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Article

The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway

  • Authors:
    • Xiuying Ma
    • Deqing Wu
    • Shu Zhou
    • Feng Wan
    • Hua Liu
    • Xiaorong Xu
    • Xuanfu Xu
    • Yan Zhao
    • Maochun Tang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China
  • Pages: 189-196
    |
    Published online on: October 29, 2015
       https://doi.org/10.3892/or.2015.4357
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Abstract

In the periphery of pancreatic ductal adenocarcinoma (PDAC), high accumulation of tumor-associated macrophages (TAMs), which exhibit M2 phenotype, has been shown to be correlated with extra-pancreatic invasion, lymph vessel invasion, lymph node involvement and shortened survival time. However, mechanisms by which tumor cells educate and reprogram TAMs remain largely unclear. The phenotype of TAMs in PDAC tissues was confirmed by immunofluoresence and confocal microscopy. Human CD14+ monocytes were incubated with recombinant human REG4 (rREG4) before being stimulated with LPS and IL-10 and IL-6 were measured with ELISA. A panel of M1 and M2 genes were measured by quantitative real-time PCR. Panc1, AsPC1 and BxPC3 cells were cultured in the conditioned medium (CM) and treated with REG4. The macrophages were infected with CREB shRNA or cultured by the CM of Panc1 cells infected with REG4 shRNA. The expression of CD163, CD206 and REG4 and the phosphorylation levels of epidermal growth factor receptor (EGFR), AKT and cAMP response element-binding protein (CREB) in cells were assessed with western blotting. Cell proliferation and invasiveness were also assessed. The rREG4 or the conditioned medium of Panc1 cells which secreted REG4 induced the polarization macrophages to M2 phenotype. Treatment of human macrophages with REG4 resulted in phosphorylation of EGFR, AKT and CREB. The latter was responsible for REG4-mediated macrophage polarization to M2. The conditioned medium of macrophages treated with rREG4 promoted the proliferation and invasion of pancreatic cancer cell lines. REG4, overexpressed in PDAC and secreted by cancer cells, promoted macrophage polarization to M2, through at least in part, activation of ERK1/2 and CREB and changed the microenvironment to facilitate cancer growth and metastasis.
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View References

1 

Farrow B, Albo D and Berger DH: The role of the tumor micro-environment in the progression of pancreatic cancer. J Surg Res. 149:319–328. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Lewin CS, Allen RA and Amyes SG: Mechanisms of zidovudine resistance in bacteria. J Med Microbiol. 33:235–238. 1990. View Article : Google Scholar : PubMed/NCBI

3 

Coussens LM and Pollard JW: Leukocytes in mammary development and cancer. Cold Spring Harb Perspect Biol. 3:32011. View Article : Google Scholar

4 

Le DT, Lutz E, Uram JN, Sugar EA, Onners B, Solt S, Zheng L, Diaz LA Jr, Donehower RC, Jaffee EM, et al: Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer. J Immunother. 36:382–389. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Allavena P, Sica A, Solinas G, Porta C and Mantovani A: The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages. Crit Rev Oncol Hematol. 66:1–9. 2008. View Article : Google Scholar

6 

Mantovani A, Sozzani S, Locati M, Allavena P and Sica A: Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23:549–555. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Sica A, Schioppa T, Mantovani A and Allavena P: Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy. Eur J Cancer. 42:717–727. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Yoshikawa K, Mitsunaga S, Kinoshita T, Konishi M, Takahashi S, Gotohda N, Kato Y, Aizawa M and Ochiai A: Impact of tumor-associated macrophages on invasive ductal carcinoma of the pancreas head. Cancer Sci. 103:2012–2020. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF and Karin M: IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 118:285–296. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Karin M and Greten FR: NF-kappaB: Linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 5:749–759. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Lin EY, Li JF, Gnatovskiy L, Deng Y, Zhu L, Grzesik DA, Qian H, Xue XN and Pollard JW: Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res. 66:11238–11246. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Qian B, Deng Y, Im JH, Muschel RJ, Zou Y, Li J, Lang RA and Pollard JW: A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One. 4:e65622009. View Article : Google Scholar : PubMed/NCBI

13 

Ruffell B, Affara NI and Coussens LM: Differential macrophage programming in the tumor microenvironment. Trends Immunol. 33:119–126. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Hartupee JC, Zhang H, Bonaldo MF, Soares MB and Dieckgraefe BK: Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. Biochim Biophys Acta. 1518:287–293. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Watanabe T, Yonekura H, Terazono K, Yamamoto H and Okamoto H: Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem. 265:7432–7439. 1990.PubMed/NCBI

