Journal Articles

MicroRNAs are involved in cervical cancer development, progression, clinical outcome and improvement treatment response (Review)

Víctor González-Quintana, Lizbeth Palma-Berré, Alma D. Campos-Parra, Eduardo López‑Urrutia, Oscar Peralta-Zaragoza, Rafael Vazquez-Romo, Carlos Pérez-Plasencia

Pages: 3-12 Published online on: 30 October 2015
Open Access

Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines

Puteri Baharuddin, Nazilah Satar, Kamal Shaik Fakiruddin, Norashikin Zakaria, Moon Nian Lim, Narazah Mohd Yusoff, Zubaidah Zakaria, Badrul Hisham Yahaya

Pages: 13-25 Published online on: 02 November 2015
Open Access

Depletion of Cks1 and Cks2 expression compromises cell proliferation and enhance chemotherapy-induced apoptosis in HepG2 cells

Lingqing Lin, Zanxi Fang, Huayue Lin, Hanyu You, Jiajia Wang, Yuanhui Su, Fen Wang, Zhong‑Ying Zhang

Pages: 26-32 Published online on: 02 November 2015
Open Access

Expansion of quiescent lung adenocarcinoma CD8+ T cells by MUC1-8-mer peptide-T2 cell-β2 microglobulin complexes

J. A. Atzin-Méndez, J. S. López-González, R. Báez, M. C. Arenas-Del Angel, L. F. Montaño, D. Silva-Adaya, R. Lascurain, P. Gorocica

Pages: 33-42 Published online on: 13 October 2015
Open Access

Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo

Tao Hu, Pei Li, Zhongguang Luo, Xiaoyu Chen, Jingyang Zhang, Chunyao Wang, Ping Chen, Ziming Dong

Pages: 43-49 Published online on: 02 November 2015
Open Access

Latexin exhibits tumor-suppressor potential in pancreatic ductal adenocarcinoma

Zhanxiong Xue, Yuhui Zhou, Cheng Wang, Jihang Zheng, Pu Zhang, Lingling Zhou, Liang Wu, Yunfeng Shan, Mengsi Ye, Yun He, Zhenzhai Cai

Pages: 50-58 Published online on: 27 October 2015

Suppressive effects of 3-bromopyruvate on the proliferation and the motility of hepatocellular carcinoma cells

Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige

Pages: 59-63 Published online on: 02 November 2015

Methylation-induced silencing of miR-34a enhances chemoresistance by directly upregulating ATG4B-induced autophagy through AMPK/mTOR pathway in prostate cancer

Haiqiu Liao, Yang Xiao, Yingbin Hu, Yangming Xiao, Zhaofa Yin, Liang Liu, Xiaopeng Kang, Yonggang Chen

Pages: 64-72 Published online on: 16 October 2015

MicroRNA-21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF-β pathways

Mingli Han, Fang Wang, Yuanting Gu, Xinhong Pei, Guangcheng Guo, Chao Yu, Lin Li, Mingzhi Zhu, Youyi Xiong, Yimeng Wang

Pages: 73-80 Published online on: 29 October 2015

TMPRSS3 modulates ovarian cancer cell proliferation, invasion and metastasis

Dan Zhang, Shuang Qiu, Qi Wang, Jianhua Zheng

Pages: 81-88 Published online on: 29 October 2015

Effects of lentivirus-mediated shRNA targeting integrin-linked kinase on oral squamous cell carcinoma in vitro and in vivo

Lin Que, Dan Zhao, Xiu-Fa Tang, Ji-Yuan Liu, Xiang-Yu Zhang, Yu-Hua Zhan, Lei Zhang

Pages: 89-98 Published online on: 02 November 2015

Effects of HPV-16 infection on hypopharyngeal squamous cell carcinoma and FaDu cells

Wuhao Lu, Long Feng, Ping Li, Yuanyuan Wang, Yuwen Du, Xiaonan Chen, Shujun Wu, Guoqiang Zhao, Weihua Lou

Pages: 99-106 Published online on: 20 October 2015

Lauric acid can improve the sensitization of Cetuximab in KRAS/BRAF mutated colorectal cancer cells by retrievable microRNA-378 expression

Wen-Hui Weng, Wai-Hung Leung, Yeu-Jye Pang, Hsi-Hsien Hsu

Pages: 107-116 Published online on: 19 October 2015

The natural compound codonolactone attenuates TGF-β1-mediated epithelial-to-mesenchymal transition and motility of breast cancer cells

