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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-2016 Volume 35 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

MicroRNAs are involved in cervical cancer development, progression, clinical outcome and improvement treatment response (Review)

Víctor González-Quintana, Lizbeth Palma-Berré, Alma D. Campos-Parra, Eduardo López‑Urrutia, Oscar Peralta-Zaragoza, Rafael Vazquez-Romo, Carlos Pérez-Plasencia
Pages: 3-12
Published online on: 30 October 2015

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Article Open Access

Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines

Puteri Baharuddin, Nazilah Satar, Kamal Shaik Fakiruddin, Norashikin Zakaria, Moon Nian Lim, Narazah Mohd Yusoff, Zubaidah Zakaria, Badrul Hisham Yahaya
Pages: 13-25
Published online on: 02 November 2015

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Article Open Access

Depletion of Cks1 and Cks2 expression compromises cell proliferation and enhance chemotherapy-induced apoptosis in HepG2 cells

Lingqing Lin, Zanxi Fang, Huayue Lin, Hanyu You, Jiajia Wang, Yuanhui Su, Fen Wang, Zhong‑Ying Zhang
Pages: 26-32
Published online on: 02 November 2015

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Article Open Access

Expansion of quiescent lung adenocarcinoma CD8+ T cells by MUC1-8-mer peptide-T2 cell-β2 microglobulin complexes

J. A. Atzin-Méndez, J. S. López-González, R. Báez, M. C. Arenas-Del Angel, L. F. Montaño, D. Silva-Adaya, R. Lascurain, P. Gorocica
Pages: 33-42
Published online on: 13 October 2015

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Article Open Access

Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo

Tao Hu, Pei Li, Zhongguang Luo, Xiaoyu Chen, Jingyang Zhang, Chunyao Wang, Ping Chen, Ziming Dong
Pages: 43-49
Published online on: 02 November 2015

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Article Open Access

Latexin exhibits tumor-suppressor potential in pancreatic ductal adenocarcinoma

Zhanxiong Xue, Yuhui Zhou, Cheng Wang, Jihang Zheng, Pu Zhang, Lingling Zhou, Liang Wu, Yunfeng Shan, Mengsi Ye, Yun He, Zhenzhai Cai
Pages: 50-58
Published online on: 27 October 2015

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Article

Suppressive effects of 3-bromopyruvate on the proliferation and the motility of hepatocellular carcinoma cells

Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige
Pages: 59-63
Published online on: 02 November 2015

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Article

Methylation-induced silencing of miR-34a enhances chemoresistance by directly upregulating ATG4B-induced autophagy through AMPK/mTOR pathway in prostate cancer

Haiqiu Liao, Yang Xiao, Yingbin Hu, Yangming Xiao, Zhaofa Yin, Liang Liu, Xiaopeng Kang, Yonggang Chen
Pages: 64-72
Published online on: 16 October 2015

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Article

MicroRNA-21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF-β pathways

Mingli Han, Fang Wang, Yuanting Gu, Xinhong Pei, Guangcheng Guo, Chao Yu, Lin Li, Mingzhi Zhu, Youyi Xiong, Yimeng Wang
Pages: 73-80
Published online on: 29 October 2015

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Article

TMPRSS3 modulates ovarian cancer cell proliferation, invasion and metastasis

Dan Zhang, Shuang Qiu, Qi Wang, Jianhua Zheng
Pages: 81-88
Published online on: 29 October 2015

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Article

Effects of lentivirus-mediated shRNA targeting integrin-linked kinase on oral squamous cell carcinoma in vitro and in vivo

Lin Que, Dan Zhao, Xiu-Fa Tang, Ji-Yuan Liu, Xiang-Yu Zhang, Yu-Hua Zhan, Lei Zhang
Pages: 89-98
Published online on: 02 November 2015

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Article

Effects of HPV-16 infection on hypopharyngeal squamous cell carcinoma and FaDu cells

Wuhao Lu, Long Feng, Ping Li, Yuanyuan Wang, Yuwen Du, Xiaonan Chen, Shujun Wu, Guoqiang Zhao, Weihua Lou
Pages: 99-106
Published online on: 20 October 2015

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Article

Lauric acid can improve the sensitization of Cetuximab in KRAS/BRAF mutated colorectal cancer cells by retrievable microRNA-378 expression