16 

Unno M, Itoh T, Watanabe T, Miyashita H, Moriizumi S, Teraoka H, Yonekura H and Okamoto H: Islet beta-cell regeneration and reg genes. Adv Exp Med Biol. 321:61–66; discussion 67–69. 1992. View Article : Google Scholar : PubMed/NCBI

17 

Hayashi T, Matsubara A, Ohara S, Mita K, Hasegawa Y, Usui T, Arihiro K, Norimura S, Sentani K, Oue N, et al: Immunohistochemical analysis of Reg IV in urogenital organs: Frequent expression of Reg IV in prostate cancer and potential utility as serum tumor marker. Oncol Rep. 21:95–100. 2009.

18 

Oue N, Hamai Y, Mitani Y, Matsumura S, Oshimo Y, Aung PP, Kuraoka K, Nakayama H and Yasui W: Gene expression profile of gastric carcinoma: Identification of genes and tags potentially involved in invasion, metastasis, and carcinogenesis by serial analysis of gene expression. Cancer Res. 64:2397–2405. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Oue N, Mitani Y, Aung PP, Sakakura C, Takeshima Y, Kaneko M, Noguchi T, Nakayama H and Yasui W: Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma. J Pathol. 207:185–198. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Tamura H, Ohtsuka M, Washiro M, Kimura F, Shimizu H, Yoshidome H, Kato A, Seki N and Miyazaki M: Reg IV expression and clinicopathologic features of gallbladder carcinoma. Hum Pathol. 40:1686–1692. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Violette S1, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, et al: Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. Int J Cancer. 103:185–193. 2003. View Article : Google Scholar

22 

Legoffic A, Calvo E, Cano C, Folch-Puy E, Barthet M, Delpero JR, Ferrés-Masó M, Dagorn JC, Closa D and Iovanna J: The reg4 gene, amplified in the early stages of pancreatic cancer development, is a promising therapeutic target. PLoS One. 4:e74952009. View Article : Google Scholar : PubMed/NCBI

23 

He XJ, Jiang XT, Ma YY, Xia YJ, Wang HJ, Guan TP, Shao QS and Tao HQ: REG4 contributes to the invasiveness of pancreatic cancer by upregulating MMP-7 and MMP-9. Cancer Sci. 103:2082–2091. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Takayama R, Nakagawa H, Sawaki A, Mizuno N, Kawai H, Tajika M, Yatabe Y, Matsuo K, Uehara R, Ono K, et al: Serum tumor antigen REG4 as a diagnostic biomarker in pancreatic ductal adenocarcinoma. J Gastroenterol. 45:52–59. 2010. View Article : Google Scholar

25 

Rafa L, Dessein AF, Devisme L, Buob D, Truant S, Porchet N, Huet G, Buisine MP and Lesuffleur T: REG4 acts as a mitogenic, motility and pro-invasive factor for colon cancer cells. Int J Oncol. 36:689–698. 2010.PubMed/NCBI

26 

Zhang Y, Lai M, Lv B, Gu X, Wang H, Zhu Y, Zhu Y, Shao L and Wang G: Overexpression of Reg IV in colorectal adenoma. Cancer Lett. 200:69–76. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Bishnupuri KS, Luo Q, Sainathan SK, Kikuchi K, Sureban SM, Sabarinathan M, et al: Reg IV regulates normal intestinal and colorectal cancer cell susceptibility to radiation-induced apoptosis. Gastroenterology. 138:616–626.e2. 2010. View Article : Google Scholar :

28 

Tao HQ, He XJ, Ma YY, Wang HJ, Xia YJ, Ye ZY and Zhao ZS: Evaluation of REG4 for early diagnosis and prognosis of gastric cancer. Hum Pathol. 42:1401–1409. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Kuniyasu H, Oue N, Sasahira T, Yi L, Moriwaka Y, Shimomoto T, Fujii K, Ohmori H and Yasui W: Reg IV enhances peritoneal metastasis in gastric carcinomas. Cell Prolif. 42:110–121. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Miyagawa K, Sakakura C, Nakashima S, Yoshikawa T, Fukuda K, Kin S, Nakase Y, Shimomura K, Oue N, Yasui W, et al: Overexpression of RegIV in peritoneal dissemination of gastric cancer and its potential as A novel marker for the detection of peritoneal micrometastasis. Anticancer Res. 28:1169–1179. 2008.PubMed/NCBI