Jianjiang Fu, Xiaoqin Ke, Songlin Tan, Ting Liu, Shan Wang, Junchao Ma, Hong Lu

Pages: 117-126 Published online on: 04 November 2015

The MRTF-A/B function as oncogenes in pancreatic cancer

Zhao Song, Zhao Liu, Jing Sun, Feng-Lei Sun, Chuan-Zhi Li, Jiu-Zheng Sun, Li-You Xu

Pages: 127-138 Published online on: 15 October 2015

Promoter hypermethylation of PTPL1, PTPN6, DAPK, p16 and 5-azacitidine inhibits growth in DLBCL

Wenming Wang, Jing Wang, Zhengqian Li, Mingxia Zhu, Zhe Zhang, Yanfang Wang, Hongmei Jing

Pages: 139-146 Published online on: 26 October 2015

Multidrug resistance-associated protein 4 is a determinant of arsenite resistance

Bo Yuan, Yuta Yoshino, Hisayo Fukushima, Svetlana Markova, Norio Takagi, Hiroo Toyoda, Deanna L. Kroetz

Pages: 147-154 Published online on: 22 October 2015

Significance of DEK overexpression for the prognostic evaluation of non-small cell lung carcinoma

Xin Liu, Dongdong Qi, Jujie Qi, Zeshu Mao, Xiangdan Li, Jinhui Zhang, Jinzi Li, Wenbin Gao

Pages: 155-162 Published online on: 30 October 2015

Recombinant HE4 protein promotes proliferation of pancreatic and endometrial cancer cell lines

Qinsheng Lu, Haibin Chen, Christopher Senkowski, Jianhao Wang, Xue Wang, Steven Brower, Wayne Glasgow, David Byck, Shi-Wen Jiang, Jinping Li

Pages: 163-170 Published online on: 20 October 2015

Platelet-activating factor promotes motility in breast cancer cells and disrupts non-transformed breast acinar structures

V. Libi Anandi, K. A. Ashiq, K. Nitheesh, M. Lahiri

Pages: 179-188 Published online on: 03 November 2015

The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway

Xiuying Ma, Deqing Wu, Shu Zhou, Feng Wan, Hua Liu, Xiaorong Xu, Xuanfu Xu, Yan Zhao, Maochun Tang

Pages: 189-196 Published online on: 29 October 2015

Imatinib mesylate induces mitochondria-dependent apoptosis and inhibits invasion of human pigmented villonodular synovitis fibroblast-like synovial cells

Kang Chen, Qiao Ren, Xiao-Rui Han, Xiao-Nan Zhang, Bo Wei, Xi-Zhuang Bai

Pages: 197-204 Published online on: 26 October 2015

Nicotine enhances invasion and metastasis of human colorectal cancer cells through the nicotinic acetylcholine receptor downstream p38 MAPK signaling pathway

Tao Xiang, Rushan Fei, Zhe Wang, Zhonglei Shen, Jing Qian, Wenbin Chen

Pages: 205-210 Published online on: 30 October 2015

Identification of the metastasis potential and its associated genes in melanoma multinucleated giant cells using the PHA-ECM830 fusion method

Ruifang Mi, Chunxiao Pan, Yiqiang Zhou, Yuanbo Liu, Guishan Jin, Fusheng Liu

Pages: 211-218 Published online on: 02 November 2015

The differentiation of hMSCs counteracts their migration capability and pro‑angiogenic effects in vitro

A. Scherzed, S. Hackenberg, K. Froelich, K. Rak, P. Schendzielorz, T. Gehrke, R. Hagen, N. Kleinsasser

Pages: 219-226 Published online on: 03 November 2015

β-elemonic acid inhibits the cell proliferation of human lung adenocarcinoma A549 cells: The role of MAPK, ROS activation and glutathione depletion

Tsu‑Tuan Wu, Chien‑Lin Lu, Hen‑I Lin, Bing‑Fang Chen, Guey‑Mei Jow

Pages: 227-234 Published online on: 30 October 2015

Sirtuin inhibitors, EX527 and AGK2, suppress cell migration by inhibiting HSF1 protein stability

Hyun-Woo Kim, Soo -A Kim, Sang-Gun Ahn

Pages: 235-242 Published online on: 02 November 2015

Adenovirus-mediated p53 and ING4 gene co‑transfer elicits synergistic antitumor effects through enhancement of p53 acetylation in breast cancer

Jie Wu, Yanbo Zhu, Chun Xu, Hong Xu, Xiumin Zhou, Jicheng Yang, Yufeng Xie, Min Tao

Pages: 243-252 Published online on: 03 November 2015

Impact of KITENIN on tumor angiogenesis and lymphangiogenesis in colorectal cancer