Wen-Hui Weng, Wai-Hung Leung, Yeu-Jye Pang, Hsi-Hsien Hsu
Pages: 107-116
Published online on: 19 October 2015

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Article

The natural compound codonolactone attenuates TGF-β1-mediated epithelial-to-mesenchymal transition and motility of breast cancer cells

Jianjiang Fu, Xiaoqin Ke, Songlin Tan, Ting Liu, Shan Wang, Junchao Ma, Hong Lu
Pages: 117-126
Published online on: 04 November 2015

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Article

The MRTF-A/B function as oncogenes in pancreatic cancer

Zhao Song, Zhao Liu, Jing Sun, Feng-Lei Sun, Chuan-Zhi Li, Jiu-Zheng Sun, Li-You Xu
Pages: 127-138
Published online on: 15 October 2015

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Article

Promoter hypermethylation of PTPL1, PTPN6, DAPK, p16 and 5-azacitidine inhibits growth in DLBCL

Wenming Wang, Jing Wang, Zhengqian Li, Mingxia Zhu, Zhe Zhang, Yanfang Wang, Hongmei Jing
Pages: 139-146
Published online on: 26 October 2015

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Article

Multidrug resistance-associated protein 4 is a determinant of arsenite resistance

Bo Yuan, Yuta Yoshino, Hisayo Fukushima, Svetlana Markova, Norio Takagi, Hiroo Toyoda, Deanna L. Kroetz
Pages: 147-154
Published online on: 22 October 2015

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Article

Significance of DEK overexpression for the prognostic evaluation of non-small cell lung carcinoma

Xin Liu, Dongdong Qi, Jujie Qi, Zeshu Mao, Xiangdan Li, Jinhui Zhang, Jinzi Li, Wenbin Gao
Pages: 155-162
Published online on: 30 October 2015

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Article

Recombinant HE4 protein promotes proliferation of pancreatic and endometrial cancer cell lines

Qinsheng Lu, Haibin Chen, Christopher Senkowski, Jianhao Wang, Xue Wang, Steven Brower, Wayne Glasgow, David Byck, Shi-Wen Jiang, Jinping Li
Pages: 163-170
Published online on: 20 October 2015

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Article

Construction of human single-chain variable fragment antibodies of medullary thyroid carcinoma and single photon emission computed tomography/computed tomography imaging in tumor-bearing nude mice

Qiong Liu, Hua Pang, Xiaoli Hu, Wenbo Li, Jimei Xi, Lu Xu, Jing Zhou
Pages: 171-178
Published online on: 23 October 2015

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Article

Platelet-activating factor promotes motility in breast cancer cells and disrupts non-transformed breast acinar structures

V. Libi Anandi, K. A. Ashiq, K. Nitheesh, M. Lahiri
Pages: 179-188
Published online on: 03 November 2015

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Article

The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway

Xiuying Ma, Deqing Wu, Shu Zhou, Feng Wan, Hua Liu, Xiaorong Xu, Xuanfu Xu, Yan Zhao, Maochun Tang
Pages: 189-196
Published online on: 29 October 2015

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Article

Imatinib mesylate induces mitochondria-dependent apoptosis and inhibits invasion of human pigmented villonodular synovitis fibroblast-like synovial cells

Kang Chen, Qiao Ren, Xiao-Rui Han, Xiao-Nan Zhang, Bo Wei, Xi-Zhuang Bai
Pages: 197-204
Published online on: 26 October 2015

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Article

Nicotine enhances invasion and metastasis of human colorectal cancer cells through the nicotinic acetylcholine receptor downstream p38 MAPK signaling pathway

Tao Xiang, Rushan Fei, Zhe Wang, Zhonglei Shen, Jing Qian, Wenbin Chen
Pages: 205-210
Published online on: 30 October 2015

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Article

Identification of the metastasis potential and its associated genes in melanoma multinucleated giant cells using the PHA-ECM830 fusion method

Ruifang Mi, Chunxiao Pan, Yiqiang Zhou, Yuanbo Liu, Guishan Jin, Fusheng Liu
Pages: 211-218
Published online on: 02 November 2015

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Article

The differentiation of hMSCs counteracts their migration capability and pro‑angiogenic effects in vitro