31 

Chanmee T, Ontong P, Konno K and Itano N: Tumor-associated macrophages as major players in the tumor microenvironment. Cancers (Basel). 6:1670–1690. 2014. View Article : Google Scholar

32 

Pollard JW: Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer. 4:71–78. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Sica A and Bronte V: Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest. 117:1155–1166. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Mantovani A, Bottazzi B, Colotta F, Sozzani S and Ruco L: The origin and function of tumor-associated macrophages. Immunol Today. 13:265–270. 1992. View Article : Google Scholar : PubMed/NCBI

35 

Qian BZ, Li J, Zhang H, Kitamura T, Zhang J, Campion LR, Kaiser EA, Snyder LA and Pollard JW: CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature. 475:222–225. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Mantovani A, Savino B, Locati M, Zammataro L, Allavena P and Bonecchi R: The chemokine system in cancer biology and therapy. Cytokine Growth Factor Rev. 21:27–39. 2010. View Article : Google Scholar

37 

Zhang J, Patel L and Pienta KJ: CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis. Cytokine Growth Factor Rev. 21:41–48. 2010. View Article : Google Scholar :

38 

Andreu P, Johansson M, Affara NI, Pucci F, Tan T, Junankar S, Korets L, Lam J, Tawfik D, DeNardo DG, et al: FcRgamma activation regulates inflammation-associated squamous carcinogenesis. Cancer Cell. 17:121–134. 2010. View Article : Google Scholar : PubMed/NCBI

39 

DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N and Coussens LM: CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell. 16:91–102. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Ruffell D, Mourkioti F, Gambardella A, Kirstetter P, Lopez RG, Rosenthal N and Nerlov C: A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair. Proc Natl Acad Sci USA. 106:17475–17480. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Lanaya H, Natarajan A, Komposch K, Li L, Amberg N, Chen L, Wculek SK, Hammer M, Zenz R, Peck-Radosavljevic M, et al: EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation. Nat Cell Biol. 16:972–981. 2014. View Article : Google Scholar :

42 

Li YG, Ji DF, Zhong S, Zhu JX, Chen S and Hu GY: Anti-tumor effects of proteoglycan from Phellinus linteus by immunomodulating and inhibiting Reg IV/EGFR/Akt signaling pathway in colorectal carcinoma. Int J Biol Macromol. 48:511–517. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ma X, Wu D, Zhou S, Wan F, Liu H, Xu X, Xu X, Zhao Y and Tang M: The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway. Oncol Rep 35: 189-196, 2016.
APA
Ma, X., Wu, D., Zhou, S., Wan, F., Liu, H., Xu, X. ... Tang, M. (2016). The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway. Oncology Reports, 35, 189-196. https://doi.org/10.3892/or.2015.4357
MLA
Ma, X., Wu, D., Zhou, S., Wan, F., Liu, H., Xu, X., Xu, X., Zhao, Y., Tang, M."The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway". Oncology Reports 35.1 (2016): 189-196.
Chicago
Ma, X., Wu, D., Zhou, S., Wan, F., Liu, H., Xu, X., Xu, X., Zhao, Y., Tang, M."The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway". Oncology Reports 35, no. 1 (2016): 189-196. https://doi.org/10.3892/or.2015.4357
Copy and paste a formatted citation
x
Spandidos Publications style
Ma X, Wu D, Zhou S, Wan F, Liu H, Xu X, Xu X, Zhao Y and Tang M: The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway. Oncol Rep 35: 189-196, 2016.
APA
Ma, X., Wu, D., Zhou, S., Wan, F., Liu, H., Xu, X. ... Tang, M. (2016). The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway. Oncology Reports, 35, 189-196. https://doi.org/10.3892/or.2015.4357
MLA
Ma, X., Wu, D., Zhou, S., Wan, F., Liu, H., Xu, X., Xu, X., Zhao, Y., Tang, M."The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway". Oncology Reports 35.1 (2016): 189-196.
Chicago
Ma, X., Wu, D., Zhou, S., Wan, F., Liu, H., Xu, X., Xu, X., Zhao, Y., Tang, M."The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway". Oncology Reports 35, no. 1 (2016): 189-196. https://doi.org/10.3892/or.2015.4357
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