Lun Huang, Wei-Ching Chen, Hui-Ping Hsu, Chien-Yu Cho, Yu‑Hsuan Hung, Chih-Yang Wang, Ming-Derg Lai
Pages: 3131-3139
Published online on: 16 September 2015

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Article

Silencing β-linked N-acetylglucosamine transferase induces apoptosis in human gastric cancer cells through PUMA and caspase-3 pathways

Ti Wen, Kezuo Hou, Zhi Li, Lu Li, Hanjie Yu, Yunpeng Liu, Yangguang Li, Zhinan Yin
Pages: 3140-3146
Published online on: 15 September 2015

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Article

Autophagy in human skin squamous cell carcinoma: Inhibition by 3-MA enhances the effect of 5-FU-induced chemotherapy sensitivity

Lili Zhang, Jie Zhang, Li Chen, Jianli Wang
Pages: 3147-3155
Published online on: 22 September 2015

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Article

RSK4 knockdown promotes proliferation, migration and metastasis of human breast adenocarcinoma cells

Jia Zhu, Qiu-Yun Li, Jian-Lun Liu, Wei Wei, Hua-Wei Yang, Wei Tang
Pages: 3156-3162
Published online on: 18 September 2015

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Article

Combined expression of aldehyde dehydrogenase 1A1 and β-catenin is associated with lymph node metastasis and poor survival in breast cancer patients following cyclophosphamide treatment

Mingli Sun, Haishan Zhao, Qinghuan Xiao, Zhaojin Yu, Zhiguo Song, Weifan Yao, Hongtao Tang, Shu Guan, Feng Jin, Minjie Wei
Pages: 3163-3173
Published online on: 15 September 2015

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Article

Loss of function of Notch1 identifies a poor prognosis group of early stage hepatocellular carcinoma following hepatectomy

Jian Liu, Jing-Feng Liu, Kui Wang, Zhen-Lin Yan, Xu-Ying Wan, Ai-Min Huang, Yi-Zhou Wang, Jun Li, Yong Xia, Le-Hua Shi, Bing-Hua Jiao, Yongjie Zhang, Feng Shen
Pages: 3174-3186
Published online on: 21 September 2015

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Article

Knockdown of Cul4A increases chemosensitivity to gemcitabine through upregulation of TGFBI in lung cancer cells

Ming‑Szu Hung, I‑Chuan Chen, Liang You, David M. Jablons, Ya‑Chin Li, Jian‑Hua Mao, Zhidong Xu, Meng‑Jer Hsieh, Yu‑Ching Lin, Cheng‑Ta Yang, Shih‑Tung Liu, Ying‑Huang Tsai
Pages: 3187-3195
Published online on: 02 October 2015

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Article

Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma

Jieyu Zhou, Yongmei Li, Dongmin Wei, Ye Qian, Wenming Li, Dayu Liu, Guojun Li, Xinliang Pan, Dapeng Lei
Pages: 3196-3202
Published online on: 28 September 2015

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Article

Antiproliferation effect of evodiamine in human colon cancer cells is associated with IGF-1/HIF-1α downregulation

Jun Huang, Zhen-Hua Chen, Chun-Mei Ren, Dong-Xu Wang, Shuang‑Xue Yuan, Qiu-Xiang Wu, Qian-Zhao Chen, Yu-Hua Zeng, Ying Shao, Yang Li, Ke Wu, Yu Yu, Wen-Juan Sun, Bai-Cheng He
Pages: 3203-3211
Published online on: 24 September 2015

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Article

Long non-coding RNA growth arrest-specific transcript 5 is involved in ovarian cancer cell apoptosis through the mitochondria-mediated apoptosis pathway

Jiayin Gao, Meimei Liu, Yiting Zou, Min Mao, Tingting Shen, Chen Zhang, Shasha Song, Meiling Sun, Song Zhang, Beidi Wang, Daling Zhu, Peiling Li
Pages: 3212-3221
Published online on: 01 October 2015