A. Scherzed, S. Hackenberg, K. Froelich, K. Rak, P. Schendzielorz, T. Gehrke, R. Hagen, N. Kleinsasser
Pages: 219-226
Published online on: 03 November 2015

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Article

β-elemonic acid inhibits the cell proliferation of human lung adenocarcinoma A549 cells: The role of MAPK, ROS activation and glutathione depletion

Tsu‑Tuan Wu, Chien‑Lin Lu, Hen‑I Lin, Bing‑Fang Chen, Guey‑Mei Jow
Pages: 227-234
Published online on: 30 October 2015

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Article

Sirtuin inhibitors, EX527 and AGK2, suppress cell migration by inhibiting HSF1 protein stability

Hyun-Woo Kim, Soo -A Kim, Sang-Gun Ahn
Pages: 235-242
Published online on: 02 November 2015

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Article

Adenovirus-mediated p53 and ING4 gene co‑transfer elicits synergistic antitumor effects through enhancement of p53 acetylation in breast cancer

Jie Wu, Yanbo Zhu, Chun Xu, Hong Xu, Xiumin Zhou, Jicheng Yang, Yufeng Xie, Min Tao
Pages: 243-252
Published online on: 03 November 2015

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Article

Impact of KITENIN on tumor angiogenesis and lymphangiogenesis in colorectal cancer

Hyung-Hoon Oh, Kang-Jin Park, Nuri Kim, Sun-Young Park, Young‑Lan Park, Chan-Young Oak, Dae-Seong Myung, Sung-Bum Cho, Wan‑Sik Lee, Kyung-Keun Kim, Young-Eun Joo
Pages: 253-260
Published online on: 20 October 2015

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Article

Snail-induced EMT promotes cancer stem cell-like properties in head and neck cancer cells

Ichiro Ota, Takashi Masui, Miyako Kurihara, Jong-In Yook, Shinji Mikami, Takahiro Kimura, Keiji Shimada, Noboru Konishi, Katsunari Yane, Toshiaki Yamanaka, Tadashi Kitahara
Pages: 261-266
Published online on: 26 October 2015

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Article

Type III TGF-β receptor inhibits cell proliferation and migration in salivary glands adenoid cystic carcinoma by suppressing NF-κB signaling

Dongyang Xu, Duo Li, Zhiyong Lu, Xingli Dong, Xiaofeng Wang
Pages: 267-274
Published online on: 03 November 2015

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Article

miR-146b-5p promotes invasion and metastasis contributing to chemoresistance in osteosarcoma by targeting zinc and ring finger 3

Enjie Xu, Jianquan Zhao, Jun Ma, Ce Wang, Chenglin Zhang, Heng Jiang, Jianyang Cheng, Rui Gao, Xuhui Zhou
Pages: 275-283
Published online on: 04 November 2015

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Article

miR-124 suppresses the migration and invasion of glioma cells in vitro via Capn4

Jia-Jun Cai, Zeng-Xin Qi, Ling-Chao Chen, Yu Yao, Yan Gong, Ying Mao
Pages: 284-290
Published online on: 27 October 2015

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Article

Gallic acid, a phenolic compound, exerts anti-angiogenic effects via the PTEN/AKT/HIF-1α/VEGF signaling pathway in ovarian cancer cells

Zhiping He, Allen Y. Chen, Yon Rojanasakul, Gary O. Rankin, Yi Charlie Chen
Pages: 291-297
Published online on: 27 October 2015

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Article

Correlation between the promoter methylation status of ATP-binding cassette sub-family G member 2 and drug sensitivity in colorectal cancer cell lines

Hyun‑Hye Moon, Sung‑Hee Kim, Ja‑Lok Ku
Pages: 298-306
Published online on: 21 October 2015

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Article

Resolvin D1 and E1 alleviate the progress of hepatitis toward liver cancer in long-term concanavalin A-induced mice through inhibition of NF-κB activity

Haoyu Kuang, Xiaoli Hua, Jianhui Zhou, Rui Yang
Pages: 307-317
Published online on: 03 November 2015

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Article

Upregulation of long non-coding RNA PRNCR1 in colorectal cancer promotes cell proliferation and cell cycle progression

