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Article

Malignant transformation of host stromal fibroblasts derived from the bone marrow traced in a dual-color fluorescence xenograft tumor model

  • Authors:
    • Xingliang Dai
    • Hua Chen
    • Yanming Chen
    • Jinding Wu
    • Haiyang Wang
    • Jia Shi
    • Xifeng Fei
    • Zhimin Wang
    • Aidong Wang
    • Jun Dong
    • Qing Lan
    • Qiang Huang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, the Second Affiliated Hospital of Soochow University, Jinchang, Suzhou 215004, P.R. China, Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Neurosurgery, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Jinchang, Suzhou, 215021, P.R. China
  • Pages: 2997-3006
    |
    Published online on: September 17, 2015
       https://doi.org/10.3892/or.2015.4281
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Abstract

Solid tumors are abnormal tissues containing tumor and non-tumor cells, also known as tumor stromal cells. However, the malignant potential of tumor stromal cells remains largely unknown. The aim of the present study was to investigate the malignant potential of host bone marrow‑derived stroma cells in transplanted subcutaneous tumors of the glioma stem/progenitor cells (GSPCs) labeled using the dual-color fluorescent tracer technique. The previously established human glioma stem/progenitor cell line SU3 was transfected with red fluorescence protein (SU3-RFP) and transplanted subcutaneously into green fluorescent protein (GFP) transgenic nude mice and chimeric mice in which GFP was only expressed by bone marrow-derived cells (BMDCs). The xenograft tumors were subcultured in vitro and two immortalized GFP-expressing stromal cell lines were cloned from the transplanted tumors. The two cloned cell lines showed an accelerated growth rate, loss of cell contact inhibition, high cloning efficiency, and high DNA content and telocentric (murine) chromosomes with heteroploid characteristics. The tumorigenesis rate (10/10, 1x106) of these host stromal cells was further evidence of malignant transformation. Immunofluorescence assay of the two host cell lines showed that they expressed fibroblast markers such as FAP, S100A4 and α-SMA, as well as mesenchymal cell markers such as CD44 and CD105. In conclusion, bone marrow-derived stromal fibroblasts recruited to tumors have the potential for malignant transformation induced by the tumor microenvironment, which provides new evidence for the role of the stroma in malignant transformation.
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View References

1 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Tarin D: Role of the host stroma in cancer and its therapeutic significance. Cancer Metastasis Rev. 32:553–566. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Casazza A, Di Conza G, Wenes M, Finisguerra V, Deschoemaeker S and Mazzone M: Tumor stroma: A complexity dictated by the hypoxic tumor microenvironment. Oncogene. 33:1743–1754. 2014. View Article : Google Scholar

4 

De Wever O, Demetter P, Mareel M and Bracke M: Stromal myofibroblasts are drivers of invasive cancer growth. Int J Cancer. 123:2229–2238. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Melo SA, Sugimoto H, O'Connell JT, Kato N, Villanueva A, Vidal A, Qiu L, Vitkin E, Perelman LT, Melo CA, et al: Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. Cancer Cell. 26:707–721. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Räsänen K and Vaheri A: Activation of fibroblasts in cancer stroma. Exp Cell Res. 316:2713–2722. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Worthley DL, Ruszkiewicz A, Davies R, Moore S, Nivison-Smith I, Bik To L, Browett P, Western R, Durrant S, So J, et al: Human gastrointestinal neoplasia-associated myofibroblasts can develop from BMDCS following allogeneic stem cell transplantation. Stem Cells. 27:1463–1468. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Quante M, Tu SP, Tomita H, Gonda T, Wang SS, Takashi S, Baik GH, Shibata W, Diprete B, Betz KS, et al: Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell. 19:257–272. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Bergfeld SA and DeClerck YA: Bone marrow-derived mesenchymal stem cells and the tumor microenvironment. Cancer Metastasis Rev. 29:249–261. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Hanahan D and Coussens LM: Accessories to the crime: Functions of cells recruited to the tumor microenvironment. Cancer Cell. 21:309–322. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Mishra PJ, Mishra PJ, Humeniuk R, Medina DJ, Alexe G, Mesirov JP, Ganesan S, Glod JW and Banerjee D: Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells. Cancer Res. 68:4331–4339. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Kalluri R and Zeisberg M: Fibroblasts in cancer. Nat Rev Cancer. 6:392–401. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Ostman A and Augsten M: Cancer-associated fibroblasts and tumor growth - bystanders turning into key players. Curr Opin Genet Dev. 19:67–73. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Hayward SW, Wang Y, Cao M, Hom YK, Zhang B, Grossfeld GD, Sudilovsky D and Cunha GR: Malignant transformation in a nontumorigenic human prostatic epithelial cell line. Cancer Res. 61:8135–8142. 2001.PubMed/NCBI