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Article

Autophagy is upregulated during colorectal carcinogenesis, and in DNA microsatellite stable carcinomas

Paola Sena, Francesco Mariani, Stefano Mancini, Marta Benincasa, Giulia Magnani, Monica Pedroni, Carla Palumbo, Luca Roncucci
Pages: 3222-3230
Published online on: 02 October 2015

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Article

Expression of ADAM12 is regulated by E2F1 in small cell lung cancer

Zunling Li, Yaopeng Wang, Lijun Kong, Zhen Yue, Ying Ma, Xufang Chen
Pages: 3231-3237
Published online on: 01 October 2015

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Article

Mitochondrial dysfunction rather than mtDNA sequence mutation is responsible for the multi-drug resistance of small cell lung cancer

Lijie Ma, Ruixuan Wang, Hongtao Duan, Yandong Nan, Qingwei Wang, Faguang Jin
Pages: 3238-3246
Published online on: 30 September 2015

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Article

Differences in urinary proteins related to surgical margin status after radical prostatectomy

Zbynek Heger, Petr Michalek, Roman Guran, Natalia Cernei, Katerina Duskova, Stepan Vesely, Jiri Anyz, Olga Stepankova, Ondrej Zitka, Vojtech Adam, Rene Kizek
Pages: 3247-3255
Published online on: 02 October 2015

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Article

Caveolin-1 mediates chemoresistance in cisplatin‑resistant ovarian cancer cells by targeting apoptosis through the Notch-1/Akt/NF-κB pathway

Wei Zou, Xiangdong Ma, Wei Hua, Biliang Chen, Guoqing Cai
Pages: 3256-3263
Published online on: 01 October 2015

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Article

LMP1 promotes nasal NK/T-cell lymphoma cell function by eIF4E via NF-κB pathway

Lu Sun, Yu Zhao, Huaiyin Shi, Chao Ma, Lixin Wei
Pages: 3264-3271
Published online on: 23 September 2015

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Article

miR-154 targeting ZEB2 in hepatocellular carcinoma functions as a potential tumor suppressor Retraction in /10.3892/or.2021.8113

Xiaoli Pang, Kexin Huang, Qianqian Zhang, Yujiao Zhang, Junqi Niu
Pages: 3272-3279
Published online on: 01 October 2015

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Article

The role of Pyk2 in the CCR7-mediated regulation of metastasis and viability in squamous cell carcinoma of the head and neck cells in vivo and in vitro

Yang Yue, Zhen-Ning Li, Qi-Gen Fang, Xu Zhang, Liang‑Liang Yang, Chang-Fu Sun, Fa-Yu Liu
Pages: 3280-3287
Published online on: 09 September 2015

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Article

PBK/TOPK mediates promyelocyte proliferation via Nrf2-regulated cell cycle progression and apoptosis

Yuhong Liu, Hui Liu, Huiqin Cao, Bin Song, Wen Zhang, Wanggang Zhang
Pages: 3288-3296
Published online on: 24 September 2015

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Article

Overexpression of osteopontin promotes resistance to cisplatin treatment in HCC

Kun Ding, Lu Fan, Shijun Chen, Yanna Wang, Haifeng Yu, Yanni Sun, Jiguang Yu, Li Wang, Xiangzhong Liu, Youde Liu
Pages: 3297-3303
Published online on: 23 September 2015

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Article

The flavonoid p-hydroxycinnamic acid exhibits anticancer effects in human pancreatic cancer MIA PaCa-2 cells in vitro: Comparison with gemcitabine

Masayoshi Yamaguchi, Tomiyasu Murata, Bassel F. El‑Rayes, Mamoru Shoji
Pages: 3304-3310
Published online on: 17 September 2015

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Article

Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway

Lichuan Wu, Liangxia Guo, Yuehui Liang, Xu Liu, Lihe Jiang, Lisheng Wang
Pages: 3311-3317
Published online on: 16 September 2015

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January-2026 Volume 55 Issue 1

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Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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