Liu Yang, Mantang Qiu, Youtao Xu, Jie Wang, Yanyan Zheng, Ming Li, Lin Xu, Rong Yin
Pages: 318-324
Published online on: 30 October 2015

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Article

Comparison of human gut microbiota in control subjects and patients with colorectal carcinoma in adenoma: Terminal restriction fragment length polymorphism and next-generation sequencing analyses

Chika Kasai, Kazushi Sugimoto, Isao Moritani, Junichiro Tanaka, Yumi Oya, Hidekazu Inoue, Masahiko Tameda, Katsuya Shiraki, Masaaki Ito, Yoshiyuki Takei, Kojiro Takase
Pages: 325-333
Published online on: 04 November 2015

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Article

Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy

Xiu-Wu Pan, Lin Li, Yi Huang, Hai Huang, Dan-Feng Xu, Yi Gao, Lu Chen, Ji-Zhong Ren, Jian-Wei Cao, Yi Hong, Xin-Gang Cui
Pages: 334-342
Published online on: 16 October 2015

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Article

Resveratrol sensitizes glioblastoma-initiating cells to temozolomide by inducing cell apoptosis and promoting differentiation

Hao Li, Yaodong Liu, Yumin Jiao, Anchen Guo, Xiaoxue Xu, Xianjun Qu, Shuo Wang, Jizong Zhao, Ye Li, Yong Cao
Pages: 343-351
Published online on: 23 October 2015

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Article

Jumonji domain containing 2A predicts prognosis and regulates cell growth in lung cancer depending on miR-150

Weihua Xu, Kanqiu Jiang, Mingjing Shen, Yongbing Chen, Hao-Yue Huang
Pages: 352-358
Published online on: 26 October 2015

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Article

TCEB2 confers resistance to VEGF‑targeted therapy in ovarian cancer

Zhuo Deng, Jiancheng Zhou, Xi Han, Xu Li
Pages: 359-365
Published online on: 03 November 2015

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Article

MicroRNA-616 promotes the migration, invasion and epithelial-mesenchymal transition of HCC by targeting PTEN

Di Zhang, Peihua Zhou, Wei Wang, Xiaolong Wang, Junhui Li, Xuejun Sun, Li Zhang
Pages: 366-374
Published online on: 16 October 2015

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Article

Matrine inhibits the proliferation, invasion and migration of castration-resistant prostate cancer cells through regulation of the NF-κB signaling pathway

Qi Li, Yiming Lai, Chengbin Wang, Guibin Xu, Zheng He, Xiaohong Shang, Yi Sun, Fan Zhang, Leyuan Liu, Hai Huang
Pages: 375-381
Published online on: 21 October 2015

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Article

Selecting molecular therapeutic drug targets based on the expression profiles of intrahepatic cholangiocarcinomas and miRNA-mRNA regulatory networks

Boshi Sun, Changming Xie, Tongsen Zheng, Dalong Yin, Jiabei Wang, Yingjian Liang, Yuejin Li, Guangchao Yang, Huawen Shi, Tiemin Pei, Jihua Han, Lianxin Liu
Pages: 382-390
Published online on: 15 October 2015

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Article

Clinical significance of Gremlin 1 in cervical cancer and its effects on cancer stem cell maintenance

Masakazu Sato, Kei Kawana, Asaha Fujimoto, Mitsuyo Yoshida, Hiroe Nakamura, Haruka Nishida, Tomoko Inoue, Ayumi Taguchi, Juri Takahashi, Katsuyuki Adachi, Kazunori Nagasaka, Yoko Matsumoto, Osamu Wada‑Hiraike, Katsutoshi Oda, Yutaka Osuga, Tomoyuki Fujii
Pages: 391-397
Published online on: 30 October 2015

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Article

miRNA expression profile of vulvar squamous cell carcinoma and identification of the oncogenic role of miR-590-5p

Xiuhua Yang, Xin Wu
Pages: 398-408
Published online on: 22 October 2015

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Article

Paxillin is positively correlated with the clinicopathological factors of colorectal cancer, and knockdown of Paxillin improves sensitivity to cetuximab in colorectal cancer cells

Chuang Du, Xin Wang, Junling Zhang, Xiangzheng Liu, Jing Zhu, Yucun Liu
Pages: 409-417
Published online on: 27 October 2015