15 

Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD and Cunha GR: Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 59:5002–5011. 1999.PubMed/NCBI

16 

Bhowmick NA, Chytil A, Plieth D, Gorska AE, Dumont N, Shappell S, Washington MK, Neilson EG and Moses HL: TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science. 303:848–851. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Kuperwasser C, Chavarria T, Wu M, Magrane G, Gray JW, Carey L, Richardson A and Weinberg RA: Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci USA. 101:4966–4971. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Bhowmick NA, Neilson EG and Moses HL: Stromal fibroblasts in cancer initiation and progression. Nature. 432:332–337. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Russell PJ, Bennett S and Stricker P: Growth factor involvement in progression of prostate cancer. Clin Chem. 44:705–723. 1998.PubMed/NCBI

20 

Tlsty TD and Hein PW: Know thy neighbor: Stromal cells can contribute oncogenic signals. Curr Opin Genet Dev. 11:54–59. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Hu M, Yao J, Cai L, Bachman KE, van den Brûle F, Velculescu V and Polyak K: Distinct epigenetic changes in the stromal cells of breast cancers. Nat Genet. 37:899–905. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Paterson RF, Ulbright TM, MacLennan GT, Zhang S, Pan CX, Sweeney CJ, Moore CR, Foster RS, Koch MO, Eble JN, et al: Molecular genetic alterations in the laser-capture-microdissected stroma adjacent to bladder carcinoma. Cancer. 98:1830–1836. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Moinfar F, Man YG, Arnould L, Bratthauer GL, Ratschek M and Tavassoli FA: Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: Implications for tumorigenesis. Cancer Res. 60:2562–2566. 2000.PubMed/NCBI

24 

Houghton J, Li H, Fan X, Liu Y, Liu JH, Rao VP, Poutahidis T, Taylor CL, Jackson EA, Hewes C, et al: Mutations in bone marrow-derived stromal stem cells unmask latent malignancy. Stem Cells Dev. 19:1153–1166. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Bernardo ME, Zaffaroni N, Novara F, Cometa AM, Avanzini MA, Moretta A, Montagna D, Maccario R, Villa R, Daidone MG, et al: Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms. Cancer Res. 67:9142–9149. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Gou S, Wang C, Liu T, Wu H, Xiong J, Zhou F and Zhao G: Spontaneous differentiation of murine bone marrow-derived mesenchymal stem cells into adipocytes without malignant transformation after long-term culture. Cells Tissues Organs. 191:185–192. 2010. View Article : Google Scholar

27 

Luetzkendorf J, Nerger K, Hering J, Moegel A, Hoffmann K, Hoefers C, Mueller-Tidow C and Mueller LP: Cryopreservation does not alter main characteristics of Good Manufacturing Process-grade human multipotent mesenchymal stromal cells including immunomodulating potential and lack of malignant transformation. Cytotherapy. 17:186–198. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Goldenberg DM and Pavia RA: Malignant potential of murine stromal cells after transplantation of human tumors into nude mice. Science. 212:65–67. 1981. View Article : Google Scholar : PubMed/NCBI

29 

Sparrow S, Jones M, Billington S and Stace B: The in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts. Br J Cancer. 53:793–797. 1986. View Article : Google Scholar : PubMed/NCBI

30 

Røsland GV, Svendsen A, Torsvik A, Sobala E, McCormack E, Immervoll H, Mysliwietz J, Tonn JC, Goldbrunner R, Lønning PE, et al: Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Res. 69:5331–5339. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Liu J, Zhang Y, Bai L, Cui X and Zhu J: Rat bone marrow mesenchymal stem cells undergo malignant transformation via indirect co-cultured with tumour cells. Cell Biochem Funct. 30:650–656. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Cui X, Liu J, Bai L, Tian J and Zhu J: Interleukin-6 induces malignant transformation of rat mesenchymal stem cells in association with enhanced signaling of signal transducer and activator of transcription 3. Cancer Sci. 105:64–71. 2014. View Article : Google Scholar

33 

Serrano-Heras G, Domínguez-Berzosa C, Collantes E, Guadalajara H, García-Olmo D and García-Olmo DC: NIH-3T3 fibroblasts cultured with plasma from colorectal cancer patients generate poorly differentiated carcinomas in mice. Cancer Lett. 316:85–90. 2012. View Article : Google Scholar

