Open Access

CMTM8 inhibits the carcinogenesis and progression of bladder cancer

  • Authors:
    • Denghui Gao
    • Hao Hu
    • Ying Wang
    • Weidong Yu
    • Jianhua Zhou
    • Xiaofeng Wang
    • Weiping Wang
    • Chunyan Zhou
    • Kexin Xu
  • View Affiliations

  • Published online on: September 24, 2015     https://doi.org/10.3892/or.2015.4310
  • Pages: 2853-2863
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Bladder cancer is the most common tumor of the urinary tract. The incidence of bladder cancer has increased in the last few decades, thus novel molecular markers for early diagnosis and more efficacious treatment are urgently needed. Chemokine‑like factor (CKLF)‑like MARVEL transmembrane domain containing 8 (CMTM8) is downregulated in several types of cancers and is associated with tumor progression. However, CMTM8 expression has been unexplored in bladder cancer to date. Our results revealed that the expression of CMTM8 was negative in 46 of 74 (62.2%) bladder cancer samples via immunohistochemistry assay. CMTM8 downregulation was associated with advancing tumor stage and tumor grade. CMTM8 was successfully overexpressed by lentivirus in EJ and T24 cells, and the CCK‑8 and Transwell assays showed that CMTM8 overexpression decreased cell proliferation, migration and invasion in vitro. In tumor xenografts upregulation of CMTM8 inhibited tumor growth and lymph node metastasis in vivo. In conclusion, overexpression of CMTM8 in bladder cancer results in reduced malignant cell growth, migration and invasion, which could make it a potential therapeutic target in the treatment of bladder cancer.
View Figures
View References

Related Articles

Journal Cover

December-2015
Volume 34 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gao D, Hu H, Wang Y, Yu W, Zhou J, Wang X, Wang W, Zhou C and Xu K: CMTM8 inhibits the carcinogenesis and progression of bladder cancer. Oncol Rep 34: 2853-2863, 2015
APA
Gao, D., Hu, H., Wang, Y., Yu, W., Zhou, J., Wang, X. ... Xu, K. (2015). CMTM8 inhibits the carcinogenesis and progression of bladder cancer. Oncology Reports, 34, 2853-2863. https://doi.org/10.3892/or.2015.4310
MLA
Gao, D., Hu, H., Wang, Y., Yu, W., Zhou, J., Wang, X., Wang, W., Zhou, C., Xu, K."CMTM8 inhibits the carcinogenesis and progression of bladder cancer". Oncology Reports 34.6 (2015): 2853-2863.
Chicago
Gao, D., Hu, H., Wang, Y., Yu, W., Zhou, J., Wang, X., Wang, W., Zhou, C., Xu, K."CMTM8 inhibits the carcinogenesis and progression of bladder cancer". Oncology Reports 34, no. 6 (2015): 2853-2863. https://doi.org/10.3892/or.2015.4310