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Article

The flavonoid p-hydroxycinnamic acid exhibits anticancer effects in human pancreatic cancer MIA PaCa-2 cells in vitro: Comparison with gemcitabine

  • Authors:
    • Masayoshi Yamaguchi
    • Tomiyasu Murata
    • Bassel F. El‑Rayes
    • Mamoru Shoji
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA, Laboratory of Analytical Neurobiology, Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468‑8503, Japan
  • Pages: 3304-3310
    |
    Published online on: September 17, 2015
       https://doi.org/10.3892/or.2015.4282
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Abstract

Pancreatic cancer is a highly aggressive malignancy with a notoriously dismal prognosis. A major contributor to this poor clinical outcome is pancreatic cancer's prominent chemoresistance. The present study was undertaken to determine whether the flavonoid p‑hydroxycinnamic acid (HCA), which is a botanical factor, possesses anticancer effects on cloned human pancreatic cancer MIA PaCa‑2 cells that possess resistance to radiation therapy in vitro. Proliferation of MIA PaCa‑2 cells was suppressed after culture with HCA (10‑1,000 nM). Such an effect was also noted in human pancreatic cancer Pt45P1 cells. In the MIA PaCa‑2 cells, HCA induced G1 and G2/M phase cell cycle arrest in the cells. The suppressive effects of HCA on proliferation were suggested to be mediated through the inhibition of various signaling pathways related to nuclear factor‑κB (NF‑κB), extracellular signal‑regulated kinase (ERK), protein kinase C, phosphatidylinositol 3‑kinase (PI3K) or nuclear transcription activity. Moreover, HCA was found to stimulate cell death in the MIA PaCa‑2 and Pt45P1 cells in vitro. The anticancer effects of HCA on MIA PaCa‑2 cells were exhibited at a lower concentration than gemcitabine, a potent cancer drug. The flavonoid HCA may be a useful tool in the therapy of human pancreatic cancer in vivo.
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Copy and paste a formatted citation
Spandidos Publications style
Yamaguchi M, Murata T, El‑Rayes BF and Shoji M: The flavonoid p-hydroxycinnamic acid exhibits anticancer effects in human pancreatic cancer MIA PaCa-2 cells in vitro: Comparison with gemcitabine. Oncol Rep 34: 3304-3310, 2015.
APA
Yamaguchi, M., Murata, T., El‑Rayes, B.F., & Shoji, M. (2015). The flavonoid p-hydroxycinnamic acid exhibits anticancer effects in human pancreatic cancer MIA PaCa-2 cells in vitro: Comparison with gemcitabine. Oncology Reports, 34, 3304-3310. https://doi.org/10.3892/or.2015.4282
MLA
Yamaguchi, M., Murata, T., El‑Rayes, B. F., Shoji, M."The flavonoid p-hydroxycinnamic acid exhibits anticancer effects in human pancreatic cancer MIA PaCa-2 cells in vitro: Comparison with gemcitabine". Oncology Reports 34.6 (2015): 3304-3310.
Chicago
Yamaguchi, M., Murata, T., El‑Rayes, B. F., Shoji, M."The flavonoid p-hydroxycinnamic acid exhibits anticancer effects in human pancreatic cancer MIA PaCa-2 cells in vitro: Comparison with gemcitabine". Oncology Reports 34, no. 6 (2015): 3304-3310. https://doi.org/10.3892/or.2015.4282
Copy and paste a formatted citation
x
Spandidos Publications style
Yamaguchi M, Murata T, El‑Rayes BF and Shoji M: The flavonoid p-hydroxycinnamic acid exhibits anticancer effects in human pancreatic cancer MIA PaCa-2 cells in vitro: Comparison with gemcitabine. Oncol Rep 34: 3304-3310, 2015.
APA
Yamaguchi, M., Murata, T., El‑Rayes, B.F., & Shoji, M. (2015). The flavonoid p-hydroxycinnamic acid exhibits anticancer effects in human pancreatic cancer MIA PaCa-2 cells in vitro: Comparison with gemcitabine. Oncology Reports, 34, 3304-3310. https://doi.org/10.3892/or.2015.4282
MLA
Yamaguchi, M., Murata, T., El‑Rayes, B. F., Shoji, M."The flavonoid p-hydroxycinnamic acid exhibits anticancer effects in human pancreatic cancer MIA PaCa-2 cells in vitro: Comparison with gemcitabine". Oncology Reports 34.6 (2015): 3304-3310.
Chicago
Yamaguchi, M., Murata, T., El‑Rayes, B. F., Shoji, M."The flavonoid p-hydroxycinnamic acid exhibits anticancer effects in human pancreatic cancer MIA PaCa-2 cells in vitro: Comparison with gemcitabine". Oncology Reports 34, no. 6 (2015): 3304-3310. https://doi.org/10.3892/or.2015.4282
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