34 

Yu F, Hsieh WS, Petersson F, Yang H, Li Y, Li C, Low SW, Liu J, Yan Y, Wang DY, et al: Malignant cells derived from 3T3 fibroblast feeder layer in cell culture for nasopharyngeal carcinoma. Exp Cell Res. 322:193–201. 2014. View Article : Google Scholar

35 

Yang M, Reynoso J, Jiang P, Li L, Moossa AR and Hoffman RM: Transgenic nude mouse with ubiquitous green fluorescent protein expression as a host for human tumors. Cancer Res. 64:8651–8656. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Dong J, Dai XL, Lu ZH, Fei XF, Chen H, Zhang QB, Zhao YD, Wang ZM, Wang AD, Lan Q, et al: Incubation and application of transgenic green fluorescent nude mice in visualization studies on glioma tissue remodeling. Chin Med J. 125:4349–4354. 2012.PubMed/NCBI

37 

Iyer S, Arindkar S, Mishra A, Manglani K, Kumar JM, Majumdar SS, Upadhyay P and Nagarajan P: Development and evaluation of transgenic nude mice expressing ubiquitous green fluorescent protein. Mol Imaging Biol. 17:471–478. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Ricard C and Debarbieux FC: Six-color intravital two-photon imaging of brain tumors and their dynamic microenvironment. Front Cell Neurosci. 8:572014. View Article : Google Scholar : PubMed/NCBI

39 

Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Moriwaki H, Bouvet M, Saji S and Hoffman RM: Multi-color palette of fluorescent proteins for imaging the tumor microenvironment of orthotopic tumorgraft mouse models of clinical pancreatic cancer specimens. J Cell Biochem. 113:2290–2295. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B and Jain RK: Differential transplantability of tumor-associated stromal cells. Cancer Res. 64:5920–5924. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Wang A, Dai X, Cui B, Fei X, Chen Y, Zhang J, Zhang Q, Zhao Y, Wang Z, Chen H, et al: Experimental research of host macrophage canceration induced by glioma stem progenitor cells. Mol Med Rep. 11:2435–2442. 2015.

42 

Huang Q, Zhang QB, Dong J, Wu YY, Shen YT, Zhao YD, Zhu YD, Diao Y, Wang AD and Lan Q: Glioma stem cells are more aggressive in recurrent tumors with malignant progression than in the primary tumor, and both can be maintained long-term in vitro. BMC Cancer. 8:3042008. View Article : Google Scholar : PubMed/NCBI

43 

Wan Y, Fei XF, Wang ZM, Jiang DY, Chen HC, Yang J, Shi L and Huang Q: Expression of miR-125b in the new, highly invasive glioma stem cell and progenitor cell line SU3. Chin J Cancer. 31:207–214. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Okabe M, Ikawa M, Kominami K, Nakanishi T and Nishimune Y: 'Green mice' as a source of ubiquitous green cells. FEBS Lett. 407:313–319. 1997. View Article : Google Scholar : PubMed/NCBI

45 

Seabright M: A rapid banding technique for human chromosomes. Lancet. 2:971–972. 1971. View Article : Google Scholar : PubMed/NCBI

46 

Bouvet M and Hoffman RM: Tumor imaging technologies in mouse models. Methods Mol Biol. 1267:321–348. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Suetsugu A, Osawa Y, Nagaki M, Saji S, Moriwaki H, Bouvet M and Hoffman RM: Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer. J Cell Biochem. 112:949–953. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Zhu L, Cheng X, Ding Y, Shi J, Jin H, Wang H, Wu Y, Ye J, Lu Y, Wang TC, et al: Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway. Cancer Lett. 343:80–89. 2014. View Article : Google Scholar

49 

Goldenberg DM, Rooney RJ, Loo M, Liu D and Chang CH: In-vivo fusion of human cancer and hamster stromal cells permanently transduces and transcribes human DNA. PLoS One. 9:e1079272014. View Article : Google Scholar : PubMed/NCBI

50 

Goldenberg DM, Gold DV, Loo M, Liu D, Chang CH and Jaffe ES: Horizontal transmission of malignancy: In-vivo fusion of human lymphomas with hamster stroma produces tumors retaining human genes and lymphoid pathology. PLoS One. 8:e553242013. View Article : Google Scholar : PubMed/NCBI

51 

He X, Li B, Shao Y, Zhao N, Hsu Y, Zhang Z and Zhu L: Cell fusion between gastric epithelial cells and mesenchymal stem cells results in epithelial-to-mesenchymal transition and malignant transformation. BMC Cancer. 15:242015. View Article : Google Scholar : PubMed/NCBI