Hyung-Hoon Oh, Kang-Jin Park, Nuri Kim, Sun-Young Park, Young‑Lan Park, Chan-Young Oak, Dae-Seong Myung, Sung-Bum Cho, Wan‑Sik Lee, Kyung-Keun Kim, Young-Eun Joo

Pages: 253-260 Published online on: 20 October 2015

Snail-induced EMT promotes cancer stem cell-like properties in head and neck cancer cells

Ichiro Ota, Takashi Masui, Miyako Kurihara, Jong-In Yook, Shinji Mikami, Takahiro Kimura, Keiji Shimada, Noboru Konishi, Katsunari Yane, Toshiaki Yamanaka, Tadashi Kitahara

Pages: 261-266 Published online on: 26 October 2015

Type III TGF-β receptor inhibits cell proliferation and migration in salivary glands adenoid cystic carcinoma by suppressing NF-κB signaling

Dongyang Xu, Duo Li, Zhiyong Lu, Xingli Dong, Xiaofeng Wang

Pages: 267-274 Published online on: 03 November 2015

miR-146b-5p promotes invasion and metastasis contributing to chemoresistance in osteosarcoma by targeting zinc and ring finger 3

Enjie Xu, Jianquan Zhao, Jun Ma, Ce Wang, Chenglin Zhang, Heng Jiang, Jianyang Cheng, Rui Gao, Xuhui Zhou

Pages: 275-283 Published online on: 04 November 2015

miR-124 suppresses the migration and invasion of glioma cells in vitro via Capn4

Jia-Jun Cai, Zeng-Xin Qi, Ling-Chao Chen, Yu Yao, Yan Gong, Ying Mao

Pages: 284-290 Published online on: 27 October 2015

Gallic acid, a phenolic compound, exerts anti-angiogenic effects via the PTEN/AKT/HIF-1α/VEGF signaling pathway in ovarian cancer cells

Zhiping He, Allen Y. Chen, Yon Rojanasakul, Gary O. Rankin, Yi Charlie Chen

Pages: 291-297 Published online on: 27 October 2015

Upregulation of long non-coding RNA PRNCR1 in colorectal cancer promotes cell proliferation and cell cycle progression

Liu Yang, Mantang Qiu, Youtao Xu, Jie Wang, Yanyan Zheng, Ming Li, Lin Xu, Rong Yin

Pages: 318-324 Published online on: 30 October 2015

Comparison of human gut microbiota in control subjects and patients with colorectal carcinoma in adenoma: Terminal restriction fragment length polymorphism and next-generation sequencing analyses

Chika Kasai, Kazushi Sugimoto, Isao Moritani, Junichiro Tanaka, Yumi Oya, Hidekazu Inoue, Masahiko Tameda, Katsuya Shiraki, Masaaki Ito, Yoshiyuki Takei, Kojiro Takase

Pages: 325-333 Published online on: 04 November 2015

Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy

Xiu-Wu Pan, Lin Li, Yi Huang, Hai Huang, Dan-Feng Xu, Yi Gao, Lu Chen, Ji-Zhong Ren, Jian-Wei Cao, Yi Hong, Xin-Gang Cui

Pages: 334-342 Published online on: 16 October 2015

Resveratrol sensitizes glioblastoma-initiating cells to temozolomide by inducing cell apoptosis and promoting differentiation

Hao Li, Yaodong Liu, Yumin Jiao, Anchen Guo, Xiaoxue Xu, Xianjun Qu, Shuo Wang, Jizong Zhao, Ye Li, Yong Cao

Pages: 343-351 Published online on: 23 October 2015

Jumonji domain containing 2A predicts prognosis and regulates cell growth in lung cancer depending on miR-150

Weihua Xu, Kanqiu Jiang, Mingjing Shen, Yongbing Chen, Hao-Yue Huang

Pages: 352-358 Published online on: 26 October 2015

TCEB2 confers resistance to VEGF‑targeted therapy in ovarian cancer

Zhuo Deng, Jiancheng Zhou, Xi Han, Xu Li

Pages: 359-365 Published online on: 03 November 2015

MicroRNA-616 promotes the migration, invasion and epithelial-mesenchymal transition of HCC by targeting PTEN

Di Zhang, Peihua Zhou, Wei Wang, Xiaolong Wang, Junhui Li, Xuejun Sun, Li Zhang

Pages: 366-374 Published online on: 16 October 2015

Matrine inhibits the proliferation, invasion and migration of castration-resistant prostate cancer cells through regulation of the NF-κB signaling pathway

Qi Li, Yiming Lai, Chengbin Wang, Guibin Xu, Zheng He, Xiaohong Shang, Yi Sun, Fan Zhang, Leyuan Liu, Hai Huang