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Article

Cell motility and spreading promoted by CEACAM6 through cyclin D1/CDK4 in human pancreatic carcinoma

Lu Yan, Yuan Wang, Zhi-Zhi Wang, Yan-Ting Rong, Lin-Lin Chen, Qian Li, Ting Liu, Yong-Heng Chen, Yan-Dong Li, Zhao-Hong Huang, Jie Peng
Pages: 418-426
Published online on: 20 October 2015

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Article

Schwann cells promote EMT and the Schwann-like differentiation of salivary adenoid cystic carcinoma cells via the BDNF/TrkB axis

Chun Shan, Jianhua Wei, Rui Hou, Baolei Wu, Zihui Yang, Lei Wang, Delin Lei, Xinjie Yang
Pages: 427-435
Published online on: 30 October 2015

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Article

The clinical significance of transforming acidic coiled-coil protein 3 expression in non-small cell lung cancer

Feng Jiang, Bohua Kuang, Yi Que, Zhirui Lin, Li Yuan, Wei Xiao, Ruiqing Peng, Xiaoshi Zhang, Xing Zhang
Pages: 436-446
Published online on: 02 November 2015

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Article

Fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung cancer cells by the P53 signaling pathway

Guangwei Zhong, Xi Chen, Xia Fang, Dongsheng Wang, Mingxuan Xie, Qiong Chen
Pages: 447-453
Published online on: 04 November 2015

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Article

Biomarker triplet NAMPT/VEGF/HER2 as a de novo detection panel for the diagnosis and prognosis of human breast cancer

Yanyan Zhu, Meiyan Guo, Lingyun Zhang, Tao Xu, Li Wang, Guoxiong Xu
Pages: 454-462
Published online on: 03 November 2015

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Article

Esophageal squamous cell carcinoma cell proliferation induced by exposure to low concentration of cigarette smoke extract is mediated via targeting miR-101-3p/COX-2 pathway

Jian Gong, Yi Chu, Meili Xu, Jirong Huo, Liang Lv
Pages: 463-471
Published online on: 02 November 2015

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Article

Resveratrol induces cell cycle arrest in human gastric cancer MGC803 cells via the PTEN‑regulated PI3K/Akt signaling pathway

Xiaoping Jing, Weiwei Cheng, Shiying Wang, Pin Li, Li He
Pages: 472-478
Published online on: 03 November 2015

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Article

Knockdown of long non-coding RNA HOTAIR inhibits proliferation and invasiveness and improves radiosensitivity in colorectal cancer

Xiao-Dong Yang, Hong-Tao Xu, Xiao-Hui Xu, Gan Ru, Wei Liu, Jun-Jia Zhu, Yong-You Wu, Kui Zhao, Yong Wu, Chun-Gen Xing, Shu-Yu Zhang, Jian-Ping Cao, Ming Li
Pages: 479-487
Published online on: 04 November 2015

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Article

PBOV1 correlates with progression of ovarian cancer and inhibits proliferation of ovarian cancer cells

Lan Wang, Chun-Hao Niu, Shu Wu, Hong-Mei Wu, Fei Ouyang, Mian He, Shan-Yang He
Pages: 488-496
Published online on: 04 November 2015

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Article

miR-296-5p suppresses cell viability by directly targeting PLK1 in non-small cell lung cancer

Chun Xu, Sen Li, Tengfei Chen, Haibo Hu, Cheng Ding, Zhenlei Xu, Jun Chen, Zeyi Liu, Zhe Lei, Hong-Tao Zhang, Chang Li, Jun Zhao
Pages: 497-503
Published online on: 04 November 2015

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Article

n-3 polyunsaturated fatty acids reverse the development of polyps in ApcMin/+ transgenic mice

Maria Notarnicola, Valeria Tutino, Maria Gabriella Caruso, Antonio Francavilla
Pages: 504-510
Published online on: 29 October 2015

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Pien Tze Huang inhibits the proliferation, and induces the apoptosis and differentiation of colorectal cancer stem cells via suppression of the Notch1 pathway

Fei Qi, Lihui Wei, Aling Shen, Youqin Chen, Jiumao Lin, Jianfeng Chu, Qiaoyan Cai, Jie Pan, Jun Peng
Pages: 511-517
Published online on: 02 November 2015