52 

Goldenberg DM, Zagzag D, Heselmeyer-Haddad KM, Berroa Garcia LY, Ried T, Loo M, Chang CH and Gold DV: Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells in vivo. Int J Cancer. 131:49–58. 2012. View Article : Google Scholar :

53 

Pathak S, Nemeth MA, Multani AS, Thalmann GN, von Eschenbach AC and Chung LW: Can cancer cells transform normal host cells into malignant cells? Br J Cancer. 76:1134–1138. 1997. View Article : Google Scholar : PubMed/NCBI

54 

Jacobsen BM, Harrell JC, Jedlicka P, Borges VF, Varella-Garcia M and Horwitz KB: Spontaneous fusion with, and transformation of mouse stroma by, malignant human breast cancer epithelium. Cancer Res. 66:8274–8279. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Rappa G, Mercapide J and Lorico A: Spontaneous formation of tumorigenic hybrids between breast cancer and multipotent stromal cells is a source of tumor heterogeneity. Am J Pathol. 180:2504–2515. 2012. View Article : Google Scholar : PubMed/NCBI

56 

Zhou XG, Yang Y, Yang JS, Zhou J, Fang TL, Dai WD and Chen ZR: Granulocyte-macrophage colony-stimulating factor and interleukin 4 induce the malignant transformation of the bone marrow-derived human adult mesenchymal stem cells. Chin Med J. 124:729–733. 2011.PubMed/NCBI

57 

Al-Nedawi K, Meehan B, Micallef J, Lhotak V, May L, Guha A and Rak J: Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol. 10:619–624. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dai X, Chen H, Chen Y, Wu J, Wang H, Shi J, Fei X, Wang Z, Wang A, Dong J, Dong J, et al: Malignant transformation of host stromal fibroblasts derived from the bone marrow traced in a dual-color fluorescence xenograft tumor model. Oncol Rep 34: 2997-3006, 2015.
APA
Dai, X., Chen, H., Chen, Y., Wu, J., Wang, H., Shi, J. ... Huang, Q. (2015). Malignant transformation of host stromal fibroblasts derived from the bone marrow traced in a dual-color fluorescence xenograft tumor model. Oncology Reports, 34, 2997-3006. https://doi.org/10.3892/or.2015.4281
MLA
Dai, X., Chen, H., Chen, Y., Wu, J., Wang, H., Shi, J., Fei, X., Wang, Z., Wang, A., Dong, J., Lan, Q., Huang, Q."Malignant transformation of host stromal fibroblasts derived from the bone marrow traced in a dual-color fluorescence xenograft tumor model". Oncology Reports 34.6 (2015): 2997-3006.
Chicago
Dai, X., Chen, H., Chen, Y., Wu, J., Wang, H., Shi, J., Fei, X., Wang, Z., Wang, A., Dong, J., Lan, Q., Huang, Q."Malignant transformation of host stromal fibroblasts derived from the bone marrow traced in a dual-color fluorescence xenograft tumor model". Oncology Reports 34, no. 6 (2015): 2997-3006. https://doi.org/10.3892/or.2015.4281
Copy and paste a formatted citation
x
Spandidos Publications style
Dai X, Chen H, Chen Y, Wu J, Wang H, Shi J, Fei X, Wang Z, Wang A, Dong J, Dong J, et al: Malignant transformation of host stromal fibroblasts derived from the bone marrow traced in a dual-color fluorescence xenograft tumor model. Oncol Rep 34: 2997-3006, 2015.
APA
Dai, X., Chen, H., Chen, Y., Wu, J., Wang, H., Shi, J. ... Huang, Q. (2015). Malignant transformation of host stromal fibroblasts derived from the bone marrow traced in a dual-color fluorescence xenograft tumor model. Oncology Reports, 34, 2997-3006. https://doi.org/10.3892/or.2015.4281
MLA
Dai, X., Chen, H., Chen, Y., Wu, J., Wang, H., Shi, J., Fei, X., Wang, Z., Wang, A., Dong, J., Lan, Q., Huang, Q."Malignant transformation of host stromal fibroblasts derived from the bone marrow traced in a dual-color fluorescence xenograft tumor model". Oncology Reports 34.6 (2015): 2997-3006.
Chicago
Dai, X., Chen, H., Chen, Y., Wu, J., Wang, H., Shi, J., Fei, X., Wang, Z., Wang, A., Dong, J., Lan, Q., Huang, Q."Malignant transformation of host stromal fibroblasts derived from the bone marrow traced in a dual-color fluorescence xenograft tumor model". Oncology Reports 34, no. 6 (2015): 2997-3006. https://doi.org/10.3892/or.2015.4281
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