Pages: 375-381 Published online on: 21 October 2015

Selecting molecular therapeutic drug targets based on the expression profiles of intrahepatic cholangiocarcinomas and miRNA-mRNA regulatory networks

Boshi Sun, Changming Xie, Tongsen Zheng, Dalong Yin, Jiabei Wang, Yingjian Liang, Yuejin Li, Guangchao Yang, Huawen Shi, Tiemin Pei, Jihua Han, Lianxin Liu

Pages: 382-390 Published online on: 15 October 2015

Clinical significance of Gremlin 1 in cervical cancer and its effects on cancer stem cell maintenance

Masakazu Sato, Kei Kawana, Asaha Fujimoto, Mitsuyo Yoshida, Hiroe Nakamura, Haruka Nishida, Tomoko Inoue, Ayumi Taguchi, Juri Takahashi, Katsuyuki Adachi, Kazunori Nagasaka, Yoko Matsumoto, Osamu Wada‑Hiraike, Katsutoshi Oda, Yutaka Osuga, Tomoyuki Fujii

Pages: 391-397 Published online on: 30 October 2015

Paxillin is positively correlated with the clinicopathological factors of colorectal cancer, and knockdown of Paxillin improves sensitivity to cetuximab in colorectal cancer cells

Chuang Du, Xin Wang, Junling Zhang, Xiangzheng Liu, Jing Zhu, Yucun Liu

Pages: 409-417 Published online on: 27 October 2015

Cell motility and spreading promoted by CEACAM6 through cyclin D1/CDK4 in human pancreatic carcinoma

Lu Yan, Yuan Wang, Zhi-Zhi Wang, Yan-Ting Rong, Lin-Lin Chen, Qian Li, Ting Liu, Yong-Heng Chen, Yan-Dong Li, Zhao-Hong Huang, Jie Peng

Pages: 418-426 Published online on: 20 October 2015

Schwann cells promote EMT and the Schwann-like differentiation of salivary adenoid cystic carcinoma cells via the BDNF/TrkB axis

Chun Shan, Jianhua Wei, Rui Hou, Baolei Wu, Zihui Yang, Lei Wang, Delin Lei, Xinjie Yang

Pages: 427-435 Published online on: 30 October 2015

The clinical significance of transforming acidic coiled-coil protein 3 expression in non-small cell lung cancer

Feng Jiang, Bohua Kuang, Yi Que, Zhirui Lin, Li Yuan, Wei Xiao, Ruiqing Peng, Xiaoshi Zhang, Xing Zhang

Pages: 436-446 Published online on: 02 November 2015

Fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung cancer cells by the P53 signaling pathway

Guangwei Zhong, Xi Chen, Xia Fang, Dongsheng Wang, Mingxuan Xie, Qiong Chen

Pages: 447-453 Published online on: 04 November 2015

Biomarker triplet NAMPT/VEGF/HER2 as a de novo detection panel for the diagnosis and prognosis of human breast cancer

Yanyan Zhu, Meiyan Guo, Lingyun Zhang, Tao Xu, Li Wang, Guoxiong Xu

Pages: 454-462 Published online on: 03 November 2015

Resveratrol induces cell cycle arrest in human gastric cancer MGC803 cells via the PTEN‑regulated PI3K/Akt signaling pathway

Xiaoping Jing, Weiwei Cheng, Shiying Wang, Pin Li, Li He

Pages: 472-478 Published online on: 03 November 2015

Knockdown of long non-coding RNA HOTAIR inhibits proliferation and invasiveness and improves radiosensitivity in colorectal cancer

Xiao-Dong Yang, Hong-Tao Xu, Xiao-Hui Xu, Gan Ru, Wei Liu, Jun-Jia Zhu, Yong-You Wu, Kui Zhao, Yong Wu, Chun-Gen Xing, Shu-Yu Zhang, Jian-Ping Cao, Ming Li

Pages: 479-487 Published online on: 04 November 2015

PBOV1 correlates with progression of ovarian cancer and inhibits proliferation of ovarian cancer cells

Lan Wang, Chun-Hao Niu, Shu Wu, Hong-Mei Wu, Fei Ouyang, Mian He, Shan-Yang He

Pages: 488-496 Published online on: 04 November 2015

miR-296-5p suppresses cell viability by directly targeting PLK1 in non-small cell lung cancer

Chun Xu, Sen Li, Tengfei Chen, Haibo Hu, Cheng Ding, Zhenlei Xu, Jun Chen, Zeyi Liu, Zhe Lei, Hong-Tao Zhang, Chang Li, Jun Zhao