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A positive feedback loop of p53/miR-19/TP53INP1 modulates pancreatic cancer cell proliferation and apoptosis

Xiaofang Wang, Lei Wang, Qingjiang Mo, Ankui Jia, Yuqian Dong, Guoqiang Wang
Pages: 518-523
Published online on: 30 October 2015

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Article

Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, Sirt1

Ju-Hee Lee, Jin-Shang Kim, Sang-Youel Park, You-Jin Lee
Pages: 524-529
Published online on: 16 October 2015

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Article

Ezrin-radixin-moesin-binding phosphoprotein-50 regulates EGF-induced AKT activation through interaction with EGFR and PTEN

Junfang Zheng, Yuanping Dai, Zhiyu Yang, Longyan Yang, Zhiqiang Peng, Ran Meng, Ying Xiong, Junqi He
Pages: 530-537
Published online on: 02 November 2015

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Article

Human chorionic gonadotropin β subunit affects the expression of apoptosis-regulating factors in ovarian cancer

Anna Szczerba, Aleksandra Śliwa, Marta Kubiczak, Ewa Nowak-Markwitz, Anna Jankowska
Pages: 538-545
Published online on: 03 November 2015

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Article

Auranofin induces mesothelioma cell death through oxidative stress and GSH depletion

Bo Ra You, Woo Hyun Park
Pages: 546-551
Published online on: 02 November 2015

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Article

Klotho inhibits human follicular thyroid cancer cell growth and promotes apoptosis through regulation of the expression of stanniocalcin-1

Dong Dai, Qi Wang, Xiaofeng Li, Jianjing Liu, Xiaoying Ma, Wengui Xu
Pages: 552-558
Published online on: 29 October 2015

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Article

MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma Retraction in /10.3892/or.2021.8194

Shoulin Zhang, Dongmei Zhang, Chunguang Yi, Yinping Wang, Hongan Wang, Jian Wang
Pages: 559-567
Published online on: 16 October 2015

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Article

Bergapten induces metabolic reprogramming in breast cancer cells

Marta Santoro, Carmela Guido, Francesca De Amicis, Diego Sisci, Erika Cione, Vincenza Dolce, Ada Donà, Maria Luisa Panno, Saveria Aquila
Pages: 568-576
Published online on: 08 October 2015

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Article Open Access

Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF‑2α expression in lung cancer cells under normoxia and hypoxia

Arnoldo Aquino-Gálvez, Georgina González-Ávila, Javier Delgado-Tello, Manuel Castillejos-López, Criselda Mendoza-Milla, Joaquín Zúñiga, Marco Checa, Héctor Aquiles Maldonado-Martínez, Axel Trinidad-López, José Cisneros, Luz María Torres-Espíndola, Claudia Hernández-Jiménez, Bettina Sommer, Carlos Cabello-Gutiérrez, Luis H. Gutiérrez-González
Pages: 577-583
Published online on: 04 November 2015

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Article

Overexpression of lysine-specific demethylase 1 promotes androgen-independent transition of human prostate cancer LNCaP cells through activation of the AR signaling pathway and suppression of the p53 signaling pathway

Xuechao Li, Tao Li, Dehong Chen, Peng Zhang, Yarong Song, Hongxue Zhu, Yajun Xiao, Yifei Xing
Pages: 584-592
Published online on: 30 October 2015

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Article

Time-staggered inhibition of JNK effectively sensitizes chemoresistant ovarian cancer cells to cisplatin and paclitaxel

Manabu Seino, Masashi Okada, Hirotsugu Sakaki, Hiroyuki Takeda, Hikaru Watarai, Shuhei Suzuki, Shizuka Seino, Kenta Kuramoto, Tsuyoshi Ohta, Satoru Nagase, Hirohisa Kurachi, Chifumi Kitanaka
Pages: 593-601
Published online on: 02 November 2015

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Correction Open Access

[Corrigendum] Trastuzumab and docetaxel in a preclinical organotypic breast cancer model using tissue slices from mammary fat pad: Translational relevance

Loredana Vesci, Valeria Carollo, Giuseppe Roscilli, Luigi Aurisicchio, Fabiana Fosca Ferrara, Luigi Spagnoli, Rita De Santis
Pages: 602-602
Published online on: 26 October 2015

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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