Pages: 497-503 Published online on: 04 November 2015

n-3 polyunsaturated fatty acids reverse the development of polyps in ApcMin/+ transgenic mice

Maria Notarnicola, Valeria Tutino, Maria Gabriella Caruso, Antonio Francavilla

Pages: 504-510 Published online on: 29 October 2015

Pien Tze Huang inhibits the proliferation, and induces the apoptosis and differentiation of colorectal cancer stem cells via suppression of the Notch1 pathway

Fei Qi, Lihui Wei, Aling Shen, Youqin Chen, Jiumao Lin, Jianfeng Chu, Qiaoyan Cai, Jie Pan, Jun Peng

Pages: 511-517 Published online on: 02 November 2015

A positive feedback loop of p53/miR-19/TP53INP1 modulates pancreatic cancer cell proliferation and apoptosis

Xiaofang Wang, Lei Wang, Qingjiang Mo, Ankui Jia, Yuqian Dong, Guoqiang Wang

Pages: 518-523 Published online on: 30 October 2015

Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, Sirt1

Ju-Hee Lee, Jin-Shang Kim, Sang-Youel Park, You-Jin Lee

Pages: 524-529 Published online on: 16 October 2015

Ezrin-radixin-moesin-binding phosphoprotein-50 regulates EGF-induced AKT activation through interaction with EGFR and PTEN

Junfang Zheng, Yuanping Dai, Zhiyu Yang, Longyan Yang, Zhiqiang Peng, Ran Meng, Ying Xiong, Junqi He

Pages: 530-537 Published online on: 02 November 2015

Human chorionic gonadotropin β subunit affects the expression of apoptosis-regulating factors in ovarian cancer

Anna Szczerba, Aleksandra Śliwa, Marta Kubiczak, Ewa Nowak-Markwitz, Anna Jankowska

Pages: 538-545 Published online on: 03 November 2015

Auranofin induces mesothelioma cell death through oxidative stress and GSH depletion

Bo Ra You, Woo Hyun Park

Pages: 546-551 Published online on: 02 November 2015

Klotho inhibits human follicular thyroid cancer cell growth and promotes apoptosis through regulation of the expression of stanniocalcin-1

Dong Dai, Qi Wang, Xiaofeng Li, Jianjing Liu, Xiaoying Ma, Wengui Xu

Pages: 552-558 Published online on: 29 October 2015

MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma

Shoulin Zhang, Dongmei Zhang, Chunguang Yi, Yinping Wang, Hongan Wang, Jian Wang

Pages: 559-567 Published online on: 16 October 2015

Bergapten induces metabolic reprogramming in breast cancer cells

Marta Santoro, Carmela Guido, Francesca De Amicis, Diego Sisci, Erika Cione, Vincenza Dolce, Ada Donà, Maria Luisa Panno, Saveria Aquila

Pages: 568-576 Published online on: 08 October 2015
Open Access

Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF‑2α expression in lung cancer cells under normoxia and hypoxia

Arnoldo Aquino-Gálvez, Georgina González-Ávila, Javier Delgado-Tello, Manuel Castillejos-López, Criselda Mendoza-Milla, Joaquín Zúñiga, Marco Checa, Héctor Aquiles Maldonado-Martínez, Axel Trinidad-López, José Cisneros, Luz María Torres-Espíndola, Claudia Hernández-Jiménez, Bettina Sommer, Carlos Cabello-Gutiérrez, Luis H. Gutiérrez-González

Pages: 577-583 Published online on: 04 November 2015

Time-staggered inhibition of JNK effectively sensitizes chemoresistant ovarian cancer cells to cisplatin and paclitaxel

Manabu Seino, Masashi Okada, Hirotsugu Sakaki, Hiroyuki Takeda, Hikaru Watarai, Shuhei Suzuki, Shizuka Seino, Kenta Kuramoto, Tsuyoshi Ohta, Satoru Nagase, Hirohisa Kurachi, Chifumi Kitanaka

Pages: 593-601 Published online on: 02 November 2015
Open Access

[Corrigendum] Trastuzumab and docetaxel in a preclinical organotypic breast cancer model using tissue slices from mammary fat pad: Translational relevance

Loredana Vesci, Valeria Carollo, Giuseppe Roscilli, Luigi Aurisicchio, Fabiana Fosca Ferrara, Luigi Spagnoli, Rita De Santis

Pages: 602-602 Published online on: 26 October 2015
Journal Cover

January-2016
Volume 35 Issue 1

Print ISSN: 1021-335X
Online ISSN: 1791-2431

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